[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acl-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acl-surgery":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100640618","human-tendon-tissue-collection-100640618",false,"NCT07606092","Human Tendon Tissue Collection","Human Tendon Tissue Collection for In Vitro Models and Tissue Analysis","Inclusion Criteria:\n\n* 18 years or older\n* Scheduled to undergo orthopaedic lower limb surgery that involve tendon tissue waste\n* Have provided informed consent to take part in the study\n\nExclusion Criteria:\n\n* Under the age of 18\n* Unable or unwilling to give informed consent (including those with limited English proficiency)\n* Cases where tendon tissue is required for clinical care and therefore not surplus.","ALL","18 Years",{"count":19,"type":20},400,"ESTIMATED","OBSERVATIONAL","The goal of this study is to improve understanding of tendon health and disease by using surplus tendon tissue that is routinely removed during planned orthopaedic surgeries in adults. The main questions it aims to answer are:\n\n\\- What can tendon tissue and tendon cells tell us about how healthy and diseased tendons function?\n\nParticipants will not undergo any extra procedures. Instead, researchers will use only tissue that is already being removed as part of normal surgical care and would otherwise be discarded.\n\nParticipants will:\n\n* Be asked for permission (consent) before their surgery to donate any surplus tendon tissue.\n* Have a small piece of tendon tissue (normally waste material) collected during their planned operation.\n* Allow the research team to access some non-identifiable medical information (such as age, reason for surgery, and relevant medical history) to help interpret research findings.\n\nWhat the researchers will do with the donated tissue:\n\n* Isolate different types of human tendon cells.\n* Build advanced laboratory cellular models to study how tendon diseases develop.\n* Analyse whole tendon tissue sections to understand cell types, tissue organisation, and disease-related changes.\n\nThis study does not involve testing treatments, and it does not change any aspect of a participant's clinical care. Although there is no direct benefit to participants, the donated tissue may help researchers develop better ways to study tendon injuries and improve future treatment options for tendon disease.",[24,25,26,27],"Tendinopathy","Musculoskeletal Diseases or Conditions","ACL Surgery","Achilles Tendon Surgery",[29],"Tendon tissue collection","NOT_YET_RECRUITING","2026-05-18",{"date":33,"type":34},"2026-05-26","ACTUAL",{"date":36,"type":20},"2026-06",{"date":38,"type":20},"2031-06",{"name":40,"class":41},"Queen Mary University of London","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100605127","phase-4-efficacy-of-methylprednisolone-for-pain-control-after-acl-repair-100605127","NCT07158476","Efficacy of Methylprednisolone for Pain Control After ACL Repair","Efficacy of Methylprednisolone for Pain Control After ACL Repair: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patient undergoing ACL repair or ACL reconstruction with tendon autograft\n* Age 13-50 years old\n* Able to provide informed consent or parent\u002Flegal guardian is able for minors\n\nExclusion Criteria:\n\n* Concurrent and significant injury to other bones or organs (Injury Severity Score of 4 or greater)\n* Revision ACL reconstruction\n* Concomitant additional ligament reconstruction or high tibial osteotomy\n* A history of alcohol abuse, substance abuse or chronic opioid use (filled opioid medication ×2 within 6 months of the surgery)\n* A history of renal failure (\\\u003C60 mL\u002Fmin\u002F1.73 m2), liver dysfunction (child class, \\>B), severe heart disease (NYHA Class 4), diabetes, neurological or psychiatric diseases that may affect pain perception, and pre-existing immune suppression.\n* A history or active peptic ulcer disease, gastrointestinal bleeding, or current use of anticoagulation.\n* Patients currently taking oral or injectable glucocorticoids and those who have taken either within 1 month of the procedure.\n* Patients who are currently pregnant.\n* Patients who are unable to undergo the multimodal pain standardized protocol including those with comorbidities or medical allergies precluding the use of corticosteroids, gabapentin, hydrocodone, acetaminophen, ketorolac, and\u002For meloxicam.","13 Years","50 Years",{"count":52,"type":20},90,"INTERVENTIONAL",[55],"PHASE4","Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.",[26,58],"Pain Management",[60,61,62],"pain","opioids","orthopedic surgery","RECRUITING","2025-10-22",{"date":66,"type":34},"2025-10-24",{"date":68,"type":34},"2025-10-21",{"date":70,"type":20},"2031-09",{"name":72,"class":41},"St. Louis University",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":53,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100596048","kea-vs-towel-for-early-quad-activation-post-anterior-cruciate-ligament-reconstruction-100596048","NCT07040384","KEA vs Towel for Early Quad Activation Post Anterior Cruciate Ligament Reconstruction","Knee Extensors Activation Device Versus Rolled Towel for Early Quadriceps Activation After ACL Reconstruction: Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to 45 years\n* Undergoing primary unilateral anterior cruciate ligament (ACL) reconstruction (any graft type, any surgical technique)\n* Able and willing to participate in postoperative rehabilitation\n* Able to provide written informed consent\n* Able to comply with study procedures and complete the 5-day inpatient exercise program\n\nExclusion Criteria:\n\n* Bilateral knee surgeries (e.g., simultaneous ACL reconstruction on both knees)\n* Significant neuromuscular disorders that may affect rehabilitation or EMG readings\n* Cognitive impairment that would interfere with understanding or performing exercises\n* History of major lower limb surgery within the past year (excluding the current ACL surgery)\n* Concomitant injuries requiring extensive repair (e.g., complex ligament reconstructions beyond minor meniscal or collateral work)\n* Any medical condition or postoperative complication that would prevent safe participation in the exercise program","45 Years",{"count":83,"type":20},40,[85],"NA","The goal of this clinical trial is to learn if a novel Knee Extensors Activation (KEA) device can improve quadriceps muscle activation in adults after anterior cruciate ligament (ACL) reconstruction surgery. The study focuses on adults aged 18-45 years undergoing primary unilateral ACL reconstruction, a population commonly affected by this injury.\n\nThe main questions it aims to answer are:\n\nDoes using the KEA device lead to greater quadriceps muscle activation (measured via EMG) by postoperative Day 5 compared to standard care using a rolled towel?\n\nDoes the KEA device improve early knee function, reduce pain, and decrease fear of movement compared to the towel method?\n\nResearchers will compare participants using the KEA device versus a control group using the conventional rolled towel during early postoperative rehabilitation to see if the KEA device provides better outcomes.\n\nParticipants will:\n\nBegin quadriceps strengthening exercises on the first day after ACL surgery.\n\nBe randomly assigned to use either the KEA device or a rolled towel for isometric quadriceps exercises.\n\nPerform 3 sets of 10 repetitions of knee extension exercises, twice daily for 5 consecutive days.\n\nUndergo assessment of quadriceps EMG activation and complete questionnaires (KOOS, IKDC, TSK, and VAS) on Day 5.",[26,88],"Quadriceps Strength",[90,91,92,93,94,95,96],"Anterior cruciate ligament","quadriceps activation","biofeedback","rehabilitation","electromyography","knee","randomized controlled trial","2025-06-25",{"date":99,"type":34},"2025-06-27",{"date":101,"type":20},"2025-08-25",{"date":103,"type":20},"2026-12-10",{"name":105,"class":41},"Jouf University"]