[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-coronary-syndrome-without-st-elevation-on-electrocardiogram\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-coronary-syndrome-without-st-elevation-on-electrocardiogram":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100625169","calibration-study-predict---prehospital-triage-for-suspected-acute-coronary-syndrome-without-st-segment-elevation-100625169",false,"NCT07419139","Calibration Study PREDICT - Prehospital Triage for Suspected Acute Coronary Syndrome Without ST-segment Elevation","PREDICT","Inclusion Criteria:\n\n* Suspected myocardial infarction\n* Symptom onset \\>30 minutes before arrival of emergency medical services\n* Written informed consent\n\nExclusion Criteria:\n\n* STEMI on initial ECG\n* Unstable angina, hemodynamic instability, life-threatening arrhythmias, cardiac arrest\n* Non-ischemic causes requiring hospitalization\n* Emergency physician dispatch at the request of a primary care physician\n* Age \\\u003C18 years",true,"ALL","18 Years",{"count":20,"type":21},304,"ESTIMATED","OBSERVATIONAL","The PREDICT calibration study is a prospective, non-interventional trial aiming to adapt and calibrate the ACS-Pathfinder algorithm for prehospital triage of patients with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS) in Germany. Approximately 304 patients will be enrolled by six emergency medical service (EMS) stations. All patients will receive standard care and an additional point-of-care troponin test (POCT) performed in the ambulance. Clinical and biomarker data will be collected using a study app, without influencing patient management. Follow-up will be conducted up to 90 days through telephone interviews and hospital record review.\n\nThe primary objective is to determine the true prevalence of myocardial infarction and calibrate the ACS-Pathfinder algorithm accordingly. Secondary objectives include assessing feasibility, workflow, acceptance, and data processes within the EMS as preparation for a subsequent cluster-randomized main study.\n\nThe study is coordinated by Prof. Holger Thiele (Heart Center Leipzig) with co-investigators from Leipzig and Hamburg. The sponsor is Leipzig Heart Science gGmbH. Study duration is planned from January to November 2026.",[25],"Acute Coronary Syndrome Without ST Elevation on Electrocardiogram",[27,28,29,30,31,32,33],"chest pain","shortness of breath","high-sensitivity troponin","ECG changes","Myocardial infarction (MI)","Pre-hospital care","Acute coronary syndrome without ST-segment elevation","NOT_YET_RECRUITING","2026-02-10",{"date":37,"type":38},"2026-02-18","ACTUAL",{"date":40,"type":21},"2026-04",{"date":42,"type":21},"2026-11",{"name":44,"class":45},"Leipzig Heart Science gGmbH","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100601596","occurrence-of-severe-cardiac-rhythm-and-conduction-disturbances-in-emergency-department-patients-with-non-st-elevation-acute-coronary-syndrome-100601596","NCT07112547","Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome","SurvSCA","Inclusion Criteria:\n\n* Adult (≥ 18 years old) patient admitted to the emergency department\n* Able to understand the information provided\n* Diagnosis of non-ST segment elevation ACS established according to the lastest guidelines from the European Society of Cardiology and the 4th Universal Definition of myocardial infarction\n* No objection to participation in the study after receiving appropriate information\n\nExclusion Criteria:\n\n* Patients subject to legal protection\n* Patient with cognitive impairment\n* Myocardial injury and\u002For symptoms attributable to Takotsubo syndrome, myocarditis, pericarditis, or acute heart failure\n* Clinical evidence suggestive of type 2 myocardial infarction, including acute anemia with hemoglobin \\\u003C 10 g\u002FdL, sepsis, acute hypoxemic respiratory failure",{"count":54,"type":21},500,"Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death. There are two main types of ACS: ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation ACS (NSTE-ACS). While the occurrence of serious heart rhythm and conduction disturbances is well established in STEMI, these complications are believed to be much less frequent in NSTE-ACS. However, their actual frequency in this population remains unclear due to limited studies, especially in emergency settings.\n\nThe main purpose of this study is to estimate the frequency of serious rhythm and conduction disorders in patients presenting with NSTE-ACS in emergency departments. The hypothesis is that these events are rare in this population and may not justify routine continuous cardiac monitoring for all such patients, as currently recommended.\n\nSecondary objectives include identifying risk factors for these complications, estimating their frequency during hospitalization, assessing the frequency of minor rhythm and conduction disorders, evaluating care times and patient flow in emergency departments, and assessing patient outcomes up to 30 days-including hospitalizations, length of stay, discharge disposition, all-cause mortality, and the occurrence of five major adverse cardiovascular events (5-point MACE).",[25,57,58],"Acute Coronary Syndromes (ACS)","Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease",[60,61,62,63,64,65],"Non-ST Segment Elevation Acute Coronary Syndrome","Cardiac Arrhythmias","Heart Conduction System Disease","Hospital Emergency Service","Electrocardiographic monitoring","Cardiovascular diseases","2025-08-01",{"date":68,"type":38},"2025-08-08",{"date":70,"type":21},"2025-09-01",{"date":72,"type":21},"2028-10-01",{"name":74,"class":45},"University Hospital, Strasbourg, France",10]