[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-aortic-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-aortic-syndrome":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,38,59,82,107,129],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100643486","aortic-dissection-detection-risk-score-with-d-dimer-to-rule-out-acute-aortic-syndrome-100643486",false,"NCT07640334","Aortic Dissection Detection Risk Score With D-dimer to Rule-Out Acute Aortic Syndrome","The Combination of Aortic Dissection Detection Risk Score With D-dimer to Rule-Out Acute Aortic Syndrome: Multicentre Prospective Study in Emergency Departments","Inclusion Criteria:\n\n* Adult patients aged ≥ 18 years; AND\n* Presentation to the ED with any of the following symptoms: acute onset (\\\u003C14 days) chest pain, abdominal pain, back pain, syncope, or signs of malperfusion (e.g. limb ischemia, neurological deficit); AND\n* AAS is considered as a possible differential diagnosis by the treating physician. Enrolment in the study will be determined by the attending physician during initial medical consultation in the ED and prior to establishing a final diagnosis.\n\nExclusion Criteria:\n\n* An alternative diagnosis to AAS established by the treating physician after the initial assessment; OR\n* Trauma cases; OR\n* Patients with a known diagnosis of AAS before the index ED visit (e.g. with a diagnostic imaging done before the ED visit or referral from other institutions for AAS); OR\n* Clinical severity or other conditions not allowing complete evaluation\u002Fproper enrolment; OR\n* Patient who refuse to participate.","ALL","18 Years",{"count":19,"type":20},448,"ESTIMATED","OBSERVATIONAL","The goal of this study is to evaluate the safety of integrating the Aortic Dissection Detection Risk Score (ADD-RS) and D-dimer testing for ruling out acute aortic syndrome (AAS) in the emergency department (ED). The main question it aims to answer: Can the combination of the ADD-RS \\\u003C2, and D dimer \\\u003C500ng\u002FmL rule-out AAS in ED patients without CTA? The researchers will recruit patients suspected with AAS in the ED, and the patients will receive a ADD-RS score, a D-dimer testing after signing a written consent.",[24],"Acute Aortic Syndrome","NOT_YET_RECRUITING","2026-06-08",{"date":28,"type":29},"2026-06-10","ACTUAL",{"date":31,"type":20},"2026-07-13",{"date":33,"type":20},"2028-12-31",{"name":35,"class":36},"Chinese University of Hong Kong","OTHER",1,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":48,"conditions":49,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":4},"100628887","the-envscore-aorte-diagnostic-study-protocol-for-the-identification-of-acute-aortic-syndrome-100628887","NCT07467486","The EnvScore-Aorte Diagnostic Study Protocol for the Identification of Acute Aortic Syndrome","Diagnostic Performance of a Modified AORTAs Score Integrated With Environmental Exposure Data for Acute Aortic Syndrome Identification : The EnvScore-Aorte Diagnostic Study Protocol","EnvScore Aorte","Inclusion Criteria (Cases - AAS+) :\n\n* Adults (\\>18 years)\n* Diagnosis of AAS (aortic dissection, intramural hematoma, or penetrating atherosclerotic ulcer) identified according to medicalization programs for information systems\n* Diagnosis confirmed by imaging (CTA, TTE, or TOE)\n\nInclusion Criteria (Controls - AAS-):\n\n* Adults (\\>18 years)\n* Presenting in the emergency department for chest, back, or abdominal pain.-\n* Confirmed differential diagnosis by CTA, ruling out AAS\n\nExclusion Criteria:\n\n* Post-traumatic or iatrogenic AAS.\n* Subacute (8-30 days) or chronic symptoms (\\>30 days).\n* Patients under legal protection or unable to provide consent\u002Fnon-opposition.",{"count":47,"type":20},580,"The goal of this retrospective observational study is to evaluate the diagnostic performance of the AORTAs score integrated with environmental exposure data (AORTAs-E) for the identification of Acute Aortic Syndrome (AAS) during initial maangement in the emergency departement.\n\nThe main question it aims to answer is:\n\nCan the integration of real-time meteorological and atmospheric pollution data improve the early identification of AAS in patients presenting in the emergency department for chest, abdominal, or back pain?\n\nResearchers will analyze medical records and environmental data for 580 adult patients (290 cases with confirmed AAS and 290 controls) managed at the University Hospital of Besançon between 2014 and 2026. Environmental exposure, including temperature and pollutant concentrations, will be calculated based on each patient's residential address to determine if adding these factors to clinical data increases diagnostic accuracy.",[24],"2026-03-09",{"date":52,"type":29},"2026-03-12",{"date":54,"type":20},"2026-04",{"date":56,"type":20},"2028-12",{"name":58,"class":36},"Centre Hospitalier Universitaire de Besancon",{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":4,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":66,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":68,"conditions":69,"keywords":70,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100393128","additive-anti-inflammatory-action-for-aortopathy--arteriopathy-100393128","NCT04398992","Additive Anti-inflammatory Action for Aortopathy & Arteriopathy","Chinese Registry of Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (5A) Protocol: Rationale, Design and Methodology","Inclusion criteria\n\n* Aged 18 years or older.\n* Patients with diagnosis of AAS, including aortic dissection, penetrating aortic ulcer or intramural hematoma.\n* Symptoms started within 14 days from surgery.\n* Patients received medical therapy, open surgical, endovascular, or hybrid repair.\n* Any other major cardiac surgical procedure concomitant with surgery for AAS, such as coronary artery bypass grafting or carotid artery replacement;\n* The patient or guardian agrees to participate in this study. Exclusion criteria\n* Patients aged \\\u003C 18 years.\n* Onset of symptoms \\> 14 days from surgery.\n* AAS secondary to traumatic or iatrogenic injury.\n* Patients who declined participation in registration and follow-up investigation.",{"count":67,"type":20},10000,"Acute aortic syndrome (AAS) is a life-threatening condition. Inflammation plays a key role in the pathogenesis, development and progression of AAS, and is associated with significant mortality and morbidity. Understanding the inflammatory responses and inflammation resolutions is essential for an appropriate management of AAS.\n\nTwenty Chinese cardiovascular centers have collaborated to create a multicenter observational registry (named Chinese registry of Additive Anti-inflammatory Action for Aortopathy \\& Arteriopathy \\[5A\\]), with consecutive enrollment of adult patients who underwent surgery for AAS that was started on Jan 1, 2016 and will be ended on December 31, 2040. Specially, the impact of inflammation and anti-inflammatory strategies on the early and late adverse events are investigated. Primary outcomes are severe systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), Sequential Organ Failure Assessment (SOFA) scores at 7 days following this current surgery. Secondary outcomes are SISR, 30-day mortality, operative mortality, hospital mortality, new-onset stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit.",[24],[24],"RECRUITING","2026-02-05",{"date":74,"type":29},"2026-02-09",{"date":76,"type":29},"2016-01-01",{"date":78,"type":20},"2030-12-31",{"name":80,"class":36},"Nanjing Medical University",34,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},"100416178","protective-effect-of-statin-against-negative-cardiovascular-remodeling-and-organ-dysfunction-after-acute-aortic-syndrome-surgery-panda-iii-100416178","NCT04699279","Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)","PANDA","Inclusion Criteria:\n\n* (1) Patients with aortic dissection\u002Fulceration\u002Fintermural hematoma\u002Faortic aneurysm who underwent aortic arch replacement or endoluminal isolation or hybrid therapy;\n* (2) Paitents without clinically significant hyperlipidemia but with cardiovascular disease risk factors (such as male ≥45 years old, female ≥55 years old, hypertension, diabetes, chronic kidney disease, obesity, low HDL cholesterol, smoking, alcohol consumption, family history of early onset ischemic cardiovascular disease) and no previous use of statins;\n* (3) Patients are between 18 and 85 years old, male or female;\n* (4) Agree to participate in the study and sign the informed consent.\n\nExclusion Criteria:\n\n* (1) Patients with allergy to statins;\n* (2) patients with active liver disease;\n* (3) patients with myopathy;\n* (4) Lactating women and pregnant women;\n* (5) Patients with mental diseases, drug and alcohol dependence;\n* (6) Refuse to participate in the study or sign the informed consent.","85 Years",{"count":91,"type":20},300,"INTERVENTIONAL",[94],"NA","Acute Aortic Syndrome (AAS)\u002FAortic Aneurysm is a common feature of aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year between the ages of 65 and 75 years. Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, the authors hypothesized that people with acute aortic syndrome but without hyperlipidemia might benefit from statin treatment.",[24,97],"Aortopathy","2024-12-10",{"date":100,"type":29},"2024-12-13",{"date":102,"type":29},"2021-01-01",{"date":104,"type":20},"2024-12-31",{"name":80,"class":36},5,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":87,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":92,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},"100465346","protective-effect-of-thymosin-1-against-negative-immune-dysregulation-and-organ-dysfunction-after-acute-aortic-dissection-surgery-panda-ii-100465346","NCT05339529","Protective Effect of Thymosin Α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA II)","Inclusion Criteria:\n\n* The patients are conformed to 2010 ACC\u002FAHA guidelines for the diagnosis and treatment of thoracic aortic disease (TAD) within two weeks of onset;\n* Patients with acute aortic syndrome confirmed clinically and radiologically and planning to undergo emergency surgery were enrolled.\n* The patients' age between 18 \\~90 years old.\n* Agree to participate in the study and sign the informed consent.\n\nExclusion Criteria:\n\n* Patients allergic to Thymosin α1;\n* Lactating women and pregnant women;\n* Patients with mental diseases, drug and alcohol dependence;\n* Refuse to participate in this study and refuse to sign the informed consent.","90 Years",{"count":115,"type":20},330,[94],"Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with acute aortic syndrome (AAS). Therefore, the prevention of SIRS and MODS is of great clinical value, and immunomodulatory therapy with thymosin alpha 1 may be beneficial. This study was designed to test the hypothesis that the administration of thymosin alpha 1 during the acute phase of AAS will result in a reduced incidence of SIRS and MODS.",[24,119],"Aortic Dissection Type a","2024-12-09",{"date":122,"type":29},"2024-12-12",{"date":124,"type":29},"2022-07-01",{"date":126,"type":20},"2025-12-31",{"name":80,"class":36},15,{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":37},"100513437","evaluation-of-the-castor-single-branch-stent-graft-in-treatment-of-acute-aortic-syndrome-100513437","NCT05965453","Evaluation of the Castor Single Branch Stent Graft in Treatment of Acute Aortic Syndrome","Real-world Experience With the Castor Single Branch Stent Graft in the Management of Acute Aortic Syndrome","ECAAS","Inclusion Criteria:\n\n* Patients with acute Stanford type B aortic syndrome who received thoracic endovascular aortic repair by meant of Castor single branch stent graft from June 2018 to June 2022\n\nExclusion Criteria:\n\n* Patients with acute type B aortic syndrome with an adequate proximal landing zone (≥15mm)\n* Previous endovascular repair of the aorta\n* Patients with missing data and loss of follow-up","95 Years",{"count":139,"type":20},205,"The objective of this study to evaluate the safety and effectiveness of the Castor single branch stent graft for endovascular repair of acute aortic syndrome patients without an inadequate proximal landing zone (\\\u003C15mm)",[24],"2023-07-20",{"date":144,"type":29},"2023-07-28",{"date":146,"type":29},"2018-06-01",{"date":148,"type":20},"2032-06-01",{"name":150,"class":36},"First Affiliated Hospital Xi'an Jiaotong University"]