[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-kidney-injury-due-to-sepsis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-kidney-injury-due-to-sepsis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100555878","quelimmune-scd-ped-pediatric-surveillance-registry-100555878",false,"NCT06517810","QUELIMMUNE (SCD-PED) PediAtric SurVeillance REgistry","Pediatric Selective Cytopheretic Device (SCD-PED, QUELIMMUNE) for Critically Ill Children With Acute Kidney Injury: A Humanitarian Device Exemption (HDE) Surveillance Registry Protocol","SAVE","Inclusion Criteria:\n\n* All patients initiated on QUELIMMUNE therapy under the HDE-approved indication\n\nExclusion Criteria:\n\n* Weight \\\u003C10kg\n* Age \\>22 years\n* Known allergy to any components of QUELIMMUNE","ALL","22 Years",{"count":20,"type":21},50,"ESTIMATED","90 Days","OBSERVATIONAL","QUELIMMUNE is FDA-approved under an HDE for the treatment of pediatric patients (weight ≥10kg and age ≤22 years) with AKI due to sepsis or a septic condition on antibiotic therapy and requiring RRT.\n\nThe purpose of this surveillance registry is to prospectively collect safety data among all patients treated with QUELIMMUNE under the HDE. More specifically, we intend on comparing the incidence of new (secondary) blood stream infections in the first 28 days after SCD-PED initiation to a comparator group of matched CKRT patients with sepsis who did not receive treatment with QUELIMMUNE",[26,27],"Acute Kidney Injury","Acute Kidney Injury Due to Sepsis",[29,30,31,32,33,34],"continuous kidney replacement therapy","continuous renal replacement therapy","acute kidney injury","organ failure","inflammation","dialysis","RECRUITING","2026-05-11",{"date":38,"type":39},"2026-05-14","ACTUAL",{"date":41,"type":39},"2024-07-19",{"date":43,"type":21},"2026-08",{"name":45,"class":46},"SeaStar Medical","INDUSTRY",15,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":79},"100629932","hemodynamic-resuscitation-guided-by-non-invasive-mean-systemic-filling-pressure-to-prevent-acute-kidney-injury-in-septic-shock-100629932","NCT07481097","Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic Shock","Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic Shock: A Randomized Controlled Trial Integrating Renal Doppler Indices","Inclusion Criteria:\n\n* Adult patients (Age 18 years or older) admitted to the Intensive Care Unit.\n* Primary diagnosis of Septic Shock defined according to the Third International Consensus Definitions for Sepsis (Sepsis-3): Sepsis with persisting hypotension requiring vasopressors to maintain MAP 65 mmHg or greater and having a serum lactate level greater than 2 mmol\u002FL despite adequate volume resuscitation.\n* Patients must be mechanically ventilated and sedated to ensure baseline hemodynamic stability.\n* Presence of an invasive arterial catheter and a central venous catheter.\n\nExclusion Criteria:\n\n* Known pre-existing chronic kidney disease (CKD Stage 4 or 5) or patients on chronic renal replacement therapy.\n* Contraindications to arm cuff inflation, including upper limb trauma, -lymphedema, arteriovenous fistula, or peripheral vascular disease.\n* Severe valvular heart disease, specifically severe tricuspid regurgitation, which invalidates CVP interpretation.\n* Intra-abdominal hypertension (Intra-abdominal pressure greater than 15 mmHg) which mechanically alters venous return independent of blood volume.\n* Moribund patients with a predicted mortality within 24 hours.","18 Years",{"count":57,"type":21},100,"INTERVENTIONAL",[60],"NA","The goal of this clinical trial is to evaluate the efficacy of a hemodynamic resuscitation protocol guided by the Venous Return Gradient (Pmsf - CVP), measured via the non-invasive arm cuff technique, in reducing the incidence of Acute Kidney Injury (AKI) in patients with septic shock compared to standard care and to assess the precision and reproducibility of the non-invasive arm cuff Pmsf measurement in the septic shock population and to determine the correlation between the systemic Venous Return Gradient and the renal micro-circulatory Resistance Index (RRI).",[27],[64,31,65,66,67],"sepsis","resuscitation","mean systemic filling pressure","renal resistive index","NOT_YET_RECRUITING","2026-03-15",{"date":71,"type":39},"2026-03-18",{"date":73,"type":21},"2026-04-01",{"date":75,"type":21},"2028-08",{"name":77,"class":78},"Assiut University","OTHER",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":79},"100483437","hemodynamic-stability-in-septic-shock-patients-undergoing-continuous-renal-replacement-therapy-with-oxiris-membrane-100483437","NCT05575024","Hemodynamic Stability in Septic Shock Patients Undergoing Continuous Renal Replacement Therapy With oXiris Membrane","Real-time Monitoring of Hemodynamic Stability in Septic Shock Patients Undergoing Continuous Renal Replacement Therapy: Propensity Score-matched Comparison Between oXiris and Polysulfone Membranes","HISTORIX","Inclusion Criteria:\n\n* Aged ≥ 18 years\n* Sepsis related acute kidney injury requiring continuous renal replacement therapy\n\nExclusion Criteria:\n\n• No monitoring of blood pressure and ECG",{"count":89,"type":21},98,"The new adsorbing membrane for continuous renal replacement therapy (CRRT), oXiris, can reduce plasma cytokines and endotoxins in septic shock patients with severe acute kidney injury, compared with standard membranes. However, its hemodynamic stability or benefits have not been thoroughly evaluated although this is reasonable.",[27],"2025-05-12",{"date":94,"type":39},"2025-05-15",{"date":96,"type":39},"2024-01-01",{"date":98,"type":21},"2026-12-31",{"name":100,"class":78},"Seoul National University Hospital"]