[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-malnutrition-with-no-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-malnutrition-with-no-complications":66},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100576982","effectiveness-of-an-alternative-protocol-in-the-management-of-acute-malnutrition-100576982",false,"NCT06792370","Effectiveness of an Alternative Protocol in the Management of Acute Malnutrition","Effectiveness of an Alternative Protocol in the Management of Acute Malnutrition in Children Aged 6-59 Months in Burkina Faso: Reduced Dose of RUTF for SAM Children and RUTF Instead of RUSF for MAM Children","Alternat-MAL","1. MAM\n\n   Inclusion Criteria:\n   * Anthropometric measures:\n\n     * (115 mm ≤ MUAC\\\u003C 125 mm and -3 SDs ≤ WLZ \\\u003C -2 SDs) OR\n     * (115 mm ≤ MUAC\\\u003C 125 mm and WLZ ≥ -2 SDs) OR\n     * (MUAC ≥ 125 mm and -3 SDs ≤ WLZ \\\u003C -2 SDs).\n   * Age: 6 to 59 months\n   * Parents' acceptance of biweekly visits until programme discharge and monthly visits for the post-programme follow up\n\n   Exclusion Criteria:\n   * Failure of appetite test\n   * Medical complications requiring hospital treatment\n   * Presence of any congenital anomaly or underlying chronic disease that may affect growth or the risk of infection\n   * Presence of bilateral oedema\n   * History of allergies to peanuts, milk, or soya\n   * Relapse from MAM treatment or transfer from SAM treatment\n   * Children who have recently (\\\u003C2 months) taken part in a nutrition programme;\n   * Residence outside the study area\n   * Mother or caregivers deemed unable to comply with the necessary requirements of the study (particular medical condition of the mother or caregivers, etc.)\n2. SAM\n\nInclusion Criteria:\n\n* Anthropometric measures MUAC\\\u003C 115 mm or WLZ\\\u003C - 3 SDs;\n* Age: 6-59 months;\n* Parents' acceptance of weekly visits until programme discharge and monthly visits for the post-programme follow up.\n\nExclusion Criteria:\n\n* Failure of appetite test\n* Medical complications requiring hospital treatment\n* Presence of any congenital anomaly or underlying chronic disease that may affect growth or the risk of infection\n* Presence of bilateral oedema\n* History of allergies to peanuts, milk or soya\n* Relapse from MAM treatment or transfer from SAM treatment\n* Children who have recently (\\\u003C2 months) taken part in a nutrition programme;\n* Residence outside the study area;\n* Mother or caregivers deemed unable to comply with the necessary requirements of the study (particular medical condition of the mother or caregivers, etc.)","ALL","6 Months","59 Months",{"count":21,"type":22},3521,"ESTIMATED","INTERVENTIONAL",[25],"NA","This experimental study aims to test an alternative protocol for managing acute malnutrition in children aged 6-59 months in Burkina Faso. This alternative protocol consists of using RUTF instead of RUSF for the management of moderate acute malnutrition and reduced-dose RUTF instead of standard-dose RUTF for the treatment of severe acute malnutrition.\n\nThe main questions are:\n\n1. Does treating children with moderate acute malnutrition using RUTF lead to a non-inferior programmatic and sustained recovery rate compared to the standard care with RUSF?\n2. Does treating children with uncomplicated severe acute malnutrition using a reduced dose of RUTF lead to a non-inferior programmatic and sustained recovery rate compared to the standard care with a standard dose of RUFT?\n\nSecondly, the study will investigate the effect of this alternative protocol compared to the standard protocol on cost-effectiveness, psychomotor development, weight and linear growth and incidence of relapses.",[28],"Acute Malnutrition with No Complications",[30,31,32,33,34,35,36,37,38],"Effectiveness","acute malnutrition","management","treatment","reduced dose","Ready-to-Use Supplementary Foods","Ready-to-Use Therapeutic Foods","uncomplicated","without complication","NOT_YET_RECRUITING","2025-01-20",{"date":42,"type":43},"2025-01-24","ACTUAL",{"date":45,"type":22},"2025-05",{"date":47,"type":22},"2026-12",{"name":49,"class":50},"Institut de Recherche en Sciences de la Sante, Burkina Faso","OTHER_GOV",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":73,"locationsCount":51},"100484292","microbiome-directed-food-for-sustained-recovery-from-acute-malnutrition-100484292","NCT05586139","Microbiome-Directed Food for Sustained Recovery From Acute Malnutrition","Efficacy of a Food Targeting the Microbiota for a Sustained Recovery of Children With Uncomplicated Acute Malnutrition","MDF","Inclusion Criteria:\n\n* Age between 6 and 23 months\n* Moderate wasting: WHZ \\\u003C -2 and ≥ -3 or MUAC \\\u003C 125 mm and ≥ 115mm or - Severe wasting: WHZ \\\u003C -3 or MUAC \\\u003C 115 mm\n\nExclusion Criteria:\n\n* Bilateral pitting edema\n* Not eating\u002Flack of appetite\n* Current illness medical complications requiring inpatient treatment\n* Presence of any congenital abnormality or underlying chronic disease that may affect growth or risk of infection\n* Known contraindication\u002Fhypersensitivity\u002Fallergy to MDCF of RUSF ingredients (chickpea flour, soy flour, banana, peanut)\n* Relapse from MAM treatment or transfer from SAM treatment\n* Children recently (\\\u003C2 months) or enrolled in a nutrition program\n* Residence outside the study area","23 Months",{"count":62,"type":22},6200,[25],"The goal of this experimental study is to test the efficacy of a new formulation - The microbiome-directed food (MDF) to treat acute malnutrition among children aged 6 to 23 months. The main questions are:\n\n* Does treating children with moderate or severe uncomplicated malnutrition using MDF leads to higher programmatic recovery rate compared to standard of care ?\n* Does treating children with moderate or severe uncomplicated malnutrition using MDF leads to higher sustained recovery rate compared to standard of care ? The MDF will be compared to Ready-to-use supplementary food (RUSF) for moderately malnourished children, and to Ready-to-use therapeutic food (RUTF) for severely malnourished children to see the effects on recovery and sustained recovery rate.",[66],"Acute Malnutrition With no Complications","2024-03-12",{"date":69,"type":43},"2024-03-13",{"date":71,"type":22},"2024-10",{"date":47,"type":22},{"name":49,"class":50}]