[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-hypercapnic-respiratory-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-hypercapnic-respiratory-failure":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,44,70,96,123,147,175],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100605021","asymmetrical-high-flow-oxygen-versus-noninvasive-ventilation-in-acute-hypercapnic-respiratory-failure-100605021",false,"NCT07157098","Asymmetrical High Flow Oxygen Versus Noninvasive Ventilation in Acute Hypercapnic Respiratory Failure","HIFOLD2","Inclusion Criteria:\n\n* Diagnosed with acute hypercapnic respiratory failure\n* Admitted to the intensive care unit\n* Being treated with either high-flow oxygen treatment or non-invasive ventilation\n\nExclusion Criteria:\n\n* Clinical instability - defined as the presence of one of the followings: respiratory rate \\> 40 breaths\u002Fminute, SpO2 \\\u003C 80%, active broncho-pleural fistula, Glasgow Coma Scale \\\u003C 8, mean arterial pressure below 60 mmHg despite usage of vasopressors\n* Requiring immediate need of endotracheal intubation, according to the judgement of the attending physician\n* Contraindications of monitoring with electrical impedance tomography (e.g. pacemaker, chest wall burns wounds limiting electrode placement).","ALL","18 Years",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23],"NA","NIV is a life-saving treatment for people with breathing failure and carbon dioxide (CO2) retention. It helps remove this waste gas from the lungs and reduces the effort needed to breathe. However, the standard masks used for NIV can become uncomfortable over time, which may lead patients to stop using them. Stopping treatment can be dangerous and may cause breathing problems to worsen. That's why finding devices that are more comfortable and possibly more effective is very important. This study aims to take a first step in that direction.\n\nThis is the first study comparing new devices designed to help people with chronic CO2 buildup during breathing flare-ups. Devices tested include a new type of asymmetrical nasal cannula for high-flow oxygen therapy and a new mask called OptiNIV, which has a comfortable design that may help remove more CO2.\n\nThese devices will be compared to standard NIV masks currently used in hospitals. Outcome of interests include their effects on the effort needed to breathe, on how much CO2 is cleared, and on how comfortable they are.",[26],"Acute Hypercapnic Respiratory Failure",[28,29,30],"acute hypercapnic respiratory failure","non-invasive ventilation","high-flow oxygen","NOT_YET_RECRUITING","2025-08-27",{"date":34,"type":35},"2025-09-05","ACTUAL",{"date":37,"type":20},"2025-08-25",{"date":39,"type":20},"2026-07",{"name":41,"class":42},"Unity Health Toronto","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":43},"100440175","the-simplify-project-100440175","NCT05011877","The Simplify Project","A Strategy to Improve Management and Prolong LIFe Without Readmission for hYpercapnic Patients: The Simplify Project","SIMPLIFY","Inclusion Criteria:\n\n* Adult patients requiring an unplanned hospitalization or emergency room visit due to an acute hypercapnic respiratory failure exacerbation (AHRF), not on home noninvasive or invasive ventilation, neuromuscular disease (e.g., spinal cord injury) or central nervous system disorders (e.g., cerebral vascular accident, Alzheimer), absence of tracheotomy, and non-morbidly obese.\n\nExclusion Criteria:\n\n* Patients with AHRF due to drug overdose\n* Ventilatory support (noninvasive or invasive ventilation) is needed before or during the sleep studies or if an acute deterioration (e.g., cerebral vascular accident, cardiac arrest) happens before or during the sleep studies.",{"count":53,"type":20},50,"OBSERVATIONAL","The high frequency of unplanned hospital visits of patients with chronic hypercapnic respiratory failure (e.g., chronic obstructive pulmonary disease, obesity-related hypoventilation) constitutes a major public health problem. Most patients admitted for acute exacerbations (AHRF) have additional comorbidities, especially sleep disorders. Often untreated, sleep disorders contribute to multiple readmissions (≈70% at one year) and increase readmission costs. The investigators will: 1) identify these patients early during unplanned hospital admissions and perform sleep studies using EEG and oximetry before hospital discharge and two months after to compare sleep abnormalities in the two moments; 2) investigate the association between sleep abnormalities in the two sleep studies with clinical outcomes (1-year readmission and death); 3) investigate the acute effects of high-flow nasal cannula (HFNC) to treat sleep abnormalities as a simplified alternative. The investigators anticipate sleep abnormalities during the hospital stay and two months after discharge will be associated with poor clinical outcomes (readmission, death) and HFNC to acutely reduce sleep abnormalities.",[26],[26,58,59,60],"Patient Readmission","Mortality","Sleep Disorders, Intrinsic","RECRUITING","2025-05-15",{"date":64,"type":35},"2025-05-20",{"date":66,"type":35},"2021-09-01",{"date":68,"type":20},"2026-07-01",{"name":41,"class":42},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":91,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":95,"locationsCount":43},"100288326","high-flow-nasal-cannula-versus-non-invasive-ventilation-in-exacerbations-of-chronic-obstructive-pulmonary-disease-100288326","NCT03033251","High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease","High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease and Hypercapnic Respiratory Failure","HiFOLD","Inclusion Criteria:\n\n1. COPD exacerbation and acute hypercapnic respiratory failure with acute respiratory failure defined by\n\n   * Respiratory acidosis (pH ≤7.35 and PaCO2 ≥45 mmHg);\n   * Respiratory rate≥20 breaths\u002Fmin;\n   * Activation of accessory respiratory muscles;\n2. Undergone at NIV or HFNC since their admission\n3. English speaking\n4. Adult patient with age \\> 40 year old.\n\nExclusion Criteria:\n\n1. Severe respiratory acidosis defined by pH\\\u003C7.25\n2. Decreased level of consciousness (Glasgow Coma Score Scale \\\u003C 11)\n3. Urgent intubation required\n4. Pneumothorax with pleural drainage and persistent air leak\n5. Hemodynamic instability requiring vasopressors\n6. Uncooperative\n7. Patients with skin or chest wall or abdominal trauma (potentially worsened by placement of a surface sensor)\n8. Clinical judgement of the attending physician\n9. Body mass index \\> 40 kg\u002Fm2","40 Years",{"count":80,"type":20},30,[23],"Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide. The disease is marked by multiples episode of worsening, termed exacerbations necessitating frequent hospitalizations. During these exacerbations, patients present breathless, and in the most severe cases, are admitted to an Intensive Care Unit (ICU) for respiratory assistance. Currently, respiratory assistance is provided by a ventilator via a oronasal mask (referred to non-invasive ventilation, NIV), that helps patients to cope with their breathless. The mask is not always well tolerated and the ventilator sessions are delivered intermittently. In the past decade, a new technique that provides air-oxygen with high flow has been developed. This technique, called High Flow via Nasal Cannula (HFNC) can deliver from 21 to 100% heated and humidified air-oxygen at a high flow of gas via simple nasal cannula. Recent studies have shown that the technique is very efficient to treat patients presenting with acute respiratory failure who don't have any underlying chronic pulmonary disease. Whether the technique would be also efficient in patients with COLD presenting with severe exacerbations has not yet been demonstrated. Since HFNC does not require any mask, it is thought that the comfort of the patient would be much better in comparison to NIV and could potentially help to treat many patients with the disease. The objective of the present study is to study the physiological effect of HFNC as compared to NIV in patients with severe exacerbations of COPD and to show that it is non-inferior to NIV.",[84,85,26],"Exacerbation Copd","Acute Respiratory Distress",[87,88,89,90,26],"COPD exacerbation","Work of breathing","Non invasive ventilation","High Flow Oxygen Cannula",{"date":64,"type":35},{"date":93,"type":35},"2018-09-02",{"date":68,"type":20},{"name":41,"class":42},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":104,"briefSummary":105,"conditions":106,"keywords":109,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":122},"100335022","the-effects-of-music-therapy-on-adult-patients-requiring-mechanical-ventilation-in-the-icu-100335022","NCT03642002","The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU","Inclusion Criteria:\n\n* Adult patients with acute hypoxemic respiratory failure, acute hypercapnic respiratory failure, and ARDS admitted to the ICU requiring mechanical ventilation\n* Patients that are anticipated to remain on invasive mechanical ventilation for 48 hours or more will be screened for participation in the study\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Identified hearing disorder\n* Prior history of chronic respiratory failure requiring mechanical ventilation\n* RASS score of -4, or -5\n* Active seizures, or status epilepticus\n* Cardiac arrest\n* Coma\n* End of life\n* More than 2 vasopressors",{"count":103,"type":20},178,[23],"While most studies in the medical literature that indicate \"music\" as an intervention may recognize its impact and capacity to decrease pain perception, anxiety, and\u002For its role in the regulation of cardiac and respiratory function in ICU patients, no identifiable studies have implemented entrained live music therapy protocols into clinical trials. Music therapy treatment is a non-pharmacological intervention that is individually tailored to the patient's needs and focuses on the assessment and intervention of a specific music application that is provided by a certified music therapist. Entrained music therapy focuses on a dynamic interaction between the patient and music therapist in which the music therapist attempts to promote relaxation and comfort through the patient's identified Song of Kin (SOK). This study measures the effects of live music therapy entrained to the vital signs of adult patients on duration of mechanical ventilation.",[107,108,26],"Acute Respiratory Distress Syndrome","Acute Hypoxemic Respiratory Failure",[110,111,112],"music therapy","song of kin","music medicine","2025-04-07",{"date":115,"type":35},"2025-04-09",{"date":117,"type":35},"2018-12-12",{"date":119,"type":20},"2028-12",{"name":121,"class":42},"Icahn School of Medicine at Mount Sinai",3,{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":21,"phases":131,"briefSummary":132,"conditions":133,"keywords":134,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":146},"100516666","pilot-physiological-evaluation-of-an-investigational-mask-with-expiratory-washout-100516666","NCT06007495","Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout.","Inclusion Criteria:\n\n* No indication of intubation upon evaluation by physician in the next 2 hours\n* Fits the investigational mask\n\nSpecific for hypercapnic patients 1 of the following criteria\n\n* Patients hospitalized with acute respiratory failure (ARF) stabilized and tolerating NIV or;\n* Patient admitted to hospital with ARF with one criteria for NIV among the following:\n\n  * Acute hypercapnic respiratory failure with hypercapnia and acidosis (Partial pressure of arterial carbon dioxide (PaCO2) \\> 45 millimeters of mercury (mmHg) and pH \\\u003C 7.38) or\n  * Post-extubation period within 48 hours, in patients with high risk of re-intubation\n\nSpecific for hypoxemic patients\n\n1 of the following criteria\n\n* Hypoxemic respiratory failure without hypercapnia requiring nasal high flow or;\n* Hypoxemic respiratory failure without hypercapnia requiring NIV or;\n* Conventional oxygen therapy (COT) \\> 6 liters per minute (L\u002Fmin) with peripheral oxygen saturation (SpO2) \\\u003C 92%\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Inability to provide informed consent\n* Infectious isolation\n* Facial deformity, burns or morphology that prevents adequate mask placement\n* Claustrophobia\n* Nausea\n* Presence of nasogastric tube\n* Pneumothorax\n* Confusion or loss of consciousness\n* Severe upper gastro-intestinal bleeding\n* Any other condition, which at the investigators discretion, is believed may present a safety risk or impact the feasibility of the study or study results",{"count":130,"type":20},32,[23],"The goal of this pilot randomized cross-over study is to compare the effect of a full-face mask with expiratory washout to a conventional full face mask on non-invasive ventilation (NIV) in patients with acute hypercapnic, and acute hypoxemic, respiratory failure. The main questions it aims to answer are:\n\n* Does a mask with expiratory washout improve minute ventilation in patients using non-invasive ventilation compared with a conventional single-limb NIV mask\n* How does a mask with expiratory washout affect respiratory variables compared with a dual-limb NIV mask.\n\nParticipants already prescribed NIV will undergo 3 arms of the investigation in a randomized order:\n\n* Single-limb NIV with investigation mask (with expiratory washout)\n* Single-limb NIV with conventional mask\n* Dual-limb NIV with conventional mask",[26,108],[135],"Non-invasive Ventilation","2025-03-12",{"date":138,"type":35},"2025-03-14",{"date":140,"type":35},"2024-05-06",{"date":142,"type":20},"2025-12",{"name":144,"class":145},"Fisher and Paykel Healthcare","INDUSTRY",2,{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":21,"phases":156,"briefSummary":157,"conditions":158,"keywords":161,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":146},"100544876","closed-loop-o2-use-during-high-flow-oxygen-treatment-of-critical-care-adult-patients-cloudhfot-100544876","NCT06374589","Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT)","Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT)- a Randomized Cross-over Study","CLOUDHFOT","Inclusion Criteria:\n\n* Patient admitted to the ER\n* Requiring NHFO\n* Requiring FiO2 ≥ 30% to keep SpO2 in the target ranges defined by the clinician\n* Aged over 18 years\n* Written informed consent signed and dated by the patient or one relative in case that the patient is unable to consent, after full explanation of the study by the investigator and prior to study participation\n* In case that the consent is given by the relative, patient consent will be requested as soon as the patient will be able to provide informed written consent\n\nExclusion Criteria:\n\nPatients who fulfil any of the following exclusion criteria are not eligible for study participation:\n\n* Patient with indication for immediate CPAP, NIV, or invasive mechanical ventilation\n* Hemodynamic instability defined as a need of continuous infusion of epinephrine or norepinephrine \\> 1 mg\u002Fh\n* Low quality on the SpO2 measurement using finger and ear sensor (quality index below 60% on the Massimo SpO2 sensor, which is displayed by a red or orange color bar)\n* Severe acidosis (pH ≤ 7.30)\n* Pregnant woman\n* Patients deemed at high risk for need of mechanical ventilation within the next 12 hours\n* Chronic or acute dyshemoglobinemia: methemoglobin, CO poisoning, sickle cell disease\n* Tracheotomized patient\n* Formalized ethical decision to withhold or withdraw life support\n* Patient under guardianship\n* Patient deprived of liberties\n* Patient included in another interventional research study under consent\n* Patient already enrolled in the present study in a previous episode of acute respiratory failure\n\nPost enrollment exclusion criteria\n\n* Apparition of a persistent low quality SpO2 signal\n* Need for an emergent intubation\n* Discharge from ER",{"count":53,"type":20},[23],"High flow nasal oxygen therapy (HFNO) is an established modality in the supportive treatment of patients suffering from acute hypoxemic respiratory failure. The high humidified gas flow supports patient's work of breathing, reduces dead space ventilation, and improves functional residual capacity while using an unobtrusive patient's face interface \\[Mauri et al, 2017; Möller et al, 2017\\].\n\nAs hyperoxia is considered not desirable \\[Barbateskovic et al, 2019\\] during any oxygen therapy, the inspired O2 concentration is usually adapted to a pre-set SpO2 target-range of 92-96% in patients without hypercapnia risk, and of 88-92% if a risk of hypercapnia is present \\[O'Driscoll et al, 2017; Beasley et al, 2015\\]. In most institutions, the standard of care is to manually adapt the FiO2, although patients frequently have a SpO2 value outside the target range.\n\nA new closed loop oxygen controller designed for HFNO was recently developed (Hamilton Medical, Bonaduz, Switzerland). The clinician sets SpO2 targets, and the software option adjusts FiO2 to keep SpO2 within the target ranges. The software option offers some alarms on low and high SpO2 and high FiO2. Given the capability, on the one hand, to quickly increase FiO2 in patients developing sudden and profound hypoxia, and, on the other hand, of automatically preventing hyperoxia in patients improving their oxygenation, such a system could be particularly useful in patients treated with HFNO.\n\nA short-term (4 hours vs 4 hours) crossover study indicated that this technique improves the time spent within SpO2 pre-defined target for ICU patients receiving high-flow nasal oxygen therapy \\[Roca et al, 2022\\]. Due to its simplicity, HFNO is increasingly used outside the ICU during transport and in the Emergency Room (ER). This environment poses specific challenges, as patients may deteriorate very quickly and depending on patient's flow, healthcare providers can easily be overwhelmed. We thus propose to evaluate closed loop controlled HFNO in ER patients.\n\nThe hypothesis of the study is that closed loop oxygen control increases the time spent within clinically targeted SpO2 ranges and decreases the time spent outside clinical target SpO2 ranges as compared to manual oxygen control in ER patients treated with HFNO.",[108,26,159,160],"Respiratory Depression","Respiratory Failure",[162,163,164],"Acute respiratory failure (ARF)","HFNC","Closed-loop","2025-01-27",{"date":167,"type":35},"2025-01-28",{"date":169,"type":35},"2024-03-21",{"date":171,"type":20},"2026-05-30",{"name":173,"class":174},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":183,"targetDuration":4,"studyType":21,"phases":185,"briefSummary":186,"conditions":187,"keywords":190,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":43},"100478710","the-rotational-use-of-interface-study-100478710","NCT05513508","The ROTAtional-USE of Interface STUDY","A Pragmatic Open Label, Multi-center, Spontaneous, No-profit, Randomized Controlled Clinical Trial With Non-significant Risk Medical Device on the Rotational Use of Interfaces Versus Standard of Care for Patients Treated With NPPV for AHRF.","ROTA-USE","Inclusion Criteria:\n\n* Age\\>18 years old\n* Patients with chronic obstructive pulmonary disease (COPD) exacerbation or with AHRF of a different etiology needing NPPV to avoid intubation (pH \\\u003C 7.35 with PaCO2 \\> 45 mmHg and partial pressure of oxygen (PaO2) \\\u003C 65 mmHg plus respiratory rate \\> 25 breath\u002Fmin with clinical signs of respiratory muscle distress); or as alternative to invasive ventilation with a forecast of treatment of at least 24 hours admitted to the intensive care unit, intermediate respiratory care unit, respiratory medicine service or internal medicine service according to hospital organization; or patients with chronic pulmonary disease intubated for a COPD exacerbation or for pneumonia who are early extubated and weaned in the intensive care unit with NPPV with a forecast of treatment of at least 24 hours.\n\nExclusion Criteria:\n\n* Patient with skin breakdown or non-blanchable erythema in one of the following areas i.e., nasal bridge, nasolabial fold, cheek or scalp at hospital entrance;\n* Patients who refuse to consent to the study protocol;\n* Patient known to be pregnant;\n* Patients with contraindication to NPPV (lack of spontaneous breathing; gasping; anatomical or functional airway obstruction; gastrointestinal bleeding or ileus; coma; massive agitation; massive retention of secretions despite bronchoscopy and aggressive physiotherapy; hemodynamic instability (cardiogenic shock, myocardial infarction); status post upper gastrointestinal surgery);\n* Patients entering hospital with asthma, with cardiogenic pulmonary edema;\n* Patients with tracheostomy;\n* Patients needing NPPV only for palliation of symptoms (relief of dyspnea) i.e., category 3 defined by the Task Force on the Palliative Use of NPPV of the Society of Critical Care Medicine;\n* Use of high flow nasal cannula integrated with NPPV for weaning strategy;\n* Pre-existing skin erythematosus diseases;\n* Known hypersensitivity to skin protective devices (i.e., polyurethan films, colloids, foams);\n* More than 2 hours of NPPV application before randomization;\n* Patients already included in the study protocol at an earlier stage of the hospitalization;\n* Refuse to wear NPPV interface due to comfort;",{"count":184,"type":20},478,[23],"In this trial investigators will explore if a protocolized rotational use of interfaces i.e., masks, during noninvasive positive pressure ventilation (NPPV) compared to standard care is clinically effective and cost-effective in reducing the incidence of pressure sores in patients with hypercapnic acute respiratory failure (AHRF) treated continuously i.e., for more than 24 hours, with NPPV (to avoid intubation, as alternative to invasive ventilation and after early extubation and weaning).",[188,189,26],"Pressure Ulcer","Noninvasive Positive Pressure Ventilation",[191],"Rotational use of noninvasive interfaces","2024-11-13",{"date":194,"type":35},"2024-11-14",{"date":196,"type":35},"2022-12-08",{"date":198,"type":20},"2028-09",{"name":200,"class":42},"Azienda Ospedaliero Universitaria Maggiore della Carita"]