[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acl-reconstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acl-reconstruction":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,48,79,104,132,160,182,205,241,262,289,314,341,366,395,416],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644340","effects-of-blood-flow-restriction-training-and-instrument-assisted-soft-tissue-mobilization-for-pain-strength-range-of-motion-and-kinesiophobia-among-acl-reconstruction-patients-100644340",false,"NCT07662850","Effects of Blood Flow Restriction Training and Instrument-Assisted Soft Tissue Mobilization for Pain, Strength, Range of Motion, and Kinesiophobia Among ACL Reconstruction Patients.","Inclusion Criteria:\n\n* Age between 18 and 40 years.\n* Both genders.\n* Undergoing Primary Unilateral ACLR (using autologous tendon graft).\n* Medically cleared for low load rehabilitation (Wound healed, stable graft per surgeon).\n* Active knee flexion of ≥100° on the operative limb.\n* 8-16 weeks after reconstructive surgery.\n* Willing to comply with all rehabilitation sessions and follow up assessments; give informed consent\n\nExclusion Criteria:\n\n* Significant meniscectomy requiring protected weight-bearing\n* Active DVT, vascular disease, uncontrolled hypertension or other BFR contraindications\n* Patients exhibiting extension lag (inability to achieve full active knee extension) on the operated limb.\n* Neuromuscular disorders\n* Skin lesions preventing IASTM\n* Pregnancy\n* Contraindications to exercise","ALL","18 Years","40 Years",{"count":19,"type":20},46,"ESTIMATED","INTERVENTIONAL",[23],"NA","This randomized clinical trial aims to compare the effects of Blood Flow Restriction Training (BFR) and Instrument-Assisted Soft Tissue Mobilization (IASTM) on pain, quadriceps muscle strength, knee range of motion (ROM), and kinesiophobia in patients following anterior cruciate ligament reconstruction (ACLR). ACLR patients commonly experience persistent muscle weakness, limited ROM, pain, and fear of movement, which can delay functional recovery and return to activity. A total of 46 participants (8-16 weeks post-ACLR) will be randomly allocated into two groups: a BFR group and an IASTM group. Both groups will receive interventions twice weekly for 8 weeks alongside standard physiotherapy. The BFR group will perform low-load resistance exercises under controlled vascular occlusion, while the IASTM group will receive soft tissue mobilization using specialized instruments combined with conventional rehabilitation. Outcome measures will include quadriceps strength (handheld dynamometer), pain (Numeric Pain Rating Scale), knee ROM (goniometer), and kinesiophobia (Tampa Scale of Kinesiophobia), assessed at baseline and post-intervention. The study aims to determine which intervention provides superior improvements in physical and psychological outcomes during early rehabilitation after ACL reconstruction.",[26],"ACL Reconstruction",[28,29,30,31,32,33,34],"Anterior Cruciate Ligament Reconstruction","Blood Flow Restriction Training","Instrument-Assisted Soft Tissue Mobilization","Quadriceps Strength","Range Of Motion","Pain","Kinesiophobia","RECRUITING","2026-06-25",{"date":38,"type":39},"2026-06-29","ACTUAL",{"date":41,"type":20},"2026-06-12",{"date":43,"type":20},"2026-11-20",{"name":45,"class":46},"Lahore University of Biological and Applied Sciences","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":15,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":47},"100638015","phase-4-methylprednisolone-addition-to-multimodal-pain-regimens-after-anterior-cruciate-ligament-reconstruction-100638015","NCT07605923","Methylprednisolone Addition to Multimodal Pain Regimens After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* aged 14-65\n* undergoing ACL Reconstruction.\n\nExclusion Criteria:\n\n* contraindications to corticosteroids","14 Years","65 Years",{"count":57,"type":20},64,[59],"PHASE4","Patients who are being seen for ACL tears will be approached in the UAB Orthopedic Clinic. Included patients will be those aged 14-65 undergoing ACL Reconstruction. Excluded patients will be those with contraindications to corticosteroids. If the patient meets the criteria and agrees to participate, then the consent form will be signed, and the patient will be enrolled. Enrolled patients will be randomized to one of two groups. Patients in the treatment group will receive a 4 mg oral 6-day methylprednisolone taper in addition to standard post-operative pain control. Patients in the control group will receive standard post-operative pain control. All patients will receive the surgeon's standard ACL postoperative multimodal pain regimen. Endpoints will include narcotic consumption assessed daily and at one week post-op through a patient self-reported diary. The VAS pain score will be collected each day for the first week. Secondary endpoints will include range of motion and patient-reported outcomes, including IKDC, KOOS Jr, Tegner Activity Scale, ACL-RSI, and PROMIS Global collected at baseline, 2 weeks, 6 weeks and 3 months. All outcomes will be collected through PatientIQ.",[26],[63,64,65,66,67,68],"ACL","Anterior Cruciate ligament reconstruction","postoperative pain","corticosteroid taper","methylprednisolone taper","multimodal pain protocol","NOT_YET_RECRUITING","2026-05-18",{"date":72,"type":39},"2026-05-26",{"date":74,"type":20},"2026-09",{"date":76,"type":20},"2031-08",{"name":78,"class":46},"University of Alabama at Birmingham",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":47},"100596746","clinical-and-biomechanical-outcomes-of-anterior-cruciate-ligament-acl-reconstruction-associated-with-lateral-extra-articular-tenodesis-let-100596746","NCT07049484","Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET)","Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET): a Short-term Prospective Arthrometric Study","LETOTT","Inclusion Criteria:\n\n* Patients undergoing isolated ACL reconstruction using gracilis and semitendinosus tendons with the over-the-top technique and LET.\n* Both male and female patients.\n* Patients who have given consent to participate in the study.\n* Age between 18 and 50 years at the time of surgery.\n\nExclusion Criteria:\n\n* Previous surgery on the same limb (meniscectomy, prior ACL reconstruction, displaced fractures).\n* Surgical technique different from Over-the-Top with LET using autologous gracilis and semitendinosus tendons.\n* Other concomitant ligament injuries requiring surgical treatment.\n* Patients undergoing additional procedures at the same time as ACL reconstruction and LET (e.g., concomitant osteotomy, meniscus transplant, cartilage procedure…).\n* Patients who did not provide informed consent.","50 Years",{"count":89,"type":20},51,"OBSERVATIONAL","The anterior cruciate ligament (ACL) is one of the main stabilizers of the knee joint, and its injury is among the most common soft tissue injuries of the knee. Several surgical reconstruction techniques are available, utilizing various tissues as a graft for the neo-ligament, including both autografts and allografts.\n\nThe \"Over-the-top single-bundle technique with gracilis and semitendinosus tendons combined with lateral extra-articular tenodesis (LET)\" was developed in 1998 by Prof. Marcacci and Prof. Zaffagnini, and it is still the preferred method for ACL reconstruction at the Second Clinic of the Rizzoli Orthopaedic Institute.\n\nCadaveric biomechanical studies have shown that combining LET with ACL reconstruction improves knee joint stability in both the anteroposterior and rotational planes. However, a recent in vivo study has challenged this hypothesis, showing that in patients undergoing surgery, the addition of LET enhances knee stability only in the anteroposterior direction and only for a limited period of six months. At twelve months postoperatively, joint laxity appeared similar to that of patients who did not undergo the additional procedure. Furthermore, the same study did not assess rotational instability using the pivot-shift test, an essential parameter as it is closely linked to knee stability and the patient's subjective perception of surgical success.\n\nDespite the increasing use of LET in conjunction with ACL reconstruction, few studies have analyzed the short-term postoperative effects of lateral extra-articular tenodesis and its potential benefits during the early stages of rehabilitation and return to sport.\n\nThis study was conceived in response to this clinical question, with the goal of evaluating anteroposterior and rotational laxity in a group of patients who underwent ACL reconstruction combined with LET, in order to analyze clinical outcomes and, most importantly, any changes in stability during the early postoperative period.\n\nThe results aim to improve understanding of knee stability in the initial phase following surgery, providing valuable information for rehabilitation teams to optimize recovery protocols and more effectively guide return-to-sport decisions for patients undergoing both procedures.",[26,93,94],"Tenodesis","ACL Injuries","2026-04-21",{"date":97,"type":39},"2026-04-22",{"date":99,"type":39},"2026-03-24",{"date":101,"type":20},"2029-06",{"name":103,"class":46},"Stefano Zaffagnini",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":15,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":21,"phases":115,"briefSummary":116,"conditions":117,"keywords":118,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":47},"100629573","readiness-outcomes-affecting-return-to-sport-30-100629573","NCT07476430","Readiness Outcomes Affecting Return to Sport 3.0","ROAR 3","Inclusion Criteria:\n\n* Diagnosis of a complete ACL tear\n* Undergoing ACL reconstruction at Boston Children's Hospital by a study-participating surgeon\n* Age at time of surgery between 8 and \\\u003C=25\n* English-speaking patient\n\nExclusion Criteria:\n\n* Previous ACL tear\n* Torn MCL, LCL, or PCL that require reconstruction in addition to ACL\n* Non-English speaking patient\u002Ffamily\n* Lack of intention to return to sports\u002Fsporting activities","8 Years","25 Years",{"count":114,"type":20},130,[23],"The primary aim is to determine if MST will improve coping skills in young athletes returning to sport after ACLR as measured by ACSI-28. Participants will undergo MST led by masters-level mental skills specialist pre-operatively, 3 months, 6 months, and 9 months post-operatively. Power analysis suggested at least 52 pairs are needed (α=0.05, β=0.80). There will be 65 patients enrolled in both the MST group and the control group (no MST) for a total of 130 patients. This will allow for a 4-point difference in ACSI and a 20% dropout rate.\n\nThe secondary aim is to determine if MST will improve psychological readiness and athletic identity as well as decrease psychological stress, anxiety, depression, and PTSD symptoms of young athletes returning to sport after ACLR as measured by ACL-RSI, AIMS, PROMIS-PSE, GAD-7, PHQ-9, and CRIES, respectively.",[26],[119,120,121,122],"psychological readiness","mental skills training","pediatric","adolescent","2026-03-12",{"date":125,"type":39},"2026-03-17",{"date":127,"type":20},"2026-06-01",{"date":129,"type":20},"2028-06-01",{"name":131,"class":46},"Boston Children's Hospital",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":87,"enrollmentInfo":139,"targetDuration":4,"studyType":21,"phases":141,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":47},"100629108","phase-2-comparison-of-functional-outcomes-following-arthroscopic-acl-reconstruction-with-peroneus-longus-autograft-with-and-without-intra-articular-platelet-rich-plasma-injection-100629108","NCT07470359","Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection.","Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection: A Randomized Controlled Trial","Inclusion Criteria: Age between 18 and 50 years. Diagnosis of a primary, complete ACL tear requiring reconstruction. Willingness to undergo arthroscopic ACL reconstruction with peroneus longus autograft.\n\nActive individuals participating in sports or regular physical activity. Willingness to provide informed consent and adhere to the study protocol, including follow-up visits and rehabilitation.\n\nAbility to understand and complete study questionnaires. - Exclusion Criteria: Previous knee surgery on the affected limb. Concomitant ligamentous injuries requiring additional reconstruction (e.g., PCL, MCL, LCL Grade III).\n\nSignificant chondral damage (Outerbridge grade \\> 2 on pre-operative MRI or intra-operative assessment).\n\nPre-existing knee osteoarthritis (Kellgren-Lawrence grade \\> 2). Systemic inflammatory conditions (e.g., rheumatoid arthritis). Bleeding disorders or coagulopathies. Current use of anticoagulants. Corticosteroid injection into the knee within 6 weeks prior to surgery. Pregnancy or lactation. Inability to comply with the rehabilitation protocol. Infection or history of infection in the affected knee. History of previous contralateral ACL injury (to isolate primary injury outcomes).\n\n\\-",{"count":140,"type":20},60,[142],"PHASE2","This prospective RCT investigates if a single 4 ml intra-articular PRP injection improves knee function after ACL reconstruction using peroneus longus autograft. In Pakistan's resource-limited context, 88 patients (18-50 years) with isolated ACL tears receive either PRP or saline during surgery, then randomized equally. KOOS4 scores compared at 3, 6, and 12 months via ANCOVA (adjusted baseline, α=0.05). Positive results could establish affordable enhancement for recovery and guide practice in similar settings.",[26,145,146],"Intraarticular Injection","PRP",[148,149],"Anterior Cruciate Ligament, ACL Reconstruction, Peroneus Longus Autograft, Platelet-Rich Plasma, Intra-articular Injection","Randomized Controlled Trial, KOOS4 Score, Functional Outcomes, Graft Healing, Resource-Limited Settings","2026-03-10",{"date":152,"type":39},"2026-03-13",{"date":154,"type":39},"2026-02-20",{"date":156,"type":20},"2027-11-30",{"name":158,"class":159},"Lahore General Hospital","OTHER_GOV",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":167,"enrollmentInfo":168,"targetDuration":4,"studyType":21,"phases":170,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":47},"100557791","effect-of-internal-brace-on-outcomes-following-acl-reconstruction-with-btb-autograft-100557791","NCT06542705","Effect of Internal Brace on Outcomes Following ACL Reconstruction With BTB Autograft","Effect of Internal Brace on Outcomes Following ACL Reconstruction With Bone Patellar Bone (BTB) Autograft: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients undergoing ACLR with BTB autograft\n* Patients ages 18-35, inclusive\n* Ability to undergo standard rehab protocol and full, painless range of motion at the time of surgery of their operative knee\n\nExclusion Criteria:\n\n* Osteoarthritis defined by Kellgren-Lawrence grade 2 or higher on preoperative weightbearing radiographs\n* Significant chondral injury as defined by grade 3-4 lesion greater than 2cm2\n* History of autoimmune or inflammatory disease\n* Prior ipsilateral knee ligament surgery or multi-ligament knee injury\n* Concomitant Lateral extra-articular tenodesis (LET) procedure\n* History of contralateral ACL surgery\n* Younger than 18 years of age\n* Older than 35 years of age","35 Years",{"count":169,"type":20},90,[23],"The purpose of this study is to assess Anterior Cruciate Ligament (ACL) healing through analyzing clinical, radiographic, functional and patient-reported outcomes following ACL reconstruction with bone-tendon-bone autograft with and without internal bracing.",[26],"2026-03-03",{"date":175,"type":39},"2026-03-05",{"date":177,"type":39},"2025-03-17",{"date":179,"type":20},"2029-03",{"name":181,"class":46},"NYU Langone Health",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":87,"enrollmentInfo":190,"targetDuration":4,"studyType":21,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":204},"100561950","personalized-digital-training-intervention-to-reduce-inflammation-by-correcting-pathological-movement-patterns-in-pre-stage-knee-osteoarthritis-after-anterior-cruciate-ligament-reconstruction-100561950","NCT06596824","Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction","Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis (OA)","PROTO-WP4","Inclusion Criteria:\n\n* Signed written informed consent\n* Adult subjects between 18 to 50 years old at the time of screening\n* Primary ACL reconstruction within a maximum of 6 months after a unilateral ACL injury\n* Complete baseline assessment between 8 and 12 weeks after ACL reconstruction\n\nExclusion Criteria:\n\n* Significant trauma to a weight-bearing joint within 12 months prior to study initiation (excluding the ACL injury)\n* Previous surgeries on the study knee (except for the ACL reconstruction)\n* Signs of knee OA as defined by the OARSI-Joint Space Narrowing (JSN) Score of two or more (standing AP x-ray)\n* Physical activity level: Tegner activity score before injury of 0-2 (very low activity) or 8-10 (very high activity)\n* Body mass index ≥ 30 kg\u002Fm2;\n* Inflammatory arthropathies;\n* Immunosuppression due to illness or medication;\n* Sepsis or hemostasis disorders;\n* Severe uncontrolled inflammatory disease or autoimmune disease (e.g., ulcerative colitis, Crohn's disease, etc.);\n* Having malignancy and undergoing treatment including chemotherapy, radiotherapy, or immunotherapy;\n* Contraindications for MRI, including pacemakers, defibrillators, metal implants, pregnancy, sensorineural hearing loss above 30 dB, tinnitus and claustrophobia\n* Unable to freely give their informed consent (e.g., individuals under legal guardianship).\n* Currently enrolled in or has not yet completed a period of at least 5 times as the half-life time of the drug used in the previous trial since ending other investigational device or drug trial(s)\n* Patients who are dependent on the sponsor, investigator, or study site;\n* Pregnant or breast-feeding women or women of childbearing potential not protected by an effective contraceptive method of birth control (defined as pearl index \\\u003C 1);\n* Any form of substance abuse, psychiatric disorder, or other condition that, in the opinion of the Investigator, may invalidate communication with the Investigator and\u002For designated study personnel;\n* Patients who are committed to an institution by virtue of an order issued by either the judicial or the administrative authorities;",{"count":140,"type":20},[23],"Osteoarthritis (OA) is a condition that causes pain and stiffness in the joints, often due to injuries like torn ligaments. Even after surgery, these injuries can lead to long-term joint problems. Current treatments don\\'t fully prevent OA from developing. This study is testing a new 12-week exercise program designed to improve how the knee moves, using a special sensor-based system. The goal is to reduce joint inflammation and prevent the development of OA in patients who have had knee surgery.",[194,26],"Osteoarthritis (OA) of the Knee","2026-02-27",{"date":197,"type":39},"2026-03-02",{"date":199,"type":39},"2024-09-01",{"date":201,"type":20},"2027-12-31",{"name":203,"class":46},"Charite University, Berlin, Germany",2,{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":212,"sex":15,"minAge":16,"maxAge":167,"enrollmentInfo":213,"targetDuration":4,"studyType":21,"phases":214,"briefSummary":215,"conditions":216,"keywords":218,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":4},"100622527","isokinetic-exercise-combined-with-blood-flow-restriction-high-load-vs-low-load-training-100622527","NCT07384780","Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training","Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training : A Randomized Controlled Trial in Post-ACL Reconstruction Populations","Inclusion Criteria:\n\nFor ACLR group:\n\n•Isolated unilateral ACL reconstruction 8-16 weeks post-surgery with medical clearance for moderate to high resistance training.\n\nFor control group(healthy population):\n\n* Healthy adults with no musculoskeletal pathology.\n\nExclusion Criteria:\n\n* History of cardiovascular or metabolic diseases\n* Deep vein thrombosis\n* Coagulopathy\n* Hypertension\n* Skin lesions or infections at the site of BFR cuff administration\n* Neuromuscular disorders\n* Non-clearance from the surgeon or physiotherapist or resistance training.",true,{"count":140,"type":20},[23],"The goal of this clinical trial is to see which type of strengthening exercise with a tight band (blood flow restriction) helps people recover better after ACL reconstruction. The study includes adults after ACL surgery who are doing physiotherapy to rebuild thigh muscle strength and knee function.\n\nThe main questions are:\n\n* Does heavy strengthening with blood flow restriction improve thigh strength, knee function, and daily activities more than light strengthening with blood flow restriction after ACL surgery?\n* Can light strengthening with blood flow restriction give similar benefits to heavy strengthening while putting less strain on the knee?\n\nResearchers will compare a heavy-exercise program plus blood flow restriction to a light-exercise program plus blood flow restriction to see which gives better strength and functional improvements.\n\nParticipants will:\n\n* Come for supervised physiotherapy sessions and do knee exercises on a machine, using either heavy or light loads while a cuff on the thigh gently squeezes to reduce blood flow.\n* Have their leg strength, and knee questionnaires checked several times during the study.",[26,217],"ACL Repair",[219,220,221,222,26,223,224,225,226,227,228,229,63,230,231],"blood flow restriction training ACL","Blood flow restriction","ACL Rehab","ACLR","BFR therapy anterior cruciate ligament reconstruction","BFR therapy ACLR","BFR Therapy","low-load versus high-load BFR knee rehabilitation","isokinetic strength training after ACL surgery","physiotherapy rehabilitation protocol ACL isokinetic BFR","Knee physiotherapy","ACL Isokinetic","ACLٍ Isokinetic","2026-02-03",{"date":234,"type":39},"2026-02-05",{"date":236,"type":20},"2026-02",{"date":238,"type":20},"2026-06",{"name":240,"class":46},"Gulf Medical University",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":21,"phases":250,"briefSummary":251,"conditions":252,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":260,"locationsCount":47},"100618537","phase-4-study-the-anti-inflammatory-effect-of-tranexamic-acid-when-used-in-anterior-cruciate-ligament-reconstruction-100618537","NCT07332910","Study the Anti-inflammatory Effect of Tranexamic Acid When Used in Anterior Cruciate Ligament Reconstruction.","Tranexaminc Acid : Single Dose vs Placebo to Modulate Postoperative Inflammation After ACL Reconstruction : A Prospective, Randomized, Double-blind Trial","TXA","Inclusion Criteria\n\n* Adults aged 18 years or older.\n* Male or female patients scheduled for primary anterior cruciate ligament (ACL) reconstruction.\n* Surgery performed under spinal anesthesia, combined with a postoperative adductor canal block for analgesia.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Procedure performed by a single, standardized surgical team.\n* Ability to provide written informed consent.\n\nExclusion Criteria\n\n* Age under 18 years.\n* Pregnancy or breastfeeding.\n* Preoperative treatment with anticoagulant or antiplatelet therapy that cannot be safely discontinued.\n* Known coagulation disorders or history of abnormal bleeding.\n* Known hypersensitivity or allergy to tranexamic acid.\n* History of seizure disorders or epilepsy.",{"count":140,"type":20},[59],"Tranexamic acid (TXA) is widely used in orthopedic surgery to reduce perioperative blood loss, particularly in total hip and knee arthroplasty, due to its antifibrinolytic mechanism, low cost, broad availability, and established safety profile. Its use has recently expanded to minimally invasive procedures such as knee arthroscopy and ACL reconstruction, where postoperative hemarthrosis-rather than intraoperative bleeding-is a major cause of pain, swelling, reduced range of motion, delayed rehabilitation, and impaired early recovery.\n\nRandomized trials and meta-analyses in arthroscopic ACL reconstruction show that TXA, administered intravenously, intra-articularly, or both, reduces postoperative hemarthrosis, joint swelling, drainage volume, and early pain, while improving early functional outcomes. These benefits are mainly short term, with no consistent long-term differences, and no increased risk of thromboembolic events. Evidence in arthroscopic meniscectomy is more limited but suggests modest improvements in early recovery, which may still be clinically meaningful given TXA's favorable risk-benefit profile.\n\nBeyond its antifibrinolytic effects, TXA may influence inflammatory pathways by inhibiting plasmin, which is involved in complement activation and inflammatory modulation. However, existing data are conflicting, with reports of both anti- and pro-inflammatory effects depending on surgical context and dosing. Importantly, most arthroscopy studies focus on clinical outcomes rather than systemic inflammation. To date, no study has comprehensively evaluated perioperative inflammatory responses to TXA in arthroscopic knee surgery, making this low-trauma setting an ideal model to investigate its potential inflammatory effects.",[26,253],"Hemarthrosis","2025-12-31",{"date":256,"type":39},"2026-01-12",{"date":258,"type":20},"2026-01-20",{"date":127,"type":20},{"name":261,"class":46},"Chirec",{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":4,"eligibilityCriteria":268,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":269,"enrollmentInfo":270,"targetDuration":4,"studyType":21,"phases":272,"briefSummary":273,"conditions":274,"keywords":276,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":47},"100568984","efficacy-of-focused-extracorporeal-shock-wave-therapy-after-anterior-cruciate-ligament-reconstruction-100568984","NCT06688344","Efficacy of Focused Extracorporeal Shock Wave Therapy After Anterior Cruciate Ligament Reconstruction","Effectiveness of Focused Extracorporeal Shock Wave Therapy Applied as an Addition to Conventional Physiotherapy Program After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Age between 18 and 45 years\n* Unilateral ACL rupture\n* Isolated ACL injury\n* Hamstring graft\n\nExclusion Criteria:\n\n* Previous knee injury and anterior cruciate ligament revision\n* Synovitis, stiffness, tension\n* History of systemic diseases such as rheumatoid arthritis, osteoarthritis, osteoporosis\n* Presence of tumor\n* Deep vein thrombosis or vascular pathology in the lower extremity\n* RA or accompanying comorbidities\n* Having had intra-articular injection within 6 months\n* Cognitive impairment","45 Years",{"count":271,"type":20},32,[23],"The aim of this clinical trial is to determine the effectiveness of fESWT in rehabilitation after ACL reconstruction. The main questions it aims to answer are:\n\nIs fESWT applied in addition to conventional physiotherapy effective in physiotherapy-related parameters?\n\nResearchers will compare conventional physiotherapy and conventional physiotherapy + fESWT to see if fESWT provides benefits in addition to conventional physiotherapy.\n\nParticipants:\n\nThey will receive the conventional physiotherapy program 2 days per week. In addition, the intervention group will receive low-intensity fESWT 1 day per week.\n\nParticipants' muscle strength, postural balance, range of motion, pain scores and functional status will be assessed.",[26,275],"Extracorpereal Shock Wave Therapy",[277,278,279],"Physiotherapy and rehabilitation","ESWT","ACL reconstruction","2025-12-18",{"date":282,"type":39},"2025-12-19",{"date":284,"type":39},"2024-12-01",{"date":286,"type":20},"2027-05-01",{"name":288,"class":46},"Berivan Beril Kılıç",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":212,"sex":15,"minAge":16,"maxAge":167,"enrollmentInfo":297,"targetDuration":299,"studyType":90,"phases":4,"briefSummary":300,"conditions":301,"keywords":302,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":47},"100615815","application-of-multiple-vertical-jump-tests-in-return-to-play-assessment-for-anterior-cruciate-ligament-reconstruction-athletes-100615815","NCT07297511","Application of Multiple Vertical Jump Tests in Return-to-Play Assessment for Anterior Cruciate Ligament Reconstruction Athletes","The Application of Vertical Jump Performance in Return-to-Play Assessment for Anterior Cruciate Ligament Reconstruction Athletes","RTP-VJ","Inclusion Criteria:\n\n* 1.Age 18-35 years\n\n  2.Unilateral anterior cruciate ligament (ACL) rupture confirmed by magnetic resonance imaging (MRI)\n\n  3.Positive Lachman test grade ≥2 pre-operatively\n\n  4.Anterior cruciate ligament reconstruction (ACLR) using hamstring or gracilis autograft\n\n  5.Post-operative time ≥6 months\n\n  6.Completed rehabilitation program with clearance from orthopedic surgeon or physical therapist\n\n  7.Quadriceps strength symmetry index ≥90%\n\n  .Elite athlete status (prior participation in national-level competitions)\n\nExclusion Criteria:\n\n1. Other lower extremity injuries or pathologies (including other knee ligament injuries)\n2. Contralateral lower limb injury within the past 3 months\n3. Quadriceps strength symmetry index \\\u003C90%\n4. Non-elite athlete status (no prior national-level competition participation)\n5. Incomplete rehabilitation or lack of medical clearance",{"count":298,"type":20},36,"1 Day","Anterior cruciate ligament (ACL) injury is a common sports-related injury, particularly in sports that require extensive jumping and cutting movements. Although anterior cruciate ligament reconstruction (ACLR) surgery can restore knee stability, many athletes still face the risk of re-injury after returning to competition.Current return-to-play assessment relies primarily on single-plane horizontal hop tests and symmetry indices (LSI ≥ 90%); however, an increasing body of research suggests that these tests may not comprehensively reflect functional deficits in the vertical plane, repeated hopping, or high-intensity sport-specific activities.This study hypothesizes that incorporating multiple vertical jump tests-including single-leg vertical jumps and 10-second repeated vertical jumps-combined with advanced force plate analytics (such as Reactive Strength Index \\[RSI\\] and Time to Stabilization \\[TTS\\])-can more sensitively reveal residual neuromuscular control deficits following surgery. This approach would provide evidence-based guidance for return-to-play decision-making, thereby improving athletes' long-term athletic performance and safety.",[26],[279,303,304],"vertical jump test","return to play","2025-12-09",{"date":307,"type":39},"2025-12-22",{"date":309,"type":20},"2025-12-29",{"date":311,"type":20},"2026-01-30",{"name":313,"class":46},"Kaohsiung Medical University",{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":320,"eligibilityCriteria":321,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":167,"enrollmentInfo":322,"targetDuration":4,"studyType":21,"phases":324,"briefSummary":325,"conditions":326,"keywords":327,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":204},"100607584","kinesiophobia-vs-task-specific-fear-defining-movement-related-fear-in-acl-reconstruction-patients-100607584","NCT07190456","Kinesiophobia vs. Task-Specific Fear: Defining Movement-Related Fear in ACL Reconstruction Patients","Kinesiophophia or Task-specific Fear of Movement? What Are we Talking About in Patients Post Anterior Cruciate Ligament Reconstruction?","Ki-TASK-ACLR","Inclusion Criteria:\n\n* The patient must have given their informed consent and signed the consent form.\n* The patient must have enough comprehension of the Portuguese language to complete the written questionnaires.\n* The patient must have suffered an ACL injury, with or without a history of concomitant meniscal pathology, while playing or training for sport (recreational or organized).\n* The patient must have undergone anterior cruciate ligament reconstruction surgery.\n* The patient must be between 18 and 35 years old.\n* The patient must still be under medical care\u002Frehabilitation due to the ACL injury.\n* The patient must have started jump landing tasks.\n\nExclusion Criteria:\n\n* The subject has a history of repeated ACLR.\n* The subject has not injured the ACL while playing sports.\n* The subject presents a concurrent psychiatric disorder\n* The subject has a history of heart disease and\u002For peripheral vascular disease and\u002For metabolic disease and\u002For Raynaud´s Syndrome.\n* The subject is taking any medications known to affect heart rate or blood pressure\n* The subject is currently a smoker.",{"count":323,"type":20},21,[23],"Kinesiophobia, defined as an excessive and irrational fear of physical movement due to perceived vulnerability to injury, has gained significant attention in clinical and scientific communities. This condition can act as a barrier to physical activity, negatively impacting patients' disability, quality of life, and the implementation of rehabilitation programs. It is particularly prevalent after anterior cruciate ligament reconstruction (ACLR), affecting physical function, return to sport rates, and patient performance.\n\nWhile the Tampa Scale for Kinesiophobia (TSK) is considered a gold standard for assessing kinesiophobia, recent studies have raised concerns about its validity, especially in ACLR patients. The TSK may not adequately capture fear of specific sports activities, which is more common in ACLR patients than a general phobia of movement. Some researchers argue for an assessment approach similar to that used for pain experiences, emphasizing the subjective nature of fear.\n\nBased on the specific phobia model, assessing kinesiophobia in the presence of a trigger, such as visualizing or confronting the movement associated with the injury, may be more relevant. This approach is supported by evidence showing that sports situations evoking the greatest fear after ACLR are cutting, jumping, and contact. Further research is needed to investigate alternative methodologies for assessing fear of movement in ACLR patients, considering the prevalence and repercussions of kinesiophobia in this population.\n\nThe objectives of this study are threefold:\n\n* To compare the magnitude of kinesiophobia through the TSK, the subjective feeling of fear when visualising feared movements, and the subjective feeling of fear in anticipation of the feared situation.\n* Evaluate the impact of focusing on feared activities on motor behavior and Autonomic Nervous System (ANS) markers.\n* To assess the relation between the three methods of assessing fear of movement and indicators of motor behaviour, ANS activity, fear-avoidance beliefs, anxiety, avoidance behaviour, and physical function.",[26],[328,329,330,331,332],"Motor behavior","gait complexity","Autonomic Nervous System","Heart Rate Variability","Skin Conductance",{"date":334,"type":39},"2025-12-17",{"date":336,"type":20},"2026-01-01",{"date":338,"type":20},"2026-12-01",{"name":340,"class":46},"Egas Moniz - Cooperativa de Ensino Superior, CRL",{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":348,"targetDuration":4,"studyType":21,"phases":350,"briefSummary":351,"conditions":352,"keywords":355,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":47},"100603374","phase-4-study-to-use-oral-losartan-to-decrease-the-risk-of-postoperative-scarring-following-acl-reconstruction-100603374","NCT07135687","Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction","Oral Losartan to Decrease the Risk of Postoperative Arthrofibrosis Following Primary and Revision Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Must be undergoing a primary ACLR with or without the following:\n* Chondroplasty\n* Synovectomy\n* Loose body removal\n* Removal of hardware\n* Meniscal surgery (excluding meniscal allograft transplantation\u002FMAT)\n* Lateral extra-articular tenodesis\n* Must have skeletal maturity in the distal femur and proximal tibial physes\n* Must be age 18 years or older at time of enrollment\n\nExclusion Criteria:\n\n* \\\u003C18 years at time of enrollment\n* No diagnosis of ACL tear\n* ACL repairs\n* Revision ACL reconstructions\n* Open distal femur or proximal tibia physes\n* Major concomitant procedures (such as osteotomy, MAT, or cartilage restoration surgery)\n* History of prior proximal or distal femur fracture (including those receiving nonoperative treatment)\n* History of prior ipsilateral femur or tibia osteomyelitis\n* Medical history\n* History of hypotensive disease, including postural orthostatic hypotension syndrome (POTS), autonomic dysreflexia, or Shy-Drager syndrome (aka multiple system atrophy), baseline hypotension \\\u003C90 systolic or \\\u003C60 diastolic mmHg.\n* History of significant hepatic disease (liver transplantation, cirrhosis of any cause, or any liver disease with Child-Pugh classification B or C) due to hepatic metabolism of ARBs.\n* Chronic kidney disease\n* Rheumatologic disorders on immunologic medications\n* Current medications including diuretics (i.e. furosemide), lithium, and spironolactone\n* Current hypertension with prescription of an ARB or ACE-I\n* Allergy to losartan\n* Current pregnancy or breastfeeding",{"count":349,"type":20},144,[59],"The purpose of this study to investigate the effect of using losartan (a blood pressure lowering drug with anti-scarring properties) on preventing primary postoperative arthrofibrosis (formation of abnormal scar tissue) in the knees in participants undergoing anterior cruciate ligament (ACL) repair surgery of their knee.",[353,26,354],"ACL Injury","Scar Formation",[63,356,357],"Postoperative Arthrofibrosis","Losartan",{"date":359,"type":39},"2025-12-15",{"date":361,"type":20},"2026-08",{"date":363,"type":20},"2028-12",{"name":365,"class":46},"Rush University Medical Center",{"id":367,"slug":368,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":4,"eligibilityCriteria":372,"healthyVolunteers":11,"sex":15,"minAge":373,"maxAge":55,"enrollmentInfo":374,"targetDuration":4,"studyType":21,"phases":376,"briefSummary":377,"conditions":378,"keywords":381,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":47},"100591390","a-comparison-of-outcomes-after-anterior-cruciate-ligament-acl-or-anterior-cruciate-ligament-and-meniscus-aclmeniscus-surgery-using-semiconductor-fabric-products-100591390","NCT06979804","A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products","A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products: A Randomized, Double-Blinded, Placebo-Controlled Prospective Clinical Study","Inclusion Criteria:\n\n* Patients undergoing ACL or ACL+Meniscus surgery\n* Age 16 - 65\n* Patients with Body Mass Index (BMI) \\\u003C40\n* Patients who are willing and able to adhere to follow-up schedule and protocol guidelines.\n* Patients who are willing and able to sign corresponding research subject consent\u002Fassent form.\n\nExclusion Criteria:\n\n* Patient has a history of neurological conditions, including multiple sclerosis or Parkinson's disease\n* Patient has severe medical condition, including recent myocardial infarction, unstable angina, heart failure, severe anemia\n* Patient has had prior surgical treatment of the knee in the last 5 years or injection treatment(s) in the last 6 months\n* Patient has chronic pain conditions unrelated to knee condition\n* Patient has auto-immune or auto-inflammatory diseases\n* Patient has poorly controlled diabetes (HgA1c \\> 7.5)\n* Patient has BMI \\> 39.9\n* Patient has varicosities on the operative leg\n* Patient has severe peripheral artery disease (ABI \\\u003C 0.6)\n* Patient is considered a pain management patient\n* Patient has had previous blood clots or stroke\n* Patient has used tobacco within the last 90 days\n* Patient is not within the ages of 16-65\n* Patient has an active infection (local or systemic), or an open (non-surgical) wound in the areas of product application\n* Patient is unwilling or unable to sign the corresponding research subject consent\u002Fassent form\n* Patient meets any other criteria or has any other condition that, in the opinion of the investigator, would prevent them from completing the study or that, in the opinion of the investigator, would confound study results.","16 Years",{"count":375,"type":20},135,[23],"The goal of this clinical trial is to determine the effect of semiconductor sleeves on the treatment of Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) arthroscopic surgery. The effect of the sleeves will be analyzed through patient reported and clinically measured outcomes. The main questions it aims to answer are:\n\n* Do the semiconductor sleeves improve the functional outcomes compared to the placebo?\n* Will patients experience improved functional outcomes in a shorter period of time compared to the placebo?\n\nResearchers will compare semiconductor fabric sleeves to a placebo (a look-alike sleeve that contains no semiconductor material) to see if the semiconductor fabric better treats ACL and ACL+meniscus surgical patients.\n\nParticipants will:\n\n* Wear semiconductor or placebo leg sleeve for 4 weeks and knee sleeve for the following 12 weeks\n* Complete patient reported outcome surveys",[26,379,380],"Meniscus Tears","Anterior Cruciate Ligament Rupture",[63,382,383,384,385,279],"Meniscus tear","ACL tear","Compression sleeve","Semiconductor fabric","2025-05-19",{"date":388,"type":39},"2025-05-22",{"date":390,"type":39},"2024-09-11",{"date":392,"type":20},"2026-10-01",{"name":394,"class":46},"Illinois Center for Orthopaedic Research and Education",{"id":396,"slug":397,"hasResults":11,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":4,"eligibilityCriteria":401,"healthyVolunteers":11,"sex":15,"minAge":373,"maxAge":17,"enrollmentInfo":402,"targetDuration":4,"studyType":21,"phases":404,"briefSummary":405,"conditions":406,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":47},"100539993","protein-supplementation-after-acl-surgery-100539993","NCT06311058","Protein Supplementation After ACL Surgery","The Effect of Protein Supplementation on Muscle Atrophy After ACL Reconstruction","Inclusion Criteria:\n\n* Subjects will include patients age 16 to 40 undergoing primary ACL reconstruction for an acute ACL tear with the PI or Sub-investigators\n\nExclusion Criteria:\n\n* Subjects will not be included if they meet one of the following criteria\n\n  * History of meniscectomy or meniscus repair\n  * Obesity (BMI\\>35)\n  * Diabetes\n  * Cardiovascular, renal, liver or pulmonary disease\n  * Active infections\n  * Cancer (current or treated within the past 2 years) or coagulation disorder\n  * Rapid weight change within the past year\n  * Physically unable to participate in the intervention\n  * Are currently taking, or recently (w\u002Fin 1 month of participation) taken prescribed, or over the counter ergogenic aids or compounds known to be banned by the NCAA.\n  * Less than 16 years of age\n  * Vegan patients\n  * Patient over the age of 40\n  * Pregnancy ( As part of standard of care, all female participants will be administered a urine pregnancy test prior to surgery. A negative test result is required to participate in the study.)\n  * Any known or diagnosed kidney, GI, or liver disorders\n  * Taking any medications known to affect protein metabolism. This includes, but is not limited to any drugs involved in hormone replacement therapy to treat conditions such as:\n\n    * Hypothyroidism: example - levothyroxine\n    * Hypogonadism: example - exogenous testosterone, estrogen, or any other forms of androgenic or anabolic hormone compounds\n    * Growth hormone or growth hormone analogues\n    * Type I or Type II diabetes requiring insulin\n  * Currently taking protein supplements, amino acid supplements, or any known ergogenic aids.\n  * Notably, all patients would need to confirm they will be doing their rehab through Houston Methodist\n  * Patients diagnosed with protein intolerance or digestive issues associated with consuming protein",{"count":403,"type":20},102,[23],"The purpose of the study is to assess the longitudinal post-operative care effects of protein supplementation on muscle atrophy in the post-operative period following ACL reconstruction. The main outcome will be muscle size\u002Fmass as measured using dual energy x-ray absorptiometry (DEXA) scanning. The primary objective is to assess for any beneficial impact of protein supplementation, with implications of standardizing a recommended protocol for protein supplementation after ACL reconstruction.\n\nSecondary outcomes will be to evaluate the survey data from the KOOS JR and Tampa Scale surveys, as well as functional measures recorded during physical therapy.",[26],"2025-05-05",{"date":409,"type":39},"2025-05-06",{"date":411,"type":39},"2024-02-16",{"date":413,"type":20},"2027-12-01",{"name":415,"class":46},"The Methodist Hospital Research Institute",{"id":417,"slug":418,"hasResults":11,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":11,"sex":15,"minAge":54,"maxAge":423,"enrollmentInfo":424,"targetDuration":4,"studyType":21,"phases":426,"briefSummary":427,"conditions":428,"keywords":430,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":47},"100293170","does-blood-flow-restriction-training-improve-quadriceps-function-after-arthroscopic-knee-surgery-100293170","NCT03096366","Does Blood Flow Restriction Training Improve Quadriceps Function After Arthroscopic Knee Surgery?","Does Blood Flow Restriction Training Improve Quadriceps Function After Arthroscopic Knee Surgery? A Randomized Clinical Trial","Inclusion Criteria:\n\n* Anterior cruciate ligament (ACL) reconstruction with concomitant meniscus or cartilage restoration procedures\n* Adherence to modified weight bearing status before initiation of PT\n* Expected participation in recreational or competitive sports after release to full activities\n\nExclusion Criteria:\n\n* Unable to attend (or participate in) physical therapy\n* Pregnancy\n* Malignancy\n* Fracture\n* Peripheral vascular disease\n* History of deep vein thrombosis (DVT)","55 Years",{"count":425,"type":20},150,[23],"The purpose of this study is to evaluate the effectiveness of physical therapy (PT) plus BFR training compared to PT alone (without BFR training) after ACL reconstruction in patients who require extended limited weight bearing through assessment of patient reported outcomes and functional testing. The hypothesis is that PT plus BFR training will mitigate the loss of quadriceps muscle cross-sectional area, strength, and function while also improving early clinical and functional results.",[429,26],"Quadriceps Atrophy",[431],"anterior cruciate ligament reconstruction","2022-05-03",{"date":434,"type":39},"2022-05-04",{"date":436,"type":39},"2017-11-21",{"date":438,"type":20},"2022-12",{"name":440,"class":46},"The University of Texas Health Science Center, Houston"]