[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acquired-brain-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acquired-brain-injury":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,25,0,[8,47,90,119,148,172,199,229,260,285,310,336,363,391,417,442,468,492,517,542,570,601,635,662,684],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100609061","describing-the-effect-of-familiar-song-on-arousal-and-awareness-for-children-with-disorders-of-consciousness-doc-100609061",false,"NCT07209657","Describing the Effect of Familiar Song on Arousal and Awareness for Children With Disorders of Consciousness (DoC)","A Parallel Mixed Methods Investigation of a Music Interventions in Paediatric Disorders of Consciousness (DoC)","SongDoC","Inclusion Criteria:\n\n* Diagnosis of a severe ABI, as indicated by at least one of the following:\n\n  * Glasgow Coma Scale (GCS) 3-8 at admission to RCH\n  * Mass pathology evident on neuroimaging\n  * Expert opinion of treating consultant\n* Diagnosis of a DoC, as indicated by at least one of the following:\n\n  * Rancho Los Amigos Scale I, II, III or IV\n  * Expert opinion of treating consultant\n* Legally acceptable representative capable of understanding the informed consent document and providing consent on the participant's behalf. Interpreters will be employed as necessary.\n\nExclusion Criteria:\n\n* ABI not compatible with life\u002Fchild expected to die\n* ABI resulting from suspected non-accidental causes, including assault\u002Fabuse\n* Diagnosed premorbid or acquired severe hearing loss\n* Inability or unwillingness of legally acceptable representative to give written informed consent","ALL","1 Year","18 Years",{"count":21,"type":22},10,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to compare the effect of live music therapy and recorded music on recovery of consciousness in children aged 1 to 18 years who have a disorder of consciousness (DoC) after a severe brain injury. Researchers also want to learn how children respond during music and noise, whether early responses to music are linked to recovery at 6 months, and how parents experience music therapy during their child's hospital stay at The Royal Children's Hospital (RCH) in Melbourne.\n\nParticipants will:\n\n* Take part in a 10-day study period while in hospital. On 8 of the 10 days, they will receive either live or recorded familiar music in random order. Their level of consciousness will be measured before and after each session using a simple behavioural checklist. On the other 2 days, they will take part in video-recorded sessions to compare behavioural responses during live music, recorded music, and white noise. Videos will help capture small changes in movement, eye gaze, or facial expression.\n* Have their level of consciousness checked again at 6 months after injury to see if early responses relate to later recovery.\n\nParents and caregivers will be invited to take part in an interview about their experiences and observations of music therapy with their child.\n\nThis study will help researchers understand whether live music therapy provides benefits beyond recorded music and will guide how music therapy is best used to support children and families during recovery from severe brain injury.",[28,29],"Disorder of Consciousness","Acquired Brain Injury",[31,32,33],"music therapy","music","paediatric disorder of consciousness","NOT_YET_RECRUITING","2026-06-23",{"date":37,"type":38},"2026-06-25","ACTUAL",{"date":40,"type":22},"2026-08",{"date":42,"type":22},"2028-11-30",{"name":44,"class":45},"Murdoch Childrens Research Institute","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":66,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":46},"100469490","regulating-emotions-and-behaviors-after-brain-injury-100469490","NCT05393492","Regulating Emotions and Behaviors After Brain Injury","Dialectical Behavior Therapy for Challenging Behaviors and Emotional Distress After Acquired Brain Injury : a Pilot Study","GREMO-LCA","Eligibility Criteria: \\* (Limit: 15,000 characters)\n\nSummary criteria for participant selection.\n\nMain eligibility criteria\n\nGREMO patients :\n\n* Inclusion criteria:\n\n  * Persons with acquired brain injury regardless of the type or location of the injury\n  * Age between 18 and 68\n  * Over 18 months since the acquired brain injury (or 6 month if mild traumatic brain injury)\n  * Challenging behaviors or emotional dysregulation or high level of anxiety \u002F depression or family's complaints about emotional dysregulation\n  * Secondary or exacerbated by an acquired brain injury\n  * Causing important suffering for themselves or their families\n  * Being affiliated to a social security\n  * Fluent in French\n  * Being able to understand goals and risks and to give a dated and signed consent\n* Exclusion criteria:\n\n  * Clinically evident severe lack of insight, lack of abstract reasoning, or severe anosognosia\n  * Patients without any complaints\n  * Severe cognitive impairments, aphasia or intellectual impairments that doesn't allow to understand DBT skills, questionnaires or group intreactions\n  * Non fluent in French\n  * Associated brain degenerative disease\n  * Cancerous brain injury with uncertain progression\n  * Non-stabilized psychotic disorder\n  * Following a third wave cognitive behavioral therapy during the research study (for example : acceptance and commitment therapy)\n\nControls without brain injury\n\n* Inclusion criteria :\n\n  * Being 18 years old or more\n  * Without brain injury\n* Exclusion criteria :\n\n  * Non fluent in French\n  * History of brain injury or brain disease\n  * History of psychiatric disorder\n  * Personality disorder\n  * GREMO patient's family member living together\n  * Psychologist, neuropsychologist or people with an emotional regulation knowledge linked to their profession\n  * Being under guardianship or curatorship\n  * Being pregnant or breastfeeding\n\nGREMO patients' family members\n\n* Inclusion criteria :\n\n  * Being 18 years old or more\n  * GREMO patient's family member\n  * Living with a GREMO patient\n  * Agreeing to rate an emotion-behavior-skills diary cards\n* Exclusion criteria :\n\n  * GREMO patient's refusal for their family member to participate\n  * Non fluent in French\n  * Brain injury or brain disease\n  * Major lack of insight\n  * Being under trusteeship or curatorship\n\nQualitative research ABI patients and families\n\n* Inclusion criteria :\n\n  * Person with ABI attending the same medico-social service as GREMO patients\n  * Ineligible for GREMO patients group (participation refusal, major insight difficulty…)\n  * Agreeing to talk about their free will or spirituality\n* Exclusion criteria :\n\n  * Aphasia or dysarthria not allowing understandable recording\n  * Impossibility to understand oral questions\n  * Non fluent in French",true,{"count":57,"type":22},77,[25],"After acquired brain injury (ABI), persons can experience emotional and behavioral difficulties, that can be painful both for the person and his\u002Fher family. This clinical study aims at measuring the effectiveness of a third wave cognitive behavioral therapy called \"dialectical behavior therapy\" (DBT). DBT aims at teaching persons emotion regulation skills, interpersonal effectiveness skills, mindfulness and distress tolerance skills through group and individual sessions.\n\nThe study's hypothesis is that DBT, in an adapted format for persons with ABI can lead to\n\n* a better quality of life, emotional and behavioral regulation, and self-esteem\n* decrease in problematic behaviors\n* progress in life goals\n* increase post traumatic growth and spirituality\n* better family functioning and lesser burden for care givers\n* experiencing more emotions and more free will\n\n  45 persons with an ABI sustained more than 18 month back, will follow a 3 phases, follow-up with care as usual for 5 months, followed by 5 months of DBT, followed by 5 months of care as usual + DBT monthly sessions.\n\nSelf- and family-questionnaire will explore quality of life, emotional regulation, self-esteem, stress, anxiety, cognitive difficulties, family functioning and coping, post traumatic growth and spirituality and will be compared across the 3 phases. Results will be analyzed at a group level but also at an individual level (each patient separately) to test for decrease in unwanted behaviors and at a dyadic level (the person and his\u002Fher spouse) to test for the mutual effect of regulating emotions. Persons' memories will by analyzed at 3 time points by a linguistic analysis, and experience of free will after ABI will be analyzed by transcribed narratives of participants.",[29,61,62,63,64,65],"Stroke\u002F Cerebrovascular Accident (Ischemic or Hemorrhagic)","Brain Tumor (After Recovery)","Encephalitis","Cerebral Anoxia","Meningitis",[67,68,69,70,71,72,73,74,75,76,77,78,79],"brain injury","dialectical behavior therapy","emotions","emotional dysregulation","behavioral disorders","spirituality","challenging behaviors","linguistic markers","emotional distress","family burden","free will","interpretative phenomenological analysis","single-case experimental design","RECRUITING","2026-06-05",{"date":83,"type":38},"2026-06-09",{"date":85,"type":38},"2022-05-19",{"date":87,"type":22},"2028-12",{"name":89,"class":45},"University Hospital, Strasbourg, France",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":97,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":101,"conditions":102,"keywords":105,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":46},"100637794","fareon-open-label-device-clinical-trial-100637794","NCT07600320","Fareon Open Label Device Clinical Trial","Microtesla Magnetic Therapy (MMT) Treatment of Cognitive Impairment: Open Label Pilot Study","IncInclusion Criteria:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Any sex\u002Fgender\n* 16 years of age or older\n* English Speaking\n* Experiencing symptoms of at least self-reported mild cognitive impairment associated with a confirmed diagnosis of a condition such as Long COVID, Traumatic Brain Injury, other Acquired Brain Injuries, and other neurodegenerative diagnoses including but not limited to Alzheimer's disease\n* Individuals of childbearing age agreeing to use a highly effective form of birth control for the duration of their participation\n* Willing and able to sign informed consent or have a parent or LAR able to sign informed consent form\n* Willing and able to attend all study visits virtually or in person\n\nExclusion Criteria:\n\nIndividual who meets any of the following criteria will be excluded from participation in this study:\n\n* Enrollment in another interventional clinical trial in the last 90 days or during the study period\n* Change in anti-depressant or other psychoactive medication or dose in the last 90 days\n* Cranially implanted devices or metal\n* Pacemaker\n* History of seizure disorder\n* Pregnant or plan to become pregnant during the study as indicated by proof of a positive pregnancy test\n* Inability to achieve appropriate positioning of the study device on the head\n* Any medical, psychiatric, or neurological condition, or concurrent treatment, that in the opinion of the Principal Investigator would interfere with study participation, interpretation of results, or pose additional risk to the participant.","16 Years",{"count":99,"type":22},30,[25],"The purpose of this study is to assess the safety and feasibility of an at-home MMT treatment in patients with cognitive dysfunction related to acquired brain injury, Long COVID, traumatic brain injury, myalgic encephalomyelitis (ME\u002FCFS), and other neurodegenerative diagnoses including but not limited to Alzheimer's disease and to collect data on safety and efficacy to inform the design of larger clinical studies.",[103,29,104],"Cognitive Dysfunction","Traumatic Brain Injury",[106,107,108,109],"Long COVID","Myalgic encephalomyelitis\u002FChronic fatigue syndrome","Neurodegenerative","Alzheimer's disease","2026-05-14",{"date":112,"type":38},"2026-05-20",{"date":114,"type":22},"2026-05-01",{"date":116,"type":22},"2027-04-30",{"name":118,"class":45},"Icahn School of Medicine at Mount Sinai",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":23,"phases":127,"briefSummary":128,"conditions":129,"keywords":131,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":46},"100508221","clinical-feasibility--validation-of-the-augmented-reality-glenxrose-acquired-brain-injury-rehabilitation-programs-100508221","NCT05897593","Clinical Feasibility & Validation of the Augmented Reality GlenxRose Acquired Brain Injury Rehabilitation Programs","Clinical Feasibility & Validation of the Augmented Reality-Delivered GlenxRose Programs for Acquired Brain Injury","Inclusion Criteria:\n\n* Adults receiving care at the Glenrose Rehabilitation Hospital (Edmonton, Canada) for mild to moderate Acquired Brain Injury\n* Proficiency in English\n* Adequate upper-limb strength and coordination to utilize AR headset (determined by clinicians)\n\nExclusion Criteria:\n\n* Pediatric populations\n* Severe acquired brain injury\n* severe cognitive and behavioural disorders (e.g. agitation, confusion, aggressive behaviour), which is Level V or higher on the Rancho Los Amigos Levels of Cognitive Functioning Scale\n* Severe aphasia, impacting language comprehension\n* Communication disorders that impact comprehension of verbal commands and understanding of scale used in the study\n* Previous neurological and\u002For psychiatric disorders\n* Substance misuse disorders\n* Previously acquired brain injury\n* Impairments that limit the interaction with the AR device",{"count":99,"type":22},[25],"Factors related to successful rehabilitation in acquired brain injury (ABI) are often directly related to adherence; for instance, dosage, frequency, and intensity can burden the patient regarding time and motivational factors. Regarding salience, patients may lose interest or find a traditional intervention boring after a few sessions. It is well documented that nonadherence not only impacts rehabilitation for patients but can also further prolong treatment, and increase hospital and clinician costs, in addition to a higher prevalence of future comorbidities. Additionally, the same factors that are related to can impact adherence are also related to neuroplasticity. Therefore, strategies that improve patient adherence can significantly help optimize patient care and treatment outcomes for those with ABI.\n\nThe gamification of rehabilitation therapies using augmented reality (AR) may help promote adherence. Gamification of rehabilitation therapy can make mass practice required in rehabilitation therapies seemingly fun and more personally engaging for the patient. Additionally, the experience achieved through AR can further promote salience and be customizable to individual patient requirements. As AR systems are now highly portable, cost-effective, and relatively simple to utilize, they can provide an excellent opportunity to provide more engaging rehabilitation approaches compared to standard care alone. AR gamification of rehabilitation may increase adherence by shifting patients' perspectives of therapy as tedious, boring, or a hassle, to a fun and engaging game that ultimately helps their recovery processes.\n\nThe GlenXRose AR-delivered ABI program (developed by the Cognitive Projections Lab, University of Alberta) has been created in collaboration with the Glenrose Rehabilitation Hospital with the overall goal of increasing patient adherence, treatment outcomes, and satisfaction with ABI rehabilitation therapy. The proposed studies are to investigate the feasibility of implementing this technology alongside routine clinical care, obtaining clinician feedback, examining associated financial costs, and continuing to examine the effect of the GlenXRose AR ABI-therapies on patient adherence and clinical outcomes, compared to traditional clinical care alone.",[29,130,104],"Stroke",[132,133,134,135,136,130,137,138],"Augmented Reality","AR","Virtual Reality","VR","Brain Injury","Rehabilitation","Occupational Therapy","2026-05-07",{"date":141,"type":38},"2026-05-12",{"date":143,"type":22},"2026-08-01",{"date":145,"type":22},"2027-08-31",{"name":147,"class":45},"University of Alberta",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":156,"targetDuration":4,"studyType":23,"phases":158,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":46},"100636054","feasibility-of-web-based-therapy-sessions-100636054","NCT07560696","Feasibility of Web-based Therapy Sessions","A Feasibility Study to Explore Rehabilitation Outcomes, Usability and User Experience of a Web-Based Platform for Delivering Treatment for Cognitive and Language Impairment Amongst Adults With Acquired Neurological Disorders","Cognishine","Inclusion Criteria:\n\n* Patients with cognitive impairment and\u002For speech impairment being treated at the LUHFT Intensive Care Units and the Stroke wards\n* Need for Cognitive and\u002For speech and Language rehabilitation\n\nExclusion Criteria:\n\n* Inability to obtain consent\n* Refusal to take part in the study\n* Failure to engage with the Cognishine platform\n* Inability to operate a mobile device\u002F tablet with support\n* Unavailability of study therapist to provide training of patients\n* Unstable medical condition",{"count":157,"type":22},80,[25],"The goal of this feasibility study is to explore rehabilitation outcomes, usability and user experience of a web-based platform for delivering treatment for cognitive and language impairment amongst adults with acquired neurological disorders in critical illness and stroke disorders.\n\nThe main question it aims to answer is:\n\n\" Is it feasible to use a web-based platform for delivering rehabilitation treatment in a large acute National Health Care Organisation\"\n\nParticipants will undergo therapy sessions prescribed by therapists on a web-based platform instead of the conventional paper-based therapy sessions for their cognitive and speech rehabilitation needs.",[161,162,29],"Cognitive Impairment","Speech Dysfunction","2026-04-28",{"date":114,"type":38},{"date":166,"type":38},"2024-07-03",{"date":168,"type":22},"2026-07-01",{"name":170,"class":171},"Liverpool University Hospitals NHS Foundation Trust","OTHER_GOV",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":17,"minAge":179,"maxAge":97,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":181,"briefSummary":182,"conditions":183,"keywords":184,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":46},"100627397","hospital-and-home-rehabilitation-based-on-social-care-robotics-and-artificial-intelligence-for-pediatric-patients-100627397","NCT07448103","Hospital and Home Rehabilitation Based on Social Care Robotics and Artificial Intelligence for Pediatric Patients","INROBICS","Inclusion Criteria:\n\n* Children\u002Fadolescents 7-16 years with confirmed acquired brain injury\n* Clinically stable\n* Able to understand and follow basic instructions\n* Able to maintain sitting independently (with or without postural supports)\n\nExclusion Criteria:\n\n* Unstable upper-limb orthopedic injuries (e.g., non-consolidated fractures\u002Funstable osteosynthesis).\n* Severe pain\u002Frigidity and\u002For severe upper-limb spasticity\n* Severe pulmonary or cardiac disease requiring constant monitoring\n* History of abnormal response to exertion prior to acquired brain injury\n* Severe visual impairment, severe cognitive impairment or disabling psychiatric disease, or any other condition that makes participation unsafe or not feasible per the medical team.","7 Years",{"count":99,"type":22},[25],"This study describes a prospective, longitudinal, randomized controlled trial evaluating Inrobics Rehab, a CE-marked Class I medical device (reg. RPS\u002F777\u002F2021) that combines socially assistive robotics with virtual training for pediatric rehabilitation. The trial will assess usability, user experience, and clinical effectiveness. It is based on the premise that an interactive, motivating, monitored digital environment can improve engagement and adherence while enabling objective tracking of progress. The main hypothesis is that Inrobics Rehab will enhance motor, cognitive, and socio-emotional outcomes in children with acquired brain injury (ABI) and will be well accepted by users.\n\nParticipants will be children aged 7-16 years with confirmed ABI, adequate comprehension to follow instructions, clinical stability, and the ability to maintain sitting (with or without supports). Exclusion criteria include unstable upper-limb orthopedic injuries; severe pain, rigidity, or severe upper-limb spasticity; severe cardiopulmonary disease requiring constant monitoring; abnormal pre-ABI response to exertion; severe visual or cognitive impairment; disabling psychiatric disease; or any condition preventing safe participation. Additional safeguards are included due to the pediatric\u002Fvulnerable population.\n\nThirty participants will be recruited at Hospital Infantil Universitario Niño Jesús and split into two etiological cohorts (15 oncological, 15 non-oncological). Eligible patients will be enrolled by convenience sampling and randomized within each cohort to experimental or control arms (about half per arm) using sequentially numbered sealed envelopes based on a computer-generated random list. Outcome assessors are intended to remain blinded to allocation.\n\nThe experimental arm completes 30 sessions over 5 weeks: 15 supervised in-hospital sessions (Inrobics Rehab Clinic) and 15 home-based sessions (Inrobics Rehab Virtual). Hospital sessions are delivered three times per week for 30 minutes. Home sessions are completed three times per week on a tablet, guided by an interactive avatar, with gamification and automatic collection of performance metrics; a ±2-week window is allowed only to make up missed sessions. The control arm receives no intervention and undergoes evaluations at comparable timepoints; after study completion, controls may access the virtual platform for 1-3 months or complete the full program.\n\nAssessments occur at baseline, post-intervention, and 3-month follow-up, with session-level monitoring of satisfaction, fatigue and\u002For pain. Heart rate is monitored only during hospital sessions (Polar Verity Sense). Outcomes include motor function (TCMS, Box \\& Block, ABILHAND-Kids), neuropsychological and emotional measures (attention, working memory, depression\u002Fanxiety, executive functioning), health perception and burden (EQoL-5D-Y5L, pain VAS, fatigue, caregiver burden), and usability\u002Fengagement analytics (accuracy, reaction time, engagement, execution speed). Data will be pseudonymized, stored securely with restricted access, and retained for at least 10 years (or longer if required by medical device regulations).",[29],[29,185,186,187,188,189],"Social Robots","Neurorehabilitation","Children with Disability","Telemedicine","Oncology","2026-03-03",{"date":192,"type":38},"2026-03-04",{"date":194,"type":22},"2026-02-01",{"date":196,"type":22},"2027-02",{"name":198,"class":45},"Inrobics Social Robotics, S.L.",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":209,"phases":4,"briefSummary":210,"conditions":211,"keywords":213,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":46},"100626401","acures-acoustic-and-respiratory-parameters-for-dysarthria-assessment-100626401","NCT07435155","ACURES: Acoustic and Respiratory Parameters for Dysarthria Assessment","Evaluating Dysarthria Through Acoustic and Respiratory Parameters: A Clinical Protocol","ACURES","Inclusion Criteria:\n\n* Adults aged 18 years or older at the time of enrollment.\n\nDiagnosed with acquired brain injury (ABI), including:\n\n* Stroke\n* Traumatic brain injury (TBI)\n* Brain tumor\n* Ability to provide written informed consent (or via a legally authorized representative if necessary).\n* Cognitive function preserved, defined as a Mini-Mental State Examination (MMSE) score ≥ 24.\n\nExclusion Criteria:\n\n* History of chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) or asthma.\n* History of hearing impairments that could affect speech evaluation.\n* Presence of additional neurological or neurodegenerative disorders other than the acquired brain injury.\n* History of voice disorders or dysphonia prior to the acquired brain injury.\n* Presence of persistent pharyngeal symptoms, such as mucus, secretions, or foreign body sensation, which may interfere with speech assessment.\n* Participants unable to comply with the assessment protocol or complete the required sessions.\n* Presence of apahasia that prevents participation in speech tasks, such as reading, repetition, or spontaneous speech priduction.",{"count":208,"type":22},100,"OBSERVATIONAL","The goal of this observational study is to describe speech and breathing patterns in adults after acquired brain injury (ABI) and understand how these patterns relate to the presence, severity, and type of dysarthria. The main questions it aims to answer are:\n\n* What changes in voice and breathing are observed in adults with dysarthria after ABI?\n* Can combining acoustic, respiratory, and clinical assessments help identify dysarthria severity and subtype?\n\nParticipants will:\n\n* Have their speech recorded to measure voice and articulation features, such as pitch, clarity, and the ability to sustain sounds.\n* Perform breathing tests using a spirometer to assess lung function.\n* Complete the Frenchay Dysarthria Assessment-2 (FDA-2), adapted to Spanish, to classify dysarthria type and severity.\n\nAbout 97 to 101 participants will take part. The results will help speech therapists better detect, evaluate, and treat dysarthria in adults after brain injury.",[212,29],"Dysarthria",[214,215,216,217,218,219],"acquired brain injury","dysarthria","Spirometry","Speech therapy","voice disorders","Phono-respiratory assessment","2026-02-19",{"date":222,"type":38},"2026-02-27",{"date":224,"type":38},"2025-10-15",{"date":226,"type":22},"2026-10-15",{"name":228,"class":45},"University of Salamanca",{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":235,"eligibilityCriteria":236,"healthyVolunteers":55,"sex":17,"minAge":237,"maxAge":238,"enrollmentInfo":239,"targetDuration":4,"studyType":209,"phases":4,"briefSummary":241,"conditions":242,"keywords":244,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":46},"100454455","evaluation-of-macroscopic-muscle-growth-in-infants-and-young-children-with-spastic-cerebral-palsy-100454455","NCT05197764","Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy","The Integration of Macroscopic and Microscopic Muscle Properties With Cell Modelling to Feature Altered Neuromuscular Behavior in Cerebral Palsy: 3D-Macroscopic Muscle Architecture in Cerebral Palsy","3D-MMAP","Inclusion Criteria:\n\n* Confirmed diagnosis of spastic cerebral palsy or patients at high-risk for spastic cerebral palsy\n* Suspected GMFCS levels I-III (GMFCS = Gross Motor Function Classification Scale, expressing the overall functional level of impairment)\n\nExclusion Criteria:\n\n* Non-ambulatory\n* Botulinum neurotoxin type-A injections six months prior to enrollment\n* Lower limb surgery two years prior to enrollment\n* Muscle surgery at the muscles in the lower limb\n* Selective dorsal rhizotomy as treatment history\n* Presence of ataxia or dystonia\n* Severe co-morbidities (severe epilepsy, severe behavior problems that impede the cooperation)","6 Months","9 Years",{"count":240,"type":22},229,"A mixed longitudinal design study will be carried out to explore the onset and time course of morphological muscle changes on a macroscopic level in children with spastic cerebral palsy (SCP). Therefore, this project aims to (1) describe the macroscopic morphological muscle changes with increasing age and (2) evaluate the onset and development of muscle alterations in relation to the brain lesion (e.g., timing, extent and location), to the neuromuscular impairments and to treatment. Overall, this project will evaluate the macroscopic muscle properties by means of 3D freehand ultrasound (3DfUS).",[243,29],"Spastic Cerebral Palsy",[243,29,245,246,247,248,249,250],"Brain imaging","3D freehand ultrasound","Muscle morphology","Range of motion","Stiffness","Spasticity","2026-02-09",{"date":253,"type":38},"2026-02-12",{"date":255,"type":38},"2019-02-11",{"date":257,"type":22},"2026-12",{"name":259,"class":45},"Universitaire Ziekenhuizen KU Leuven",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":267,"enrollmentInfo":268,"targetDuration":4,"studyType":23,"phases":270,"briefSummary":271,"conditions":272,"keywords":273,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":281,"leadSponsor":283,"locationsCount":4},"100622645","motor-and-cognitive-telerehabilitation-for-acquired-brain-injury-100622645","NCT07386314","Motor and Cognitive Telerehabilitation for Acquired Brain Injury","TELEGCA","Inclusion Criteria:\n\nOutcome of Severe Acquired Brain Injury (GAI) of various etiologies;\n\n* Age between 18 and 75 years\n* Level of Cognitive Functioning (LCF) at discharge from the hospital ward \\>= 6;\n* One or more neuropsychological deficits in the areas of attention, memory, language, and executive functions;\n* Possible upper limb motor deficit;\n* Absence of general clinical complications that could interfere with rehabilitation treatment;\n* Cognitive and language functions sufficient to understand the instructions provided and give consent -\n\nExclusion Criteria:\n\n* Level of Cognitive Functioning (LCF) at discharge from hospitalization ward \\\u003C 6;\n* Presence of previous deficits in neuropsychological and motor functions prior to the acute event;\n* Vulnerable subjects or those in emergency situations\n* Failure to provide informed consent.\n* Pregnant or intending to become pregnant during the enrollment period -","75 Years",{"count":269,"type":22},62,[25],"The overall objective of the study is to compare upper limb cognitive and motor rehabilitation programs delivered via tele-rehabilitation and in-person, in order to evaluate their overall impact on the rehabilitation process of subjects with GCA outcomes at the end of the subacute phase.",[29],[136,274,275,276],"tele-rehabilitation","motor","cognitive","2026-01-27",{"date":279,"type":38},"2026-02-04",{"date":194,"type":22},{"date":282,"type":22},"2026-11-30",{"name":284,"class":45},"Azienda USL Toscana Nord Ovest",{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":292,"targetDuration":4,"studyType":23,"phases":294,"briefSummary":295,"conditions":296,"keywords":297,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":46},"100622051","driving-simulator-training-for-adults-with-acquired-brain-injuries-100622051","NCT07378592","Driving Simulator Training For Adults With Acquired Brain Injuries","Use Of Driving Simulator To Provide Pre-Driving Training For Adults With Acquired Brain Injuries.","Inclusion Criteria:\n\n* Adult participants over 18 years\n* Diagnosed acquired brain injury\n* A valid driver's license\n* History of driving prior to injury\n\nExclusion Criteria:\n\n* Age less than 18 years\n* Moderate to severe cognitive impairment, as measured on the Montreal Cognitive Assessment\n* Visual acuity or visual field issues",{"count":293,"type":22},50,[25],"The aim of this project is to prepare adults with acquired brain injuries for on-road driving by using the driving simulator and increase participant's comfort level, confidence, and independence within their occupation of driving. The occupational therapy faculty are interested in identifying the impact driving simulation training has on individuals with acquired brain injuries and how it prepares them for on-road driving. We hope that the information from this project will help us gather information on how driving simulation training improves pre-driving skills related to comfort, confidence, and independence.",[29],[138,298,299,300],"Pre-Driving","Behind-the-Wheel Assessments","Driving Simulation","2026-01-22",{"date":303,"type":38},"2026-01-30",{"date":305,"type":38},"2025-11-15",{"date":307,"type":22},"2026-12-31",{"name":309,"class":45},"Sacred Heart University",{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":11,"sex":17,"minAge":316,"maxAge":19,"enrollmentInfo":317,"targetDuration":4,"studyType":209,"phases":4,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":46},"100310789","the-fbri-vtc-neuromotor-research-clinic-100310789","NCT03325946","The FBRI VTC Neuromotor Research Clinic","Inclusion Criteria:\n\n* Neuromotor Impairment\n\nExclusion Criteria:\n\n* fragile health","3 Months",{"count":318,"type":22},500,"The FBRI VTC Neuromotor Research Clinic was established and opened in May of 2013 to provide intensive therapeutic services to individuals with motor impairment secondary to neuromotor disorders. It is direct by Dr. Stephanie DeLuca and based on the principles surrounding ACQUIREc Therapy.\n\nACQUIREc Therapy is an evidenced-based approach to pediatric constraint-induced movement therapy, which refers to a multi-component form of therapy that is focused on helping children who have asymmetric motor abilities between the two sides of the body. Historically, ACQUIREc Therapy has the unimpaired or less impaired upper extremity constrained (by a cast or a splint) while also receiving active therapy from a specially trained therapist who shapes new skills and functional activities with the child's more impaired upper extremity but who is also a licensed Occupational or Physical Therapist (OT\u002FPT). Therapy dosages are high much higher than tradition OT or PT - often lasting many hours per day, up to 6 hours a day, 5 days a week, for 2-4 weeks.\n\nInvestigators have developed further treatments based on the same principles of intensive services combined with behavior shaping for other areas of the body that are also affected by weakness (e.g., the leg and trunk) also, but which usually do not involve constraint. These have been more generally labeled ACQUIRE Therapy.\n\nAll forms involve intensive, play-based therapy for children with asymmetric motor impairments of the arms and hands. The primary focus of treatment is to facilitate the acquisition of new motor skills in the child's weaker body parts through high levels of intensive therapy using scientifically-based behavioral guidelines. Therapy is also delivered in naturalistic environments.\n\nACQUIREc Therapy as a treatment method has been tested in two randomized controlled trials, and a specific manual for its implementation has been developed. Dr. (s) Ramey and DeLuca previously founded a similar clinic, The Pediatric Neuromotor Research Clinic, at the University of Alabama at Birmingham where Dr. DeLuca directed the research clinic for 13 years and oversaw the implementation of the ACQUIREc Therapy treatment protocol in more than 400 cases.\n\nThis research will involve analyzing and interpreting the clinical data of children going through clinical procedures at the FBRI VTC Neuromotor Research Clinic. All participation is voluntary and no children will denied services if families choose not to participate.",[321,322,323,324,325,29,326],"Neuromotor Impairments","Cerebral Palsy","Microcephaly","Autism","Trauma, Brain","Pediatric Stroke","2026-01-16",{"date":329,"type":38},"2026-01-21",{"date":331,"type":38},"2013-01-01",{"date":333,"type":22},"2029-12-31",{"name":335,"class":45},"Virginia Polytechnic Institute and State University",{"id":337,"slug":338,"hasResults":11,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":11,"sex":17,"minAge":344,"maxAge":4,"enrollmentInfo":345,"targetDuration":4,"studyType":23,"phases":347,"briefSummary":348,"conditions":349,"keywords":350,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":4},"100616243","family-centred-act-after-paediatric-abi-100616243","NCT07303075","Family-Centred ACT After Paediatric ABI","Family-Centred Acceptance and Commitment Therapy After Paediatric Acquired Brain Injury","FamilyCARE-ABI","Inclusion Criteria Both the CYP-ABI and parent participants must meet the inclusion criteria to be recruited to the study.\n\nCYP-ABI participant inclusion criteria include:\n\n* Aged 11 to 18 years at time of recruitment.\n* Living at home with parent\u002Fguardian.\n* Received treatment for an ABI.\n* Have sufficient cognitive ability to engage with therapy sessions.\n* Has capacity to provide verbal or written informed consent (aged 16 and above) or assent (aged 15 and younger).\n* Has the ability to speak sufficient English to understand and engage with the therapeutic and research materials\n* Consents for parent\u002Fguardian participant involvement in study.\n\nParent participant inclusion criteria include:\n\n* Aged \\> 18 at time of recruitment. There is no upper age limit.\n* Has the ability to speak sufficient English to understand and engage with the therapeutic and research materials\n* Has capacity to provide verbal or written informed consent for self and CYP participant.\n\nExclusion Criteria:\n\nCYP-ABI and parent participant exclusion criteria include:\n\n• CYP or parent participants are currently accessing or have accessed structured psychological intervention within 6 months of study recruitment.","11 Years",{"count":346,"type":22},6,[25],"Children and young people with acquired brain injury (ABI) commonly experience long-term emotional, behavioural, and participation difficulties that can affect quality of life for both them and their families. Parents and caregivers also often experience high levels of stress and reduced wellbeing. Despite these needs, family-centred psychological interventions remain limited. Acceptance and Commitment Therapy (ACT) is a values-focused cognitive-behavioural approach designed to increase psychological flexibility and has shown promise for children with long-term health conditions and for parents of children with ABI, but it has not been directly evaluated as a joint therapeutic approach for children with ABI and their parents.\n\nThis study (Family CARE-ABI) evaluates the feasibility, acceptability, and preliminary effectiveness of delivering ACT simultaneously to a young person aged 11-18 with an ABI and their parent\u002Fguardian. Up to six dyads will be recruited. The study uses a non-concurrent, multiple-baseline, single-case experimental design in which dyads are randomised to begin a 12-week ACT intervention after either a 3- or 4-week baseline period. Sessions (up to 12, one hour each) are delivered via Microsoft Teams by a trainee clinical psychologist under specialist supervision. Therapy integrates the DNA-V model of ACT-developed for young people-with ABI-specific psychoeducation and skills practice tailored to each dyad's needs.\n\nOutcome measures include mental health and wellbeing (Outcome Rating Scale), psychological flexibility (CompACT or AFQ-Y8), symptoms of anxiety and depression (GAD-7, PHQ-9, or RCADS-25), community participation (CASP\u002FCASP-Y), and needs after ABI (MANTIC). Measures are collected at baseline, post-intervention, and 12-week follow-up, with weekly wellbeing ratings throughout participation. Therapeutic alliance (SRS) is obtained after each intervention session. All dyads will also take part in separate qualitative interviews exploring their experiences of the intervention and its impact.\n\nSafety is closely monitored, including assessment of distress, adverse events, and any safeguarding concerns. Participation is voluntary, and dyads may withdraw at any time without affecting usual care. Data are stored securely and anonymised for analysis.\n\nThe study aims to generate early evidence regarding whether family-centred ACT may support psychological wellbeing, flexibility, and participation for young people with ABI and their parents, and to inform future intervention development and larger-scale trials.",[29],[351,352,353,29,104],"Paediatric","Acceptance and Commitment Therapy","Psychological Flexibility","2025-12-11",{"date":356,"type":38},"2025-12-24",{"date":358,"type":22},"2025-12-05",{"date":360,"type":22},"2026-06-27",{"name":362,"class":45},"University of Nottingham",{"id":364,"slug":365,"hasResults":11,"nctId":366,"briefTitle":367,"officialTitle":367,"acronym":4,"eligibilityCriteria":368,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":369,"enrollmentInfo":370,"targetDuration":4,"studyType":23,"phases":372,"briefSummary":373,"conditions":374,"keywords":376,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":46},"100562502","goal-management-training-gmt-for-improvement-of-cognitive-control-function-after-acquired-brain-injury-100562502","NCT06604000","Goal Management Training (GMT) for Improvement of Cognitive Control Function After Acquired Brain Injury","Inclusion Criteria:\n\n* Patients aged 18-65 with acquired brain injury with no concomitant diseases minimum 12 months' post-injury\u002Fsurgery, reporting cognitive control problems by structured interview or clinical performance measures.\n\nExclusion Criteria:\n\n* Non-fluency in Norwegian Language\n* Major psychiatric disorder or reported ongoing alcohol or substance abuse.\n* Premorbid neurological disease or insult and\u002For comorbid neurological disease.\n* Aphasia or other specified language problems causing potential communication problems.\n* Impaired basic linguistic, mnemonic, motor, or perceptual function that can interfere with the ability to engage with training or estimated IQ \\\u003C 85","65 Years",{"count":371,"type":22},116,[25],"The goal of this clinical trial is to investigate predictors of treatment outcome, and the effect of individual treatment components of Goal Management Training (GMT) for improvement of cognitive control function in people with acquired brain injury (ABI).\n\nPrimary aim: To identify demographic, clinical and cognitive predictors of treatment response in Goal Management Training after acquired brain injury (ABI)?\n\nSecondary aims: To investigate the effects of a) extended cuing (via a smartphone) and b) a booster module?\n\n* All included participants will receive Goal Management Training in groups of 4-6 patients, as implemented in a rehabilitation hospital setting (St. Olavs Hospital, Trondheim University Hospital). The standard treatment (\"GMT Usual\") consists of 10 sessions, delivered as 2 sessions a day, one day per week, over 5 weeks.\n* All participants will be asked to complete self-report measures and performance-based cognitive testing at baseline (T1), immediately after the main treatment period (T2), at 6 months (T3), and 1 year (T4) after treatment.\n* After baseline assessment, 50% of participants will be randomized to receive extended cuing through a smartphone application (\"GMT Cuing\") - intended to facilitate the effect of between-session tasks (homework) completed by the participants. These participants will, in addition to the standard treatment, on a daily basis receive a message that says \"STOP\" as a reminder to do their home assignments.\n* After completion of the 10 GMT sessions and the first post-treatment assessment immediately after the main treatment period, 50% of the participants will be randomized to receive an additional booster module (\"GMT Boost\") 3 months after the last ordinary GMT module - intended to facilitate a prolonged treatment response. The remaining 50% will receive no booster module (\"GMT No Boost\")\n* Randomization will be carried out on treatment group-level (all patients in the same group receive the same treatment). The total anticipated sample size is N = 116 patients.\n* The Global Executive Composite (GEC) score derived from BRIEF-A will be used as the primary outcome measure. A selection of other included measures will be used as secondary outcome measures.",[29,375],"Executive Function Disorder",[214,377,378,379,380,381],"goal management training","executive function","cognitive control","GMT","cognitive rehabilitation","2025-12-01",{"date":384,"type":38},"2025-12-02",{"date":386,"type":38},"2023-09-26",{"date":388,"type":22},"2030-01-01",{"name":390,"class":45},"St. Olavs Hospital",{"id":392,"slug":393,"hasResults":11,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":397,"eligibilityCriteria":398,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":267,"enrollmentInfo":399,"targetDuration":4,"studyType":23,"phases":401,"briefSummary":402,"conditions":403,"keywords":404,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":415,"locationsCount":346},"100552199","robotic-vs-traditional-verticalization-in-patients-with-severe-acquired-brain-injury-a-randomized-controlled-trial-100552199","NCT06469983","Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled Trial","Multicentric Study on Combined Verticalization and Mobilization in Patients With Severe Acquired Brain Injury: A Randomized Controlled Trial","VEM-sABI","Inclusion Criteria:\n\n* Age between 18 and 75 years;\n* sABI due to traumatic, vascular, anoxic, or mixed etiology;\n* Stable behavioral\u002Fcognitive diagnosis on at least 4 behavioral evaluations in 1 week using the Italian version of the CRS-R in patients with pDoC, or the LCF-based cognitive assessment in patients with eDoC;\n* Time post-injury between 28 days and 6 months \\[1\\];\n* Not recovered upright station;\n* Written informed consent by the patient's legal rep-resentative\u002Fprimary caregiver.\n\nExclusion Criteria:\n\n* Severe medical conditions hampering verticalization (e.g., severe hypotension or conditions realizing hemodynamic instability, end stage or severe symptomatic heart failure with reduced ejection fraction, cardiac arrhythmia of new diagnosis or arrhythmic flare, severe hepatic failure, chronic severe lower limb arterio-venous disease, sep-sis\u002Fseptic shock, thrombus venous embolism of new diag-nosis, severe autonomic dysreflexia);\n* Severe medical conditions hampering lower limb mobili-zation (e.g., fractures, heterotopic ossifications);\n* Severe medical conditions impacting EEG activity (e.g., sub-continuous or abundant EEG epileptiform abnormali-ties);\n* Severe medical conditions influencing conscious-ness\u002Fcognitive status, such as severe hyponatremia or hy-poglycemia;\n* Contraindications to the use of Erigo®Basic and\u002For Eri-go®Pro (Hocoma, Volketswil, Switzerland) as per technical data sheet (see Appendix A);\n* Presence of prohibited drugs",{"count":400,"type":22},118,[25],"In the rehabilitation project for patients with severe Acquired Brain Injury (sABI), it is essential to include exercises that facilitate the recovery of the upright position (or verticalization). Recently, tilt-table equipped with the robot-assisted lower limbs cyclic mobilization has been proposed as a safe and suitable device for accelerating the adaptation to vertical posture in bedridden patients with brain-injury since the acute phase. The present multicentre study aims at evaluating the effectiveness of robotic assisted verticalization plus mobilization (VEM) versus traditional verticalization (TV) in a large cohort of patients with sABI.",[29,28],[405,406,407,408],"Disorders of Consciousness","rehabilitation","verticalization","robotic","2025-11-17",{"date":411,"type":38},"2025-11-20",{"date":413,"type":38},"2024-12-02",{"date":282,"type":22},{"name":416,"class":45},"Anna Estraneo",{"id":418,"slug":419,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":423,"targetDuration":4,"studyType":23,"phases":424,"briefSummary":425,"conditions":426,"keywords":428,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":438,"leadSponsor":440,"locationsCount":46},"100611192","comparing-the-ceriter-stride-one-a-pressure-sensitive-smart-insole-with-gait-parameters-measured-on-the-grail-in-neurological-populations-100611192","NCT07237386","Comparing the Ceriter Stride One, a Pressure-sensitive Smart Insole, With Gait Parameters Measured on the GRAIL in Neurological Populations","Inclusion Criteria:\n\n* Persons suffering a lesion of the central nervous system (stroke, incomplete spinal cord injury, acquired brain injury) who are admitted to the rehabilitation center of the Ghent University hospital or who follow therapy at the rehabilitation center of the Ghent University hospital as outpatients.\n* Patients need to be able to walk independently during at least 6 minutes without the need of an extra person (Functional ambulation category 3 or higher).\n\nExclusion Criteria:\n\n* Severe orthopedic trauma or acute trauma of the lower limbs influencing walking\n* body weight that exceeds 120 kg.\n* severe dizziness that makes exercising in standing position impossible\n* severe cardio-pulmonary disorders that require monitoring during exercising\n* patients who do not understand the task that needs to be performed in this study.",{"count":99,"type":22},[25],"Ceriter Stride-One soles have been available on the market for several years. One of the features of these soles is that they can measure gait parameters while patients walk around in a functional environment. This can provide a more realistic picture of gait patterns compared to measurements taken in a laboratory setting.\n\nAt UZ Ghent, we use an advanced gait lab to measure gait parameters before and after a training period on this system, the GRAIL system. We measure similar parameters to the Ceriter Stride-One soles (support phase, swing phase, pressure on the left leg and on the right leg). In this study, we would apply these insoles to patients who are tested on the GRAIL system, according to standard care, during the test in order to compare the parameters measured by the insoles and the parameters measured by the GRAIL system. This information will give us more insight into the accuracy of the data measured with these soles so that we can apply them in future studies conducted not in the gait lab but in functional environments.\n\nPatients who are eligible for GRAIL therapy and are therefore routinely tested are patients who are admitted or undergoing outpatient rehabilitation at the rehabilitation centre of UZ Ghent after a brain injury, stroke, spinal cord injury or amputation. Given the subject of the research and the difficulty of fitting a sole into the shoe of a prosthetic leg, only people with brain and spinal cord injuries are asked to participate in the study.\n\nParticipants must be able to step onto the GRAIL treadmill with the help of one therapist and must be able to walk for at least six minutes. Participants have to weigh less than 120 kg (treadmill safety system restriction).\n\nAs standard in our setting, participants train for 5 weeks, twice a week for 30 minutes on the GRAIL treadmill. Before and after their training period, they walk on the GRAIL for about 2 minutes and we measure a number of gait parameters: speed, step width, step length, duration of the support phase and swing phase, and how much they support on their left and right legs.\n\nSome of these parameters can also be measured by the Ceriter Stride One sole. The aim is to investigate how comparable these data are. If these data are sufficiently comparable, the soles can be used to measure the ratio of the support and swing phases during walking in everyday tasks or in environments other than a laboratory setting.",[130,427,104,29],"Incomplete Spinal Cord Injury",[429,430,431,67,432,433],"Gait","stroke","spinal cord injury","smart insoles","spatiotemporal","2025-11-14",{"date":436,"type":38},"2025-11-19",{"date":224,"type":38},{"date":439,"type":22},"2026-10-01",{"name":441,"class":45},"University Hospital, Ghent",{"id":443,"slug":444,"hasResults":11,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":448,"eligibilityCriteria":449,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":450,"enrollmentInfo":451,"targetDuration":4,"studyType":23,"phases":453,"briefSummary":454,"conditions":455,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":46},"100581271","using-non-invasive-brain-stimulation-to-treat-word-finding-difficulty-in-chronic-traumatic-brain-injury-100581271","NCT06848140","Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury","Using High Definition Transcranial Direct Current Stimulation to Treat Verbal Retrieval Deficits Secondary to Chronic Traumatic Brain Injury (STIM-CTBI)","STIM-CTBI","Inclusion Criteria:\n\n* Age between 18 and 85\n* Fluent in speaking and reading English\n* Able to provide informed consent\n* Has a TBI at least one year prior to enrollment and not related to military experience\n* Has a confirmation of verbal retrieval difficulties as measured by the Verbal Retrieval Difficulty Interview questions\n\nExclusion Criteria:\n\n* Lifetime major or active neurologic conditions (e.g., stroke, epilepsy, brain tumor, dementia, seizure occurrence less than one year ago)\n* Lifetime major or active cardiovascular conditions (e.g., cardiac arrythmia, heart failure, heart attack)\n* Current substance use disorder\n* Lifetime major psychiatric disorders (e.g., schizophrenia, bipolar disorder)\n* Severe depression at the time of enrollment (BDI-II \\>= 29) or psychiatric ER visits or hospitalization less than 6 months ago prior to enrollment\n* Current sensory (e.g., blind, deaf) or physical (e.g., severe motor weakness) impairment that interferes with testing\n* Contraindications for tDCS or MRI\n* The person cannot be left alone for 8+ hours.\n* Not verbally communicative.\n* Currently undergoing and not wishing to discontinue speech and cognitive therapy during study participation.\n* Incapable of understanding the consent or unable to consent for oneself.\n* Unable to travel to BIDMC's Berenson-Allen Center\n* Pregnancy","85 Years",{"count":452,"type":22},24,[25],"The purpose of this study is to learn more about how brain stimulation affects word finding problems in people who have a traumatic brain injury (TBI). The type of brain stimulation used is called transcranial direct current stimulation (tDCS). tDCS delivers low levels of electric current to the brain and high definition tDCS (HD-tDCS) delivers the current with multiple electrodes on the scalp. This current is delivered with HD-tDCS to parts of the brain that may help with remembering things. The investigators hope that this can help to improve word finding and memory problems in people with TBI.",[104,456,457,458,29],"Word Finding Difficulty","Cognitive Symptom","Cognitive Change","2025-10-19",{"date":461,"type":38},"2025-10-21",{"date":463,"type":38},"2025-10-01",{"date":465,"type":22},"2028-04-30",{"name":467,"class":45},"Beth Israel Deaconess Medical Center",{"id":469,"slug":4,"hasResults":11,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":473,"eligibilityCriteria":474,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":267,"enrollmentInfo":475,"targetDuration":4,"studyType":23,"phases":477,"briefSummary":478,"conditions":479,"keywords":480,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":487,"completionDateStruct":489,"leadSponsor":490,"locationsCount":491},"100552575","NCT06474871","Virtual Reality vs Traditional Cognitive Training in Patients With Severe Acquired Brain Injury","Multicentric Study on Implementation of Virtual Reality for Rehabilitation of Cognitive Functions in Patients With Severe Acquired Brain Injury: a Randomized Controlled Trial","VR-sABI","Inclusion Criteria:\n\n* LCF ≥4 at study entry;\n* Age 18-75\n* Stable clinical diagnosis (i.e., stable LCF);\n* Time post-injury between 28 days and 6 months;\n* Ability to complete the pre-test A section of the Italian version of the Trail Making Test (TMT);\n* A pathological B-A score of the TMT according to normative data adjusted for age and education;\n* Signed informed consent by the patient or by the patient's primary caregiver.\n\nExclusion Criteria:\n\n* Severe medical conditions that might hamper participation in the rehabilitation sessions, or influence diagnosis;\n* Previous neurodegenerative or acquired neurological diseases that affect cognitive domains (e.g., dementia)",{"count":476,"type":22},28,[25],"Considerable evidence exists for using Virtual Reality (VR) for rehabilitation of acquired brain injury (ABI), with a particular focus on stroke. However, to date very little evidence has been collected in patients with ABI with different aetiologies (i.e., traumatic or anoxic brain injury) and level of severity (i.e., severe, sABI). The present multicentre study aims to overcome current literature issues as heterogeneity of populations and outcomes, small sample sizes and a lack of randomized controlled trials, which can affect the level of evidence and generalizability of results, to determine the effectiveness of a non immersive VR-based rehabilitation versus traditional cognitive training (TCT).",[29],[481,406,482,483],"severe acquired brain injury","virtual reality","executive functions","2025-09-24",{"date":486,"type":38},"2025-09-29",{"date":488,"type":38},"2024-10-28",{"date":282,"type":22},{"name":416,"class":45},3,{"id":493,"slug":494,"hasResults":11,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":498,"eligibilityCriteria":499,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":500,"targetDuration":4,"studyType":23,"phases":502,"briefSummary":503,"conditions":504,"keywords":505,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":508,"lastUpdatePostDateStruct":509,"startDateStruct":511,"completionDateStruct":513,"leadSponsor":515,"locationsCount":46},"100520575","abi-aftercare-in-motion-multidisciplinary-aftercare-in-the-home-environment-in-patients-with-acquired-brain-injury-100520575","NCT06058351","ABI-aftercare in Motion: Multidisciplinary Aftercare in the Home Environment in Patients With Acquired Brain Injury","ABI-aftercare in Motion: Multidisciplinary Aftercare in the Home Environment in Patients With Acquired Brain Injury; an Implementation Study","ABI-motion","Inclusion Criteria:\n\n* Diagnosed with ABI\n* Follows an outpatient rehabilitation program for ABI in Rijndam Rehabilitation\n\nExclusion Criteria:\n\n* Having a contra-indication for participation in moderate to vigorous exercise\n* Life expectancy \\\u003C 1 year\n* Incapacitated persons",{"count":501,"type":22},60,[25],"The goal of this implementation study is to improve aftercare for patients with ABI receiving outpatient rehabilitation. The ABI-motion program was developed to improve and active lifestyle and to prevent persistent complaints after ABI and poor HR-QoL.The main questions it aims to answer are:\n\n* Is the ABI-motion program feasible?\n* What are the health benefits of the ABI-motion program?\n\nParticipants will receive brain education, a joint therapy session with a physical or occupational or movement therapist and a buddy from a patient support organization during outpatient rehabilitation, followed by community buddy support after discharge from outpatient rehabilitation, and follow-up by a rehabilitation physician.",[29],[29,137,506,507],"Aftercare","Implementation","2025-08-28",{"date":510,"type":38},"2025-08-29",{"date":512,"type":38},"2024-03-01",{"date":514,"type":22},"2027-03-01",{"name":516,"class":45},"Majanka H. Heijenbrok-Kal, PhD",{"id":518,"slug":519,"hasResults":11,"nctId":520,"briefTitle":521,"officialTitle":521,"acronym":522,"eligibilityCriteria":523,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":524,"enrollmentInfo":525,"targetDuration":4,"studyType":23,"phases":526,"briefSummary":527,"conditions":528,"keywords":529,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":538,"leadSponsor":540,"locationsCount":4},"100584889","exercise-and-physical-activity-in-adults-with-acquired-brain-injury-100584889","NCT06895226","Exercise and Physical Activity in Adults with Acquired Brain Injury","PA_ABI","Inclusion Criteria:\n\n* Aged more than 18 years of age and present a medical diagnosis of acquired brain injury.\n* Have the informed consent completed and signed\n* Present a state that allows following indications for the practice of exercise and physical activity.\n\nExclusion Criteria:\n\n* Have medical comorbidities that contraindicate the safe performance of the program (i.e., cardiac or respiratory instability, uncontrolled seizures).\n* Have additional disabling conditions, such as cognitive impairment and\u002For an inability to communicate with the researcher verbally, in writing, or through an emissary.","90 Years",{"count":99,"type":22},[25],"Exercise and physical activity in adults with acquired brain injury",[29],[530,531,532],"Acquired brain injury","physical activity","intervention","2025-03-24",{"date":535,"type":38},"2025-03-26",{"date":537,"type":22},"2025-04-01",{"date":539,"type":22},"2025-11-01",{"name":541,"class":45},"Universidade da Coruña",{"id":543,"slug":544,"hasResults":11,"nctId":545,"briefTitle":546,"officialTitle":547,"acronym":548,"eligibilityCriteria":549,"healthyVolunteers":11,"sex":17,"minAge":550,"maxAge":551,"enrollmentInfo":552,"targetDuration":4,"studyType":209,"phases":4,"briefSummary":554,"conditions":555,"keywords":556,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":568,"locationsCount":46},"100564908","improving-the-diagnostic-accuracy-of-children-with-doc-ideal-desire-100564908","NCT06635291","Improving the Diagnostic Accuracy of Children with DoC (IDeAl DesiRE)","Improving the Diagnostic Accuracy of Children with Disorders of Consciousness in the REhabilitation Process (IDeAl DesiRE)","IDeAl DesiRE","Inclusion Criteria:\n\n* suffering from an ABI due to: traumatic brain injury, hypoxic events\u002Fanoxia, cerebral infections, cerebrovascular accident;\n* age: 2 months-25.11 years;\n* having a Glasgow Coma Scale (GCS; Teasdale \\& Jennett, 1974) at injury or onset ≤8);\n* being in vegetative state (VS) or minimally conscious state (MCS) at admission;\n* being in subacute or chronic phase.\n\nExclusion Criteria:\n\n\\- ABI due to brain tumor or neurodegenerative disease.","2 Months","25 Years",{"count":553,"type":22},113,"The present study aims to investigate the clinical evolution of children with severe ABI and DoC both by using the traditional behavioral scales, namely the CRS-R, CRS-P and CNCS, and by trying to establish whether it is possible to identify any clinical markers of Emergency (E-Markers). E-Markers are behaviors that indicate a content of consciousness irrespective of the processes investigated by behavioral scales, thus they could be combined with the items of these scales to improve the diagnosis.\n\nA particular focus will be given to the identification of specific E-Markers for children aged less than 12 months, for which the CRS-P scale cannot be used. In this case, the E-markers will be compared with the specific developmental stages of newborns, giving great importance to motor abilities.",[29,28],[67,557,558,559,560,561],"disorder of consciousness","diagnosis","behavioral scale","children","pediatric","2024-12-11",{"date":564,"type":38},"2024-12-16",{"date":566,"type":38},"2024-05-20",{"date":307,"type":22},{"name":569,"class":45},"IRCCS Eugenio Medea",{"id":571,"slug":572,"hasResults":11,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":576,"eligibilityCriteria":577,"healthyVolunteers":11,"sex":17,"minAge":97,"maxAge":578,"enrollmentInfo":579,"targetDuration":4,"studyType":23,"phases":581,"briefSummary":582,"conditions":583,"keywords":590,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":592,"lastUpdatePostDateStruct":593,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":599,"locationsCount":46},"100498995","music-therapy-in-complex-specialist-neurorehabilitation-100498995","NCT05777499","MUSic Therapy In Complex Specialist Neurorehabilitation","Pilot Study to Evaluate MUSic Therapy in Complex Specialist Neurorehabilitation","MUSICS","Inclusion Criteria:\n\n* Age 16 years or above.\n* Clinical diagnosis of a neurological injury involving the brain, spinal cord, and\u002For peripheral nerves, sustained during the current hospital admission.\n* Participant has complex rehabilitation needs warranting admission to a specialist neurorehabilitation unit.\n* Willing and able to provide written informed consent. If the participant is unable to demonstrate sufficient mental capacity to provide informed consent, the multidisciplinary team will liaise with the participant to identify a suitable consultee to determine suitability to participate in the study in their best interests.\n\nExclusion Criteria:\n\n* Participant is medically unstable or excessively drowsy, and is unexpected to be able to tolerate an intensive rehabilitation program.\n* Participant is expected to be discharged from hospital before 10 weeks.\n* Concurrent and\u002For recent involvement in other research that is likely to interfere with the intervention within the last 3 months of study enrolment.","80 Years",{"count":580,"type":22},75,[25],"Aim: Investigate whether patients undergoing specialist rehabilitation after complex neurological injury show different functional outcomes if music therapy is included in their rehabilitation program compared to usual care.\n\nBackground: Patients with complex needs following a brain, spinal cord, and\u002For peripheral nerve injury often require a period of specialist neurorehabilitation. This involves multiple therapy disciplines, led by a Consultant in Rehabilitation Medicine, Neurology, or Neuropsychiatry. Although music therapy is suggested to enhance neuroplasticity and recovery in patients with brain injury, it is not routinely commissioned in clinical care due to a lack of supportive evidence.\n\nHypothesis: Patients undergoing music therapy in addition to complex specialist rehabilitation show better functional outcomes compared to usual care.\n\nNumber of participants: 75, aged 16-80 years. Methods: Patients undergo baseline assessments and are randomised to MUSIC or CONTROL Therapy. Both arms receive 1-3 additional therapy sessions per week, matched for duration and number, total 15 hours. After approximately 10-weeks intervention, assessments are repeated. All participants then have access to music therapy until they are discharged from Neurorehabilitation Unit (NRU), with additional qualitative data collection using semi-structured interviews, field notes, staff reports, staff stress surveys, and broader ecological observations.\n\nDuration for Participants: From consent to discharge from NRU. Primary Outcome: Change in Functional Independence Measure+Functional Assessment Measure (FIM+FAM), Northwick Park Dependency Scale (NWPDS), and Barthel Activities of Daily Living pre and post 15 hours intervention.\n\nSecondary Outcome: Change in quality of life (Flourishing Scale), psychological distress (Hospital Anxiety and Depression Scale, Depression Intensity Scale Circles), social interaction (Sickness Impact Profile Social Interaction Subscale), well-being (WHO Well-Being Index), and communication (Communication Outcomes After Stroke Scale), pre and post 15 hours intervention. Mean difference in well-being (WHO Well-Being Index) throughout the intervention period between music therapy and control therapy groups. Mean difference in post-intervention pain and mood visual analogue scores between music therapy and control therapy groups.",[130,584,104,585,586,587,29,588,589],"Subarachnoid Hemorrhage","Tumor, Brain","Autoimmune Diseases","Meningitis\u002FEncephalitis","Spinal Cord Injuries","Peripheral Nervous System Diseases",[591],"Neurological injury","2024-10-21",{"date":594,"type":38},"2024-10-23",{"date":596,"type":38},"2023-06-05",{"date":598,"type":22},"2025-10",{"name":600,"class":45},"University College, London",{"id":602,"slug":603,"hasResults":11,"nctId":604,"briefTitle":605,"officialTitle":606,"acronym":4,"eligibilityCriteria":607,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":608,"targetDuration":4,"studyType":23,"phases":610,"briefSummary":611,"conditions":612,"keywords":615,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":627,"startDateStruct":629,"completionDateStruct":631,"leadSponsor":633,"locationsCount":46},"100515581","efficacy-of-efa-in-acquired-brain-injury-100515581","NCT05993364","Efficacy of EFA in Acquired Brain Injury","Role of Expiratory Flow Acceleration in the Management of Bronchial Secrections in Severe Acquired Brain Injury: a Pilot Randomized Controlled Study","Inclusion Criteria:\n\n* Age higher than 18 years old;\n* Hospitalization after diagnosis of Acquired Brain Injury (both traumatic and vascular)\n* Levels of Cognitive Functioning Scale (LCFS) score between 1and 5;\n* Presence of spontaneous breathing, at least during the day\n\nExclusion Criteria:\n\n* Need of mechanical ventilation for more than 12 hours a day;\n* Presence of tracheal stoma not properly healed after the removal of the tracheal cannula.",{"count":609,"type":22},20,[25],"Acquired brain injury (ABI) is one of the biggest cause of death and disability in the world. Patients with ABI often have difficulties with swallow and breath.\n\nThe study purpose is to evaluate if the Expiratory Flow Accelerator (EFA) technology has positive effects on the respiratory and swallowing function in patients with acquired brain injury (ABI). Researchers recruit patients at Centro Ettore Spalenza-Fondazione Don Carlo Gnocchi in Rovato, Italy.\n\nTo partecipate, patients should satisfy certain eligibility criteria; they will not be enrolled if they satisfy exclusion criteria.\n\nIf a patient can be recruited, researchers conduct the baseline assessment lasting 1 one week. After that, the patient will be randomized to the study or control group. If the patient is in the control group, he will receive a traditional rehabilitation treatment. Otherwise, the patient will receive an additional treatment with the EFA device.\n\nResearchers will assess again the patient (with the same procedures of baseline assessment) after 8 weeks of treatment. They want to see if the EFA device could help patients with ABI to improve their health conditions.",[29,613,614],"Comparative Effectiveness Research","Lung Diseases, Obstructive",[616,617,618,619,620,621,622,623,624,29,625],"Expiratory Flow Accelerator","Tracheobronchial secretions","Tracheobronchial clearance","Airways clearance","Pulmonary infections","Pulmonary obstruction","Decannulation","Tracheal cannula","Effectiveness","Controlled study","2024-08-08",{"date":628,"type":38},"2024-08-09",{"date":630,"type":38},"2024-02-19",{"date":632,"type":22},"2025-12",{"name":634,"class":45},"Fondazione Don Carlo Gnocchi Onlus",{"id":636,"slug":637,"hasResults":11,"nctId":638,"briefTitle":639,"officialTitle":640,"acronym":641,"eligibilityCriteria":642,"healthyVolunteers":11,"sex":17,"minAge":643,"maxAge":19,"enrollmentInfo":644,"targetDuration":4,"studyType":23,"phases":646,"briefSummary":647,"conditions":648,"keywords":649,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":653,"lastUpdatePostDateStruct":654,"startDateStruct":656,"completionDateStruct":658,"leadSponsor":660,"locationsCount":491},"100508465","implementation-of-a-habit-ile-intervention-at-william-lennox-neurological-hospital-neureha-100508465","NCT05900778","Implementation of a HABIT-ILE Intervention at William Lennox Neurological Hospital (NeuREHA)","Implementation of a HABIT-ILE Intervention at William Lennox Neurological : a Randomized Controlled Trial","NeuREHA","Inclusion Criteria:\n\n* children with acquired brain injury of school\n* age 5 to 18 years inclusive\n\nExclusion Criteria:\n\n* Unstable seizure\n* programmed botulinum toxin or orthopedic surgery in the 6 months previous to the intervention, during intervention period or 3months after the intervention time\n* Severe visual or cognitive impairments likely to interfere with intervention or testing session completion","5 Years",{"count":645,"type":22},40,[25],"Using a randomized controlled trial design, in an hospital environment, possible changes induced by the \"Hand-arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE)\" treatment program will be investigated in functional activities of daily living, motor and cognitive assessment of children with acquired brain injury.",[29],[650,378,651,652,214],"motor skill learning","activity of daily living","intensive therapy","2023-06-15",{"date":655,"type":38},"2023-06-18",{"date":657,"type":38},"2023-06-10",{"date":659,"type":22},"2028-06-10",{"name":661,"class":45},"Université Catholique de Louvain",{"id":663,"slug":664,"hasResults":11,"nctId":665,"briefTitle":666,"officialTitle":667,"acronym":4,"eligibilityCriteria":668,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":669,"targetDuration":4,"studyType":23,"phases":671,"briefSummary":672,"conditions":673,"keywords":674,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":676,"lastUpdatePostDateStruct":677,"startDateStruct":679,"completionDateStruct":681,"leadSponsor":682,"locationsCount":46},"100359228","the-parkwood-pacing-and-planning-app-100359228","NCT03957343","The Parkwood Pacing and Planning™ App","Efficacy of the Pacing and Planning App for Persons With Mild Acquired Brain Injury","Inclusion Criteria:\n\n1. Experienced a mild traumatic brain injury\u002Fconcussion\n2. Disclosure of mechanism of injury and whether they were diagnosed with a mild traumatic brain injury\u002Fconcussion by a registered health care practitioner\n3. 18 yeas of age or older\n4. Access to a smartphone or tablet\n5. Able to read, write, and understand English\n\nExclusion Criteria:\n\n1. Did not experience a mild traumatic brain injury\u002Fconcussion\n2. Unwilling to disclose mechanism of injury and whether they were diagnosed with a mild traumatic brain injury\u002Fconcussion\n3. Under 18 years of age\n4. No access to a smartphone or tablet\n5. Inability to read, write, and understand English",{"count":670,"type":22},200,[25],"In efforts to assist people who have had a concussion (mild traumatic brain injury), the Parkwood Pacing and Planning™ app has been developed and tested and will be released to the public. The app uses a point system where users have a daily point maximum assigned based on symptom severity with daily activities (recorded by the users). Users can then schedule their daily activities based on their allowed points. The goal is to help users with symptom self-management by facilitating activity planning and pacing.\n\nPatients and clinicians have provided positive feedback on the initial version of the app. Using this as a foundation, the investigators envision enhancing the app to provide a more personalized user experience and to enable further discovery and innovations in the recovery from concussion. This will be accomplished through data analytics and machine-learning techniques, informed by the results of a large-scale research trial. This strategy will be used to customize the point system to facilitate the user with pacing and planning.",[29],[214,675],"concussion","2023-03-23",{"date":678,"type":38},"2023-03-24",{"date":680,"type":38},"2021-02-01",{"date":257,"type":22},{"name":683,"class":45},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's",{"id":685,"slug":686,"hasResults":11,"nctId":687,"briefTitle":688,"officialTitle":689,"acronym":4,"eligibilityCriteria":690,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":691,"targetDuration":4,"studyType":209,"phases":4,"briefSummary":693,"conditions":694,"keywords":697,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":700,"lastUpdatePostDateStruct":701,"startDateStruct":703,"completionDateStruct":705,"leadSponsor":707,"locationsCount":46},"100477173","clinical-and-instrumental-treatments-predictors-in-subjects-with-neurological-diseases-using-g-eo-robotic-system-100477173","NCT05493514","Clinical and Instrumental Treatment's Predictors in Subjects With Neurological Diseases Using G-EO Robotic System","Clinical and Instrumental Treatment's Predictors in Subjects With Neurological Diseases Using G-EO Robotic System: an Observational Longitudinal Study","Inclusion Criteria:\n\n* Diagnosis of Multiple Sclerosis, Parkinson Disease, Stroke or acquired brain injury\n* Minimum number of sessions: 10 sessions with the GEO system\n* Minimum frequency of sessions: 2 per week\n* Age ≥ 18 years\n* Ability to walk for at least 10 meters, also with aid\n* Indication of robotic treatment in the therapeutic plan\n* Body size suitable for the robotic device\n* ability to maintain verticality for 7 minutes;\n* ability to maintain the sitting position without support for 30 seconds;\n\nExclusion Criteria:\n\n* severe limitations of articular range of motion;\n* medical problems compromising walking (e.g. fractures, pain, severe osteoporosis or severe spasticity);\n* Presence of skin lesions in the areas of contact with the device;\n* Presence of seizures that may be triggered by the use of the G-EO system.",{"count":692,"type":22},260,"The aim of this work is to elaborate a statistical model to predict the effectiveness of robotic treatment in subjects with neurological diseases. The model will be used to understand which subjects are most responsive to this type of treatment",[695,130,696,29],"Multiple Sclerosis","Parkinson Disease",[695,130,696,29,698,699],"Robotic","End-effector","2022-08-08",{"date":702,"type":38},"2022-08-09",{"date":704,"type":38},"2022-05-13",{"date":706,"type":22},"2027-04-01",{"name":634,"class":45}]