[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-abdomen\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-abdomen":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100600625","rectus-sheath-catheters-following-midline-laparotomy-100600625",false,"NCT07099924","Rectus Sheath Catheters Following Midline Laparotomy","Bilateral Rectus Sheath Catheters Following Midline Laparotomy. A Randomized, Placebo-controlled Trial","Inclusion Criteria:\n\n* Median laparotomy\n* Age over 18 years\n* Informed consent has been obtained\n\nExclusion Criteria:\n\n* Local signs of inflammation\n* known allergy to local anesthetics used\n* chronic pain syndrome\n* drug addiction\n* post-operative ventilation that cannot be completed on the day of surgery\n* lack of consent or cooperation\n* pregnancy\n* participation in another medical study\n* sepsis","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC. The target structures are the anterior cutaneous branches of the spinal nerves Th7-Th12. RSC can be used in particular if thoracic epidurals are contraindicated (compromised coagulation), technically unfeasible or refused by the patient.\n\nThe study investigates placebo-controlled weather RSC have a significant additional analgesic effect in a multimodal analgesic concept. Primary outcome parameters are the maximum pain score, the Quality-of-Recovery-15-Score (QoR-15GE) and the opioid consumption (morphine equivalents) in the first 72h postoperatively.",[26,27,28],"Acute Abdomen","Ileus","Colorectal Carcinoma",[30,31,32,33],"postoperative analgesia","rectus sheath catheter","ultrasound","midline laparotomy","NOT_YET_RECRUITING","2025-07-30",{"date":37,"type":38},"2025-08-01","ACTUAL",{"date":40,"type":20},"2025-07",{"date":42,"type":20},"2027-09",{"name":44,"class":45},"Asklepios Kliniken Hamburg GmbH","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":46},"100527964","upper-gastrointestinal-perforations-a-nationwide-registry-based-study-100527964","NCT06154603","Upper Gastrointestinal Perforations: a Nationwide Registry-based Study","Risk Factors for and Survival After Oesophageal, Gastric and Small Intestinal Perforations: a National Observational Registry-based Cohort Study","Inclusion Criteria:\n\n* age of at least 18 years\n* perforation in either oesophagus, stomach or small intestine\n* treatment carried out in Sweden\n* diagnosis set between January 2005 and August 2023\n\nExclusion Criteria:\n\n* children",{"count":55,"type":20},2000,"OBSERVATIONAL","The primary aim of this project is to increase the knowledge about how perforations in the esophagus, stomach and small intestine are treated on a national level. Furthermore, secondary aims include assessment of how different treatment options and type of treating facilities relate to patient survival. This will be done by studying information about all adult patients with an upper GI perforation treated in Sweden during 2005-2023.",[26],[60,61,62],"Clinical outcomes","General surgery","Upper gastrointestinal perforation","2024-12-02",{"date":65,"type":38},"2024-12-05",{"date":67,"type":20},"2025-08",{"date":69,"type":20},"2026-08",{"name":71,"class":72},"Region Stockholm","OTHER_GOV",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":5},"100377570","phase-4-intravenous-contrast-computed-tomography-versus-native-computed-tomography-in-patients-with-acute-abdomen-and-impaired-renal-function-100377570","NCT04196244","Intravenous Contrast Computed Tomography Versus Native Computed Tomography in Patients With Acute Abdomen and Impaired Renal Function","INtravenous Contrast Computed Tomography Versus Native Computed Tomography in Patients With Acute Abdomen and Impaired Renal functiOn (INCARO) - a Multicentre, Open-label, Randomised Controlled Trial","INCARO","Inclusion Criteria:\n\n* Patients requiring emergency abdominal or body CT with eGFR 15-45 ml\u002Fmin\u002F1.73 m2\n\nExclusion Criteria:\n\n* Age less than 18 years\n* Pregnancy\n* eGFR less than 15 or more than 45 ml\u002Fmin\u002F1.73 m2\n* Renal replacement therapy within 30 days prior enrolment\n* CT with IV contrast less than 72 hours prior enrolment\n* Suspicion of vascular occlusion, dissection or bleeding (i.e. need for IV-contrast)\n* CT needed without IV-contrast to detect or rule out ureteral stone\n* IV contrast allergy\n* Inability to give written consent.",{"count":82,"type":20},994,[84],"PHASE4","Computer tomography (CT) is the primary imaging option for acute abdominal pain in adults. Intravenous (IV) contrast media is used to improve the CT quality. In patients with impaired renal function, post-contrast acute kidney injury (PC-AKI) has remained a significant concern. Modern retrospective studies have shown no association between worsened baseline renal function and IV-contrast CT. However, no randomised controlled trial has been done to conclude this. The INCARO (INtravenous Contrast computed tomography versus native computed tomography in patients with acute Abdomen and impaired Renal functiOn) trial is a multicentre, open-label, parallel group, superiority, individually randomised controlled trial comparing IV-contrast enhanced CT to native CT in patients with impaired renal function. Patients requiring emergency abdominal or body CT with eGFR 15-45 ml\u002Fmin\u002F1.73 m2 are included in the study. The primary outcome is a composite outcome of all-cause mortality or renal replacement therapy within 90 days from CT.",[26,87],"Radiocontrast Nephropathy","RECRUITING","2021-02-01",{"date":91,"type":38},"2021-02-02",{"date":93,"type":38},"2020-09-18",{"date":95,"type":20},"2033-09",{"name":97,"class":45},"Helsinki University Central Hospital"]