[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-postoperative-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-postoperative-pain":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,47,74,103,133,163,188,215,241,266,289,314],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100639174","crops-study-chronification-of-post-surgical-pain-and-risk-assessment-100639174",false,"NCT07629453","CROPS Study: Chronification of Post-Surgical Pain and Risk Assessment","Chronification of Post-Surgical Pain and Validation of a Novel Risk Assessment Tool: A Prospective Multicenter Randomized Controlled Trial","CROPS","Inclusion Criteria:\n\n* Age ≥18 years\n* Elective cardiac surgery requiring median sternotomy, including:\n* coronary artery bypass grafting (CABG)\n* aortic valve replacement or repair\n* mitral valve replacement or repair\n* ascending aorta surgery\n* Ability to understand study information\n* Ability to provide written informed consent\n* Expected postoperative hospital stay longer than 3 days\n* Availability for follow-up at 1 week and 3 months after surgery\n\nExclusion Criteria:\n\n* Emergency surgery\n* Cognitive impairment preventing study participation\n* Serious psychiatric illness interfering with study participation\n* Language barrier preventing questionnaire completion\n* Participation in another interventional study affecting pain outcomes\n* Reoperation for postoperative bleeding\n* Severe chronic renal failure\n* Allergy or contraindication to study medication or regional anesthesia techniques\n* Pregnancy or breastfeeding\n* Chronic opioid therapy exceeding 60 mg morphine equivalents daily\n* Extensive emergency aortic surgery (e.g., Thoraflex implantation for acute aortic dissection)","ALL","18 Years",{"count":20,"type":21},180,"ESTIMATED","INTERVENTIONAL",[24],"NA","Chronic post-surgical pain (CPSP) represents a major clinical problem associated with impaired functional recovery, reduced quality of life, prolonged opioid use, and increased healthcare utilization. The mechanisms underlying pain chronification are multifactorial and involve complex interactions among surgical trauma, inflammatory responses, central sensitization, neuroimmune activation, and psychosocial risk factors.\n\nThe CROPS study (Chronification of Post-Surgical Pain and Risk Assessment) is a prospective multicenter randomized controlled trial designed to evaluate the impact of perioperative analgesic strategies on the development of chronic post-surgical pain and to validate a novel questionnaire-based pain chronification risk assessment tool in adult patients undergoing cardiac surgery.\n\nParticipants will be randomized to receive either standard multimodal opioid-based perioperative analgesia or regional anesthesia-based perioperative analgesia incorporating chest wall plane block techniques, including erector spinae plane block, paravertebral block, or PECS block, according to institutional practice.\n\nThe study will compare postoperative pain intensity, opioid consumption, postoperative recovery, postoperative complications, health-related quality of life, and the incidence of chronic post-surgical pain at 3 months after surgery. In parallel, the predictive performance of the pain chronification risk assessment questionnaire will be evaluated using discrimination and calibration analyses.\n\nThe study is conducted as an investigator-initiated academic collaboration between the East Slovakia Institute of Cardiovascular Diseases, Košice, Slovakia, and Uppsala University Hospital, Uppsala, Sweden.",[27,28,29],"Chronic Post-surgical Pain","Acute Postoperative Pain","Cardiac Surgery",[31,32,33,34],"chronic post-surgical pain","cardiac surgery","regional anesthesia","postoperative analgesia","NOT_YET_RECRUITING","2026-06-04",{"date":38,"type":39},"2026-06-05","ACTUAL",{"date":41,"type":21},"2026-09-01",{"date":43,"type":21},"2029-06-01",{"name":45,"class":46},"Kočan Ladislav","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100618717","intertransverse-process-block-for-postoperative-analgesia-after-thoracotomy-and-lobectomy-100618717","NCT07335250","Intertransverse Process Block for Postoperative Analgesia After Thoracotomy and Lobectomy","Postoperative Pain Control With Intertransverse Process Block in Patients Undergoing Thoracotomy With Lobectomy","Inclusion Criteria:\n\n* Provision of written informed consent\n\nAge between 18 and 85 years\n\nASA Physical Status classification I-III\n\nElective thoracotomy with planned unilateral lobectomy\n\nAnticipated hospital stay of at least one night\n\nExpected requirement for parenteral opioid analgesia for at least 24 hours postoperatively\n\nAbility to operate an intravenous patient-controlled analgesia (PCA) device\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery\n\nPresence of infection or open wound at the injection site\n\nCoagulopathy\n\nHepatic or renal failure\n\nPatients undergoing reoperation\n\nPatients with missing or incomplete data\n\nPregnancy or lactation\n\nTracheal malformation or tracheostomy\n\nChronic opioid use (≥30 days within the last 3 months, ≥15 mg\u002Fday morphine equivalent)\n\nPatients exceeding the maximum safe local anesthetic dose based on weight (2.5 mg\u002Fkg, max 150 mg)\n\nPatients who refuse data privacy consent will be excluded from the study","85 Years",{"count":56,"type":21},66,[24],"This prospective, randomized, triple-blind, placebo-controlled clinical trial will investigate the effectiveness of the intertransverse process block (ITPB) for postoperative analgesia in patients undergoing elective thoracotomy with unilateral lobectomy. The study will be conducted at a single tertiary center in accordance with the principles of the Declaration of Helsinki, and written informed consent will be obtained from all participants.\n\nPatients will be randomized in a 1:1 ratio to receive either ultrasound-guided ITPB with 0.5% bupivacaine or placebo (normal saline) prepared in identical syringes to ensure allocation concealment. The block will be performed by an experienced anesthesiologist immediately after surgery and before emergence from anesthesia. Both groups will receive standardized general anesthesia, multimodal perioperative analgesia, and postoperative intravenous morphine patient-controlled analgesia (PCA).\n\nThe trial aims to evaluate the analgesic efficacy and opioid-sparing effect of ITPB while maintaining safety and adherence to routine clinical practice. Outcomes will include postoperative pain scores, opioid consumption, rescue analgesia requirement, and adverse events.",[28,60,61],"Thoracotomy Surgery","Intertransverse Process Block",[61,63,28],"Thoracotomy Lobectomy","RECRUITING","2026-04-08",{"date":67,"type":39},"2026-04-09",{"date":65,"type":39},{"date":70,"type":21},"2027-03-01",{"name":72,"class":46},"Konya City Hospital",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":102},"100627706","dipb-vs-sifib-for-postoperative-analgesia-after-hip-surgery-100627706","NCT07452120","DIPB vs. SIFIB for Postoperative Analgesia After Hip Surgery","Comparison of the Effects of Deep Iliacus Plane Block (DIPB) and Suprainguinal Fascia Iliaca Block (SIFIB) on Postoperative Analgesia in Patients Undergoing Hip Surgery: A Randomized Controlled Study","Inclusion Criteria:\n\n* Patients aged ≥18 years\n* ASA physical status I-III\n* Scheduled for elective primary total hip arthroplasty under spinal anesthesia\n* Ability to understand the study procedures and provide informed consent\n\nExclusion Criteria:\n\n* Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia\n* Infection at the block application site\n* Hemodynamic instability\n* Known allergy to local anesthetics\n* Pre-existing significant neurological or motor deficits in the lower extremities\n* Cognitive impairment preventing pain assessment\n* Refusal to participate or inability to provide informed consent",{"count":82,"type":21},70,[24],"This randomized, double-blind clinical trial aims to compare the effectiveness of the Deep Iliacus Plane Block (DIPB) and the Suprainguinal Fascia Iliaca Block (SIFIB) for postoperative pain control in patients undergoing primary total hip arthroplasty. Effective analgesia after hip surgery is essential for early mobilization, reduction of complications, and improved recovery outcomes.\n\nSeventy patients scheduled for elective hip arthroplasty under spinal anesthesia will be randomly assigned to receive either DIPB or SIFIB at the end of surgery. Postoperative pain scores, opioid consumption, motor block, and block-related complications will be evaluated over a 48-hour period.\n\nThe study aims to determine whether DIPB provides superior or comparable analgesia with reduced motor blockade compared to SIFIB, thereby contributing to safer and more comprehensive postoperative pain management in hip surgery patients.",[86,87,88,28],"Hip Arthroplasty","Postoperative Pain","Regional Anesthesia",[90,91,86,87,88],"Deep Iliacus Plane Block","Suprainguinal Fascia Iliaca Block","2026-03-28",{"date":94,"type":39},"2026-04-02",{"date":96,"type":39},"2026-03-27",{"date":98,"type":21},"2026-11-01",{"name":100,"class":101},"Sivas Numune Hospital","OTHER_GOV",2,{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":115,"conditions":116,"keywords":120,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100626345","phase-4-comparison-of-the-efficacy-and-safety-of-intravenous-buprenorphine-administered-via-pca-system-versus-oxycodone-in-the-management-of-postoperative-pain-after-video-assisted-thoracoscopic-surgery-100626345","NCT07434427","Comparison of the Efficacy and Safety of Intravenous Buprenorphine Administered Via PCA System Versus Oxycodone in the Management of Postoperative Pain After Video-Assisted Thoracoscopic Surgery","Comparison of the Efficacy and Safety of Intravenous Buprenorphine Administered Via PCA System Versus Oxycodone in the Management of Postoperative Pain After Video-Assisted Thoracoscopic Surgery - A Prospective, Randomized Clinical Trial","Inclusion Criteria:\n\n* qualification for elective thoracic surgery performed using the VATS technique, physical status ASA I-III, anticipated use of PCA in the postoperative period, patient's consent to participate in the study.\n\nExclusion Criteria:\n\n* inability to provide informed consent,\n* hypersensitivity to opioids or study medications,\n* chronic opioid therapy,\n* previously diagnosed chronic pain,\n* chronic use of analgesic medications,\n* disorders of consciousness preventing appropriate use of the PCA pump,\n* severe renal or hepatic insufficiency,\n* pregnancy or breastfeeding,\n* clinically relevant drug interactions (rifampicin, carbamazepine, CYP3A4 inhibitors).","75 Years",{"count":112,"type":21},200,[114],"PHASE4","The goal of this clinical trial is to learn whether intravenous buprenorphine administered via a patient-controlled analgesia (PCA) system provides effective and safer postoperative pain control than intravenous oxycodone PCA in adults undergoing video-assisted thoracoscopic surgery (VATS). It will also evaluate the overall tolerability of buprenorphine in the early postoperative period and explore longer-term pain outcomes. The main questions it aims to answer are:\n\nDoes buprenorphine PCA provide pain control that meets predefined targets during the first 48 hours after VATS (both at rest and during respiratory rehabilitation\u002Fmobilization), compared with oxycodone PCA? Does buprenorphine PCA reduce clinically relevant respiratory safety events (e.g., apnea or oxygen desaturation requiring intervention) and excessive sedation, compared with oxycodone PCA? What opioid-related adverse effects (e.g., nausea\u002Fvomiting, pruritus, constipation, hypotension) occur with buprenorphine PCA versus oxycodone PCA? Does buprenorphine PCA affect time to first patient-initiated analgesic demand and total opioid consumption within 48 hours? Does the choice of PCA opioid influence quality of recovery and the incidence of persistent postoperative pain at follow-up?\n\nResearchers will compare buprenorphine PCA to oxycodone PCA (both as part of standardized multimodal analgesia and perioperative care, including serratus anterior plane block) to determine whether buprenorphine provides non-inferior analgesia with a superior safety profile.\n\nParticipants will:\n\nBe randomly assigned (double-blind) to receive buprenorphine PCA or oxycodone PCA for 48 hours after surgery, alongside standard multimodal analgesia Receive standardized general anesthesia for VATS with one-lung ventilation and an ultrasound-guided serratus anterior plane block at the end of surgery Have pain scores (NRS) recorded at multiple time points over 48 hours, at rest and during rehabilitation, and complete recovery questionnaires (QoR-15) early after surgery Be monitored regularly for vital signs, sedation level (RASS), respiratory events, and other adverse effects, with total opioid use recorded Provide satisfaction ratings at discharge and be followed after discharge to assess persistent postoperative pain\u002Fhyperalgesia at 1, 3, and 6 months",[28,117,118,119],"Chronic Postoperative Pain","Toracosurgery","Video-assisted Thoracis Surgery (VATS)",[121,122,123],"pain","acute postoperative pain","chronic postoperative pain","2026-02-20",{"date":126,"type":39},"2026-02-25",{"date":128,"type":21},"2026-02",{"date":130,"type":21},"2027-11",{"name":132,"class":46},"Medical University of Silesia",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":145,"conditions":146,"keywords":150,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":73},"100545373","phase-3-non-steroidal-anti-inflammatory-in-cardiac-surgery-100545373","NCT06381063","Non-steroidal Anti-inflammatory in Cardiac Surgery","Effect of Non-steroidal Anti-inflammatory Drugs in Pain Management After Cardiac Surgery","KETOPAIN","Inclusion Criteria:\n\n* scheduled for cardiac surgery (aortic valve replacement, coronary artery bypass graft, mitral valve repair or replacement, intracardiac tumor, aortic root repair)\n* under cardiopulmonary bypass\n* Affiliation to the French national healthcare system\n* Written consent obtained\n\nExclusion Criteria:\n\n* age\\\u003C18\n* weight\\\u003C50 kg\n* chronic use of NSAID\n* mini-invasive surgery\n* NSAID contraindication\n* NSAID allergy\n* Nefopam contraindication\n* Paracetamol contraindication\n* Tramadol contraindication\n* Urgent surgery\n* Endocarditis\n* Immunosuppressive drug\n* HIV infection with CD4\\\u003C200 mm3\n* Organ transplantation\n* Stage 4 or 5 chronic kidney disease\n* Gastro duodenal ulcer\n* Pregnancy\n* Depression\n* Auto immune disease",{"count":142,"type":21},238,[144],"PHASE3","Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.",[28,147,29,148,149],"Non-steroidal Anti-inflammatory Drugs","Pain Intensity","Multimodal Pain Management",[28,151,32,152,153],"non-steroidal anti-inflammatory drugs","pain intensity","multimodal pain management","2025-07-18",{"date":156,"type":39},"2025-07-23",{"date":158,"type":39},"2024-03-27",{"date":160,"type":21},"2027-07",{"name":162,"class":46},"Centre Hospitalier Universitaire, Amiens",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":173,"conditions":174,"keywords":176,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":73},"100576406","phase-4-continuous-versus-single-injection-adductor-canal-blocks-for-outpatient-total-knee-arthroplasty-100576406","NCT06784882","Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty","A Pilot Randomized Controlled Trial Assessing Pain and Opioid Outcomes Among Patients Undergoing Total Knee Arthroplasty Receiving 5-Day Outpatient Adductor Canal Continuous Versus Single Injection Blocks","Inclusion Criteria:\n\n1. Adult participants of at least 18 years of age\n2. Undergoing a primary, unilateral, total knee arthroplasty\n3. Planned single-injection adductor canal nerve block\n4. Weight \\> 50 kg (to minimize the risk of local anesthetic toxicity)\n\nExclusion Criteria:\n\n1. chronic opioid or tramadol use: daily oxycodone equivalents \\> 20 mg for \\> 4 weeks\n2. neuro-muscular deficit of the surgical limb\n3. moderate pain (NRS \\> 3) in an anatomic location other than the surgical site\n4. planned hospital admission following surgery\n5. history of opioid misuse\n6. those who lack capacity to complete informed consent\n7. inability to contact the investigators during the treatment period, and vice versa (e.g., lack of telephone access)\n8. incarceration\n9. pregnancy\n10. allergy to amide local anesthetics",{"count":171,"type":21},40,[114],"This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty. Investigators will randomize participants to either continuous nerve block or single injection nerve block for the adductor canal preoperatively. They will assess differences in pain (measured in numeric rating scale), opioid consumption, and physical therapy milestones from postoperative day 0 to 7.",[28,175],"Surgery",[33,177,178],"total knee arthroplasty","nerve block","2025-06-12",{"date":181,"type":39},"2025-06-17",{"date":183,"type":39},"2025-06-01",{"date":185,"type":21},"2025-12-01",{"name":187,"class":46},"University of California, San Diego",{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":195,"targetDuration":4,"studyType":22,"phases":197,"briefSummary":198,"conditions":199,"keywords":200,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":213,"locationsCount":4},"100587313","intertransverse-process-block-to-improve-quality-of-recovery-after-cardiac-surgery-with-sternotomy-100587313","NCT06926764","Intertransverse Process Block to Improve Quality of Recovery After Cardiac Surgery With Sternotomy","Intertransverse Process Block to Improve Quality of Recovery After Cardiac Surgery With Sternotomy: a Prospective Randomised Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 18 or older\n* undergoing elective coronary artery bypass graft (CABG), valve repair\u002Freplacement, or combined CABG\u002Fvalve procedure via sternotomy.\n\nExclusion Criteria:\n\n* Emergency surgery\n* redo surgery\n* history of thoracotomy or mastectomy\n* patients with history of chronic pain\n* patients on chronic opioids or sedatives\n* renal failure with estimated glomerular filtration rate \\\u003C30ml\u002Fmin (calculated by Cockcroft-Gault formula)\n* intraoperative use of remifentanil\n* unable to provide informed consent.",{"count":196,"type":21},100,[24],"The goal of this clinical trial is to evaluate the efficacy of intertransverse process block (ITPB) in blunting sympathetic response of sternotomy, achieving perioperative opioid-sparing and improving quality of recovery in adult patients undergoing elective cardiac surgery (e.g., coronary artery bypass graft \\[CABG\\], valve repair\u002Freplacement, or combined CABG\u002Fvalve procedures).\n\nThe main questions it aims to answer are:\n\n1. To investigate the efficacy of intertransverse process block (ITPB) on quality of recovery after cardiac surgery\n2. To investigate the efficacy of ITPB on the sympathetic response on incision, intraoperative and postoperative morphine requirement\n3. To investigate the efficacy of ITPB on surgical outcomes including time to weaning off mechanical ventilation, length of ICU\u002F hospital stay and incidence of neuropathic pain after surgery Researchers will compare patients receiving bilateral ITPB with levobupivacaine to those receiving sham blocks to determine if ITPB reduces CPSP, improves pain control, and decreases opioid consumption.",[28],[201,202,203,204,205,206],"Cardiac surgery","Intertransverse process block","ITPB","CABG","Quality of Recovery","Acute postoperative pain","2025-04-13",{"date":209,"type":39},"2025-04-16",{"date":211,"type":21},"2025-11",{"date":130,"type":21},{"name":214,"class":46},"Chinese University of Hong Kong",{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":4,"eligibilityCriteria":221,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":222,"targetDuration":4,"studyType":224,"phases":4,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":102},"100566935","clinical-prediction-of-post-surgical-pain-100566935","NCT06661642","Clinical Prediction of Post-surgical Pain","Clinical Prediction of Post-surgical Pain: External Validation","Inclusion Criteria:\n\nAll patients ≥ 18 years undergoing elective or sub-acute surgery\n\nExclusion Criteria:\n\nCognitive impairment not allowing for informed consent",{"count":223,"type":21},748,"OBSERVATIONAL","This study aims to externally validate two clinical prediction models for moderate-to-severe acute post-surgical pain and chronic post-surgical pain. This multi-centre, prospective cohort study will be conducted in Denmark and will include adult patients undergoing various types of elective or sub-acute surgical procedures.",[28,227],"Chronic Post Operative Pain",[206,229,230,231],"Chronic postoperative pain","Prediction","Risk tool","2024-10-25",{"date":234,"type":39},"2024-10-28",{"date":236,"type":39},"2024-08-26",{"date":238,"type":21},"2025-08-31",{"name":240,"class":46},"Aarhus University Hospital",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":247,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":248,"targetDuration":4,"studyType":22,"phases":249,"briefSummary":250,"conditions":251,"keywords":252,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":4},"100558664","effects-of-tdcs-and-vns-on-postoperative-analgesia-100558664","NCT06554067","Effects of tDCS and VNS on Postoperative Analgesia","Inclusion Criteria:\n\n* Adults aged 18 years or above with the capacity to provide informed consent who are undergoing an elective surgery requiring general anesthesia\n\nExclusion Criteria:\n\n* cardiac bradyarrhythmia: taking beta-blockers;\n* patients with metal implants around the chest, neck, or head (e.g. implantable pacemakers and defibrillators, deep brain stimulation devices);\n* pregnancy\n* history of epilepsy or seizures.\n* patients undergoing surgical procedures involving the head, neck or spine, or those requiring the use of cardiopulmonary bypass",true,{"count":112,"type":21},[24],"This study seeks to evaluate the efficacy of transcranial direct current stimulation (tDCS) and Afferent Vagus nerve simulation (VNS) in treating acute postoperative pain of patients in the post-anesthesia care unit after general surgery.\n\nStudy outcomes will include changes in pain levels and vital signs. For patients who are admitted after surgery, opioid consumption in the 24 hours after surgery and time from surgery to discharge are recorded as secondary outcomes.\n\nPatients will be divided in the following comparison groups:\n\n* Group +\u002F+ will receive ten minutes of active tDCS followed by ten minutes of active VNS.\n* Group +\u002F- will receive ten minutes of active tDCS followed by ten minutes of sham VNS.\n* Group -\u002F+ will receive ten minutes of sham tDCS followed by ten minutes of active VNS.\n* Group -\u002F- will receive ten minutes of sham tDCS followed by ten minutes of sham VNS.",[28],[253,254,255,256],"Postoperative pain","Chronic Pain","Transcranial direct current stimulation","Vagus nerve stimulation","2024-08-12",{"date":259,"type":39},"2024-08-14",{"date":261,"type":21},"2024-08",{"date":263,"type":21},"2026-08",{"name":265,"class":46},"Columbia University",{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":272,"enrollmentInfo":273,"targetDuration":4,"studyType":22,"phases":275,"briefSummary":276,"conditions":277,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":4},"100557183","sequential-method-determination-of-oxycodone-for-thoracoscope-surgery-median-effective-dose-of-acute-pain-treatment-100557183","NCT06534801","Sequential Method Determination of Oxycodone for Thoracoscope Surgery Median Effective Dose of Acute Pain Treatment","Inclusion Criteria:\n\n1. The first unilateral thoracoscopic lobectomy was performed under general anesthesia\n2. age 18- 80 years old\n3. American Society of Anesthesiologists (ASA) physical status I-III\n4. Sign the informed consent of the patients\n\nExclusion Criteria:\n\n1. Moderate to severe obesity (i.e., BMI \\> 30kg\u002Fm2)\n2. Allergic or hypersensitive reaction to oxycodon\n3. A history of chronic pain\n4. Patients with significant heart, pulmonary, liver or renal disease","80 Years",{"count":274,"type":21},60,[24],"The goal of this clinical trial is to measure the median effective dose of oxycodone for the treatment of acute pain after thoracoscopic lobectomy. This clinical trial was divided into two groups based on age, Group I (Age \\\u003C 65 years old) and Group II (Age ≥65 years old). We used the sequential allocation designed by Dixon. The initial oxycodone dose was set to 0.1 mg\u002Fkg.A satisfactory or an unsatisfactory analgesic response of the previous patient determined, respectively, the relative 10% decrease or increase in the dose of oxycodone the next patient received in the same group. The patient before the first crossover point was included as the first case for ED50 estimation in each group.The study was conducted until 7 crossover points were collected",[278,279,28],"Oxycodone","Thoracoscopic Lobectomy","2024-08-01",{"date":282,"type":39},"2024-08-02",{"date":284,"type":21},"2024-09-01",{"date":286,"type":21},"2026-04-01",{"name":288,"class":46},"Jianbo Wu",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":297,"targetDuration":4,"studyType":22,"phases":299,"briefSummary":300,"conditions":301,"keywords":302,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":73},"100522898","cryoneurolysis-for-acute-postoperative-pain-following-total-knee-arthroplasty-100522898","NCT06088602","Cryoneurolysis for Acute Postoperative Pain Following Total Knee Arthroplasty","The Effect of Cryoneurolysis for the Treatment of Acute Postoperative Pain Following Total Knee Arthroplasty in High Pain Responders - A Randomized, Participant- and Observer-masked, Sham-controlled Trial","CRISPP","Inclusion Criteria:\n\n* Age ≥ 18\n* Primary unilateral total knee arthroplasty\n* Ability to participate in the study (understand written and spoken Danish language, self-reported pain and satisfaction)\n* Signed written informed consent form\n* Pain (VAS 0-100 mm) ≥ 45 during a 5-meter walk test at 24 h (20-28h) postoperatively\n\nExclusion Criteria:\n\n* Ongoing treatment of systemic glucocorticoids or other immunosuppressant treatment apart from inhaled steroids\n* Insulin-dependent diabetes\n* Pregnancy or breastfeeding\n* Mental disability that could impair a patient's decision-making capability of giving informed consent and not enabling valid data collection.\n* Patients with known diagnoses of schizophrenia, ongoing psychosis, bipolar disease and\u002For a history of ongoing anti-psychotic treatment.\n* Patients with modulated pain-reception (experience) based on other diseases or injuries, e.g. spinal cord or brain injury, severe polyneuropathies or neurologic disorders.\n* Posttraumatic osteoarthritis as reason for total knee arthroplasty\n* Bleeding disorder\n* Localized infection in the treatment area\n* Cryoglobulinemia, cold urticaria, paroxysmal cold haemoglobinuria, or Raynaud's syndrome\n* Perioperative peripheral nerve block",{"count":298,"type":21},44,[24],"Cryoneurolysis is a regional anaesthetic technique that works by freezing peripheral sensory nerves. This technique can potentially provide analgesia after total knee arthroplasty (TKA). However, the technique is expensive and comprehensive. Pain 24 hours after surgery is associated with high amounts of late acute pain. Therefore, the aim of the current study was to compare the effect of postoperative cryoanalgesia with a sham treatment on acute postoperative pain in TKA patients with moderate to severe pain on the first postoperative day. The cryoanalgesia treatment will be performed 24 hours after surgery. Afterward, the patients will be followed for 24 weeks to determine the level of pain among other outcomes.",[28],[303,206,304],"Cryoanalgesia","Total knee arthroplasty","2024-07-12",{"date":307,"type":39},"2024-07-16",{"date":309,"type":39},"2024-03-19",{"date":311,"type":21},"2025-10",{"name":313,"class":46},"Copenhagen University Hospital, Hvidovre",{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":4,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":17,"minAge":321,"maxAge":4,"enrollmentInfo":322,"targetDuration":4,"studyType":224,"phases":4,"briefSummary":324,"conditions":325,"keywords":327,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":73},"100537703","a-study-of-the-association-between-frailty-and-acute-postoperative-pain-in-elderly-thoracoscopic-surgery-patients-100537703","NCT06281275","A Study of the Association Between Frailty and Acute Postoperative Pain in Elderly Thoracoscopic Surgery Patients","A Study on the Association Between Frailty and Acute Postoperative Pain in Elderly Patients Undergoing Thoracoscopic Surgery and an Investigation of the Mechanisms Involved","Inclusion Criteria:\n\n1. patients undergoing thoracic surgery under general anesthesia with 48 h of postoperative patient-controlled analgesia;\n2. age ≥60 years;\n3. ASA class I-III;\n4. signed informed consent;\n5. patients undergoing thoracoscopic surgery.\n\nExclusion Criteria:\n\n1. Patients who themselves refuse to participate in the study;\n2. Drug dependence;\n3. Patients who cannot cooperate with communication and have verbal communication difficulties;\n4. Patients who cannot assess frailty preoperatively and pain postoperatively;\n5. Failure to provide a compliant fecal sample at the agreed time;\n6. antibiotic treatment within the last month;\n7. intestinal dysfunction (e.g., irritable bowel syndrome, inflammatory bowel disease, chronic diarrhea, and other types of intestinal disorders);\n8. comorbidities of certain metabolic disorders (e.g., thyroid dysfunction, diabetes mellitus, and so on) that may affect the structure of the microbial community;","60 Years",{"count":323,"type":21},78,"To gain a clearer understanding of the association between frailty and postoperative acute pain in elderly thoracoscopic surgery patients and its underlying mechanisms, to provide new solution ideas to reduce the level of postoperative acute pain and improve the debilitating state of elderly thoracoscopic surgery patients, and consequently improve their quality of life and mental status.",[326,28],"Frailty",[326,28,328,329],"Gastrointestinal Microbiome","Thoracoscopy","2024-06-19",{"date":332,"type":39},"2024-06-21",{"date":334,"type":39},"2024-03-12",{"date":336,"type":21},"2024-10-30",{"name":338,"class":46},"Huazhong University of Science and Technology"]