[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-compartment-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-compartment-syndrome":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,73,97],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644761","my01-pressure-monitoring-in-adolescent-tibia-fractures-100644761",false,"NCT07674043","MY01 Pressure Monitoring in Adolescent Tibia Fractures","Continuous Compartment Pressure Monitoring in Adolescent Tibia Fractures","Inclusion Criteria:\n\n* Between the ages of 10 to 21 on the day of surgery\n* Undergoing operative fixation for a fracture of the proximal tibia or tibial shaft\n\nExclusion Criteria:\n\n* Preoperative diagnosis of acute compartment syndrome\n* Preexisting neuromuscular or vascular condition affecting the injured extremity\n* MY01 device malfunction","ALL","10 Years","21 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn more about anterior leg compartment pressures in adolescents who have sustained tibia fractures. It will also examine whether measuring anterior compartment pressure helps physicians diagnose acute compartment syndrome (ACS), a rare but dangerous complication that can develop following surgical treatment of a tibia fracture.\n\nThe main questions it aims to answer are:\n\n1. Are there differences in anterior compartment pressures between healthy patients and patients who develop ACS?\n2. Does compartment pressure monitoring aid physicians in accurately diagnosing ACS?\n\nParticipants will have a continuous pressure monitoring sensor placed in their knee anterior knee compartment during their surgery. This sensor will record pressure data following a patient's surgical treatment for 18+ hours.",[27,28,29],"Proximal Tibia Fracture","Tibial Shaft Fracture","Acute Compartment Syndrome",[31,32,33,34],"Tibia fracture","acute compartment syndrome","compartment pressure","pediatric","NOT_YET_RECRUITING","2026-06-25",{"date":38,"type":39},"2026-06-29","ACTUAL",{"date":41,"type":21},"2026-06-01",{"date":43,"type":21},"2028-06-01",{"name":45,"class":46},"Boston Children's Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":5},"100507605","evaluation-of-the-diagnostic-and-therapeutic-value-of-tissue-ultrafiltration-in-patients-at-risk-of-acute-compartment-syndrome-acs-100507605","NCT05889559","Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS)","INCLUSION CRITERIA The target population for this study include adults ages 18-60 with high-energy injuries of the upper leg considered at risk for ACS at time of admission by virtue of their mechanism of injury, fracture pattern, clinical signs, or need to undergo fracture fixation surgery (internal or external fixation) within 48 hours of admission. Recruitment of participants will happen during hospital admission for treatment of injury.\n\nEligible patients must meet all of the following criteria and be enrolled during one of two possible times: within 14 hours of injury, or prior to undergoing surgical intervention (internal or external fixation on the injured limb) within 48 hours of admission. Eligible patients will be:\n\n1. Between the ages of 18 and 60 years\n2. Have sustained a high-energy upper leg injury such as open or closed proximal tibial shaft fracture with displacement, comminution, or segmental pattern; proximal fibula fracture; bicondylar tibial plateau fracture; Schatzker IV medial knee fracture-dislocation; proximal leg injury due to shotgun, rifle, or other projectile, or severe crushing injury.\n3. Patient can be enrolled in the study and study procedures initiated within 14 hours of injury,\\* or be enrolled prior to undergoing urgent surgical intervention on the injured limb (defined as internal or external fixation) within 48 hours of admission.\n4. Patient (or authorized legal representative) willing to sign informed consent.\n\n   * If a patient has an eligible injury and is going to surgery within 2 hours (except for fasciotomy - which is an exclusion criteria), the patient can be enrolled and the study procedures initiated at the end of surgery. If an eligible patient is enrolled and there is no surgery anticipated within 2 hours, initiate study procedures immediately.\n\nEXCLUSION CRITERIA\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. Patients not willing to participate\n2. Patients with non-traumatic cases of acute compartment syndrome (e.g. severe exertion, snakebite, high-pressure injection injury)\n3. Patients diagnosed with ACS or impending ACS such that immediate fasciotomy is recommended\n4. Soft tissue wounds, including lacerations or abrasions, that are in a location that will interfere with safe insertion of indwelling pressure or TUF catheters (anterior - anterolateral aspect of the leg)\n5. Patients not likely to follow-up (are homeless, incarcerated, live out-of-state).\n6. Patients with known peripheral vascular disease\n7. Non-ambulatory due to an associated complete spinal cord injury; Non-ambulatory before the injury due to a pre-existing condition.\n8. Very low clinical concern for ACS at time of admission.","18 Years","60 Years",{"count":57,"type":21},60,[24],"The goal of this clinical trial is to learn if tissue ultrafiltration (TUF) catheters can reduce intramuscular pressure and prevent acute compartment syndrome (ACS) in adults ages 18-60 with severe proximal tibia or tibial shaft fractures.\n\nThe main questions it aims to answer are:\n\nWill intramuscular pressure (IMP) be lower in the TUF cohort compared to controls?\n\nWill the consensus likelihood of ACS, incidence of fasciotomy, and 6-month functional outcomes be better in the TUF cohort?\n\nAre interstitial fluid biomarkers predictive of ACS?\n\nResearchers will compare patients randomized to TUF catheters (n=30) versus control patients receiving standard-of-care only (n=30) to see if TUF lowers ACS risk and improves recovery.\n\nParticipants will:\n\nBe enrolled within 14 hours of injury or prior to high-risk surgery within 48 hours.\n\nReceive continuous anterior compartment pressure monitoring.\n\nUndergo standard-of-care clinical evaluation and treatment.\n\n(TUF arm only) Have three TUF catheters placed in the injured limb to remove interstitial fluid.\n\nReturn for a 6-month follow-up to assess complications, healing, muscle function, and patient-reported outcomes.\n\n(Hennepin Healthcare subset) Provide interstitial fluid samples for biomarker analysis.",[29,61,62],"Fracture, Bone","Tibial Fractures","RECRUITING","2025-08-21",{"date":66,"type":39},"2025-08-28",{"date":68,"type":39},"2024-01-01",{"date":70,"type":21},"2026-07-01",{"name":72,"class":46},"Major Extremity Trauma Research Consortium",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":93,"leadSponsor":95,"locationsCount":47},"100441583","the-research-about-the-acs-after-femoropopliteal-arterial-injuries-100441583","NCT05030259","The Research About the ACS After Femoropopliteal Arterial Injuries","ACS After Femoropopliteal Arterial Injuries","Inclusion Criteria:\n\n* patients with femoropopliteal arterial injuries\n* patients older than 18 years\n\nExclusion Criteria:\n\n* Patients who did not survive to discharge\n* Patients with primary amputation\n* patients younger than 18 years",{"count":81,"type":21},80,"OBSERVATIONAL","Crural Compartment syndrome is a well-known sequela after femoropopliteal arterial injuries in the lower extremity, particularly when there has been a long period of ischemia,need for ligation of a major vein, or when there is severe associated soft tissue.There is conteoversy in the treatment.",[29],[86,87,88],"ACS","femoropopliteal arterial injuries","fasciotomy","2021-08-25",{"date":91,"type":39},"2021-09-01",{"date":91,"type":21},{"date":94,"type":21},"2030-12-31",{"name":96,"class":46},"Hebei Medical University Third Hospital",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":29,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":104,"conditions":105,"keywords":106,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":115,"locationsCount":47},"100403133","the-research-about-acute-compartment-syndrome-100403133","NCT04529330","The Research About Acute Compartment Syndrome","Inclusion Criteria:\n\n* Fracture patients with Schatzker V and VI,\n* Who were older than eighteen years.\n\nExclusion Criteria:\n\n* The exclusion criteria were pathologic, extra-articular proximal tibial fracture,\n* Patients who was eighteen years or younger.\n* Patients treated with other implant,\n* underwent conservative management were also excluded.",{"count":81,"type":21},"Acute compartment syndrome (ACS) is defined as a clinical entity originated from trauma or other conditions, and remains challenging to diagnose and treat effectively. Threre is the controversy in diagnosing, treating ACS. It was found that there was no criterion about the ACS, and result unnecessary osteotomy. The presence of clinical assessment (5P) always means the necrosis of muscles and was the most serious or irreversible stage of ACS. Besides pressure methods, the threshold of pressure identifying ACS was also controversial.",[29],[86,107,108],"Tibial plateau fractures","Tibial shaft fractures","2021-07-28",{"date":111,"type":39},"2021-08-04",{"date":113,"type":39},"2019-01-01",{"date":94,"type":21},{"name":96,"class":46}]