[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-myocardial-ischemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-myocardial-ischemia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100588910","the-mechanism-of-endogenous-nociceptinorphanin-fqnofq-and-1-adrenoceptor-autoantibody-in-promoting-ischemic-arrhythmia-in-rats-100588910",false,"NCT06947551","The Mechanism of Endogenous Nociceptin\u002FOrphanin FQ(N\u002FOFQ) and β1-adrenoceptor Autoantibody in Promoting Ischemic Arrhythmia in Rats","tmoenabaaipiai","Inclusion Criteria:1) Inclusion criteria for patients with diabetes: refer to the diagnostic criteria for type 2 diabetes (T2DM) in the Chinese Guidelines for the Prevention and Treatment of Type 2 diabetes (2017) 2) Inclusion criteria for patients with coronary heart disease: patients with clinically diagnosed coronary heart disease according to the 1979 WHO Diagnostic Criteria for Ischemic Heart Disease, and exclusion criteria include heart failure, tumor, immune disease and diabetes. -\n\nExclusion Criteria:Exclusion criteria for patients with coronary heart disease: including heart failure, tumor, immune disease and diabetes. -",true,"ALL","18 Years","85 Years",{"count":21,"type":22},60,"ESTIMATED","OBSERVATIONAL","In the early stage of ischemic arrhythmia, endogenous N\u002FOFQ regulates the expression of β 1-AA, mediates the internalization of β 1-AR by PKC\u002FERK1\u002F2, and thus affects the occurrence of arrhythmia. Further clarify the regulatory mechanism of N\u002FOFQ on β 1-AR internalization and arrhythmia, providing experimental basis for drug development and target exploration of clinical ischemic arrhythmia; To observe the relationship between endogenous N\u002FOFQ and β 1-AA in serum of patients with coronary heart disease and diabetes.",[26],"Acute Myocardial Ischemia","NOT_YET_RECRUITING","2025-04-25",{"date":30,"type":31},"2025-04-27","ACTUAL",{"date":33,"type":22},"2025-05-01",{"date":35,"type":22},"2026-06-01",{"name":37,"class":38},"Second Hospital of Shanxi Medical University","OTHER"]