[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-abdomen-in-children\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-abdomen-in-children":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100054028","the-impact-of-a-diagnostic-strategy-for-acute-appendicitis-in-children-with-acute-abdominal-pain-in-primary-care-100054028",false,"NCT06762275","The Impact of a Diagnostic Strategy for Acute Appendicitis in Children With Acute Abdominal Pain in Primary Care","Optimizing Management of Children Presenting With Acute Abdominal Pain in Primary Care: a Cluster Randomized Controlled Trial Evaluating the Impact of a Clinical Prediction Rule Including C-reactive Protein for Appendicitis","ISAAK","Inclusion criteria:\n\n\\- Children aged 4 to 18 years with acute abdominal pain (onset ≤ 7 days) who present at the GP.\n\nExclusion criteria:\n\n* A history of appendectomy\n* Current pregnancy\n* Traumatic cause of abdominal pain","ALL","4 Years","18 Years",{"count":21,"type":22},566,"ESTIMATED","INTERVENTIONAL",[25],"NA","BACKGROUND Acute appendicitis (AA) in an early stage is difficult to distinguish from other (self-limiting) causes of acute abdominal pain (e.g. constipation and gastroenteritis), resulting in missing 19% of children with AA at first presentation in primary care and 70% of non-AA cases among referrals.\n\nOBJECTIVE To evaluate the impact of the use of a diagnostic strategy for acute appendicitis (AA), which consists of a clinical prediction rule (cPR) including C-reactive protein point-of-care test (CRP POCT), on referral efficiency in children with acute abdominal pain in primary care, as compared to usual care.\n\nSTUDY DESIGN This is a cluster randomized controlled trial in primary care with a process evaluation. GPs in the intervention group will use an externally validated cPR based on symptoms and signs selectively followed by a CRP POCT in the medium risk group. GPs from general practices allocated to the control group will provide care and diagnosis as usual, i.e. following recommendations of the Dutch College of GPs guideline 'abdominal pain in children'.\n\nSTUDY POPULATION Children aged 4 to 18 years presenting to their general practitioner (GP) with acute abdominal pain.\n\nOUTCOME MEASURES Primary outcome: referral efficiency (proportion non-referrals in non-AA patients during 30 days follow-up).\n\nSecondary outcomes: safety (proportion of referrals in AA patients during the first consultation or planned reassessment), proportion of children with CRP-POCT, proportion of children with planned reassessment, child anxiety, parent or child satisfaction, quality of life, and costs.",[28,29],"Appendicitis Acute","Acute Abdomen in Children",[31,32,33,34,35],"General practitioner","Appendicitis","Clinical prediction rule","C-reactive protein","Children","RECRUITING","2026-07-09",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":40},"2025-03-06",{"date":44,"type":22},"2029-03-01",{"name":46,"class":47},"University Medical Center Groningen","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100614105","diagnostic-contribution-of-early-abdominal-ultrasound-in-the-situation-of-acute-abdomen-of-premature-100614105","NCT07275268","DIAGNOSTIC CONTRIBUTION OF EARLY ABDOMINAL ULTRASOUND IN THE SITUATION OF ACUTE ABDOMEN OF PREMATURE","EchoPrémA","Inclusion Criteria:\n\nPremature under 37 weeks of amenorrhea with an adverse event of special interest such as :\n\n* altered abdomen with bloating or presence of previsouly unknow marked collateral circulation,\n* absence of spontaneous transit (\\> 48 hours),\n* episode of rectal bleeding,\n* repeated regurgitation\u002Fvomiting (during more than 50% of feedings),\n* prolonged fasting (\\>12 hours), OR\n* increase in cardiorespiratory events on continuous monitoring associated with one of the elements listed above.\n\nExclusion Criteria:\n\n* organic malformation detected during prenatal monitoring or discovered in the immediate postnatal period,\n* chromosomal abnormality detected during prenatal monitoring or discovered in the immediate postnatal period,- spontaneous perforation occurring during the first week of life.","36 Weeks",{"count":58,"type":22},100,[25],"This study will assess the diagnostic contribution of early abdominal ultrasound for acute abdomen in premature newborns.\n\nEarly ultrasound assessment would provide diagnostic assistance, in conjunction with clinical examination and biological testing, in the three main clinical situations encountered with an acute abdomen in premature infants: enterocolitis (digestive translocation of a bacterium secondary to inflammation, local fragility of the digestive tract, associated ischemic phenomena), reflex ileus (decrease in intestinal peristalsis secondary to peritoneal reactivity following inflammatory phenomena) and digestive immaturity (expressed by bloating, regurgitation, absence of spontaneous transit, related to the degree of prematurity).",[29],"NOT_YET_RECRUITING","2025-11-28",{"date":65,"type":40},"2025-12-10",{"date":67,"type":22},"2025-12",{"date":69,"type":22},"2028-06",{"name":71,"class":47},"Centre Hospitalier Universitaire de Besancon",{"id":73,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":74,"targetDuration":4,"studyType":23,"phases":75,"briefSummary":76,"conditions":77,"keywords":78,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":84,"locationsCount":48},"100574668",{"count":21,"type":22},[25],"BACKGROUND Acute appendicitis (AA) in an early stage is difficult to distinguish from other (self-limiting) causes of acute abdominal pain (e.g. constipation and gastroenteritis), resulting in missing 19% of children with AA at first presentation in primary care and 70% of non-AA cases among referrals.\n\nOBJECTIVE To evaluate the impact of the use of a diagnostic strategy for acute appendicitis (AA), which consists of a clinical prediction rule (cPR) including C-reactive protein point-of-care test (CRP POCT), on referral efficiency in children with acute abdominal pain in primary care, as compared to usual care.\n\nSTUDY DESIGN This is a cluster randomized controlled trial in primary care with a process evaluation. GPs in the intervention group will use an externally validated cPR based on symptoms and signs selectively followed by a CRP POCT in the medium risk group. GPs from general practices allocated to the control group will provide care and diagnosis as usual, i.e. following recommendations of the Dutch College of GPs guideline 'abdominal pain in children'.\n\nSTUDY POPULATION Children aged 4 to 18 years presenting to their general practitioner (GP) with acute abdominal pain.\n\nOUTCOME MEASURES Primary outcome: referral efficiency (proportion non-referrals in non-AA patients during 30 days follow-up).\n\nSecondary outcomes: safety (proportion of referrals in AA patients during the first consultation), proportion of children with CRP-POCT, proportion of children with planned reassessment, child anxiety, parent or child satisfaction, quality of life, and costs.",[28,29],[31,32,33,34,35],"2025-11-20",{"date":81,"type":40},"2025-11-26",{"date":42,"type":40},{"date":44,"type":22},{"name":46,"class":47}]