[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-pain-postoperative\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-pain-postoperative":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100632307","effect-of-rebound-pain-on-chronic-postsurgical-pain-after-total-knee-arthroplasty-100632307",false,"NCT07511985","Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty","Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty: A Prospective Observational Study","Inclusion Criteria:\n\n* Age 18 years or older\n* ASA physical status I to III\n* Scheduled for unilateral elective total knee arthroplasty\n* Planned to undergo spinal anesthesia\n* Planned to receive a peripheral nerve block as part of routine multimodal analgesia\n* Able to provide informed consent and complete study assessments\n\nExclusion Criteria:\n\n* Chronic opioid use (60 mg oral morphine equivalent per day or more, or use for 3 months or longer)\n* Significant neuropathy or radiculopathy\n* Bilateral or two-stage total knee arthroplasty during the same hospitalization\n* Contralateral total knee arthroplasty within the previous 6 months\n* Severe cognitive impairment or major psychiatric disorder\n* Chronic analgesic dependence","ALL","18 Years",{"count":19,"type":20},220,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate whether rebound pain after peripheral nerve block is associated with the development of chronic postsurgical pain following elective total knee arthroplasty. Adult patients undergoing unilateral total knee arthroplasty under spinal anesthesia and receiving a peripheral nerve block as part of routine multimodal analgesia will be included. No additional intervention, drug administration, or biological sampling will be performed beyond standard clinical care.\n\nRebound pain will be assessed during the early postoperative period using pain diaries, numeric rating scale pain scores, and analgesic consumption records. Chronic postsurgical pain and related outcomes will be evaluated at postoperative 3 and 6 months using validated instruments assessing pain severity, neuropathic pain features, psychological status, functional outcomes, and health-related quality of life. The primary outcome is the presence of chronic postsurgical pain at 3 months after surgery. Secondary outcomes include chronic pain at 6 months, pain intensity, neuropathic pain characteristics, opioid consumption, rescue analgesic requirements, sleep disturbance, and quality-of-life measures. The study also aims to explore demographic and clinical factors associated with rebound pain and chronic postsurgical pain.",[24,25,26],"Acute Pain, Postoperative","Chronic Pain","Arthroplasty, Replacement, Knee",[28,29,30],"rebound pain","chronic postsurgical pain","total knee arthroplasty","NOT_YET_RECRUITING","2026-04-05",{"date":34,"type":35},"2026-04-09","ACTUAL",{"date":37,"type":20},"2026-04-07",{"date":39,"type":20},"2026-12-12",{"name":41,"class":42},"Konya City Hospital","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100618795","characterization-of-acute-pain-100618795","NCT07336264","Characterization of Acute Pain","Characterization of Acute Nociceptive Pain and Analgesic Response in Pediatric and Adolescent Patients","Inclusion Criteria:\n\n* Children and adolescents ages 6 to 21 years\n* Undergoing elective surgical procedures without a history of chronic pain, OR undergoing or planning to undergo bone marrow transplantation (BMT)\n* Able to provide written informed assent and parental permission\u002Fconsent, as applicable\n\nExclusion Criteria:\n\n* Documented history of eye disease that precludes pupillometry\n* Unwilling or unable to participate","6 Years","21 Years",{"count":53,"type":20},100,"This study aims to better understand how acute pain and responses to pain treatment can be measured in children and adolescents using a non-invasive device. Pain is usually assessed using self-reported or observational scales, which can be difficult to interpret, especially in pediatric patients. This study will evaluate whether a novel device, the AlgometRx Nociometer, can provide an objective measure of nociceptive pain. Participants ages 6 to 21 years who are undergoing elective surgery or bone marrow transplantation will be enrolled at Children's National Hospital. The device measures changes in pupil size in response to gentle electrical stimulation, which reflects activity in pain-related nerve pathways. Measurements will be taken before and after procedures and during routine hospital care, alongside standard pain assessments. This is an observational study. Participation will not change or guide any medical treatment, and all pain management will follow standard clinical care. The information collected may help improve future pain assessment and treatment for pediatric patients.",[24,56,57],"Postoperative Pain","Acute Pain","RECRUITING","2026-01-12",{"date":61,"type":35},"2026-01-14",{"date":63,"type":35},"2025-12-02",{"date":65,"type":20},"2028-06-02",{"name":67,"class":42},"Children's National Research Institute",1]