[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-appendicitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-appendicitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,44,73,98,125,151,176,212],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100642644","feasibility-and-safety-of-a-pediatric-eras-protocol-for-laparoscopic-appendectomy-100642644",false,"NCT07643285","Feasibility and Safety of a Pediatric ERAS Protocol for Laparoscopic Appendectomy","Clinical Outcomes and Institutional Integration of the ERAS (Enhanced Recovery After Surgery) Protocol in Pediatric Appendicetomies: A Mixed Methodological IDEAL (Idea, Development, Exploration, Assessment, Long-term Study) 2a Preliminary Study","Inclusion Criteria:\n\n1. Pediatric patients aged 5 to 18 years (preschool, school-age, and adolescent).\n2. Acute appendicitis without preoperative radiologic or clinical evidence of complication\u002Fperforation, who are candidates for and accept laparoscopic surgery.\n3. ASA Physical Status I (healthy) or ASA II (mild systemic disease).\n4. Family\u002Flegal guardians literate in Turkish (or the institution's primary service language) and able to comprehend the educational materials.\n5. Written informed consent from parents\u002Flegal guardians; for children of sufficient developmental maturity (generally ≥7 years), age-appropriate written assent.\n\nExclusion Criteria:\n\n1. Preoperative imaging or clinical evidence of complicated appendicitis (perforation, generalized peritonitis, intra-abdominal abscess) anticipated to require an extended procedure (anastomosis, resection, or extensive peritoneal irrigation).\n2. History of chronic pain syndrome or regular\u002Fsustained opioid use within the past 3 months.\n3. Therapeutic preoperative antibiotic treatment for an active infection (other than surgical prophylaxis).\n4. ASA III or higher; immunosuppression, progressive neurological disease, chronic inflammatory bowel disease, or other significant comorbidities likely to interfere with postoperative recovery\u002Fmobilization.\n5. Anatomic\u002Fmechanical contraindications to laparoscopy or pneumoperitoneum (e.g., prior major open abdominal surgery with suspected adhesions, abdominal wall defects).","ALL","5 Years","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","Acute appendicitis is the most common surgical emergency in children. Despite the widespread adoption of laparoscopic appendectomy, postoperative care still varies widely between institutions, with prolonged fasting, opioid-based analgesia, delayed feeding, and routine drain placement being common. Enhanced Recovery After Surgery (ERAS) is an evidence-based, multidisciplinary care pathway that has been shown in adults - and increasingly in children - to reduce length of stay, opioid consumption, and postoperative complications.\n\nThis single-center, prospective, single-arm cohort feasibility study (IDEAL Stage 2a) tests whether a comprehensive 20-item pediatric ERAS protocol, adapted for minimally invasive appendectomy in children aged 5-18 with non-complicated acute appendicitis (ASA I-II), can be implemented with high fidelity and acceptable safety in a tertiary academic pediatric surgery department. We aim to enroll 100 patients to obtain \\~80 evaluable cases. The primary endpoint is the global ERAS compliance rate (target ≥80%, with the lower bound of the 95% confidence interval staying above 70%). Co-primary safety endpoints include Clavien-Dindo ≥III complications and 30-day unplanned readmission rates, both targeted at \\\u003C5%. Secondary endpoints include time to medical readiness for discharge, actual length of stay, opioid sparing, and parent-reported outcomes.\n\nThe study includes a structured run-in phase (first 5 patients) with explicit decision logic to either continue with the protocol unchanged or revise it before full enrollment. Audit-and-feedback cycles every 20 patients monitor compliance drift. The findings will inform a definitive institutional clinical guideline and provide hypothesis-generating data for future multi-center trials.",[27,28,29,30],"Appendectomy, Laparoscopic","Acute Appendicitis","Pediatric Surgery","ERAS","RECRUITING","2026-06-28",{"date":34,"type":35},"2026-07-01","ACTUAL",{"date":37,"type":35},"2026-06-16",{"date":39,"type":21},"2027-08",{"name":41,"class":42},"Ahmet Burak Doğan, MD","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":72},"100564057","retrospective-acute-care-appendectomy-study-100564057","NCT06624215","Retrospective Acute Care Appendectomy Study","A Retrospective Multicenter Evaluation of Short-Term Outcomes After Acute Care Appendectomy","Inclusion Criteria:\n\n* Subject is 22 years of age or older at time of procedure\n* Subject has undergone robotic-assisted or laparoscopic emergent or urgent appendectomy for acute appendicitis between 2018 and 30 days prior to IRB approval\n\nExclusion Criteria:\n\n* Subject with appendiceal neoplasms\n* Subject who underwent a single-port appendectomy\n* Subject who was pregnant or breastfeeding at the time of the procedure","22 Years",{"count":53,"type":21},1000,"OBSERVATIONAL","The purpose of this retrospective study is to compare perioperative data for subjects who have undergone an emergent or urgent robotic-assisted or laparoscopic appendectomy for acute appendicitis.",[28],[58,59,60,61],"Appendectomy","Robotic-assisted","Acute care","Laparoscopic","2026-04-20",{"date":64,"type":35},"2026-04-22",{"date":66,"type":35},"2024-11-22",{"date":68,"type":21},"2026-11",{"name":70,"class":71},"Intuitive Surgical","INDUSTRY",3,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":43},"100631134","comparison-of-diagnostic-methods-in-patients-operated-for-suspected-appendicitis-100631134","NCT07496723","Comparison of Diagnostic Methods in Patients Operated for Suspected Appendicitis","Prospective Evaluation of the Impact of Computed Tomography Reporting and AIR Scoring System on Negative Appendectomy Rates in Patients With Acute Appendicitis","APP-AIR","Inclusion Criteria:\n\n* Age 18 years or older\n* Presentation to the emergency department with suspected acute appendicitis\n* Underwent computed tomography after clinical evaluation\n* Computed tomography report compatible with acute appendicitis\n* Underwent appendectomy for presumed acute appendicitis\n* Provided informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Pregnancy\n* Planned additional surgical intervention in the same session for a reason other than appendicitis\n* Intraoperative finding of a non-appendiceal pathology requiring a different surgical procedure\n* Refusal to participate in the study",{"count":82,"type":21},200,"Acute appendicitis is one of the most common surgical emergencies, but diagnostic uncertainty may still lead to unnecessary appendectomy in some patients. This prospective observational study aims to evaluate the diagnostic performance of computed tomography (CT) reporting and the Appendicitis Inflammatory Response (AIR) score in adult patients undergoing appendectomy for suspected acute appendicitis. The primary objective is to determine the negative appendectomy rate based on final histopathology. Secondary objectives are to assess the agreement between AIR score, CT findings, intraoperative severity grading, and pathology results, and to explore diagnostic performance across patient subgroups. No study-specific intervention beyond routine clinical care will be performed.",[28],[86,58,87],"Appendicitis Inflammatory Response Score","Computed Tomography","2026-03-26",{"date":90,"type":35},"2026-04-01",{"date":92,"type":35},"2026-03-18",{"date":94,"type":21},"2027-01-31",{"name":96,"class":97},"Sanliurfa Education and Research Hospital","OTHER_GOV",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":105,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":112,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":43},"100629836","tactile--validation-of-a-teleconsultation-based-predictive-score-for-the-diagnosis-of-acute-appendicitis-in-children-using-artificial-intelligence-methods-100629836","NCT07479849","TACTILE : Validation of a Teleconsultation-Based Predictive Score for the Diagnosis of Acute Appendicitis in Children Using Artificial Intelligence Methods","TACTILE","Inclusion Criteria:\n\n* Children aged 3 to 16 years\n* Presentation to the pediatric emergency department with unexplained abdominal pain\n* Affiliation with a social security or health insurance system\n* Written informed consent from a legal guardian and assent from the child, when applicable\n\nExclusion Criteria:\n\n* Previous appendectomy\n* Hemodynamic instability\n* Known medical condition likely to cause chronic or recurrent abdominal pain\n* Inability of the child or parents to understand French\n* Referral with prior laboratory or imaging investigations\n* Participation in the study within the previous 48 hours","3 Years","16 Years",{"count":108,"type":21},1500,[24],"Acute appendicitis is the most common abdominal surgical emergency in children and a frequent cause of pediatric emergency department visits. Diagnosis may be challenging due to variable clinical presentations and overlapping symptoms with other causes of abdominal pain. The increasing use of telemedicine further limits access to direct physical examination.\n\nThis study aims to evaluate and validate a predictive clinical score designed for teleconsultation to estimate the probability of acute appendicitis in children. The score is based on symptom history and simple clinical signs assessed remotely with the assistance of a parenton a 10 item checklist. During an emergency visit for acute abdominal pain, voluntary children aged 3 to 16 years and their parents will be guided by a medical student through the checklist in conditions simulating a teleconsultation. The score will be recorded for research purposes only and will not influence clinical management. All participants will subsequently undergo standard medical evaluation and management by an emergency physician, who will independently assess the probability of acute appendicitis based on routine clinical practice. The diagnostic performance of the simulated teleconsultation will then be evaluated using advanced statistical and artificial intelligence-based methods and compared with standard in-person pediatric emergency consultation.",[28],[113,114,115],"telediagnosis","validation study","Pediatric medicine","NOT_YET_RECRUITING","2026-03-13",{"date":92,"type":35},{"date":120,"type":21},"2026-06",{"date":122,"type":21},"2029-06",{"name":124,"class":97},"University Hospital, Angers",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":131,"sex":16,"minAge":17,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":134,"conditions":135,"keywords":138,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":43},"100593565","prostaglandin-e-urinary-metabolite-pge-m-as-a-predictor-of-acute-appendicitis-in-children-100593565","NCT07008092","Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children","Inclusion Criteria:\n\n* children of age 5 -17 years with acute abdominal pain\n* children with clinical signs of acute appendicitis\n\nExclusion Criteria:\n\n* previous diagnosis of chronic and\u002For malignant disease\n* children who had previous abdominal surgery\n* pregnancy",true,"17 Years",{"count":20,"type":21},"Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery. Prostaglandin E urinary metabolites (PGE-M) have been found elevated in various inflammatory conditions, but their diagnostic value in pediatric appendicitis is not well established. This study aims to assess the potential of PGE-M as a biomarker for acute appendicitis in children.\n\nThe study will be conducted over 12 months and will include 100 children aged 5 to 17 years presenting with acute abdominal pain. In addition to routine laboratory tests, urinary PGE-M levels will be analyzed. The study involves minimal risk to participants",[28,136,137],"Acute Appendicitis With Rupture","Abdominal Pain (AP)",[139,140,141],"Acute appendicitis","PGE-M","Prostaglandin-E urinary metabolite","2025-05-29",{"date":144,"type":35},"2025-06-06",{"date":146,"type":21},"2025-06-02",{"date":148,"type":21},"2026-05-01",{"name":150,"class":42},"KBC Split",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":131,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":72},"100569837","artificial-intelligence-driven-virtual-standardized-pediatric-patients-trial-100569837","NCT06699433","Artificial Intelligence-driven Virtual Standardized Pediatric Patients Trial","Utilizing Artificial Intelligence-driven Virtual Standardized Pediatric Patients to Enhance the Capabilities of Primary Healthcare Doctors in China for Managing Common Pediatric Diseases: a Randomized Controlled Trial","1. Inclusion and Exclusion Criteria for Research Institutions\n\n   Inclusion Criteria:\n   * Primary and secondary hospitals\n   * Community health centers (stations) and clinics, as well as township health centers and village health clinics\n\n   Exclusion Criteria:\n   * Specialized medical institutions (such as specialized hospitals and dental clinics)\n   * Public health prevention and treatment institutions (such as tuberculosis prevention centers)\n   * Ethnic medicine institutions (such as Mongolian and Tibetan hospitals)\n   * Hospitals above the secondary level\n   * Hospitals that have not yet been graded (due to their short establishment time and potentially unstable operations)\n2. Inclusion and exclusion criteria for research subjects\n\nInclusion Criteria:\n\n* Practicing (assistant) doctors and rural doctors working in medical institutions that meet the above conditions\n* With a scope of practice only including general practice, internal medicine, surgery, and pediatrics\n\nExclusion Criteria:\n\n-None",{"count":159,"type":21},459,[24],"Background: China's healthcare system for children faces significant challenges, particularly due to the limited pediatric service capacity of primary healthcare institutions. A shortage of effective and accessible training tools for primary care doctors further hinders progress in addressing this gap. Technological advancements, especially in artificial intelligence, offer a potential solution to improve pediatric care. Artificial intelligence-driven virtual standardized patients (VSPs), leveraging internet and virtual simulation technologies, simulate clinical cases with specific disease characteristics, providing an innovative, efficient, and flexible training method. VSPs are increasingly utilized in medical education, clinical reasoning, and licensure exams. This study focuses on using VSPs to improve the management of common pediatric conditions, which are major health concerns for children and impose significant psychological and financial burdens on families.\n\nMethods: This study will involve a three-arm randomized controlled trial to evaluate the effectiveness of a virtual pediatric standardized patient platform in enhancing primary care doctors' management of common pediatric diseases. At least 459 participants, including general practitioners, internal medicine practitioners, surgeons, and pediatricians from more than 10 provinces across China, will be randomly assigned to one of three groups: the virtual patient platform group, the case teaching manual group, or the case teaching video group. Five virtual patient cases covering pneumococcal pneumonia, rotavirus enteritis with hypovolemic shock, hand-foot-and-mouth disease, acute appendicitis, and respiratory failure will be developed, along with corresponding case teaching materials. After a two-week learning period, participants' disease management abilities will be assessed using clinical vignettes. The primary outcome is adherence to best clinical practice guidelines, categorized into full adherence, partial adherence, and nonadherence.\n\nDiscussion: This study aims to leverage artificial intelligence for capacity enhancement, targeting the shortcomings of primary care pediatrics and using VSP to help enhance primary care pediatrics capacity. It is a randomized controlled trial involving over 300 primary healthcare institutions across more than 10 provinces in China, ensuring broad and representative participation from both developed and underdeveloped regions.",[163,164,165,28,166],"Pneumococcal Pneumonia","Rotavirus Enteritis With Hypovolemic Shock","Hand-foot-and-mouth Disease","Respiratory Failure (Pediatric Patients)","2024-12-15",{"date":169,"type":35},"2024-12-19",{"date":171,"type":21},"2024-12",{"date":173,"type":21},"2025-01",{"name":175,"class":42},"Southern Medical University, China",{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":16,"minAge":183,"maxAge":18,"enrollmentInfo":184,"targetDuration":4,"studyType":22,"phases":186,"briefSummary":188,"conditions":189,"keywords":193,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":43},"100559378","phase-4-magnesium-sulfate-in-children-undergoing-laparoscopic-appendectomy-100559378","NCT06563349","Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy","The Effect of Intravenous Magnesium Infusion on the Opioid Consumption, the Circulatory, Metabolic and Hormonal Response to Intubation and Surgical Trauma During Anaesthesia for Laparoscopy in Children. Randomized Clinical Trial.","Inclusion Criteria:\n\n* ASA (American Society of Anesthesiologists) physical status class 1E, 2E, 3E (E - emergency)\n* Patients undergoing laparoscopic appendectomy\n\nExclusion Criteria:\n\n* Allergy to the magnesium sulfate or the excipient\n* Hypermagnesemia\n* Renal failure (GFR \\\u003C30 ml\u002Fmin)\n* Myasthenia gravis\n* Preoperative atrioventricular block\n* Hypotension\n* The use of digitalis glycosides\n* The use of oral anticoagulants\n* ASA physical status class 4E or higher\n* Chronic treatment with analgesics\n* Legal guardians or patient refusal","18 Months",{"count":185,"type":21},188,[187],"PHASE4","Magnesium sulfate is one of the most commonly used co-analgetics. Its antinociceptive effect is related to antagonizing NMDA (N-methyl-D-aspartate) receptors of the nervous system, has an anti-inflammatory effect by reducing the concentration of IL-6 (interleukin 6) and tumor necrosis factor alpha. In adult patients, the need for morphine in the perioperative period is reduced when magnesium infusion is used. In current guidelines for treatment of acute pain in children, magnesium sulfate may be considered as a co-analgetic. However, the strength of such a recommendation is low due to the lack of reliable scientific research confirming the effectiveness of magnesium infusion in the pediatric population. The aim of this study is to evaluate the efficacy of intravenous magnesium sulfate infusion on the opioid consumption, the circulatory, metabolic and hormonal response to intubation and surgical trauma during anesthesia for laparoscopic appendectomy in children.",[190,191,28,192],"Opioid Consumption","Multimodal Analgesia","Complication of Treatment",[194,195,196,197,198,199,200,201,202],"multimodal analgesia","magnesium sulfate","laparoscopic appendectomy","children","pediatric population","adjuvant","metabolic stress response","hormonal response","inflammatory response","2024-11-09",{"date":205,"type":35},"2024-11-12",{"date":207,"type":35},"2024-09-09",{"date":209,"type":21},"2027-10-01",{"name":211,"class":42},"Medical University of Warsaw",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":219,"targetDuration":221,"studyType":54,"phases":4,"briefSummary":222,"conditions":223,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":43},"100335153","web-based-international-register-of-emergency-surgery-and-trauma-100335153","NCT03643718","Web-based International Register of Emergency Surgery and Trauma","WIRES-T","Inclusion Criteria:\n\n* Patients affected by an acute surgical disease\n* Patients with indication to be referred to the emergency surgeon attention\n* Patients to be operated or to be treated with non-operative approach without surgical intervention\n\nExclusion Criteria:\n\n* Patients not affected by an acute surgical disease\n* Patients without indication to be referred to the emergency surgeon attention",{"count":220,"type":21},10000,"2 Weeks","The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a worldwide register of traumatic and non traumatic surgical emergencies. This will give the opportunity to evaluate results on a macro-data basis and to give index allowing stratifying, evaluating and improving the outcomes.",[28,224,225,226,227,228,229,230,231,232,233,234,235,236,237],"Acute Cholecystitis","Acute Diverticulitis","Post-operative Complications","Acute Pancreatitis","Perforated Gastro-duodenal Ulcers","Adhesive Small Bowell Occlusion","Colonic Neoplastic Emergencies","Gynecological Emergencies","Vascular Emergencies","Intestinal Ischemia","Abdominal Wall Hernia","Foreign Bodies","Caustic Ingestion","Trauma","2020-07-10",{"date":240,"type":35},"2020-07-14",{"date":242,"type":21},"2020-07",{"date":244,"type":21},"2030-09",{"name":246,"class":42},"A.O. Ospedale Papa Giovanni XXIII"]