[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acl\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acl":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,46,71,84,109,139,158,182,210,229,257],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100053730","interventions-to-enhance-quadriceps-output-after-aclr-100053730",false,"NCT07674784","Interventions to Enhance Quadriceps Output After ACLR","Clinical Interventions to Acutely Enhance Quadriceps Output After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Have undergone ACLR within the previous 4 months\n* Are at least 2 months post-ACLR\n\nExclusion Criteria:\n\n* A history of ACLR on both legs\n* Since the most recent ACLR:\n\n  * secondary lower extremity surgery\n  * leg or foot fracture\n* Unable to walk without an assistive device\n* Pain of greater than 5\u002F10 during quadriceps strengthening exercises with the surgical limb\n* Cannot achieve 90 degrees of knee flexion with the surgical limb\n* People with contraindications to NMES\n* Anyone who had a previous skin reaction to NMES or attempted but could not tolerate NMES\n* Peripheral neuropathy or other neurological conditions","ALL","18 Years","40 Years",{"count":20,"type":21},22,"ESTIMATED","INTERVENTIONAL",[24],"NA","The investigators are interested in determining what treatments are effective in reducing inhibition after anterior cruciate ligament (ACL) surgery and helping people increase quadriceps strength. Two interventions that are often used clinically are neuromuscular electrical stimulation (NMES) and vibration. This is a study of how effective these treatments are, whether they work the same for everyone, and if one is better than the other. 22 participants will be enrolled and on study for 2 to 3 weeks.",[27],"ACL",[29,30,31,32],"ACLR","quadriceps","neuromuscular electrical stimulation","vibration","NOT_YET_RECRUITING","2026-07-09",{"date":36,"type":37},"2026-07-13","ACTUAL",{"date":39,"type":21},"2026-08",{"date":41,"type":21},"2027-08",{"name":43,"class":44},"University of Wisconsin, Madison","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":45},"100582810","long-term-clinical-and-radiographic-results-of-revision-anterior-cruciate-ligament-reconstruction-using-a-single-bundle-technique-and-external-tenodesis-with-achilles-tendon-allograft-100582810","NCT06868147","Long-term Clinical and Radiographic Results of Revision Anterior Cruciate Ligament Reconstruction Using a Single-bundle Technique and External Tenodesis With Achilles Tendon Allograft.","Long-term Clinical and Radiographic Results of Revision Anterior Cruciate Ligament Reconstruction Using Over The Top Single-bundle Technique and Lateral Extra-articular Tenodesis With Achilles Tendon Allograft.","ACL_REVISION","Inclusion Criteria:\n\n1. Age between 18 and 50 years at the time of surgery;\n2. Male and female gender;\n3. Patients who have undergone revision of anterior cruciate ligament reconstruction with a single-bundle \"Over-The-Top\" technique and external tenodesis using Achilles tendon allograft, with or without associated procedures, at least 2 years post-surgery;\n4. A radiograph taken immediately before or after the surgery of the affected knee;\n5. Patients who have provided consent to participate in the study.\n\nExclusion Criteria:\n\n1. Patients no longer accessible;\n2. Patients who deny consent to participate in the study;\n3. Advanced knee osteoarthritis (Outerbridge grade III-IV) at the time of surgery;\n4. Severe obesity (BMI \\> 35);\n5. Lower limb conditions that prevent the patient from maintaining an upright position with full weight-bearing during the assessment;\n6. Infection or hematological or rheumatic conditions at the time of the assessment.","50 Years",{"count":56,"type":21},59,"OBSERVATIONAL","Several techniques for revision of anterior cruciate ligament (ACL) reconstruction and different types of grafts have been used over the years. These include single-bundle techniques, double-bundle techniques, and single-bundle techniques with external tenodesis. We also distinguish between the use of autografts and grafts from donors, or allografts.\n\nThe choice of surgical technique and graft type is strongly influenced by the progression of damage characterizing these patients (meniscal, chondral, or ligamentous), the surgical decisions made during the initial surgery (graft used, orientation, and number of bone tunnels), or any complications that occurred.\n\nThe use of a specific type of graft is heavily dependent on its availability: it is likely that the first-choice graft for some surgeons may be unavailable because it has already been used. The use of allografts is now commonly accepted by the scientific community, with the Achilles tendon standing out for its biomechanical properties and size. Unlike autografts, it does not damage the patient's ligamentous tissue, which is thus preserved.\n\nSince osteoarthritis is one of the most debated consequences of anterior cruciate ligament revision, an analysis of the results is essential to provide a clearer understanding of the risks and benefits associated with the different types of procedures.",[27,60],"LET","RECRUITING","2026-06-30",{"date":64,"type":37},"2026-07-02",{"date":66,"type":37},"2025-03-19",{"date":68,"type":21},"2027-01",{"name":70,"class":44},"Stefano Zaffagnini",{"id":72,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":74,"briefSummary":25,"conditions":75,"keywords":76,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":45},"100644933",{"count":20,"type":21},[24],[27],[29,30,31,32],"2026-06-24",{"date":62,"type":37},{"date":80,"type":21},"2026-06",{"date":82,"type":21},"2027-06",{"name":43,"class":44},{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":105,"leadSponsor":107,"locationsCount":45},"100551144","vibracool-device-to-reduce-pain-and-opioid-use-after-anterior-cruciate-ligament-reconstruction-aclr-100551144","NCT06456268","VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)","Clinical Evaluation of an External Neuromodulation Device (VibraCool) to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR)","Inclusion Criteria:\n\n* Underwent ACL reconstruction\n\nExclusion Criteria:\n\n* Pediatric iliotibial band ACL reconstruction (known to cause significantly more pain)\n* Non-english speakers (limitations of our study group)",true,{"count":93,"type":21},130,[24],"The goal of this project is to test the effects of the VibraCool mechanical stimulation neuromodulatory therapeutic device on post-operative pain and opioid use following anterior crucitate ligament reconstruction (ACLR), and thus residual opioids in circulation.",[27,97,98,99,100],"Opioid Use","Cryotherapy Effect","Vibration; Exposure","Pain, Postoperative","2026-01-06",{"date":103,"type":37},"2026-01-07",{"date":80,"type":21},{"date":106,"type":21},"2026-11-30",{"name":108,"class":44},"Columbia University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":137,"locationsCount":45},"100556790","michigan-split-belt-treadmill-training-program-to-improve-long-term-knee-biomechanics-after-acl-reconstruction-100556790","NCT06529692","Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction","Mi-SPA: Michigan Split-belt Adaptation Paradigm to Improve Knee Loading After Anterior Cruciate Ligament Reconstruction (Aim 3)","Mi-SPA","Inclusion Criteria:\n\n* aged 14-45 years\n* suffered an acute, complete ACL rupture as confirmed by MRI and physical exam\n* have undergone ACL reconstruction w autograft within the past 10 months\n* willingness to participate in testing and follow-up as outlined in the protocol\n* English-speaking\n\nExclusion Criteria:\n\n* inability to provide written informed consent\n* female subjects who are pregnant or are planning to become pregnant (self-reported)\n* previous ACL injury\n* previous surgery to either knee\n* bony fracture accompanying ACL injury\n* patients who experienced a knee dislocation\n* patients who had their ACL reconstructed with an allograft\n* patients who underwent a multi-ligamentous and\u002For staged ACL reconstruction","14 Years","45 Years",{"count":120,"type":21},9,[24],"The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects. Nine subjects will be randomized to 2 split-belt intervention groups (one group where early stance loading is trained and the other where midstance loading is trained) and a placebo group.\n\nThe goal of this study is to explore the adaptations in knee loading from a 6-week split-belt training intervention.\n\nThe investigators' main question for this aim is:\n\n1. Does knee loading, measured by the sagittal plane knee moment, change to a greater extent in the split-belt treadmill training groups compared to the placebo group?\n2. Are there differences in training-related knee loading changes between individuals trained in the early stance vs. midstance loading split-belt training?",[27,124,125],"Anterior Cruciate Ligament","ACL Injury",[127,128,129,130],"Biomechanics","Knee Loading","Split-Belt Treadmill","Asymmetric Walking","2025-09-04",{"date":133,"type":37},"2025-09-08",{"date":135,"type":37},"2025-08-13",{"date":39,"type":21},{"name":138,"class":44},"University of Michigan",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":157,"locationsCount":45},"100596114","outcomes-and-complication-rates-of-anterior-cruciate-ligament-reconstruction-using-the-over-the-top-technique-combined-with-lateral-extra-articular-tenodesis-in-patients-over-50-years-old-compared-with-a-control-group-of-patients-under-30-100596114","NCT07041242","Outcomes and Complication Rates of Anterior Cruciate Ligament Reconstruction Using the \"Over-the-top\" Technique Combined With Lateral Extra-articular Tenodesis in Patients Over 50 Years Old, Compared With a Control Group of Patients Under 30","ACL_50_YO","Inclusion Criteria:\n\n* Patients operated on between 2007 and 2023 who were over 50 years old at the time of surgery (study group) and patients under 30 years old at the time of surgery (control group).\n* Patients who underwent ACL reconstruction using the gracilis and semitendinosus tendons with the over-the-top + LET technique.\n* Patients of both male and female sex.\n* Patients who have provided consent to participate in the study.\n\nExclusion Criteria:\n\n* Previous surgery on the same limb (meniscectomy, prior ACL reconstruction, surgically treated fractures, osteotomies, meniscal transplants).\n* Concomitant surgery on the same limb (osteotomies, meniscal transplants).\n* Surgical technique different from the over-the-top with LET using autologous gracilis and semitendinosus tendons.\n* Other concomitant ligament injuries requiring surgical treatment.\n* Patients younger than 18 years at the time of surgery (minors) or patients aged between 30 and 50 years at the time of surgery.\n* Patients who have not provided informed consent.\n* Patients with a follow-up period shorter than 2 years.",{"count":147,"type":21},164,"The anterior cruciate ligament (ACL) is one of the main stabilizers of the knee, and its injury is among the most common soft tissue injuries of the knee. Surgical reconstruction of the ACL can be performed using various techniques and different types of tissue grafts, including both autografts and allografts.\n\nAlthough ACL reconstruction is a widely performed surgical procedure in young and physically active individuals-typically patients under 30 years of age-to promote return to sports and prevent early onset of osteoarthritic degeneration, the surgical approach has historically been less common in patients over the age of 50. This is largely due to the lower functional demands typically observed in older patients.\n\nHowever, with increasing life expectancy and a corresponding rise in functional demands among older individuals, the surgical approach to ACL reconstruction has been progressively reconsidered in the over-50 population. Several recent studies have aimed to evaluate the outcomes of ACL reconstruction in older adults, showing promising results in terms of both recurrence rates and complication rates.\n\nAt the II Clinic of the Rizzoli Orthopaedic Institute, under the direction of Professor Zaffagnini, the preferred technique for ACL reconstruction is the \"single-bundle over-the-top technique using gracilis and semitendinosus tendons, combined with a lateral extra-articular tenodesis (LET).\" LET is an additional surgical step performed alongside ACL reconstruction, which has shown excellent results, especially in young patients at high risk of reinjury. Specifically, clinical data have shown that adding LET to ACL reconstruction can reduce the failure rate by approximately 30%, significantly improve knee stability, and enable a faster return to sports-all without increasing the rate of complications compared to the standard isolated ACL reconstruction technique.\n\nGiven these encouraging results in terms of safety and reduced failure rates, the combined ACL + LET procedure has historically been used at the Rizzoli Orthopaedic Institute for all patients, including those over 50 years of age.\n\nThe consistent use of this technique allows for the creation of a homogeneous patient cohort, all treated with the same surgical approach. This also enables the formation of two comparable patient groups-one over 50 and one under 30-both treated with the same technique, allowing for a meaningful comparison of primary and secondary endpoints.\n\nWhile several studies have aimed to compare ACL reconstruction outcomes in older populations with those in younger cohorts, to date, there are no studies in the literature that specifically assess the outcomes and complication rates of ACL reconstruction using the over-the-top technique combined with LET in patients over 50, and compare them with those of younger patients undergoing the same surgical procedure.\n\nGiven the growing demand for ACL reconstruction in older patients, we believe it is important to evaluate outcomes in patients over 50 and compare them with a younger cohort, to determine whether the over-the-top + LET technique may be a valid therapeutic option not only for young patients but also for older adults.\n\nOf particular interest is the assessment of the reduced risk of failure and complication rate of the ACL + LET technique performed in over-50 patients, to determine whether the excellent clinical outcomes observed in younger individuals are also confirmed in an older population.",[27,60,150],"Hamstring Muscles","2025-07-14",{"date":153,"type":37},"2025-07-17",{"date":155,"type":37},"2025-07-13",{"date":82,"type":21},{"name":70,"class":44},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":91,"sex":16,"minAge":166,"maxAge":167,"enrollmentInfo":168,"targetDuration":4,"studyType":22,"phases":170,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":45},"100469665","living-donor-allograft-for-anterior-cruciate-ligament-reconstruction-study-100469665","NCT05395767","LIVing Donor Allograft for Anterior Cruciate Ligament Reconstruction Study","A Prospective Cohort Study of Skeletally Immature Patients Requiring Endoscopic Anterior Cruciate Ligament Reconstruction, Using Living Donor Hamstring Allograft From a Parent","LivD_ACLR","Inclusion Criteria:\n\n* Patients aged 8 to 17 years inclusive and have a clinically and radiologically confirmed ACL rupture that requires reconstruction.\n* Patients who have had previous surgery for meniscal pathology .\n* Patients with current meniscal pathology\n* The child and their responsible adult are in agreement with the choice to undergo anterior cruciate ligament reconstruction using living donor allograft.\n* Donors has not previously undergone tendon harvest on the chosen donor limb\n* Patients are willing to attend follow up appointments and agree to fill in knee questionnaires and allow instrumented knee ligament testing.\n\nExclusion Criteria:\n\n* Patients who have previously undergone ACL surgery on the same limb (and therefore require revision surgery)\n* Patients who are immunosuppressed, or receiving immunosuppressive therapy\n* Patients who are unable to attend follow-up appointments for continued research purposes.\n* Donors who have previously undergone hamstring tendon surgery on the donor limb\n* Patients and donors who have a positive screening blood test for any of the transmissible infections tested\n* Donors whose answers to the 'Donor Documentation Questionnaire' indicate that there could be a risk of transmissible infection, may not included\n* Donors who are not considered healthy enough to undergo a tenotomy under General anaesthetic","8 Years","17 Years",{"count":169,"type":21},40,[24],"The Anterior Cruciate Ligament (ACL) is a major stabiliser of the knee. ACL rupture is being increasingly identified in children and skeletally immature patients. The current advice in younger patients is usually to undergo ACL reconstruction. The choice of an ideal graft in children is difficult\n\nThis study will use a technique involves the use of hamstring tendons from a living donor, where the adult (usually a parent) agrees to donate their hamstring tendons, which are dissected out of them and implanted into the child",[27],"2025-05-20",{"date":175,"type":37},"2025-05-23",{"date":177,"type":37},"2021-09-15",{"date":179,"type":21},"2028-09",{"name":181,"class":44},"Maidstone & Tunbridge Wells NHS Trust",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":191,"briefSummary":192,"conditions":193,"keywords":195,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":209},"100571983","conservative-treatment-with-blood-flow-restriction-in-patients-with-total-acl-rupture-randomized-clinical-trial-100571983","NCT06727344","Conservative Treatment With Blood Flow Restriction in Patients With Total ACL Rupture. \"Randomized Clinical Trial\"","Comparison of Conservative Treatment With Blood Flow Restriction With Standard Management in Total ACL Rupture. \"Randomized Clinical Trial\"","Inclusion Criteria:\n\n* MRI-confirmed complete rupture of ACL. Ability to communicate and read fluently in Greek and be willing to keep their leg immobilised for the required period based on the study protocol.\n\nExclusion Criteria:\n\n* Heart disease, overweight, diabetes, pregnancy, thrombophilia, atrial fibrillation, heart failure, cancer, use of drugs that may increase blood clotting, use of hormones or contraceptives, any reason for not using BFR e.g., an open wound or serious skin problems and\u002For allergies to the cuff material.",{"count":190,"type":21},20,[24],"The goal of this randomised clinical trial is to evaluate the effects of exercise with blood flow restriction (BFR) in patients with a complete anterior cruciate ligament (ACL) rupture.\n\nThe main questions it aims to answer are:\n\n1. Does blood flow restriction adds any additional benefits to conservative treatment of the ACL?\n2. Does bracing promotes spontaneous healing to the ACL\n\nResearchers will compare bracing and BFR to bracing and sham BFR to see if the intervention provides any additional benefits to the conservative management of this injury.\n\nParticipants will:\n\n1. Use a knee brace for 6 weeks with adjustments according to protocol\n2. Follow and identical exercise plan with either BFR (intervention group) or BFR sham (control group)\n3. Follow a home based exercise program.",[27,194],"ACL - Anterior Cruciate Ligament Rupture",[196,197,198,199,27],"BFR","Blood Flow Restriction","Brace","ACL rupture","2025-03-29",{"date":202,"type":37},"2025-04-03",{"date":204,"type":37},"2025-02-01",{"date":206,"type":21},"2025-09",{"name":208,"class":44},"European University Cyprus",2,{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":45},"100561029","primary-acl-reconstruction-in-patient-over-40-years-allograft-versus-autograft-100561029","NCT06584838","Primary ACL Reconstruction in Patient Over 40 Years: Allograft Versus Autograft","Primary ACL Reconstruction in Patient Over 40 Years: Allograft Versus Autograft, a Prospective Matched Paired Comparison","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study.\n* Male and female patients of fertile age can be recruited\n* Patients aged 40 years old and above, and 2 years minimum of follow-up\n* Patients that underwent primary ACL reconstruction with allograft an autograft tendons\n\nExclusion Criteria:\n\n* Multiligamentous lesion\n* Meniscal tear leading to subtotal or total meniscectomy or meniscal graft\n* Indication for major cartilage restoration or resurfacing\n* Ipsilateral knee fractures\n* History of ligament injury\n* Concomitant extracapsular procedures\n* Ipsilateral or contralateral knee surgeries",{"count":169,"type":21},"The aim of this study is to investigate the differences in graft failure between patients that underwent ACL reconstruction using allograft tendons and patients that underwent ACL reconstruction using autograft tendons in patients older than 40 y.o. and after at least 2 years of follow-up. The hypothesis of the study is that there will be a difference in graft failure and patient reported functional outcomes between allograft and autograft ACL reconstruction.",[27,125],"2024-09-02",{"date":222,"type":37},"2024-09-05",{"date":224,"type":21},"2024-12",{"date":226,"type":21},"2025-02",{"name":228,"class":44},"Università Vita-Salute San Raffaele",{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":236,"targetDuration":238,"studyType":57,"phases":4,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":253,"leadSponsor":255,"locationsCount":45},"100549189","exploring-prolonged-amr-in-acl-reconstructed-patients-100549189","NCT06430775","Exploring Prolonged AMR in ACL Reconstructed Patients","Exploring Prolonged Arthrogenic Muscle Responses and Associated Factors After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* 18-40 years old.\n* Having suffered an ACL rupture.\n* Undergoing a surgical ACL reconstruction in the AZ Delta hospital in Roeselare (Campus Brugsesteenweg).\n\nExclusion Criteria:\n\n* Revision ACL reconstruction.\n* Other severe injuries to the lower limbs within the past year.\n* Muscular or neurological disorders affecting lower limb functioning.\n* Fibromyalgia or chronic fatigue syndrome.",{"count":237,"type":21},190,"5 Months","The goal of this observational study is to explore the significance of subject-reported outcomes and clinical parameters in relation to the occurence of prolonged presence of arthrogenic muscle responses (AMR) in anterior cruciate ligament (ACL) reconstructed patients. The main questions it aims to answer are:\n\n1\\. Is there a link between the long-term occurence of AMR in ACL reconstructed patients and the level of kinesiophobia experienced before or after their ACL surgery? We hypothesize that ACL patients with higher levels of kinesiophobia are more likely to exhibit prolonged AMR as an unconscious reaction to protect their affected knee joint.\n\n2\\. Is the long-term presence of AMR in ACL reconstructed patients linked to their subjective knee function and stability (at certain time points throughout their recovery)? Our hypothesis is that poorer subjective knee function and stability might be associated with the presence of prolonged arthrogenic muscle responses in ACL reconstructed patients.\n\n3\\. Is the prolonged presence of AMR in ACL reconstructed patients linked to their pain levels (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with higher pre- and\u002For postsurgical pain levels may exhibit a higher degree of long-lasting AMR.\n\n4\\. Is the long-term presence of AMR in ACL reconstructed patients linked to clinical parameters such as swelling, isometric quadriceps and hamstrings strength and knee range of motion (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with poorer outcomes in terms of these clinical parameters may be more likely to exhibit prolonged AMR.\n\nParticipants will:\n\n* Fill in the following questionnaires 1 week before surgery and at 1 and 3 months after surgery:\n\n  * Demopgraphical information\n  * Knee Injury and Osteoarthritis Outcome Score (KOOS)\n  * Lysholm Score (only question 1)\n  * Tegner Activity Scale (current activity level, pre-injury activity level and desired activity level after recovery)\n  * Numeric Rating Score (NRS) for pain levels during the day \\& during the night\n  * ACL-Return to Sport after Injury Scale (ACL-RSI)\n* Complete a testing protocol 5 months after their surgery, which includes bilateral electromyographical measurements of the hamstrings and quadriceps during jumping tasks and a quadriceps inhibition measurement using the interpolated twitch method to evaluate the presence of prolonged AMR.",[241,242,243,27,125,244,245,246,247],"Anterior Cruciate Ligament Injuries","Anterior Cruciate Ligament Rupture","Anterior Cruciate Ligament Tear","ACL Tear","Anterior Cruciate Ligament Reconstruction","Arthrogenic Muscle Inhibition","Arthrogenic Muscle Responses","2024-06-28",{"date":250,"type":37},"2024-07-01",{"date":252,"type":37},"2023-10-15",{"date":254,"type":21},"2026-05",{"name":256,"class":44},"University Ghent",{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":267,"conditions":268,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":45},"100531045","anterior-cruciate-ligament-study-100531045","NCT06194682","Anterior Cruciate Ligament Study","\"Valutazione Dell'Epidemiologia e Dei Risultati Clinici Nel Trattamento Artroscopico Delle Lesioni Del Legamento Crociato Anteriore\"","Inclusion Criteria:\n\n* \\- Males and females- attained skeletal maturity\n* 18-65 inclusive\n* Patients operated on anterior cruciate ligament reconstruction surgery at the Hospital's Casco unit from 2010 to 2030\n* Signature informed consent for patients who will be operated on in the prospective phase (from CE approval date to 2030)\n\nExclusion Criteria:\n\n* failure to reach skeletal maturity\n\n  * Concomitant ligamentous injuries (pcl, mcl, lcl)\n  * Neuropsychiatric illness, developmental disorders\n  * Pregnant women through self-declaration or breastfeeding\n  * Minors","65 Years",{"count":266,"type":21},370,"This retrospective, prospective observational study aims to evaluate the epidemiology and rate of anterior cruciate ligament re- rupture after surgery in patients treated from January 2020 to December 2030 by recording both clinically and radiographically ligament reconstruction.\n\nThe primary outcome is the rate of rupture of the anterior cruciate ligament as measured by the Lachmann test in which a positive value for re-rupture is an anterior translation of the tibia greater than 10mm relative to the femur Secondary Objectives: Verify predisposing factors to anterior cruciate ligament injuries (so anatomical factors such as tibial slope, trochlear groove), demographic factors (age, sex, weight, sports played), and the rate of return to sports, quality of life via questionnaires, and arthrosis at the operated knee",[125,27,242],"2023-12-22",{"date":271,"type":37},"2024-01-08",{"date":273,"type":37},"2023-12-06",{"date":275,"type":21},"2030-12-31",{"name":277,"class":44},"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio"]