[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-post-operative-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-post-operative-pain":207},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,47,71,97,119,142,169],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100555715","modified-thoracoabdominal-nerve-plane-block-in-laparoscopic-sleeve-gastrectomy-100555715",false,"NCT06515691","Modified Thoracoabdominal Nerve Plane Block In Laparoscopic Sleeve Gastrectomy","Evaluation of Effectiveness of Ultrasound-Guided Modified Thoracoabdominal Nerve Plane Block Through Perichondrial Approach (M-TAPA) for Postoperative Analgesia Management in Patients Undergoing Laparoscopic Sleeve Gastrectomy Operation","Inclusion Criteria: American Society of Anesthesiologists (ASA) classification II- III Patients Scheduled for LSG under general anesthesia\n\n\\-\n\nExclusion Criteria: Patients\n\n* with a history of bleeding diathesis,\n* receiving anticoagulant treatment,\n* with allergies or sensitivity to drugs used,\n* with an infection on the puncture site\n* with a history of alcohol or drug addiction,\n* with congestive heart failure\n* with liver or kidney disease\n* who do not accept the procedure or participate in the study","ALL","18 Years","65 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Ultrasound-guided Modified Thoracoabdominal Nerve Plane Block (M-TAPA) is performed into the costochondral aspect at the 9th-10th costal level by injecting local anesthetics deep into the chondrium. It provides blockage of both the anterior and lateral cutaneous branches of the thoracoabdominal nerve. Studies show that M-TAPA block is effective for postoperative analgesia and other abdominal surgeries, but its effect on patients undergoing LSG surgery has not yet been studied. The hypothesis is that the M-TAPA block performed in patients undergoing Laparoscopic Sleeve Gastrectomy (LSG) Operation would reduce opioid consumption in the first 24 hours period after surgery.",[27,28,29,30],"Obesity","Bariatric Surgery","Laparoscopic Sleeve Gastrectomy","Acute Post Operative Pain",[32,29,28,33],"ModifiedThoracoabdominal Nerve Plane Block","Acute Postoperative Pain","RECRUITING","2025-12-18",{"date":37,"type":38},"2025-12-24","ACTUAL",{"date":40,"type":38},"2025-01-03",{"date":42,"type":21},"2026-02-15",{"name":44,"class":45},"Istanbul Medipol University Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":46},"100480358","pib-for-post-operative-analgesia-after-laparotomy--determining-the-optimum-dose-100480358","NCT05534945","PIB for Post-operative Analgesia After Laparotomy : Determining the Optimum Dose","Programmed Intermittent Epidural Bolus for Postoperative Analgesia After Laparotomy: Determining the Optimum Dose Using a Biaised Coin Up-and-down Sequential Allocation Protocol","PIBDOSE","Inclusion Criteria:\n\n* 18-85 years old\n* ASA I to III\n\nExclusion Criteria:\n\n* Contraindication to TEA: Coagulopathy, sepsis or local infection at the epidural insertion site, patient refusal\n* Inability to site the epidural catheter\n* Inability to use PCEA\u002FCommunication barrier\n* Daily opioid use\n* Planned postoperative admission to the intensive care unit\n* Patient refusal\n* Predefined criteria for exclusion after inclusion: Failure to obtain a sensory block to ice in the Post Anesthesia Care Unit (PACU)(see Methods), Reoperation within 1 postoperative day","85 Years",{"count":20,"type":21},[24],"Pain control after surgery is a crucial component of postoperative recovery. Thus, in open abdominal surgery, the use of TEA (Thoracic epidural analgesia) has become a gold standard. However, analgesia may still remain a challenge, especially in patients with large incision abdominal incisions.\n\nTo address this problem, the use of the PIEB (Programmed intermittent epidural bolus) mode has been proposed, because it offers a better spread of the epidural medication.\n\nOnly a few studies have evaluated the superiority of this PIEB mode in open abdominal surgery, yielding conflicting results. However, PIEB showed to be at least as effective in controlling pain as CEI, and clinical experience shows that it can be a valuable tool, especially in patients with a large laparotomy incision.\n\nHowever, the optimal dosage of the PIEB mode has never been determined, Furthermore, it is known whether men and women have the same dosage needs to achieve adequate analgesia since most studies have failed to account for sex-based differences in postoperative analgesia.\n\nHence, the main objective of this study will be to determine the optimal volume dose of the PIEB delivered at a fixed interval of 60 min in patients undergoing surgery using a large midline laparotomy incision. The optimal dose for male and female patients will be determined separately by evaluating men and women in two independent groups. We hypothesize that the optimal dose of the PIEB that will provide effective analgesia in 90% of patients on the first postoperative day will range between 5 and 10 mL, for both groups.\n\nThe primary outcome in both groups is successful analgesia. It is defined as a requirement of 5 or less patient-controlled epidural boluses between 8 AM and 8 PM on the first postoperative day.\n\nSecondary outcomes will be the incidence of motor block and hypotension, comparison of the level of sensory block according to group, comparison of patient satisfaction according to group and comparison of Quality of Recovery-15 score at 48h post-op according to group.",[30,60,61],"Laparotomy","Epidural Analgesia","2025-11-13",{"date":64,"type":38},"2025-11-14",{"date":66,"type":38},"2022-12-01",{"date":68,"type":21},"2026-12",{"name":70,"class":45},"Ciusss de L'Est de l'Île de Montréal",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":46},"100450138","gender-specific-preoperative-anxiety-level-and-postoperative-opioid-requirement-after-ent-surgery-100450138","NCT05141591","Gender-specific Preoperative Anxiety Level and Postoperative Opioid Requirement After ENT Surgery.","The Impact of Gender-specific Preoperative Anxiety Level on Postoperative Opioid Requirement After ENT Surgery.","Inclusion Criteria:\n\n* American Society of Anesthesiology (ASA) physical status I-IV\n* able to read and understand the information sheet and to sign the consent form\n* being scheduled for elective ENT surgery under general anesthesia\n* written informed consent\n* age≥18 years\n\nExclusion Criteria:\n\n* difficulty to understand study procedure, pain scoring system or questionnaires\n* surgical procedure warranting elective postoperative ventilation",true,{"count":80,"type":21},300,"OBSERVATIONAL","The study will be designed to investigate the impact of the preoperative anxiety level on postoperative opioid requirement during the PACU stay, in order to improve postoperative pain treatment in the long term after ENT surgery.\n\nThe present study can contribute to improve postoperative pain management in patients in the field of ENT surgery, as new influencing parameters and risk factors may be discovered.",[84,30],"Anxiety",[86,87],"catastrophizing","opioid consumption","2025-07-01",{"date":90,"type":38},"2025-07-04",{"date":92,"type":38},"2021-11-11",{"date":94,"type":21},"2026-12-30",{"name":96,"class":45},"Medical University of Vienna",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":115,"leadSponsor":117,"locationsCount":4},"100575927","postoperative-analgesic-comparison-of-spsi-block-and-sap-block-in-video-assisted-thoracoscopic-surgery-vats-100575927","NCT06778642","Postoperative Analgesic Comparison of SPSI Block and SAP Block in Video-Assisted Thoracoscopic Surgery (VATS)","Comparison of the Postoperative Analgesic Effectiveness of Serratus Posterior Superior Intercostal Plane Block and Serratus Anterior Plane Block in Video-Assisted Thoracoscopic Surgery (VATS)","Inclusion Criteria:\n\n* Patients aged 18 to 80 years undergoing Video-Assisted Thoracoscopic Surgery (VATS)\n* Scheduled at Uludağ University Faculty of Medicine Hospital Operating Room\n* Classified as ASA I, II, or III according to the American Society of Anesthesiologists (ASA) criteria\n\nExclusion Criteria:\n\n* Allergy to local anesthetics or contraindications to bupivacaine\n* Known or suspected coagulopathy\n* Infection at the injection site\n* History of thoracic surgery\n* Severe neurological or psychiatric disorders\n* Severe cardiovascular disease\n* Liver failure\n* Renal failure (glomerular filtration rate \\\u003C 15 ml\u002Fmin\u002F1.73 m²)\n* Chronic opioid use","80 Years",{"count":106,"type":21},90,[24],"In our study, we primarily aimed to compare the postoperative analgesic effectiveness of the Serratus Posterior Superior Intercostal Plane Block and the Serratus Anterior Plane Block, both routinely applied in patients undergoing Video-Assisted Thoracoscopic Surgery (VATS)",[30],"NOT_YET_RECRUITING","2025-05-12",{"date":113,"type":38},"2025-05-15",{"date":113,"type":21},{"date":116,"type":21},"2026-02-10",{"name":118,"class":45},"Uludag University",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":129,"conditions":130,"keywords":132,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":46},"100575926","transversalis-fascia-plane-block-for-laparoscopic-inguinal-hernia-repair-100575926","NCT06778629","Transversalis Fascia Plane Block for Laparoscopic Inguinal Hernia Repair","Evaluation of the Effectiveness of Transversalis Fascia Plane Block in Patients Undergoing Laparoscopic Inguinal Hernia Repair","TFPB","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) classification I- II Patients\n* Unilateral Inguinal Hernia Repair Surgery\n* Elective Operations\n\nExclusion Criteria:\n\n* Patients with a history of chronic pain\n* Evidence of infection in the intervention area\n* Allergy to local anesthetics\n* Coagulopathy\n* Body-mass index (BMI) ≥ 30\n* Body weight ≤ 50 kg\n* Patients who do not agree to participate in the study",{"count":20,"type":21},[24],"Transversalis Fascia Plane Block (TFPB) is a trunk block that blocks the T12- L2 spinal nerves by injection of local anesthetic between the transversus abdominis muscle and transversalis fascia on the lateral abdominal wall. The block's positive effects on postoperative analgesia have been shown in many abdominal surgeries, including open-technique inguinal hernia repair.\n\nThis study aimed to investigate the effectiveness of ultrasound (US) guided TFPB on postoperative pain control for postoperative analgesia management after laparoscopic inguinal hernia repair.",[131,30],"Laparoscopic Inguinal Hernia Repair",[133,33,131],"Transversalis Fascia Plane Block","2025-03-12",{"date":136,"type":38},"2025-03-14",{"date":138,"type":38},"2025-02-14",{"date":140,"type":21},"2025-12-15",{"name":44,"class":45},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":154,"conditions":155,"keywords":157,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":46},"100582559","early-phase-1-a-phase-1-study-of-arc-001-in-participants-undergoing-third-molar-extraction-100582559","NCT06864884","A Phase 1 Study of ARC-001 in Participants Undergoing Third Molar Extraction","A Phase 1 Randomized, Placebo-Controlled, Blinded Study Evaluating the Safety, Tolerability, and Pharmacokinetics of ARC-001 in Participants Undergoing Third Molar Extraction","Inclusion Criteria:\n\n* Able to provide informed consent\n* In generally good health\n* BMI 18 to 38kg\u002Fm²\n* Scheduled to undergo wisdom teeth extraction\n\nExclusion Criteria:\n\n* Serious medical condition\n* Clinically significant abnormal lab values\n* Blood donation in the last 60 days, or plasma donation in the last 7 days.","55 Years",{"count":151,"type":21},30,[153],"EARLY_PHASE1","The study will test the investigational product gel against placebo (which contains no active ingredient) to determine if it is safe after wisdom tooth extraction. The main questions the study will answer are:\n\n1. How much of the investigational product is absorbed in the blood?\n2. Are there side effects?",[30,156],"Third Molar Extraction Surgery",[158],"wisdom teeth surgery","2025-03-06",{"date":161,"type":38},"2025-03-11",{"date":163,"type":38},"2025-02-26",{"date":165,"type":21},"2026-02",{"name":167,"class":168},"Arcato Laboratories, Inc.","INDUSTRY",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":179,"conditions":180,"keywords":187,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":46},"100509958","factors-influencing-the-results-of-treatment-in-patients-with-hernias-of-various-localizations-100509958","NCT05920200","Factors Influencing the Results of Treatment in Patients With Hernias of Various Localizations","Factors Affecting the Results of Treatment of Patients With Hernias of Various Localization: Evaluation of Treatment Results Using an Automated Hernia Register","Inclusion Criteria:\n\n* All mesh and non-mesh repairs that have been registered in the KHR from January 9, 2020, until December 31, 2023.\n\nExclusion Criteria:\n\n* Patients not having a 11-digit state-assigned Personal insurance policy number.\n* Parastomal hernia;\n* infected hernias;","90 Years",{"count":178,"type":21},4000,"The study attempts to quantify the relative risks for acute postoperative pain, complications rate, chronic postoperative pain (CPIP) and recurrence rate after different methods of repair of groin, umbilical and incisional hernia depending on surgical technique, mesh type and fixation suture material.\n\nFor this purpose the investigators will analyze data from the Kalinigrad Hernia Registry (KHR).",[181,182,183,184,185,30,186],"Inguinal Hernia","Femoral Hernia","Umbilical Hernia","Ventral Hernia","Chronic Pain","Recrrence Rate",[188,189,190,191,192,193,194,195,196,197],"hernia","register","inguinal hernia","femoral hernia","umbilical hernia","ventral hernia","CPIP","postoperative complications","chronic post-operative pain","recurrence rate","2024-07-22",{"date":200,"type":38},"2024-07-23",{"date":202,"type":38},"2020-01-09",{"date":204,"type":21},"2025-12-31",{"name":206,"class":45},"Immanuel Kant Baltic Federal University","Acute Post-operative Pain"]