[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-brain-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-brain-injury":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,46,80,107,133,168,198,222,245,266,290,324,357,376],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100552185","ecmo-abi-detection-with-hyperfine-100552185",false,"NCT06469801","ECMO ABI Detection With Hyperfine","Low-Field Bedside MRI for Detection of Acute Brain Injury in Pediatric Extracorporeal Membrane Oxygenation","Inclusion Criteria\n\n* Participants that will be or are admitted to the Pediatric Intensive Care Unit, Cardiac Intensive Care Unit, or the Neonatal Intensive Care Unit\n* Ages 0-17 years\n* Participants that are at high risk for undergoing ECMO or are currently undergoing venovenous or venoarterial ECMO\n\n  • High risk participants include, but are not limited to:\n* Undergoing cardiac surgery\n* Congenital heart disease\n* Congenital diaphragmatic hernia\n* Refractory hypoxemic and\u002For hypercarbic respiratory failure\n* Vasoactive-refractory shock\n\nExclusion Criteria\n\n* Pregnancy\n* Active implants such as:\n\n  * Pacemaker\n  * Implanted defibrillator\n  * Implanted insulin pump\n  * Deep brain stimulator\n  * Vagus nerve stimulator\n  * Cochlear implant\n  * Programmable shunt\n* MRI incompatible surgical hardware (e.g., staples, screws, etc.)\n* Metal-containing tattoos or permanent make-up on head or neck\n* Suspected metal in eye, e.g.,\n* Former or current welders, metal workers, or individuals with a metal injury\n* Metal shrapnel\n* Passive implants are considered MRI-conditional","ALL","0 Days","17 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The primary objective is to characterize the prevalence and type of ABI following cannulation for pediatric patients who require ECMO support. The secondary objective is to describe the time course and rates of ABI using ultralow-field bedside MRI relative to both duration of ECMO support and clinical imaging obtained in routine care of pediatric ECMO patients.",[27,28,29,30],"Acute Brain Injury","Extracorporeal Membrane Oxygenation Complication","Hypoxia-Ischemia, Brain","Stroke, Acute",[32],"Pediatric","RECRUITING","2026-06-30",{"date":36,"type":37},"2026-07-01","ACTUAL",{"date":39,"type":37},"2024-07-23",{"date":41,"type":21},"2027-12-01",{"name":43,"class":44},"Children's Mercy Hospital Kansas City","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100640910","phase-2-feasibility-and-safety-of-targeting-neutral-vs-liberal-fluid-balance-in-traumatic-brain-injured-patients--limit-tbi-trial-100640910","NCT07625995","Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial","Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients: a Phase II Randomized Controlled Trial - LIMIT-TBI Trial","LIMIT-TBI","Inclusion Criteria:\n\n* Adult patients with traumatic brain injury (isolated or associated with extracranial injuries), with or without intracranial pressure monitoring\n* Admission to the intensive care unit\n* Age \\>18 years\n* Enrollment within 48 hours after ICU admission\n\nExclusion Criteria:\n\n* Enrollment in another clinical trial not approved for co-enrollment\n* Pregnancy or suspected pregnancy\n* Concomitant hemorrhagic shock expected to require surgical treatment within 24 hours from inclusion or requiring massive transfusion protocol\n* Hemodynamic instability at ICU admission, defined as heart rate \\>120 beats\u002Fmin and systolic arterial pressure \\\u003C100 mmHg despite at least 1 L of fluid resuscitation, or requirement for high-dose norepinephrine (\\>0.5 mcg\u002Fkg\u002Fmin) or any inotropic support\n* Need for continuous venovenous hemodiafiltration (CVVHDF) at admission\n* Expected survival \\\u003C48 hours","18 Years",{"count":56,"type":21},88,[58],"PHASE2","The LIMIT-TBI trial is a multicenter, international, randomized, phase II clinical trial designed to evaluate the feasibility and safety of targeting a neutral fluid balance compared to standard care in critically ill adult patients with traumatic brain injury (TBI).\n\nFluid therapy is a cornerstone of TBI management, but optimal fluid balance remains uncertain, with both fluid overload and restriction potentially leading to adverse outcomes. This study aims to determine whether maintaining a daily fluid balance close to zero (±500 mL) during the first 5 days of ICU admission is achievable and safe.\n\nParticipants will be randomized within 48 hours of ICU admission to either a protocolized neutral fluid balance strategy or standard care. Outcomes include feasibility of achieving the target balance, organ complications, hemodynamic parameters, ICU resource utilization, and mortality and neurological outcomes up to 6 months.",[61,62,27,63],"Traumatic Brain Injury","Severe Traumatic Brain Injury","Neurocritical Care",[65,66,67,68,69],"Fluid Balance","Fluid Therapy","Hemodynamic Management","Feasibility Study","Intracranial Pressure","2026-05-30",{"date":72,"type":37},"2026-06-04",{"date":74,"type":37},"2025-07-01",{"date":76,"type":21},"2029-02",{"name":78,"class":44},"Erasme University Hospital",3,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":18,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100638702","portable-mri-for-pediatric-hypoxic-ischemic-brain-injury-100638702","NCT07577336","Portable MRI for Pediatric Hypoxic Ischemic Brain Injury","Ultralow-Field Portable MRI for Detection of Pediatric Hypoxic Ischemic Brain Injury","pMRI for pHIBI","Inclusion Criteria\n\n* Patients hospitalized in the Pediatric Intensive Care Unit, Cardiac Intensive Care Unit, or the Neonatal Intensive Care Unit\n* Ages 0-17 years at study enrollment\n* Acute neurologic deficit suspected secondary to Hypoxic Ischemic Brain Injury (HIBI) or patients at high risk for HIBI\n\nExclusion Criteria\n\n* Pregnancy\n* Active implants such as\n\n  * Pacemaker\n  * Implanted defibrillator\n  * Implanted insulin pump\n  * Deep brain stimulator\n  * Vagus nerve stimulator\n  * Cochlear implant\n  * Programmable shunt\n* MRI incompatible surgical hardware (e.g., staples, screws, etc.)\n* Metal-containing tattoos or permanent make-up on head or neck\n* Suspected metal in eye, e.g.,\n* Former or current welders, metal workers, or individuals with a metal injury\n* Metal shrapnel",{"count":89,"type":21},200,[24],"This study will evaluate the sensitivity and specificity of low field portable MRI (pMRI) for detection of hypoxic ischemic brain injuries in pediatric patients compared to clinically obtained neuroimaging to define pediatric diagnostic limitations and to determine the diagnostic capabilities of this neuroimaging modality following optimization of image acquisition. The results of this study will help determine optimal clinical implementation opportunities in pediatric patients.",[27,93,94,95,96,97],"Hypoxia, Brain","Ischemia, Brain","Brain Injuries","Trauma, Brain","Stroke","NOT_YET_RECRUITING","2026-05-03",{"date":101,"type":37},"2026-05-11",{"date":103,"type":21},"2026-06",{"date":105,"type":21},"2027-12",{"name":43,"class":44},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":120,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":132},"100635122","physical-mobilisation-to-acquired-brain-injury-patients-in-intensive-care-units-a-prospective-cohort-study-100635122","NCT07548580","Physical Mobilisation to Acquired Brain Injury Patients in Intensive Care Units: a Prospective Cohort Study","Describing the Physical Mobilisation Provided to Patients With Acquired Brain Injury in Intensive Care Units: Protocol for a Prospective Cohort Study","FOOBScan2","Inclusion Criteria:\n\n* Adults (age ≥ 18 years)\n* Admitted to a neuro-ICU or to a regular ICU with dedicated beds for severe acquired brain injury patients in Scandinavia\n* Patients with moderate to severe traumatic brain injury (TBI) or stroke\n* Patients must be intubated and expected to require mechanically ventilation for at least 24 hours.\n\nExclusion Criteria:\n\n* Patients that are not likely to survive or for whom a decision has been made on palliative care.\n* Patients allergic to the Sens monitor patch or showing any type of allergic reactions from the patch after inclusion in the study that needs treatments or results in immediately removal of the patch.",{"count":116,"type":21},198,"OBSERVATIONAL","The objective of this study is to quantify the amount of physical mobilisation provided to patients with moderate to severe acquired brain injury in Scandinavian neuro-ICs, and the association between intensity and duration of mobilisation, physiological data perceived to be related to the safety of high-level mobilisation, and amount of high-level mobilisation during the neuro-ICU stay.",[27],[121,122],"Acute brain injury","Mobilisation","2026-04-21",{"date":125,"type":37},"2026-04-23",{"date":127,"type":37},"2025-08-25",{"date":129,"type":21},"2027-01",{"name":131,"class":44},"Rigshospitalet, Denmark",2,{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":143,"conditions":144,"keywords":149,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":45},"100598144","regional-ventilation-evaluation-during-neuro-injury-weaning-study-100598144","NCT07067671","Regional Ventilation Evaluation During Neuro-injury Weaning Study","Evaluation of Regional Ventilation in Neuro-injured Patients Undergoing Weaning From Mechanical Ventilation","ReVENtS","Inclusion Criteria:\n\n* Age 18 or older\n* Hospitalized in intensive care for an acute brain injury.\n* Mechanical ventilation for more than 48 hours.\n* Ventilator withdrawal planned in the next few days\n* Social security coverage\n\nExclusion Criteria:\n\n* Pregnancy\n* Moribund patient \u002F decision to stop treatment\n* Patient under state medical aid",{"count":142,"type":21},60,"This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury. It aims to identify predictive EIT patterns related to extubation outcomes.",[27,145,146,61,147,148],"Mechanical Ventilation","Prolonged Weaning","Hypoxic-Ischemic Brain Injury","Intracerebral Hemorrhage",[150,151,63,152,153,154,155,156,157,158],"Electrical Impedance Tomography","Ventilator Weaning","ICU Monitoring","Spontaneous Breathing Trial","Extubation Failure","Respiratory Mechanics","PulmoVista","EIT","Brain-Injured Patients","2026-02-18",{"date":161,"type":37},"2026-02-19",{"date":163,"type":21},"2026-03",{"date":165,"type":21},"2028-03",{"name":167,"class":44},"Assistance Publique - Hôpitaux de Paris",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":180,"conditions":181,"keywords":188,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":197},"100579076","phase-3-prophylaxis-against-early-ventilator-associated-infections-in-acute-brain-injury-100579076","NCT06819592","PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury","PRophylaxis Against Early VENTilator-associated Infections to Reduce Mortality in Mechanically Ventilated Intensive Care Unit (ICU) Patients With Acute Brain Injuries: a Phase 3 Randomised, Double Blind, Parallel Group, Placebo-controlled Two-side Superiority Trial","PREVENT-NEURO","Inclusion Criteria:\n\n1. ≥ 18 years of age\n2. Receiving invasive mechanical ventilation\n3. The requirement for mechanical ventilation is because of an acute brain injury due to intracranial haemorrhage, ischaemic stroke, cerebral venous sinus thrombosis, subarachnoid haemorrhage, suspected hypoxic ischaemic encephalopathy post cardiac arrest, or traumatic brain injury.\n4. Admitted to an ICU or is anticipated to be admitted to an ICU\n\nExclusion Criteria:\n\n1. Endotracheal intubation was more than 12 hours ago\n2. Hospital admission was more than 72 hours ago\n3. Anticipated inability to deliver trial intervention within 90 minutes of randomisation\n4. Documented use of antibiotic therapy in the week prior to hospitalisation\n5. Currently receiving antibiotic therapy, or intention to prescribe antibiotic therapy, excluding cephazolin for peri-operative prophylaxis\n6. Any contraindication to receiving ceftriaxone\n7. Known or suspected pregnancy\n8. Death within 90 days is deemed inevitable due to the current illness or intercurrent medical conditions\n9. Previously enrolled in the PREVENT-NEURO trial.",{"count":177,"type":21},3300,[179],"PHASE3","This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when they have been admitted to hospital with an acute severe brain injury.\n\nAn acute severe brain injury can occur as a result of a stroke, a traumatic injury or due to lack of oxygen to the brain that happens as a result of a cardiac arrest.\n\nPatients who are unconscious after an acute severe brain injury often need assistance to breath adequately, and this assistance is given by a breathing tube, connected to a mechanical ventilator. This treatment is an emergency medical treatment. The breathing tube is inserted into the patients' airway by either their mouth or neck. For patients who need assistance with their breathing from a mechanical ventilator, infections in the airways and lungs, known as pneumonia, are a common complication. Everyone naturally has bacteria in their mouth, esophagus and stomach. Clinicians think that during the process of inserting the breathing tube, small amounts of these bacteria can be introduced into the airways and lung when people are unconscious following an acute severe brain injury, or during the process of placing the breathing tube into the airways. These bacteria are now in a place they aren't meant to be and can cause an infections in the airways and lungs known as pneumonia.\n\nThe purpose of this research is to see if giving one dose of a common antibiotic can prevent patients developing pneumonia, which is associated with having a breathing tube inserted and being on a ventilator, improving the chance of recovery following the acute severe brain injury and ultimately improving the chance of surviving.\n\nWhen patients have a known infection, current guidelines are to treat them with antibiotics. Antibiotics work to kill the bacteria causing the infection. When a patient has an infection in their lungs, they often need to stay on the mechanical ventilator for longer. While current practice is to give patients with a proven infection in their airways and lungs (pneumonia) antibiotics, it is unknown if giving an antibiotic to patients to prevent these infections before they show signs of pneumonia may lead to better outcomes.",[182,183,184,185,27,186,187],"All-cause Mortality","Quality of Life","Disability, Intellectual","Neurological Disorder","Ventilation, Mechanical","Intensive Care Medicine",[27,145],"2026-02-16",{"date":161,"type":37},{"date":192,"type":37},"2025-10-30",{"date":194,"type":21},"2029-12",{"name":196,"class":44},"The George Institute",9,{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":206,"targetDuration":208,"studyType":117,"phases":4,"briefSummary":209,"conditions":210,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":45},"100622196","ventriculostomy-associated-infections-lactic-focus-on-csf-lactate-and-sampling-site-100622196","NCT07380477","VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site","CSF Lactate and Ventriculostomy Associated Infections in Patients With Acute Brain Injury - a Prospective, Observational Cohort Study.","LACTIC","Inclusion Criteria:\n\n* Age \\>18 years\n* EVD in situ\n* Admission to the neuro-ICU or neurosurgical step-down unit at Rigshospitalet, Denmark\n* Diagnosis of acute brain injury categorized as traumatic brain injury, subarachnoid haemorrhage, intracranial haemorrage, intraventricular haemorrhage\n\nExclusion Criteria:\n\n* Patient or closest relatives do not understand written and spoken Danish or English\n* Patients transferred to Rigshospitalet with an EVD\n* Patients with brain injury due to existing brain infection (e.g., meningitis, intracranial empyema or abscess, encephalitis)\n* Patients with existing ventriculoperitoneal or ventriculoatrial shunt at the time of admission\n* Patients with primary or secondary brain cancer\n* Patients died or in palliative care",{"count":207,"type":21},148,"6 Months","This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to:\n\n1. investigate various biomarkers, with a primary focus on the development of cerebrospinal fluid lactate in relation to ventriculostomy-associated infection;\n2. compare proximal and distal sample results obtained from an external ventricular drain;\n3. describe the natural progression of various biomarkers in blood and cerebrospinal fluid following acute brain injury.",[27,211,212,213],"Hydrocephalus","External Ventricular Drain","External Ventricular Drainage Associated Infection","2026-01-28",{"date":216,"type":37},"2026-02-02",{"date":218,"type":37},"2025-01-15",{"date":220,"type":21},"2029-10-01",{"name":131,"class":44},{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":229,"targetDuration":4,"studyType":22,"phases":230,"briefSummary":231,"conditions":232,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":45},"100622532","the-role-of-transcutaneous-vagus-nerve-stimulation-in-treatment-of-acute-brain-injury-100622532","NCT07384845","The Role of Transcutaneous Vagus Nerve Stimulation in Treatment of Acute Brain Injury","The Role of Transcutaneous Vagus Nerve Stimulation in Neuroprotection and the Reduction of the Systemic Inflammatory Response in Acute Brain Injury","IInclusion Criteria:\n\nPatients over 18 years of age with a diagnosis of traumatic brain injury or acute subarachnoid hemorrhage due to rupture of an intracranial aneurysm, confirmed by brain CT or MRI.\n\nExclusion Criteria:\n\nPatients under 18 years of age; patients with autoimmune diseases or malignant diseases; pregnant women; and patients for whom informed consent to participate in the study is not obtained.",{"count":142,"type":21},[24],"Acute brain injury is a major global health problem associated with high mortality and morbidity, limited therapeutic options, prolonged hospital stays, and long-term disability that significantly impairs quality of life and increases healthcare costs. Noninvasive transcutaneous VNS developed as a safer approach for treating cerebral edema, epileptic seizures, and blood-brain barrier disruption, for facilitating the recovery of motoric and cognitive functions, and for immunomodulation.\n\nTranscutaneous VNS improves cerebral perfusion pressure and tissue oxygenation, supports reperfusion of the penumbral zone, and reduces neuronal hyperexcitability, thereby suppressing seizures.It may exert anti-inflammatory effects by reducing microglial cytokine and chemokine production. Additionally, vagal stimulation promotes acetylcholine-mediated suppression of pro-inflammatory cytokines, including TNF, IL-1β, IL-6, and IL-18.\n\nAnother anti-inflammatory mechanism involves ghrelin, a peptide hormone whose serum levels increase under vagal stimulation. Elevated ghrelin reduces TNF-α and other pro-inflammatory cytokines and may limit intracerebral hemorrhage by inhibiting the NLRP3 inflammasome and activating the Nrf2\u002FARE signaling pathway. Biomarkers such as S100 protein and neuron-specific enolase (NSE) are valuable indicators of brain tissue damage and clinical outcomes; tVNS may reduce their levels and support non-invasive monitoring of disease progression.\n\nThe technique is considered safe in patients .\n\nTo date, tVNS has not been evaluated in clinical trials in Croatia, nor reported in case studies or cohort analyses. Study outcomes will be correlated with patients' clinical status, duration and course of hospitalization, complication rates, and overall treatment outcomes.",[27,233,234,235],"Transcutaneous Vagus Nerve Stimulation","Neuromodulation","Immunomodulation","2026-01-26",{"date":238,"type":37},"2026-02-03",{"date":240,"type":21},"2026-02",{"date":242,"type":21},"2028-02",{"name":244,"class":44},"Clinical Hospital Centre Zagreb",{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":22,"phases":253,"briefSummary":254,"conditions":255,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":45},"100612085","contribution-of-transthoracic-and-transcranial-ultrasonography-to-the-titration-of-peep-in-patients-with-ards-and-abi-100612085","NCT07248995","Contribution of Transthoracic and Transcranial Ultrasonography to the Titration of PEEP in Patients With ARDS and ABI","The Contribution of the Combination of Transthoracic and Transcranial Ultrasonography to the Titration of Positive End-expiratory Pressure in Patients With Acute Respiratory Distress Syndrome and Acute Brain Injury","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Severe acute brain injury (e.g., traumatic brain injury, subarachnoid hemorrhage, intracerebral hemorrhage, acute ischemic stroke)\n* Development of ARDS (according to Berlin criteria) within the first 10 days of ICU admission\n\nExclusion Criteria:\n\n* Severe chronic brain diseases\n* Brain tumor or central nervous system (CNS) infection\n* Severe chronic pulmonary or cardiovascular disease\n* Severe coagulopathy\n* Undergoing decompressive craniectomy\n* Lack of invasive neuromonitoring\n* Withdrawal of life-sustaining treatment\n* Poor acoustic window in ultrasound",{"count":20,"type":21},[24],"The present study will investigate whether the combined use of lung and brain ultrasonography is useful in selecting the optimal positive end-expiratory pressure in mechanically ventilated critically ill patients with acute respiratory distress syndrome and acute brain injury, aiming at an individualized, brain-protective ventilation strategy.",[256,27],"Acute Respiratory Distress Syndrome (ARDS)","2025-12-26",{"date":259,"type":37},"2025-12-31",{"date":261,"type":21},"2025-12-01",{"date":263,"type":21},"2027-07",{"name":265,"class":44},"Theodoros Schizodimos",{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":273,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":275,"conditions":276,"keywords":278,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":288,"locationsCount":132},"100557745","weaning-from-mechanical-ventilation-in-patients-with-acute-brain-injury-100557745","NCT06542107","Weaning From Mechanical Ventilation in Patients With Acute Brain Injury","Prediction of Weaning for Patients With Acute Brain Injury Undergoing Mechanical Ventilation","Inclusion Criteria:\n\n* acute brain injury\n* age \\>=18 years\n* invasive mechanical ventilation for at least 24 hours\n\nExclusion Criteria:\n\n* tracheostomized before ICU admission\n* pregnant or lactation\n* with cervical spinal cord injury\n* decision to receive palliative care within 24 hours of ICU admission",{"count":274,"type":21},406,"Acute brain injury (ABI) patients frequently necessate intubation and invasive mechanical ventilation (IMV). While some ABI patients are capable of breathing spontaneously, which is one of the main criteria of extubation and weaning. However, the rate of extubation failure was significantly higher in ABI patients compared with non-neurological critical care patients. In patients who have failed one or several trials of extubation, tracheostomy is recommend according to the latest ESICM consensus. Tracheostomy can enhance comfort, improve pulmonary hygiene and decrease sedation requirement, which could facilitate the liberation from ventilator.\n\nNumerous studies have explored the causes of weaning failure and provide various predictive models in guiding extubation and tracheostomy. Yet, due to limitations of such as small sample size or a lack of external validation, there is paucity of practical weaning algorithm tailored for ABI patients. The liberation from IMV in ABI patients still remains challenging with poor level of evidence in current guidelines or expert consensus.\n\nWe aim to describe the weaning outcomes in ABI patients, and further investigate the potential predictors of weaning success in ABI patients.",[277,27],"Ventilator Lung",[279,280,281],"mechanical ventilation","acute brain injury","weaning","2025-11-14",{"date":284,"type":37},"2025-11-18",{"date":286,"type":37},"2024-08-06",{"date":259,"type":21},{"name":289,"class":44},"Southeast University, China",{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":296,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":22,"phases":301,"briefSummary":302,"conditions":303,"keywords":307,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":323},"100368678","brain-injured-patients-extubation-readiness-study-100368678","NCT04080440","Brain-injured Patients Extubation Readiness Study","Stepped Wedge Cluster Randomised Controlled Trial to Assess the Readiness of Extubation in Brain-injured Patients Using a Clinical Score","Biper","Inclusion Criteria:\n\n* Acute cerebral lesion with a Glasgow Coma Scale \\\u003C13 needing admission in ICU and mechanical ventilation with tracheal intubation for neurological cause : cerebrovascular stroke either ischemic or hemorrhagic including aneurysmal subarachnoid hemorrhage, traumatic brain injury, anoxo ischemic encephalopathy after cardiac arrest or brain tumour\n* Mechanical ventilation more than 48 hours\n* 18 to 75 years old\n* Neurological stability with no intracranial hypertension with minimal sedation\n* Glasgow Coma Scale motor response \\\u003C 6\n* Spontaneous breathing trial succeeded\n* First extubation attempt\n\nExclusion Criteria:\n\n* Posterior cranial fossa lesion\n* Admission for status epilepticus or central nervous system infection\n* Spinal cord injury (tetraplegia or paraplegia)\n* Uncontrolled status epilepticus or uncontrolled central nervous system infection\n* Care limitation plan\n* Chronic respiratory failure defined as ambulatory oxygen therapy or pressure support ventilation and\u002For proven COPD and\u002For ambulatory non-invasive CPAP therapy for sleep apnoea syndrome\n* More than 3 failed spontaneous breathing trials\n* Significant chest trauma (more than 2 broken ribs \u002F broken sternum \u002F with an indication of open thoracic surgery)\n* Surgery planned within 7 days\n* Tracheotomy or previous extubation outside of the protocol\n* Previous compromised upper airway permeability\n* Pregnant or breastfeeding woman\n* Adult under the protection of the law or without social assurance system\n* Inclusion in another clinical study about mechanical ventilation or weaning","75 Years",{"count":300,"type":21},660,[24],"The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.",[304,27,305,145,306],"Mechanical Ventilator Weaning","Altered Level of Consciousness","Airway Control",[308,309,310,97,311,312,313],"Coma","Intensive care units","Critical care","Traumatic brain injury","Anoxic ischemic encephalopathy","Glasgow coma scale","2025-09-23",{"date":316,"type":37},"2025-09-24",{"date":318,"type":37},"2020-02-09",{"date":320,"type":21},"2027-10-13",{"name":322,"class":44},"University Hospital, Clermont-Ferrand",21,{"id":325,"slug":326,"hasResults":11,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":330,"eligibilityCriteria":331,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":332,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":334,"conditions":335,"keywords":342,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":4},"100607133","nucleosome-monitoring-relevance-for-outcome-prediction-in-critically-ill-patients-100607133","NCT07184593","Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients","Validation of a Point-of-care Device for Rapid Bedside Measurement of Circulating Nucleosome Levels in Critically Ill Patients and Study of Its Relevance to Prognostication","NuROPI","Inclusion Criteria:\n\n* Admission to the intensive care unit (ICU) within the past 24 hours.\n* Patient must meet one of the following conditions:\n\nSepsis, defined according to SEPSIS-3 criteria.\n\nSeptic shock, defined according to SEPSIS-3 criteria.\n\nCardiogenic shock, classified as Stage C according to the Society for Cardiovascular Angiography and Interventions (SCAI).\n\nSevere trauma requiring transfusion of four or more units of red blood cells within six hours.\n\nAcute brain injury requiring invasive neuromonitoring.\n\nPost-cardiac arrest with at least 15 minutes of no or low perfusion.\n\nSevere acute pancreatitis requiring ICU-level care.\n\n\\- Presence of an arterial or central venous catheter to allow blood sampling.\n\nExclusion Criteria\n\n* Patient who has expressed opposition to participate.\n* Age younger than 18 years.\n* Imminent death with an expected survival of less than 24 hours.\n* Presence of therapeutic limitations (e.g., no indication for intubation).\n* Active cancer.\n* Absence of the required vascular access.\n* ICU admission longer than 24 hours prior to screening.\n* Readmission of a previously enrolled patient.",{"count":333,"type":21},130,"The goal of this observational study is to evaluate whether whole blood H3.1 nucleosome levels can predict 30-day mortality in adult critically ill patients admitted to the ICU with conditions such as sepsis, septic shock, cardiogenic shock, severe trauma, post-cardiac arrest, acute brain injury, or severe acute pancreatitis.\n\nThe main questions it aims to answer are:\n\nDo initial whole blood H3.1 nucleosome levels predict 30-day mortality in critically ill patients?\n\nAre whole blood nucleosome measurements using a novel point-of-care device correlated with traditional plasma chemiluminescence immunoassays (ChLIA)?\n\nIf there is a comparison group: Researchers will compare point-of-care whole blood nucleosome results with plasma ChLIA assays to see if the device provides reliable and feasible bedside measurements.\n\nParticipants will:\n\nProvide blood samples at admission, 6h, Day 1, Day 3, and Day 7 for nucleosome analysis.\n\nUndergo point-of-care H3.1 nucleosome measurement and parallel plasma storage for ChLIA testing.\n\n(If applicable, in acute brain injury patients with external ventricular drains) provide daily cerebrospinal fluid samples until Day 5, only if otherwise discarded.\n\nHave standard ICU data (SOFA, SAPS II, etc.) collected as part of routine care.",[336,337,338,339,27,340,341],"Sepsis","Septic Shock","Cardiac Arrest (CA)","Pancreatitis","Trauma Blunt","Cardiogenic Shock",[343,344,345,346,347,348,121],"nucleosome","septic shock","Histones","Cardiac Arrest","Cardiogenic shock","Trauma","2025-09-17",{"date":351,"type":37},"2025-09-22",{"date":353,"type":21},"2025-10-01",{"date":355,"type":21},"2027-09-30",{"name":78,"class":44},{"id":358,"slug":359,"hasResults":11,"nctId":360,"briefTitle":361,"officialTitle":361,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":363,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":365,"conditions":366,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":4},"100554909","multimodal-brain-monitoring-as-an-early-warning-and-prognostic-tool-for-acute-brain-injury-100554909","NCT06505213","Multimodal Brain Monitoring as an Early Warning and Prognostic Tool for Acute Brain Injury","Inclusion Criteria\n\n1. Must be 18 years of age or older.\n2. Diagnosed with Traumatic Brain Injury (TBI) or has suffered from acute brain injury due to intracranial hemorrhage or subarachnoid hemorrhage.\n3. Defined as an admission Glasgow Coma Scale (GCS) Eye Response score of 1 (unable to open eyes) and a GCS Motor Response score of ≤5 (unable to obey commands).\n4. Occurs within 48 hours of admission, where the patient does not open eyes and motor score drops to 5 or below.\n\nExclusion Criteria\n\n1. Patients who were not admitted to the Intensive Care Unit (ICU) are excluded.\n2. Patients with forms of acute brain injury other than those specified (TBI, intracranial hemorrhage, subarachnoid hemorrhage) are also excluded.\n3. Patients with known severe liver or kidney dysfunction are excluded.\n4. Patients whose vital signs are extremely unstable after admission, with a very poor prognosis and considered unable to survive, and whose family has decided to forgo further treatment.\n5. Patients who had a Modified Rankin Scale greater than 2 before the onset of the current illness.\n6. Patients with a history of congenital or acquired hemorrhagic diseases, coagulation factor deficiencies, or thrombocytopenic disorders.\n7. Pregnant or lactating women, as well as those planning to become pregnant within the next 90 days.\n8. Patients with severe psychiatric disorders or dementia who are unable to provide informed consent or complete follow-up requirements.\n9. Patients who have participated in other interventional clinical trials within 30 days prior to randomization, or who are currently participating in other clinical research.\n10. Any other reasons that the researcher deems unsuitable for participation in this trial.",{"count":364,"type":21},490,"The primary aim of this study is to evaluate the effectiveness of multimodal brain monitoring technologies as both an early warning system and a prognostic tool in patients suffering from acute brain injuries. This research seeks to determine how effectively these tools can predict clinical outcomes and prevent complications by providing early alerts to healthcare professionals.",[27],"2024-07-10",{"date":369,"type":37},"2024-07-17",{"date":371,"type":21},"2024-07-30",{"date":373,"type":21},"2028-06-30",{"name":375,"class":44},"Xiangya Hospital of Central South University",{"id":377,"slug":378,"hasResults":11,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":382,"eligibilityCriteria":383,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":384,"targetDuration":4,"studyType":22,"phases":386,"briefSummary":387,"conditions":388,"keywords":391,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":395,"lastUpdatePostDateStruct":396,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":402,"locationsCount":45},"100548870","connectivity-and-neural-signatures-of-consciousness-in-unresponsive-states-100548870","NCT06426615","Connectivity and Neural Signatures of Consciousness in Unresponsive States","Connectivity and Neural Signatures of Consciousness In Unresponsive States (CONSCIUS) - a Study of Brain Activity in Disorders of Consciousness","CONSCIUS","Inclusion Criteria:\n\n* 18 years old or older\n* Brain injury of any kind, with impaired consciousness or suspected seizures\n\nExclusion Criteria:\n\n* \\\u003C 18 years old\n* Known pregnancy\n* Any condition that, in the judgement of the investigator, makes participation in the study unsafe or unfeasible (e.g., irreversible coagulopathy, large intracranial tumors, surgical technical problems…)",{"count":385,"type":21},20,[24],"The CONSCIUS study is a prospective, interventional study including patients with acute brain injury and impaired consciousness implanted with intracranial electrodes. The aim of the study is to investigate seizures and thalamocortical neural dynamics underlying behavioral unresponsiveness.",[27,61,389,390],"Consciousness Disorders","Seizures",[392,390,393,394],"Consciousness","Neural dynamics","Intracranial recordings and stimulation","2024-05-17",{"date":397,"type":37},"2024-05-23",{"date":399,"type":37},"2024-01-01",{"date":401,"type":21},"2027-12-31",{"name":403,"class":44},"Universitaire Ziekenhuizen KU Leuven"]