[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-cholangitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-cholangitis":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,78,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644132","composite-index-for-outcome-burden-in-acute-cholangitis-100644132",false,"NCT07667166","Composite Index for Outcome Burden in Acute Cholangitis","Development and Internal Validation of a Multidimensional Composite Index for Outcome Burden in Acute Cholangitis: A Multicentre Retrospective Cohort Study in India","CHOLINDEX-01","Inclusion Criteria\n\n* Age 18 to 80 years\n* Hospital admission with definite diagnosis of acute cholangitis meeting TG18 diagnostic criteria\n* TG18 Grade I (Mild) Grade II (moderate) or Grade III (severe) at presentation\u002Fadmission or prior to drainage.\n* Underwent biliary drainage attempt (ERCP\u002FPTBD\u002FEUS-BD) or were planned for drainage (including failures with rescue drainage).\n* First episode of index BD in case of patients undergoing multiple episodes of index BD as per operational definitions (Technical supplement 1)\n* Planned repeat BD in same admission shall be considered as continuation of the index BD and all the procedural details shall be documented and analysed.\n\nExclusion Criteria\n\n* Pregnant women\n* Missing key outcome data (minimum required: mortality status + ICU admission status + Length of stay)\n* Non-biliary sepsis without evidence of biliary obstruction\u002Finfection on review.\n* A patients with past history of BD outside the study setting (As this is akin to second episode of Index BD)\n* Subsequent episodes of Index BD (other than the first index BD episode) among patients with more than one episode of Index BD.","ALL","18 Years","80 Years",{"count":21,"type":22},514,"ESTIMATED","OBSERVATIONAL","The goal of this retrospective observational study is to construct a composite outcome to measure the success of treatment in patients who are presenting with acute cholangitis (blockage and infection of bile ducts) and undergoing a drainage procedure with different modalities. The study is not intended to test any predetermined hypothesis and does not have any comparison group. The participants' data are collated from retrospective hospital records and analysed for the purpose of the study. All the procedures are in place to ensure the confidentiality of the study participants while collating, analysing and sharing study findings.",[26,27],"Acute Cholangitis","Biliary Drainage",[29,30,31,32,33,34],"Acute cholangitis","Biliary drainage","ERCP","PTBD","EUSBD","Composite outcome","RECRUITING","2026-06-19",{"date":38,"type":39},"2026-06-24","ACTUAL",{"date":41,"type":39},"2026-04-20",{"date":43,"type":22},"2026-07-31",{"name":45,"class":46},"Asian Institute of Gastroenterology, India","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":47},"100624273","phase-2-comparative-efficacy-of-intraductal-antibiotic-during-ercp-in-acute-cholangitis-100624273","NCT07407491","Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis","Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* The patients diagnosed with mild and moderate acute cholangitis based on TG 18\n* Planned for ERCP within 48 hours\n* 18 years old and above\n\nExclusion Criteria:\n\n* Severe acute cholangitis\n* History of antibiotic hypersensitivity\n* Receiving cancer chemotherapy, steroids, or immunosuppressive agents\n* Concomitant infections\n* Recent biliary interventions such as percutaneous transhepatic biliary drainage (PTBD) within last 3 months\n* Known or suspected perforated tympanic membrane, myasthenia gravis",{"count":56,"type":22},172,"INTERVENTIONAL",[59],"PHASE2","Does intraductal administration of antibiotics during endoscopic retrograde cholangiopancreatography (ERCP), in addition to standard systemic antibiotic therapy, improve clinical outcomes in patients with acute cholangitis compared with standard systemic antibiotic therapy alone?",[26,62,63,64,65],"Biliary Tract Infection","Biliary Obstruction","Choledocholithiasis","Malignant Biliary Stricture",[26,31,67,68,64],"Intraductal antibiotics","Biliary tract infection","2026-02-05",{"date":71,"type":39},"2026-02-12",{"date":73,"type":39},"2024-07-09",{"date":75,"type":22},"2026-07-08",{"name":77,"class":46},"National University of Malaysia",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":57,"phases":87,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":47},"100622140","impact-of-positive-bile-cultures-on-plastic-biliary-stent-exchange-100622140","NCT07379749","Impact of Positive Bile Cultures on Plastic Biliary Stent Exchange","TEMPEST 2","Inclusion Criteria:\n\n* All patients between 18 and 90 years old with native papilla and obstructive jaundice of any etiology requiring plastic biliary stent placement, with a positive bile culture at index ERCP who can provide written informed consent (obtained from the patient or legal caregiver).\n\nExclusion Criteria:\n\n* prior ERCP attempts\n* patients with bilio-digestive surgical or endoscopic anastomoses\n* inability to provide informed consent due to cognitive, legal, or medical reasons\n* scheduled surgical resection within one month after ERCP.",{"count":86,"type":22},140,[88],"NA","This prospective, unicenter, randomized controlled trial evaluates whether a positive bile culture at index ERCP with plastic stenting identifies patients who benefit from earlier stent exchange. Patients with no previous history of sphincterotomy and positive bile cultures after an ERCP will be randomized to stent exchange at 1 month versus 3 months to assess whether personalized scheduling reduces early stent occlusion and secondary acute cholangitis.",[26],[92],"early onset acute cholangitis after subsequent biliary stent occlusion","NOT_YET_RECRUITING","2026-01-23",{"date":96,"type":39},"2026-01-30",{"date":98,"type":22},"2026-02",{"date":100,"type":22},"2027-02",{"name":102,"class":46},"Clinical Hospital Colentina",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":57,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":47},"100517007","modified-laparoscopic-transcystic-biliary-drainage-in-the-management-of-cholecystocholedocholithiasis-100517007","NCT06011941","Modified Laparoscopic Transcystic Biliary Drainage in the Management of Cholecystocholedocholithiasis","Safety and Feasibility of Modified Laparoscopic Transcystic Biliary Drainage in the Management of Cholecystocholedocholithiasis","Inclusion Criteria:\n\n* Patients ≥ 18 years of age;\n* Patients with gallbladder stones and known or expected concomitant bile duct stones;\n* Informed consent.\n\nExclusion Criteria:\n\n* Biliary drainage is already present, e.g. preoperative ENBD, PTCD;\n* Women who are pregnant;\n* Declined consent;\n* Inability to follow the procedures of the study, e.g. due to language problems and psychological disorders of the participant;\n* Morbid obesity (BMI \\> 40);\n* IV-VI class of the American Society of Anesthesiologists physical status classification;\n* Contraindications for general anesthesia or surgery.","90 Years",{"count":112,"type":22},310,[88],"The modified laparoscopic transcystic biliary drainage which we developed in the treatment of cholecystocholedocholithiasis has some advantages over conventional techniques.\n\nHere, a 7-Fr triple-lumen 30-cm central venous catheter was adopted to replace conventional 5-Fr ureteral catheter, which extended the function of the C-tube.\n\nThen we developed a continued suture and circling manner by the V-Loc closure device, which simultaneously covered and anchored the C-tube.\n\nTheoretically, this modified laparoscopic transcystic drainage not only provide safe and effective bile duct drainage, but also provide a convenient access of treatment for postoperatively retained bile duct stones, which may expand the indication of initially laparoscopic operation in the management of cholecysto-choledocholithiasis.",[116,117,118,26],"Common Bile Duct Calculi","Acute; Cholecystitis, Choledocholithiasis","Acute Cholecystitis With Obstruction","2023-08-22",{"date":121,"type":39},"2023-08-25",{"date":123,"type":22},"2024-01-01",{"date":125,"type":22},"2027-07-01",{"name":127,"class":46},"Peking University Third Hospital"]