[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-circulatory-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-circulatory-failure":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100634974","prediction-of-fluid-responsiveness-using-the-femoral-vein-to-artery-diameter-ratio-100634974",false,"NCT07546656","Prediction of Fluid Responsiveness Using the Femoral Vein-to-Artery Diameter Ratio","Prediction of Fluid Responsiveness Using the Femoral Vein-to-Artery Diameter Ratio: A Prospective Observational Study","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Admission to the intensive care unit where the study is being conducted\n* Receiving invasive mechanical ventilation\n* Clinical indication for a fluid challenge due to acute circulatory failure or shock, as determined by the responsible intensive care physician\n* PiCCO monitoring already in place as part of routine clinical care\n* Clinical conditions allowing collection of pre- and post-fluid challenge cardiac index and ultrasonographic measurements\n* Technical feasibility of femoral vein and femoral artery diameter measurements by ultrasonography\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Failure to obtain written informed consent from the patient or legally authorized representative before enrollment\n* Absence of PiCCO monitoring as part of routine clinical care or no clinical plan for fluid challenge\n* Inability to complete pre- and post-fluid challenge measurements (e.g., early death, urgent surgery, transfer)\n* Local conditions preventing reliable femoral ultrasonographic assessment, including open wound, infection, dressing, major anatomic obstacle, poor image quality, known femoral vein thrombosis, or severe vascular pathology on the relevant side\n* Conditions likely to significantly impair the reliability of thermodilution measurements (e.g., severe tricuspid regurgitation or significant intracardiac shunt)\n* Major treatment changes during the fluid challenge that preclude comparable measurements (e.g., major vasopressor dose change, major ventilator setting change, new arrhythmia)\n* Missing or inadequate data judged by the investigators to compromise data integrity, including absence of measurements required for the primary outcome","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","This prospective single-center observational study aims to evaluate whether the ultrasound-measured femoral vein-to-femoral artery diameter ratio can predict fluid responsiveness in mechanically ventilated adult intensive care patients with acute circulatory failure or shock. Only patients who already have PiCCO monitoring as part of routine clinical care and for whom a fluid challenge is clinically indicated will be included. No additional invasive procedure will be performed for study purposes. Cardiac index will be measured with PiCCO before and after administration of 500 mL balanced crystalloid over 10 minutes, and femoral vein and femoral artery diameters will be measured by bedside ultrasonography. Fluid responsiveness will be defined as an increase of more than 10% in cardiac index after fluid administration. The study will assess the diagnostic performance of the femoral vein-to-femoral artery diameter ratio as a practical bedside parameter to support hemodynamic decision-making in critically ill patients.",[24,25,26],"Fluid Responsiveness","Acute Circulatory Failure","Shock",[24,26,25,28,29,30,31,32],"Hemodynamic Monitoring","Ultrasonography","Femoral Vein","Femoral Artery","PiCCO","RECRUITING","2026-05-07",{"date":36,"type":37},"2026-05-11","ACTUAL",{"date":39,"type":37},"2026-05-01",{"date":41,"type":20},"2027-03-01",{"name":43,"class":44},"Istanbul University - Cerrahpasa","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100619553","fluid-balance-guided-by-modified-venous-excess-ultrasonography-versus-standard-care-in-patients-with-acute-kidney-injury-receiving-continuous-renal-replacement-therapy-100619553","NCT07346118","Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury Receiving Continuous Renal Replacement Therapy","Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury Receiving Continuous Renal Replacement Therapy: A Multicentre Randomised Controlled Trial","mVExUS-CRRT","Inclusion Criteria:\n\n* Adults (≥ 18 years of age)\n* Admitted to ICU\n* Acute kidney injury by KDIGO criteria\n* Initiated CRRT by at least one of the following indications for RRT initiation:\n* Serum potassium ≥ 6.0 mmol\u002FL, or\n* pH ≤ 7.20 or serum bicarbonate ≤ 12 mmol\u002FL, or\n* Evidence of severe respiratory failure, based on a PaO2\u002FFiO2 ≤ 200 and clinical perception of volume overload, or\n* Persistent severe AKI (sCr remains \\> 50% the value recorded at randomization) for \\> 72 hours from randomization\n* Participants giving informed consent\n\nExclusion Criteria:\n\n* Refuse to participate\n* Previous diagnosis of end-stage kidney disease (ESKD) currently on kidney replacement therapy\n* Kidney transplant recipient\n* Receive RRT before ICU admission within 90 days\n* Structural kidney diseases which will interfere with intrarenal doppler ultrasound e.g. renal artery stenosis, autosomal dominant polycystic kidney disease\n* Patients with previously known conditions that interfere with portal doppler assessment, namely liver cirrhosis, severe tricuspid regurgitation with structural heart disease or massive ascites.\n* Underlying disease process with a life expectancy less than 90 days\n* Pregnancy\n* Severe cardiac rhythm disturbances (tachyarrhythmia, supraventricular tachycardia)\n* Intra-cardiac shunts; Ventricle septal defect, patent foramen ovale, atrial septal defect\n* Aortic aneurysm\n* Intra-abdominal hypertension (intraabdominal pressure ≥20 mmHg)\n* Expected life expectancy \\\u003C48 hours\n* Receiving extracorporeal membrane oxygenation (ECMO)",{"count":55,"type":20},126,"INTERVENTIONAL",[58],"NA","The goal of this randomised controlled trial is to compare the cumulative fluid balance over the first 72 h following inclusion guided by mVExUS versus standard of care in critically ill patients with acute kidney injury receiving CRKT . It will also compare the proportion of CRRT-related complications-including intradialytic hypotension and arrhythmias-between patients managed with mVExUS-guided fluid management and those receiving standard care.\n\nThe main questions it aims to answer are:\n\nDoes fluid removal rate guided by mVExUS will reduce cumulative fluid balance over the course of the first 72 h of CRRT in ICU patients compared to standard care\n\nParticipants will:\n\nGet fluid assessment by mVExUS protocol or a strandard care every 8 hours for 72 hours",[61,62,25,63,64,65,66],"AKI - Acute Kidney Injury","Fluid Balance","Continuous Renal Replacement Therapy (CRRT)","VExUS","Passive Leg Raising","Biomarkers \u002F Blood",[68,69,70,71,72,73,74,75],"Acute kidney injury","Fluid balance","Acute circulatory failure","Continuous kidney replacement therapy","mVExUS","Modified Venous Excess Ultrasound","Passive leg raising","Biomarker","NOT_YET_RECRUITING","2026-05-05",{"date":34,"type":37},{"date":80,"type":20},"2026-07-01",{"date":82,"type":20},"2029-05-01",{"name":84,"class":44},"Chulalongkorn University",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":95,"conditions":96,"keywords":97,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":45},"100545621","peripheral-tissue-perfusion-in-intensive-care-100545621","NCT06384287","Peripheral Tissue Perfusion in Intensive Care","Effects of Therapeutic Hemodynamic Interventions on Peripheral Perfusion in Intensive Care","INPPEREA","Inclusion Criteria:\n\n* Patients in intensive care unit with acute circulatory failure related to sepsis or cardiac failure requiring therapeutic intervention\n\nExclusion Criteria:\n\n* Agitation\n* Hemorrhagic shock\n* Severe skin lesions",{"count":94,"type":20},180,"Tissue perfusion has been identified as an early prognosis factor in patients admitted to intensive care. However, little is known about the effects of different hemodynamic interventions performed in clinical routine on peripheral tissue perfusion.\n\nThe aim of this work is to study the kinetics of CRT and local skin blood flow following therapeutic intervention (fluid challenge, vasopressor or inotropic drug).",[25],[98,99,100,101,102],"Tissue perfusion","Capillary refill time","Skin blood flow","Fluid challenge","Inotrope","2025-08-25",{"date":105,"type":37},"2025-09-02",{"date":107,"type":37},"2024-06-22",{"date":109,"type":20},"2027-07",{"name":111,"class":44},"Assistance Publique - Hôpitaux de Paris"]