[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acoustic-stimulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acoustic-stimulation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100500880","acoustic-stimulation-sleep-and-cognitive-emotional-processes-in-young-adults-with-anxiety-and-depression-symptoms-100500880",false,"NCT05802004","Acoustic Stimulation, Sleep, and Cognitive-Emotional Processes in Young Adults With Anxiety and Depression Symptoms","The Effect of Acoustic Enhancement of Slow-Wave Activity on Cognitive Control and Emotional Reactivity in Young Adults With Anxiety and Depression Symptoms","SERS","Inclusion Criteria:\n\n1. Age 18-25. Equal numbers of men and women will be included.\n2. Normal hearing.\n3. Elevated anxiety or depression symptoms. This will be determined using the PROMIS anxiety and PROMIS depression scales. Participants with T-scores ≥ 60 (i.e., ≥ than 1 standard deviation above the mean) on either or both scales will be eligible for participation.\n4. Elevated sleep disturbance. This will be determined using the PROMIS sleep disturbance scale. Participants with T-scores ≥ 55 on the PROMIS sleep disturbance scale will be eligible for participation.\n\nExclusion Criteria:\n\n1. Presence of a severe chronic or psychiatric condition including psychosis, bipolar disorder, developmental disorders, or substance use disorder.\n2. Current use of psychotropic medications or medications affecting sleep\u002Fwake function, such as antidepressants, antipsychotic medications, steroids, and stimulants. Rationale: These medications may affect sleep and cognitive-emotional function.\n3. Substance abuse. Rationale: Substance abuse may affect sleep and cognitive-emotional function.\n4. Consumption of \\> 14 standard alcoholic drinks per week. Rationale: excessive alcohol consumption may interfere with sleep and cognitive-emotional function.\n5. Consumption of \\> 400mg of caffeine per day, which is roughly equivalent to 3-4 8oz cups of coffee per day.\n6. Drug or alcohol use \\< 48 hours before the in-lab overnight sessions. Rationale: Recent drug or alcohol use could affect sleep, cognitive-emotional processes, and poses a safety risk.\n7. Severe insomnia or sleep apnea symptoms. Insomnia symptoms will be determined using the Insomnia Severity Index. Participants with severe insomnia (i.e., scores \\> 21) will not be eligible. Sleep apnea symptoms will be determined using the STOP-Bang questionnaire. Participants with scores ≥ 3 will not be eligible. Rationale: Sleep disturbances which result in low sleep efficiency and frequent awakenings during the night may reduce the effectiveness of acoustic stimulation which targets the deepest stage of sleep (i.e., slow-wave sleep).\n8. Extreme bedtimes (\\< 10:00pm, \\> 1:00am) or wake times (\\< 6:00am, \\> 10:00am). Rationale: Participants with extreme bed or wake times may have difficulty falling asleep, waking up, or obtaining a sufficient amount of sleep during the in-lab overnight sessions.\n9. Short (\\<5hrs) or long (\\>9hrs) average sleep duration. Rationale: short or long sleepers may have different sleep profiles which could impact the effectiveness of the acoustic stimulation intervention.\n10. Uncorrected vision problems.\n11. Claustrophobia. Rationale: MRI safety criteria.\n12. Metal in body. Rationale: MRI safety criteria.\n13. Body Mass Index (BMI) \\> 40. Rationale: MRI safety criteria.\n14. Pregnancy. Rationale: MRI safety criteria.\n15. Left handedness. Rationale: Left-handed people may have different lateralization of neural functioning which could affect the fMRI results.\n16. Formal vocal training and Good\u002FVery Good at singing in tune. Rationale: The purpose of the karaoke task is to induce negative self-referential emotions via out-of-tune singing.\n17. Does not own a smartphone or tablet. Rationale: Participants may need to download an app (SleepMapper or Alfin) to download their sleep data from the headband device when wearing it at home.\n18. Inability or unwillingness to complete study procedures.\n19. Hairstyles that prevent access to the scalp (e.g., weave). Rationale: Polysomnography for the in-lab overnights cannot be applied with hairstyles which prevent access to the scalp to apply electrodes.","ALL","18 Years","25 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","In this study, the investigators will recruit young adults (ages 18-25 years) with elevated anxiety\u002Fdepression symptoms and sleep disturbance. Participants will complete two overnights in a sleep lab. During one of the overnights, slow-wave activity will be enhanced by delivering sub-arousal auditory tones during slow-wave sleep using a headband device (Philips SmartSleep or Dreem 2). During the other overnight, tones will not be administered. Cognitive and emotional processes will be evaluated using behavioral task performance, self-report, and functional magnetic resonance imaging (fMRI). After the second overnight, participants will take the headband device home and wear it every night for approximately 2 weeks. For half of the participants, the headband will play tones every night and, for the other half, the headband will not play tones. Participants will then return for a final testing visit in which cognitive and emotional processes and anxiety\u002Fdepression symptoms will be assessed using behavioral task performance and self-report.",[28],"Acoustic Stimulation",[30,31,32,33,34,35,36],"Acoustic stimulation","Slow-wave activity","Anxiety","Depression","Cognitive control","Emotion","Daily acoustic stimulation","RECRUITING","2025-09-12",{"date":40,"type":41},"2025-09-18","ACTUAL",{"date":43,"type":41},"2024-04-24",{"date":45,"type":22},"2027-03",{"name":47,"class":48},"Michelle Stepan","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100499366","effects-and-mechanisms-of-ras-training-on-upper-limb-movements-in-pd-patients-100499366","NCT05782322","Effects and Mechanisms of RAS Training on Upper-limb Movements in PD Patients","Effects and Neural Mechanisms of Training Involving Rhythmic Auditory Stimulation on Upper-limb Movements in Patients With Parkinson's Disease","Inclusion Criteria:\n\n* (a) idiopathic PD diagnosed by a neurologist based on the Movement Disorders Society clinical diagnostic criteria;\n* (b) the Hoehn and Yahr stage is 2 or 3, meaning that bilateral movement problems or combination with mild postural instability;\n* (c) a score of Montreal Cognitive Assessment (MoCA) is equal to or higher than 21 to ensure that they understand experimental instructions;\n* (d) a score of Edinburgh Handedness Inventory is above 60 to ensure that they are right-handed;\n* (e) types and doses of medications remain unchanged in the past month right before participation.\n* Age- and sex-matched healthy controls who filled the criteria (c) and (d) will be recruited from communities.\n\nExclusion Criteria:\n\n* the presence of medical conditions or diseases that may affect hand movements, vision, or hearing based on self-report.",true,"85 Years",{"count":60,"type":22},72,[25],"Introduction Bradykinesia (i.e., slow movements) is one of the most prominent symptoms of Parkinson's disease (PD) and has a negative impact on quality of life. Rhythmic auditory stimulation (RAS), a widely used and promising treatment technique, has been shown to effectively improve gait speed in PD patients. However, only few studies have explored effects and neural mechanisms of RAS on upper-limb movements. We will conduct two studies to investigate effects and mechanisms of RAS on upper-limb movements in PD patients. The purpose of this study is to examine effects and neural mechanisms of upper-limb movement training involving RAS in PD patients.\n\nMethods This study will recruit patients with PD and healthy controls. This study will randomly assign PD patients into two groups: the PD-RAS group and the PD-noRAS group, and healthy controls into the HC-RAS group and the HC-noRAS group. A 7-day upper-limb training involving RAS (for the PD-RAS group and the HC-RAS group) or without RAS (for the PD-noRAS group and the HC-noRAS group) will be provided. EEG and behavioral assessments will be conducted before and after the first day of training, and after the seven-day training program. Two-way repeated measures analysis of variance will be performed to investigate the group and time effects on upper-limb function and neural activity.\n\nStudy significance The training program will serve as a reference for clinical practitioners who are interested in using RAS in clinical training for PD patients.",[28,64,65],"Parkinson Disease","Electroencephalography",[28,64,67,65],"Movement","NOT_YET_RECRUITING","2025-04-08",{"date":71,"type":41},"2025-04-10",{"date":73,"type":22},"2025-05-01",{"date":75,"type":22},"2026-03-31",{"name":77,"class":48},"The Hong Kong Polytechnic University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":57,"sex":17,"minAge":18,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":49},"100463037","acoustic-stimulation-during-restricted-sleep-after-sleep-deprivation-100463037","NCT05309473","Acoustic Stimulation During Restricted Sleep After Sleep Deprivation","Slow-wave Sleep Enhancement Using Acoustic Stimulation to Facilitate Performance Recovery During Restricted Sleep After Sleep Deprivation","Inclusion Criteria:\n\n* Healthy men and non-pregnant, non-lactating women 18 to 39 years of age (inclusive)\n* Must demonstrate adequate comprehension of the protocol, by achieving a score of at least 80% correct on a short multiple-choice quiz. Individuals who fail to achieve a passing score on the initial quiz will be given one opportunity to retest after a review of protocol information. Individuals who fail the comprehension assessment for the second time will be disqualified.\n\nExclusion Criteria:\n\n* You must have learned English as your first language\n* You must have a body mass index (BMI) below 30 (this is a mathematical calculation of your height and weight)\n* You must not have current or a history of sleeping problems (for example, insomnia or sleep apnea), or symptoms that indicate a potential sleep disorder\n* You must get an average of 6-9 hours of sleep per night and maintain a normal sleep\u002Fwake schedule\n* You must not drink excessive amounts of caffeine, alcohol, or smoke cigarettes regularly\n* You must not be on certain medications (determined on a case by case basis)\n* You must test negative for illicit drugs\n* Women must not be pregnant or nursing\n* You must not be participating in another ongoing clinical trial\n* You must have a social security number or tax identification number in order to be paid for screening and participation in the study\n* You cannot have a history of the following conditions: Cardiovascular disease, a neurologic disorder, pulmonary disease requiring inhaler use, kidney disease or kidney abnormalities, liver disease of liver abnormalities, a history of psychiatric disorder requiring hospitalization or medication within the last two years or for a continuous period of more than 6 months in the last ten years","39 Years",{"count":87,"type":22},44,[25],"The purpose of this study is to determine if brief sounds or tones presented within a restricted period of recovery sleep after a period of sleep deprivation will enhance restorative properties and improve performance during a subsequent period of wakefulness.",[91,92,28,93,94],"Sleep Deprivation","Sleep Restriction","Performance","Alertness","2024-04-22",{"date":97,"type":41},"2024-04-23",{"date":99,"type":41},"2022-03-14",{"date":101,"type":22},"2026-10",{"name":103,"class":104},"Walter Reed Army Institute of Research (WRAIR)","FED"]