[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acquired-brain-injury-including-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acquired-brain-injury-including-stroke":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,44,77,105,133,164,195,231,260,285,318,352],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100619504","stimulus-equivalence-learning-in-acquired-brain-injury-100619504",false,"NCT07345481","Stimulus Equivalence Learning in Acquired Brain Injury.","The Principle of Stimulus Equivalence Learning and Its Neuropsychological Correlates in Adults With Acquired Brain Injury (ABI).","Inclusion Criteria:\n\nABI patients (\\>3 months post-injury), including stroke, traumatic brain injury, brain tumor, encephalitis, and out-of-hospital cardiac arrest (OHCA).\n\nExclusion Criteria:\n\nNeurodegenerative disorders Severe psychiatric disorders (including suicidality) Insufficient command of the Dutch language Severe cognitive impairments, aphasia, or visual or hearing problems that make test administration impossible\n\nAn additional exclusion criterion for controls was any medical condition that could lead to cognitive impairment beyond normal aging, including stroke, TBI, brain tumor, or other forms of brain injury.",true,"ALL","18 Years","75 Years",{"count":21,"type":22},40,"ESTIMATED","1 Day","OBSERVATIONAL","Stimulus Equivalence Learning (SEL) is a form of learning in which stimuli (such as words, pictures, or sounds) become linked to one another in memory, even though this specific connection has not been directly taught. In a typical SEL task, two relations are taught explicitly (A→B and A→C), and the untrained relation (B→C) is then tested. This indirect relation is not intentionally or consciously learned and is considered a form of implicit learning. The principle of stimulus equivalence learning is still rarely applied in cognitive rehabilitation after acquired brain injury (ABI), with the exception of a few small (N=1) treatment studies that have shown positive effects. However, it remains unclear to what extent ABI may affect the ability to acquire stimulus equivalence.",[27],"Acquired Brain Injury (Including Stroke)",[29,30],"acquired brain injury","implicit memory","RECRUITING","2026-05-20",{"date":34,"type":35},"2026-05-22","ACTUAL",{"date":37,"type":35},"2026-01-29",{"date":39,"type":22},"2026-07",{"name":41,"class":42},"Klimmendaal Revalidatiespecialisten","NETWORK",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":43},"100639665","virtual-reality-based-interventions-after-brain-injury-100639665","NCT07586566","Virtual Reality Based Interventions After Brain Injury","The Effectiveness of Virtual Reality Based Interventions on Cognitive Function After Brain Injury","Inclusion Criteria:\n\nParticipants will be recruited from both the inpatient and outpatient units at the Department of Rehabilitation Medicine, Danderyd Hospital.\n\nInclusion criteria:\n\n1. Patients with acquired brain injury in need of multiprofessional rehabilitation admitted to the clinic are eligible if they\n2. are between 18 and 65 years;\n3. present with attention deficits and\n4. are deemed suitable for direct attention training by the rehabilitation team.\n\nExclusion Criteria:\n\n1. Epilepsy or suspected epilepsy;\n2. non-fluent in Swedish\n3. severe fatigue or\u002Fand cognitive dysfunction that makes participation difficult.","65 Years",{"count":53,"type":22},15,"INTERVENTIONAL",[56],"NA","After a brain injury, cognitive impairments are common, affecting an individual's independence and quality of life. Although various training programs are used in rehabilitation, it remains unclear how effective they are in real-life settings. The project now being planned at CogTech, a technology-driven rehabilitation unit at Danderyd Hospital, aims to evaluate new methods that can enhance both training effectiveness and motivation.\n\nIn the project, the effect of game-based training in virtual reality (VR) on cognition will be evaluated. VR offers a more realistic and engaging environment, which may improve the transfer of training outcomes to everyday situations. In this feasibility study, ten patients at the clinic will receive VR-training at 15 occasions in addition to rehabilitation as usual.\n\nThe results may contribute to the development of more individualized rehabilitation, reduced treatment times, and improved quality of life for people with brain injury.",[27],[60,61,62,63,64,65,29],"cognition","rehabilitation","vr","virtual reality","ar","augmented reality","NOT_YET_RECRUITING","2026-05-08",{"date":69,"type":35},"2026-05-14",{"date":71,"type":22},"2026-06-01",{"date":73,"type":22},"2028-07-31",{"name":75,"class":76},"Danderyd Hospital","OTHER",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":54,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":43},"100573662","implementation-of-a-home-based-computerized-cognitive-rehabilitation-program-for-patients-with-abi-100573662","NCT06749197","Implementation of a Home-based Computerized Cognitive Rehabilitation Program for Patients With ABI","Implementation of a Home-based Computerized Cognitive Rehabilitation Program for Patients With Acquired Brain Injury","CoRe@Home","Inclusion Criteria:\n\n* diagnosed with acquired brain injury\n* receiving outpatient rehabilitation\n* sufficient command of Dutch or English language\n* internet access\n\nExclusion Criteria:\n\n* incapacitated patients like patients diagnosed with dementia",{"count":86,"type":22},30,[56],"Rationale: Patients with acquired brain injury (ABI) may suffer from persistent cognitive deficits and\u002For subjective cognitive complaints, especially in the domains of attention and working memory. Cognitive deficits are associated with anxiety and depression and may affect social participation and health-related quality of life (HR-QoL). Approximately 25% of the patients with ABI will be referred to an in- and\u002For outpatient rehabilitation center for multidisciplinary therapy to optimize recovery. Multiple studies suggest that supervised computerized cognitive training (CCT) may enhance cognitive functioning in patients with ABI. Recently, the CCT program RehaCom was introduced as an online version which is suitable for home training. In this study the feasibility and outcomes of implementing home-based CCT into a blended care pathway will be investigated in patients receiving outpatient rehabilitation therapy after ABI.\n\nObjective: The aim of this study is to assess the feasibility and to evaluate the effect of blending a home-based CCT program (RehaCom) in standard care on cognitive functioning in patients after ABI.\n\nThe secondary aim is to evaluate the effect of this CCT program on subjective cognitive complaints, self-efficacy, psychological outcome measures and HR-QoL.\n\nStudy design: Randomized cross-over trial comparing a 5-week blended care pathway to 5 weeks of standard care within 30 patients with ABI.\n\nStudy population: Adults with ABI receiving outpatient rehabilitation therapy.\n\nIntervention: A blended care pathway including 1 cognitive strategy training session of 1 hour per week in the outpatient rehabilitation center in combination with home-based CCT in 4 sessions of 30 minutes per week, during 5 weeks. The standard care pathway includes 2 cognitive training sessions of 1 hour per week in the outpatient rehabilitation center during 5 weeks.\n\nMain study parameters\u002Fendpoints: Cognitive functioning (attention and working memory), self-efficacy, psychological functioning (coping, anxiety, depression) and HR-QoL, using non-invasive neuropsychological tests and standardized online questionnaires. All outcomes will be assessed at baseline (T0), after 6 weeks (T1) and after 12 weeks (T2).\n\nNature and extent of the burden and risks associated with participation, benefit and group relatedness: In the blended care pathway patients will be instructed to follow a home-based CCT program. Training at home requires a time investment from patients but will also reduce the number of visits to the rehabilitation center. Participants can choose what time of the day is most convenient for them to engage in the program in their home environment instead of traveling to the rehabilitation center for scheduled cognitive training. Increasing patients' responsibility in their recovery process may improve their self-efficacy and HRQoL.\n\nCompletion of online questionnaires also requires a certain time investment from patients and might lead to temporary fatigue. Patients may take a break at any moment and continue completing the questionnaires at a later time. By a maximum duration of 45 to 60 minutes per measurement we aim to minimize the burden for patients. There are no risks associated with participation.",[27],[60,91,92,93,94,95],"cognitive impairment","attention deficit","memory disorder","computerized cognitive training","home-based training","2026-04-30",{"date":98,"type":35},"2026-05-01",{"date":100,"type":35},"2025-03-20",{"date":102,"type":22},"2026-12-31",{"name":104,"class":76},"Erasmus Medical Center",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":18,"enrollmentInfo":113,"targetDuration":4,"studyType":54,"phases":115,"briefSummary":116,"conditions":117,"keywords":121,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":132},"100598583","bcihome-brain-computer-interface-solutions-to-enable-youth-living-with-severe-disabilities-100598583","NCT07073378","BCI@Home: Brain Computer Interface Solutions to Enable Youth Living With Severe Disabilities","BCI@home","Inclusion Criteria:\n\n* Age 5-18 years\n* Severe motor impairment including inability to walk and minimal functional hand use, and\u002For;\n* Severe communication impairment\n* Ability to follow simple instructions and attend to simple tasks\n* Home environment suitable for the program based on clinician and family discussion;\n* Informed assent\u002Fconsent\n\nExclusion Criteria:\n\n* Epileptic encephalopathy\n* Unstable epilepsy, or\n* Brain imaging incompatible with BCI functionality","5 Years",{"count":114,"type":22},18,[56],"The goal of this trial is to evaluate use of brain computer interfaces (BCI) at home for children with severe severe physical disabilities. The main questions it aims to answer are:\n\n1. Can a home BCI program enable children with disabilities to achieve personalized life participation goals?\n2. Can a home BCI program promote implementation reach?",[118,119,120,27],"Cerebral Palsy","Pediatric Stroke","Genetic Condition",[122],"pediatric brain computer interface","2026-04-29",{"date":125,"type":35},"2026-05-05",{"date":127,"type":35},"2025-11-01",{"date":129,"type":22},"2027-08-31",{"name":131,"class":76},"University of Calgary",2,{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":54,"phases":141,"briefSummary":142,"conditions":143,"keywords":146,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":43},"100635285","clinical-investigation-to-validate-the-safety-and-performance-of-integrating-functional-electrical-stimulation-into-the-able-exoskeleton-100635285","NCT07550699","Clinical Investigation to Validate the Safety and Performance of Integrating Functional Electrical Stimulation Into the ABLE Exoskeleton","Inclusion Criteria:\n\n* 18 to 80 years old\n* Diagnosis of acquired brain injury, spinal cord injury (neurological level between C5 and L2, AIS B to AIS D), or multiple sclerosis\n* Currently undergoing physiotherapy treatment, either as an inpatient or outpatient at the investigating center\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Significant osteoporosis that may increase the risk of fracture\n* Unresolved fractures in the pelvis or limbs, or a history of fragility fractures in the lower limbs within the past 2 years\n* Spinal instability (or use of spinal orthoses, unless medically approved)\n* Deterioration \\>3 points of the total in the motor score of the International Standards for the Neurological Classification of Spinal Cord Injury (ISNCSCI) in the last 4 weeks. Loss of sensation and\u002For motor activity above the level of injury detected that has not been evaluated by a doctor.\n* Severe spasticity: Level 4 on the Modified Ashworth Scale\n* Orthostatic hypotension: Inability to tolerate at least 10 minutes in an upright position\n* Uncontrolled autonomic dysreflexia\n* Medical instability\n* Unstable cardiovascular condition, hemodynamic instability, untreated hypertension (SBP \\> 140 mmHg, DBP \\> 90 mmHg), deep vein thrombosis (DVT), or uncontrolled autonomic dysreflexia\n* Severe comorbidities, including any condition deemed inappropriate by the investigator for using the ABLE Exoskeleton or for completing the study\n* Pressure ulcers Grade I or higher (as defined by the European Pressure Ulcer Advisory Panel - EPUAP) in areas that will be in contact with the device\n* Anthropometric measurements incompatible with the ABLE Exoskeleton, specifically height outside the 1.5-1.9 m range or weight exceeding 100 kg\n* Anatomical constraints (such as leg length differences, users unable to position themselves inside the device) that are incompatible with the device\n* Range of motion restrictions preventing normal gait or sit-to-stand transitions, including: Ankle: ability to achieve at least neutral (0°) position; Knee: ability to extend to at least -10°; Hip: bilateral hip flexion of at least 100° and extension of at least 0°\n* Heterotopic ossification\n* Pregnant or breastfeeding women\n* Cognitive impairment that results in the inability to follow simple instructions, particularly psychological or cognitive problems that do not allow a participant to follow study procedures\n* Requires assisted ventilation.\n* Scoliosis \\>40-50º Cobb angle.\n* Presence of pacemakers, defibrillators, or other non-compatible electronic implants.\n* Open wounds, infections, or active irritation at the electrode placement sites.\n* Severe dermatological conditions in the stimulation area.\n* Uncontrolled active epilepsy.\n* Malignant tumors in the area of application.\n* Severe loss of sensation in the areas where electrodes are to be placed.\n* Medical conditions where electrical stimulation is contraindicated by physician recommendation.\n* Inability to communicate pain, discomfort, or adverse reactions during stimulation.\n* Venous thrombosis, thrombophlebitis, or severe arterial obstruction.\n* Chronic venous insufficiency with significant varicosities.\n* Hemophilia.\n* Ongoing infectious process or fever.\n* Presence of metallic implants in the flow area between the electrodes","80 Years",{"count":53,"type":22},[56],"The primary objective of this study is to validate the safety and clinical performance of the ABLE Exoskeleton with integrated Functional Electrical Stimulation (ABLE FES) in individuals with neurological conditions that impair gait, including spinal cord injury, acquired brain injury, and multiple sclerosis.\n\nThe secondary objective is to collect preliminary data on the potential clinical and psychosocial benefits of combining robotic gait assistance with electrical stimulation.",[27,144,145],"Spinal Cord Injury","Multiple Sclerosis",[147,148,149,150,144,145,151,152,153],"Gait training","Wearable exoskeleton","Acquired Brain Injury","Lower-limb exoskeleton","Functional Electrical Stimulation (FES)","Robotic exoskeleton","Hybrid exoskeleton-FES system","2026-04-22",{"date":156,"type":35},"2026-04-24",{"date":158,"type":35},"2026-04-20",{"date":160,"type":22},"2026-08-12",{"name":162,"class":163},"ABLE Human Motion S.L.","INDUSTRY",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":17,"minAge":172,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":54,"phases":176,"briefSummary":177,"conditions":178,"keywords":181,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":43},"100597507","concurrent-trials-on-nature-based-therapy-for-inpatients-in-dementia-and-rehabilitation-medicine-wards-100597507","NCT07059390","Concurrent Trials on Nature-Based Therapy for Inpatients in Dementia and Rehabilitation Medicine Wards","Changi General Hospital Complementary Health Therapy","TGIF","Inclusion Criteria:\n\nPatients with dementia:\n\n1. Age 65-100 years old\n2. Have a diagnosis of delirium\u002F dementia or both.\n3. Have diagnosis of dementia with and without behavioural symptoms of dementia (BPSD)\n4. Ability to communicate with the Nature-based Therapist (in languages such as English, Mandarin Chinese, Chinese dialects or Malay)\n5. Manageable behavioural symptoms and able to focus attention for minimum of 30 minutes\n\nRehabilitation Medicine patients:\n\n1. Age 21-100 years old\n2. Acquired brain injury with residual impairments, which can be either in the i) motor, and\u002For ii) cognitive domains, and\u002For iii) suspected or diagnosed mood disorders (including adjustment disorder, depression and anxiety disorders) -patients would then be stratified according to the category(s) of impairments both for consideration of interventions and for outcome measures\u002Fanalysis\n3. Additional Physical\u002FCognitive Criteria required will depend on range of specific therapeutic activities that could be prescribed\u002Fadministered (eg.at least 1 upper limb with Manual Muscle Testing (MMT) of at least 3\u002F5, with ability for active grasp\u002Frelease, ability to sustain attention for the duration of the session, cognitive Functional Independence Measure (FIM) score of at least 25 points etc)\n\nExclusion Criteria:\n\n1. In isolation due to contact, droplet or airborne precautions\n2. Unable to provide consent and lack of surrogate decision maker to provide consent\n3. Poorly managed psychiatric or behaviour symptoms with threats to others surrounding them.\n4. Age \\\u003C 21 years\n5. Patients who are haemodynamically unstable.\n6. Patients on strict bed rest","21 Years","100 Years",{"count":175,"type":22},1600,[56],"Nature-based Therapy, such as forest bathing and horticultural therapy, has been shown to have physical, psychological and emotional health benefits. We posit that personalised and guided Nature-based Therapy, which leverages the benefits of therapeutic gardens in an urban hospital setting, improves the overall wellbeing of elderly inpatients with dementia (aged \\>65 years old) and their caregivers, as well as patients undergoing inpatient rehabilitation. To determine the effectiveness of Nature-based Therapy for these two inpatient populations, we designed a pilot study, TGIF, to be conducted at the dementia and rehabilitation medicine wards at Changi General Hospital in Singapore.",[179,180],"Dementia","Acquired Brain Injury Including Stroke",[179,182,183,184,185],"Stroke","Traumatic Brain Injury","Delirium","Nature-Based Therapy","2026-03-19",{"date":188,"type":35},"2026-03-23",{"date":190,"type":22},"2027-05",{"date":192,"type":22},"2028-08",{"name":194,"class":76},"Changi General Hospital",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":201,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":54,"phases":205,"briefSummary":207,"conditions":208,"keywords":210,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":43},"100616282","phase-4-individualised-cryoneurolysis-to-treat-pain-in-the-context-of-spasticity-in-the-upper-and-lower-extremities-100616282","NCT07303582","Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities","Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities (ICE): a Pilot Randomised Controlled Trial","ICE","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the trial OR a positive opinion from a consultee is provided by a family member or carer (relative or friend) willing to provide personal consultee (PC) advice.\n* Male or Female, aged 18 years or above.\n* Diagnosed with a central neurological condition, including acquired brain injury (e.g. from ischaemic stroke, trauma, or haemorrhage), multiple sclerosis, and spinal cord injury.\n* Clinical indication for Botulinum Toxin and Cryoneurolysis treatment, including pain associated with spasticity and with a clinically meaningful response to diagnostic nerve block to specific nerves or nerve branches that can be treated with cryoneurolysis.\n* At least one rehabilitation goal related to management of pain resulting from spasticity.\n\nExclusion Criteria:\n\n* Participant has received Botulinum toxin or cryoneurolysis within the last 90 days.\n* Raynaud's syndrome.\n* Cryoglobulinaemia.\n* Cold urticaria.\n* Bleeding disorders.\n* Localised infection at intended treatment site.\n* Planned oral antispasmodic medication dose changes.\n* Pregnancy, breastfeeding, or planning pregnancy in the trial period.\n* Scheduled elective surgery or other procedures requiring general anaesthesia during the trial.\n* Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial.\n* Participants who are currently enrolled in another trial may be excluded if it is deemed (in the investigator's opinion) that participation could influence the results for either study.",{"count":204,"type":22},50,[206],"PHASE4","Spasticity is an umbrella term for impairments of muscle tone and control in people with damage to the brain and spinal cord. It is highly prevalent and results in pain, stiffness, and contribute to difficulties in activities of daily living. Current treatment options are limited, and many people experience only partial reduction in spasticity and frequent repeated treatments are needed.\n\nCryoneurolysis is a medical technique which involves the controlled freezing of the nerves. It has been approved in the UK for the treatment of pain in the context of spasticity through the targeting of nerves which control problematic muscles. Oxford University Hospitals NHS Foundation Trust has been offering this treatment routinely since January 2024. This pilot study aims to improve the understanding of the potential effectiveness of this treatment and its potential side effects when compared with a more commonly used treatment (Botulinum Toxin).\n\nParticipants will be randomly allocated to receive usual care with Botulinum Toxin (control group) or usual care with Cryoneurolysis (intervention group). The investigators will assess pain, goal attainment, side effects, spasticity, disability and independence in daily activities, and movement of the arm and leg. Assessments will be at baseline and then 6-, 12-, 18-, and 24-weeks following treatment. Participants who are randomised to the control group will have the opportunity to receive cryoneurolysis treatment after the 12 week follow up assessment.\n\nThe results of this study will help to guide future studies to examine the effectiveness of this treatment.",[209,27,145,144],"Centreal Neurological Condition",[211,212,213,149,182,145,144,214,215,216,217,218,219,220,221],"Cryoneurolysis","Spasticity","Pain","Central Neurological Condition","Botulinum Toxin (botox)","Iovera","Chemodenervation","BoNT-A","Cryoneurotomy","Cryoneurectomy","Cryoanalgesia","2025-12-10",{"date":224,"type":35},"2025-12-26",{"date":226,"type":35},"2025-12-02",{"date":228,"type":22},"2026-11-30",{"name":230,"class":76},"Oxford University Hospitals NHS Trust",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":139,"enrollmentInfo":239,"targetDuration":4,"studyType":54,"phases":241,"briefSummary":242,"conditions":243,"keywords":245,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":43},"100603008","functional-electrical-stimulation-to-treat-critical-neuromyopathy-after-severe-stroke-a-pilot-study-100603008","NCT07130929","Functional Electrical Stimulation to Treat Critical Neuromyopathy After Severe Stroke: a Pilot Study.","Intensive Rehabilitation by Functional Electrical Stimulation for the Treatment of Critical Neuromyopathy in Patients With Severe Stroke Admitted to the Highly Specialized Intensive Rehabilitation Unit: a Pilot Study","RISE","Inclusion Criteria:\n\n* Diagnosis of ischemic or hemorrhagic vascular GCA involving unilateral motor deficit \\\u003C 3 months;\n* Premorbid Modified Rankin Scale \\\u003C2;\n* Age \\>18 years and \\\u003C80 years;\n* Level of Cognitive Functioning \\> 4 for active participation in treatment.\n* MRC total sum score \\\u003C= 48 (range 0 -60) for clinical suspicion of ICU-AW\n* Clinical diagnosis of tetra\u002Fparaparesis of peripheral origin confirmed by neurophysiological examination;\n* Signature of informed consent by the patient or, if incapacitated, by their legal representative.\n\nExclusion Criteria:\n\n* Clinical cardio-respiratory or internal instability such as to prevent treatment;\n* History of previous comorbidity for ICU-AW;\n* Previous known chronic neuropathy;\n* Severe coagulopathy;\n* Skin integrity problems at the interface surfaces with the electrostimulator;\n* Epilepsy not controlled by medication;\n* Presence of implanted electronic devices;\n* Pregnancy or breastfeeding;\n* Severe spasticity with a score of \\>3 on the modified Ashworth scale;\n* Treatment with botulinum toxin;\n* Recent malignant neoplasm;\n* Conditions that put you at risk for neuropathies, e.g., history of diabetes mellitus, renal failure, hepatic failure, vitamin deficiencies, chronic alcoholism, vasculitis, previous use of neurotoxic drugs.",{"count":240,"type":22},24,[56],"This study aims to evaluate the effectiveness of physiotherapy treatment combined with functional electrical stimulation (FES) in a small group of patients with severe acquired brain injury (SABI) of vascular origin and with a clinical and instrumental diagnosis of \"Intensive Care Unit-Acquired Weakness\" (ICU-AW). Functional electrical stimulation is a technology that uses electrical impulses, generated by an external device, to reactivate the neuromuscular system through electrodes applied to the skin. In functional electrical stimulation, this process is integrated into physiotherapy sessions, with the active involvement of the patient, through the performance of exercises with the assistance and supervision of the physiotherapist. The rationale behind this is to stimulate neuroplasticity processes by facilitating movement through the application of electrical stimuli and the active participation of the patient in performing a motor task, in an attempt to promote improvement in an impaired function.\n\nIn particular, the objectives that will be pursued are: improvement of lower limb neuromyopathy assessed clinically using the Medical Research Council (MRC) scale, the Fugl-Meyer scale for lower limbs, the Short Physical Performance Battery (SPPB) scale, the assessment of active and passive Range Of Motion (ROM) of the main joints of the lower limb (hip, knee, ankle) and measured instrumentally by neurophysiological examination and ultrasound examination.\n\nAfter randomization, patients in the control arm will be treated with physiotherapy and speech therapy sessions as per the conventional protocol, and an additional 15 physiotherapy sessions lasting 60 minutes over a period of 5 weeks. Alternatively, patients in the experimental group will receive, in addition to conventional rehabilitation treatment, a treatment consisting of 15 physiotherapy sessions combined with FES lasting 60 minutes over a period of 5 weeks.\n\nAt the end of the treatment period, baseline characteristics and clinical and instrumental outcome variables will be compared between the two groups using the chi-square test for dichotomous and categorical variables and the t-test for independent samples or the Mann-Whitney U test for continuous variables, depending on whether or not they are normally distributed. In all analyses, a p-value \\\u003C0.05 will be considered significant.",[244,27],"Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)",[246,247,248,249,250],"stroke","Intensive Care Unit (ICU) acquired weakness (ICU - AW)","Functional Electrical Stimulation","FES","Rehabilitation","2025-12-04",{"date":253,"type":35},"2025-12-11",{"date":255,"type":35},"2025-09-23",{"date":257,"type":22},"2027-03-23",{"name":259,"class":76},"Fondazione Don Carlo Gnocchi Onlus",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":269,"conditions":270,"keywords":271,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":281,"leadSponsor":283,"locationsCount":43},"100609485","neuropsychiatric-outcomes-and-disrupted-sleep-following-acquired-brain-injury-100609485","NCT07215195","Neuropsychiatric Outcomes and Disrupted Sleep Following Acquired Brain Injury","NODS","Inclusion Criteria:\n\n* Willing and able to give informed consent for participation in the study.\n* Aged 18 years or above.\n* At least one week, but less than 12 months post-injury\n* Clinical diagnosis of acquired brain injury (stroke, haemorrhage or traumatic).\n* Participants with Traumatic Brain Injury will have a Mild (probable) or Moderate-severe (definite) brain injury according to the Mayo classification\n* Participants must be willing to consent to us contacting their general practitioner (GP) or direct care team if we have concerns about their mental health\n\nExclusion Criteria:\n\n* Brain injury not caused by trauma, haemorrhage or stroke\n* Previous brain injury.\n* Other relevant neurological conditions which could affect outcome measures (e.g., Parkinson's or Alzheimer's disease)\n* No stable and suitable place to sleep",{"count":268,"type":22},150,"The two most common causes of brain injury are stroke and trauma. Both sleep and mental health problems are common after brain injury; we will investigate whether there is a relationship between poor sleep quality and worse mental health in this group. We will also follow patients up, at approximately three-monthly intervals until one year after injury, to see how sleep and mental health symptoms change over time and with recovery.\n\nWe will assess sleep in detail using questionnaires, a sleep monitor worn on the wrist, a portable brain activity sensor, and a sleep mat. We will assess mental health (neuropsychiatric) symptoms using questionnaires.\n\nParticipants will be asked to complete these assessments at baseline and at approximately 3-monthly intervals until they reach 12 months post-injury.\n\nThis data will allow us to explore the types of sleep disruption seen after brain injury and examine the association between sleep and mental health symptoms.",[27],[246,272,273,274,275,276],"traumatic brain injury","neuropsychiatric disorder","movement","sleep","brain injury","2025-10-01",{"date":279,"type":35},"2025-10-10",{"date":277,"type":22},{"date":282,"type":22},"2027-11-30",{"name":284,"class":76},"University of Oxford",{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":16,"sex":17,"minAge":292,"maxAge":51,"enrollmentInfo":293,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":295,"conditions":296,"keywords":302,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":43},"100603382","monitoring-fatigue-in-daily-life-in-adults-with-cerebral-palsy-or-acquired-brain-injury-100603382","NCT07135791","Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain Injury","Real-Time Monitoring of Fatigue In Daily Life Among Adults With Cerebral Palsy or Acquired Brain Injury: An Observational Study","Inclusion Criteria:\n\n* Score of minimum 4 on the 7-item Fatigue Severity Scale (CP and ABI only)\n* Speak, read, and write Danish\n* Living in a private residence (i.e., not in institutional care or facilities providing 24-hour assistance)\n* Able to walk independently or with assistive devices over short distances\n* Able to operate a smartphone independently\n\nAdditional inclusion criteria for CP specifically:\n\n* Self-reported diagnosis of CP\n* Gross Motor Function Classification System (GMFCS) level ≤ II\n* Communication Function Classification System level ≤ II\n\nAdditional inclusion criteria for ABI specifically:\n\n* Self-reported diagnosis of ABI, including stroke, traumatic brain injury, brain infections, toxins, anoxia, or encephalopathy (transient ischemic attack, concussion or post-concussion syndrome, intracranial tumors, or progressive brain diseases are not included)\n* Between three months and two years post-injury\n* modified Rankin Scale (mRS) score ≤ 3\n\nExclusion Criteria:\n\n* History of other neurological disorders or chronic fatigue syndrome requiring treatment\n* Current substance or alcohol abuse\n* Night shift work or travel across time zones (1 to 3 zones within the last week or 4 to 6 zones within the last two weeks or at least 7 zones within the last 4 weeks)","30 Years",{"count":294,"type":22},120,"The goal of this observational study is to learn about levels and patterns of fatigue in adults with cerebral palsy (CP) and acquired brain injury (ABI) in daily life.\n\nThe main question it aims to answer is: How do adults with CP and ABI experience fatigue in daily life?\n\nResearchers will compare data from CP and ABI with healthy volunteers to see if they experience fatigue differently.\n\nParticipants will:\n\n* Monitor their symptoms, mood, and behavior in real-time by completing a brief survey on their mobile phone 10 times a day for seven consecutive days.\n* Attend a briefing session the day prior to the seven-day period of real-time monitoring.\n* Wear an accelerometer for the seven-day period.\n* Complete a daily sleep diary for the seven-day period.\n* Receive feedback on their real-time monitoring data, sleep and activity data.",[297,298,299,180,300,301],"Fatigue Symptom","Fatigue Intensity","Cerebral Palsy (CP)","Fatigue, Mental","Fatigue",[303,304,305,306,307,301,308],"Cerebral palsy","Acquired brain injury","ecological momentary assessment","experience sampling method","real-time monitoring","Real-time fatigue","2025-08-15",{"date":311,"type":35},"2025-08-22",{"date":313,"type":35},"2025-03-26",{"date":315,"type":22},"2026-10-31",{"name":317,"class":76},"Rigshospitalet, Denmark",{"id":319,"slug":320,"hasResults":11,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":11,"sex":17,"minAge":325,"maxAge":326,"enrollmentInfo":327,"targetDuration":4,"studyType":54,"phases":328,"briefSummary":329,"conditions":330,"keywords":334,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":43},"100599508","lets-co-operate-together-we-are-stronger-100599508","NCT07085403","Let's CO-OPerate! Together we Are Stronger","Let's CO-OPerate! Together we Are Stronger: Exploring the Effectiveness of the CO-OP Cognitive Problem-solving Approach in the Context of an Intensive Group Rehabilitation Training for a Paediatric Population With Executive Function Deficits and\u002For Developmental Coordination Disorders Following Brain Injury","Inclusion criteria:\n\n* Children\u002Fadolescents (8-16 years old) with coordination disorders and\u002For executive function deficits, following a acquired brain injury more than 3 months ago or a congenital brain lesion or a neurodevelopmental disorder.\n* Executive function deficits as assessed by neuropsychological tests (standardised tests and\u002For questionnaires) and\u002For coordination disorders as assessed by neuropsychological tests (standardised tests and\u002For questionnaires).\n* Vision and hearing normal or sufficient to communicate effectively (with appropriate correction where necessary).\n* Cognitive, behavioural and expressive\u002Freceptive communication skills enabling them to identify goals and participate actively in the CO-OP intervention process.\n* Membership of a health insurance scheme or beneficiary.\n* Agreement of the child\u002Fadolescent and informed consent expressed by at least one of the holders of parental authority.\n\nNon-inclusion criteria :\n\n* Children\u002Fadolescents who do not meet the inclusion criteria.\n* Children\u002Fadolescents and\u002For parents non-French-speaking.\n* Presenting intellectual difficulties, or severe problems of comprehension, memory or attention, as described in the CO-OP recommendations.\n* A diagnosed severe anxiety-depressive disorder that is not compatible with participation in the study.\n* Inability to remain involved until the end of the CO-OP intervention phase (e.g. planned move).","8 Years","16 Years",{"count":5,"type":22},[56],"The goal of this replicated single case experimental study using a randomized multiple baseline design across participants and goals is to enable children\u002Fadolescents (aged 8-16 years) with developmental coordination disorders and\u002For executive function deficits following an acquired or congenital brain injury, to achieve their occupational goals. The aim is to make them more independents and autonomous in their daily lives. To achieve this, we're going to offer them an intensive group CO-OP (Cognitive Orientation to daily Occupational Performance Approach) rehabilitation training, and actively involving the parents. The main questions it aims to answer are:\n\n* To evaluate the improvement in occupational performance\\* (and its maintenance over time) following intervention using the CO-OP Approach.\n\n  \\*Occupational performance is a person's ability to choose, organize and engage in meaningful occupations that give them satisfaction. These occupations, determined by culture and corresponding to their age group, enable them to take care of themselves, have fun and contribute to the social and economic fabric of the community.\n* To gather parents' experiences of supporting their child during the CO-OP intervention and its follow-up phase.\n\nParticipants will be asked to identify 3 goals that they would like to achieve with the CO-OP Approach. The CO-OP intervention will take the form of two half-days a week for 5 weeks, with 1 hour 30 minutes of individual CO-OP sessions and 1 hour 30 minutes of group sessions.",[331,332,27,333],"Executive Function Deficits (EFD)","Developmental Coordination Disorder","Brain Injury, Fetus and Neonate",[335,336,337,338,29,339,340,341,342],"paediatric rehabilitation","occupational therapy","executive function deficits","developmental coordination disorder","fetus and neonate brain injury","Cognitive Orientation to daily Occupational Performance (CO--OP)","intensive training","individual and group rehabilitation","2025-08-08",{"date":345,"type":35},"2025-08-13",{"date":347,"type":22},"2025-09-01",{"date":349,"type":22},"2027-05-01",{"name":351,"class":76},"Hopitaux de Saint-Maurice",{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":358,"eligibilityCriteria":359,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":360,"targetDuration":4,"studyType":54,"phases":361,"briefSummary":362,"conditions":363,"keywords":365,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":373,"leadSponsor":375,"locationsCount":132},"100594261","immersive-functional-virtual-reality-in-people-with-acquired-brain-injury-and-unilateral-spatial-neglect-100594261","NCT07017140","Immersive Functional Virtual Reality in People With Acquired Brain Injury and Unilateral Spatial Neglect","Immersive Functional Virtual Reality in People With Acquired Brain Injury and Unilateral Spatial Neglect: A Feasibility and Usability Study","REVINE","Inclusion Criteria:\n\n* Age 18 years or older.\n* Diagnosis of acquired brain injury (stroke or traumatic brain injury) in the subacute phase (\\>7 days to 6 months) or chronic phase (\\>6 months).\n* Presence of unilateral spatial neglect, defined as omission of 6 or more bells on the left hemifield in the Bells Cancellation Test.\n* Currently receiving care at the Outpatient Rehabilitation Service of the Consorci Hospitalari de Vic or at Vall d'Hebron University Hospital, or listed in the historical patient registry of these centers.\n* Presence of mild to moderate upper limb impairment, defined as a score \\>29 on the Fugl-Meyer Upper-Extremity scale.\n* Medically stable and eligible to begin a rehabilitation program.\n* Willing to participate in the study and able to provide signed informed consent.\n\nExclusion Criteria:\n\n* Delirium and\u002For behavioral disturbances that prevent the participant from following simple instructions.\n* Severe cognitive impairment, defined as a Mini-Mental State Examination (MMSE) score below 18, that interferes with the use of virtual reality.\n* Severe visual and\u002For auditory impairment that prevents the use of immersive VR goggles.\n* Severe language comprehension difficulties that interfere with the instructions during the intervention.\n* Hypersensitivity that prevents the placement of the VR headset.\n* Headache or dizziness induced by the use of VR goggles.\n* History of photosensitive epilepsy.",{"count":86,"type":22},[56],"Unilateral spatial neglect (USN) is a common and highly disabling condition following acquired brain injury (ABI), significantly impairing individuals' ability to perform daily activities and reducing their autonomy. It frequently affects patients who have suffered a stroke or traumatic brain injury, and it is often associated with worse functional outcomes and increased care needs. Despite advances in neurorehabilitation, conventional assessment and treatment tools for USN have shown limitations in sensitivity and ecological validity.\n\nImmersive Functional Virtual Reality (IFVR) is an emerging and promising technology that creates controlled, interactive environments, facilitating both assessment and rehabilitation in a motivating and safe way. The REVINE study explores the feasibility, usability, and preliminary clinical effects of an immersive VR-based intervention tailored to address motor and spatial deficits in adults with ABI and USN.\n\nThis is a prospective, non-controlled feasibility study using a single-group interrupted time series design. Participants (N=30) will be recruited from two neurorehabilitation services in Catalonia (Spain): the Neurological Rehabilitation and Brain Injury Unit at Vall d'Hebron University Hospital and the Outpatient Rehabilitation Service at Consorci Hospitalari de Vic. Eligible participants will be adults with ABI in the subacute or chronic phase, presenting USN (as measured by the Catherine Bergego Scale and the Bells Cancellation Test) and mild-to-moderate upper limb impairment.\n\nThe intervention consists of 12 supervised individual IFVR sessions (30 minutes\u002Fsession, 3 times\u002Fweek for 4 weeks), using the KINESIX system (NeuroGroup XR Inc., Montreal, Canada). A progressive series of gamified tasks will be delivered through immersive VR, targeting spatial exploration and upper limb function, with adjustable difficulty and real-time feedback.\n\nParticipants will undergo three pre-intervention and three post-intervention evaluations, spaced one month apart. Clinical outcomes include the degree of USN (measured by the Catherine Bergego Scale, the Bells Cancellation Test, and the KINESIX light-reaching test), usability (System Usability Scale), and satisfaction (User Satisfaction Evaluation Questionnaire). Feasibility outcomes include recruitment and retention rates, adherence to treatment, session completion times, adverse events, and therapist assistance level.\n\nWe hypothesize that IFVR will be a viable and well-accepted intervention, with high user satisfaction, minimal adverse effects, and measurable improvements in neglect-related outcomes. This study aims to inform the future design of larger-scale trials and support the integration of IFVR into routine neurorehabilitation settings or home-based telerehabilitation programs.",[180,364,182,183],"Unilateral Spatial Neglect (USN)",[29,366,246,272,367,368,63],"unilateral spatial neglect","cognitive and motor rehabilitation","virtual reality-based therapy","2025-06-10",{"date":371,"type":35},"2025-06-12",{"date":277,"type":22},{"date":374,"type":22},"2029-02-01",{"name":376,"class":76},"University of Vic - Central University of Catalonia"]