[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-kidney-injury-nontraumatic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-kidney-injury-nontraumatic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100627373","wisdom-uk-low-dose-intensity-versus-standard-dose-intensity-crrt-in-critically-ill-patients-100627373",false,"NCT07447791","WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients","WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity Continuous Renal Replacement Therapy in Critically Ill Patients: a Randomized Trial","WISDOM UK","Inclusion Criteria:\n\n* age ≥ 18 years\n* patient weight ≥ 55 kg\n* plan to start CRRT or within 24 hours of having started CRRT for AKI\n* expected to survive and receive CRRT for a duration of ≥ 48 hours\n\nExclusion Criteria:\n\n* indication for sustained higher dose-intensity CRRT\n* end-stage kidney disease receiving maintenance dialysis\n* previous receipt of RRT for AKI during the current hospitalization\n* inability to comply with the requirements of the study protocol","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy. Renal replacement therapy is a treatment that removes toxins and excess fluid from the blood stream. It consists of having a small plastic catheter in a vein in the neck or in the groin through which blood flows through a dialysis machine and is cleansed and excess water is removed. The cleansed blood is then returned to the patient via the same catheter.\n\nOne of the major areas of uncertainty for doctors in the ICU is \"What is the right intensity of renal replacement therapy for patients with acute kidney injury?\" A higher intensity indeed removes more toxins but also removes other substances in the blood, including vitamins, nutrients and important medications. The current usual dose is around 25 ml\u002Fkg\u002Fhr but clinical practice in the UK is very variable and some patients routinely receive higher doses and some get lower doses. Data from large databases worldwide have suggested that a lower dose is safe and effective and may potentially allow the kidneys to recover faster but confirmation is lacking.\n\nIn this study, the investigators investigate whether renal replacement therapy at a lower intensity is as effective and safe as currently used doses. Participants will be randomised to receiving renal replacement therapy at usual or lower intensity. There will be no change to any other aspects of treatment.\n\nThe results will inform the investigators whether the study protocol is feasible and how best to design a future larger research study.",[27,28],"Acute Kidney Injury (Nontraumatic)","Dialysis; Complications",[30,31,32],"renal replacement therapy","dose","acute kidney injury","RECRUITING","2026-03-03",{"date":36,"type":37},"2026-03-05","ACTUAL",{"date":39,"type":37},"2025-02-15",{"date":41,"type":21},"2027-03-30",{"name":43,"class":44},"Guy's and St Thomas' NHS Foundation Trust","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100460407","effect-of-an-intervention-to-prevent-acute-kidney-injury-versus-standard-care-in-high-risk-patients-after-major-surgery-100460407","NCT05275218","Effect of an Intervention to Prevent Acute Kidney Injury Versus Standard Care in High-risk Patients After Major Surgery","Effect of an Extended \"Kidney Disease: Improving Global Outcomes\" (KDIGO) Bundle Versus Standard of Care Therapy on Persistent Acute Kidney Injury in High-risk Patients After Major Surgery","PrevProgAKI","Inclusion Criteria:\n\n1. Adult patients (age ≥18 years)\n2. Moderate or severe AKI ((defined by the 2012 KDIGO criteria, KDIGO stage 2 and 3), determined by either serum creatinine or urine output) within 72h after a surgical procedure\n3. Written informed consent\n\nExclusion Criteria:\n\n1. Dialysis-dependent chronic kidney disease\n2. Prior kidney transplant\n3. Infections with human immunodeficiency virus or hepatitis\n4. Hepatorenal syndrome\n5. Pregnancy or breast-feeding\n6. Participation in another interventional trial that investigates a drug that affects the kidney function within the last 3 months\n7. Persons held in an institution by legal or official order\n8. Persons with any kind of dependency on the investigator or employed by the responsible institution or investigator",{"count":55,"type":21},480,[24],"There is no specific therapy for acute kidney injury. It is presumed that supportive measures improve the care and outcome of patients with acute kidney injury.\n\nTo investigate whether an implementation of a supportive extended care \"bundle\" in high-risk patients for persistent acute kidney injury (AKI) can reduce the occurrence of persistent surgical AKI.\n\nIn order to investigate whether the extended KDIGO bundle can prevent persistent AKI in patients with high chemokine ligand 14 (CCL14) as well as in patients with low CCL14, patients will be randomized with stratification by the CCL-value.",[27],[60,61,62],"surgery","biomarker","CCL14 protein","2024-07-30",{"date":65,"type":37},"2024-08-01",{"date":67,"type":37},"2023-03-22",{"date":69,"type":21},"2025-12",{"name":71,"class":44},"University Hospital Muenster",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":80,"targetDuration":82,"studyType":83,"phases":4,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":45},"100536048","aki-risk-factors-analysis-after-intentional-hypotensive-anesthesia-100536048","NCT06259760","AKI Risk Factors Analysis After Intentional Hypotensive Anesthesia","Incidence and Risk Factors Analysis of Acute Kidney Injury (AKI) After Intentional Hypotensive Anesthesia in Orthognathic Surgery Patients Following Enhanced Recovery After Surgery (ERAS) Guidelines","Inclusion Criteria:\n\n* America society anesthesiologist classification class I to II patients undergoing oro-maxillo-facial surgery\n* unlimited mouth opening\n\nExclusion Criteria:\n\n* patients with arthritis with limited mouth opening\n* persistent liver dysfunction\n* chronic renal insufficiency\n* body mass index ≧35 kg\u002Fm2.\n* past history of malignant hyperthermia or personal or family history\n* diabetes with insulin treatment\n* essential hypertension without controlled","65 Years",{"count":81,"type":21},50,"7 Days","OBSERVATIONAL","This project investigates intentionally hypotensive management such as NTG (nitroglycerin) or NTG+Trandate during general anesthesia in patients undergoing orthognathic surgery. Throughout the entire surgical procedure, blood biochemical and urine monitoring will be conducted. Serum creatinine (Cr) levels, urine analysis, and perioperative monitoring will be utilized as indicators for assessing renal function during the surgery. The objective is to assess its potential renal injury and identify early risk factors for acute kidney injury (AKI). Timely recognition of these factors will allow for the implementation of appropriate intervention strategies, aiding in the prevention of postoperative acute kidney injury. This approach contributes to achieving the goals of Enhanced Recovery After Surgery (ERAS) for surgical patients, promoting faster postoperative recovery.",[27,86],"Hypotension Drug-Induced",[88,89,90,91,92],"Acute Kidney Injury","orthognathic surgery","general anesthesia","prospective analysis","intentional hypotension","2024-02-07",{"date":95,"type":37},"2024-02-14",{"date":97,"type":21},"2024-03-01",{"date":99,"type":21},"2026-12-31",{"name":101,"class":44},"Kaohsiung Medical University Chung-Ho Memorial Hospital"]