[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-respiratory-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-respiratory-failure":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,40,0,25,[9,53,85,112,139,166,191,216,239,273,296,324,347,371,393,426,452,473,500,526,556,584,609,636,663],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100550030","simulation-trial-of-telemedical-support-for-paramedics-100550030",false,"NCT06441760","Simulation Trial of Telemedical Support for Paramedics","Efficacy of Teleconsultation to Improve Prehospital Patient Safety for Critically Ill Infants and Children - A Multicenter, Simulation-based Randomized Control Trial","R01","Inclusion Criteria:\n\n* Certified Emergency Medical Technicians (EMTs), Advanced EMTs (AEMTs), and Paramedics (EMT-Ps) who provide direct scene response.\n* Board-certified Pediatric Emergency Medicine (PEM) and Emergency Medicine (EM) physicians whose practice includes online medical support for EMS are eligible.\n* The control arm will include physicians who provide radio\u002Ftelephone support in usual care at each site. In the intervention arm, experts will be PEM with\u002Fwithout EMS board-certification as they have relevant pediatric training and experience.\n\nExclusion Criteria:\n\n* EMS personnel providing interfacility transport and\u002For pediatric specialty transport\n* Resident physicians-in-training\n* Non-physician providers","ALL","21 Years",{"count":21,"type":22},420,"ESTIMATED","INTERVENTIONAL",[25],"NA","In the United States, the current standard of prehospital (i.e. outside of hospitals) emergency care for children with life-threatening illnesses in the community includes remote physician support for paramedics providing life-saving therapy while transporting the child to the hospital. Most prehospital emergency medical services (EMS) agencies use radio-based (audio only) communication between paramedics and physicians to augment this care. However, this communication strategy is inherently limited as the remote physician cannot visualize the patient for accurate assessment and to direct treatment.\n\nThe purpose of this pilot randomized controlled trial (RCT) is to evaluate whether use of a 2-way audiovisual connection with a pediatric emergency medicine expert (intervention = \"telemedical support\") will improve the quality of care provided by paramedics to infant simulator mannequins with life threatening illness (respiratory failure). Paramedics receiving real-time telemedical support by a pediatric expert may provide better care due to decreased cognitive burden, critical action checking, protocol verification, and error correction. Because real pediatric life-threatening illnesses are rare, high stakes events and involve a vulnerable population (children), this RCT will test the effect of the intervention on paramedic performance in simulated cases of pediatric medical emergencies.\n\nThe two specific aims for this research are:\n\n* Aim 1: To test the intervention efficacy by determining if there is a measurable difference in the frequency of serious safety events between study groups\n* Aim 2: To compare two safety event detection methods, medical record review, and video review",[28,29,30,31],"Emergencies","Cardiopulmonary Arrest","Acute Respiratory Failure","Status Epilepticus",[33,34,35,36,37,38,39],"Prehospital emergency care","Emergency medical services (EMS)","Paramedics","Infant simulator mannequins","Telemedical support","Critically ill infants and children","Pediatric emergencies","RECRUITING","2026-06-29",{"date":43,"type":44},"2026-06-30","ACTUAL",{"date":46,"type":44},"2025-07-10",{"date":48,"type":22},"2028-12",{"name":50,"class":51},"Boston Medical Center","OTHER",9,{"id":54,"slug":55,"hasResults":12,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100530679","exhaled-breath-condensate-analysis-in-mechanically-ventilated-patients-100530679","NCT06189924","Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients","Proteomic Analysis of Exhaled Breath Condensate in Mechanically Ventilated Intensive Care Patients","Inclusion Criteria:\n\nIntensive care setting Mechanical ventilation Ventilator\u002Fventilator circuit technically suitable for sampling of exhaled breath condensate\n\nExclusion Criteria:\n\nMechanical ventilation challenging to the extent that the insertion of the sampling kit into the ventilator circuit would substantially increase the risk for respiratory deterioration","18 Years",{"count":62,"type":22},200,"OBSERVATIONAL","Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood.\n\nProteomic analysis of the exhaled breath condensate will be performed using mass spectrometry and in the blood sample, corresponding changes in the DNA, RNA, proteins, and metabolites will be studied. Resulting profiles will be correlated with routinely monitored parameters in order to identify patterns corresponding to various pathologies in order to enable their early detection.",[30,66],"Critical Illness",[68,69,70,71,72,73,74],"exhaled breath condensate","proteomics","genomics","mechanical ventilation","acute respiratory failure","lung injury","intensive care","2026-06-23",{"date":77,"type":44},"2026-06-25",{"date":79,"type":44},"2026-03-01",{"date":81,"type":22},"2029-12-31",{"name":83,"class":51},"The Institute of Molecular and Translational Medicine, Czech Republic",2,{"id":86,"slug":87,"hasResults":12,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":111},"100583868","phase-4-eduction-in-immunosuppressive-regimen-among-kidney-transplant-recipients-patients-admitted-to-the-intensive-care-unit-for-septic-shock-andor-acute-respiratory-failure-100583868","NCT06881927","Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and\u002For Acute Respiratory Failure","Reduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and\u002For Acute Respiratory Failure: a Multicenter, Open-label, Phase IIb Randomized Controlled Trial","REDIS","Inclusion Criteria:\n\n* \\- Adult patients, aged 18 years-old and over,\n* Kidney transplant recipients, with transplantation occurring more than 3 months prior to ICU admission\n* Patients admitted to the ICU in the setting of:\n\n  * Septic shock (sepsis requiring vasopressor support, with or without hyperlactatemia),\n  * And\u002For acute respiratory failure of presumed infectious origin (invasive or non-invasive ventilation, FiO2 greater than or equal to 50%),\n* Patients treated with at least an immunosuppressive bitherapy (including steroids, calcineurin inhibitors, mTOR inhibitors, azathioprine, or mycophenolate mofetil),\n* Patients affiliated with a social health insurance protection scheme,\n* Patients able of understanding the objectives and risks related to the research and providing a dated and signed informed consent. If patient is unable to consent: consent from relatives will be searched, and if absent, an emergency procedure will be process.\n* Women of childbearing potential, provided they have a negative blood pregnancy test on the day of the inclusion visit.\n\nExclusion Criteria:\n\n* Minor patients,\n* Patients unable to consent: under legal protection measures, patients deprived of liberty,\n* Kidney transplant recipients treated with Belatacept due to the persistent effect of Belatacept, it is not possible to modulate this treatment in a short term period,\n* Patients with severe chronic graft dysfunction (glomerular filtration rate \\\u003C 20 ml\u002Fmin\u002F1.73m² according to the CKD-EPI formula in the month prior to admission),\n* Transplant renal recipients who have already resumed RRT (hemodialysis or peritoneal dialysis),\n* Multi-organ transplant recipients,\n* Pregnant women",{"count":94,"type":22},212,[96],"PHASE4","Kidney transplantation is the treatment of choice for end-stage chronic kidney disease. Kidney transplantation is at the first rank of solid organ transplantation in France, with 3,376 grafts performed in 2022. Immunosuppressive therapy, required to prevent graft rejection, exposes graft recipients to complications related to decreased immunity, including opportunistic infections and neoplastic complications.\n\nAfter the earlt post-transplantation period, up to 10% of kidney transplant recipients will require admission to the intensive care unit (ICU). The main reasons for admission are septic shock and acute hypoxemic respiratory failure. ICU stay has a significant impact on these patients with a mortality rate reaching 40%, that remains increased even after ICU discharge. Furthermore, an impact on graft function has been demonstrated, with deterioration of graft function in 1\u002F3 of patients, and among those, up to one in two will require resumption of renal replacement therapy (RRT).\n\nAlthough the occurrence of septic shock or acute respiratory failure related to an infection is more common and severe, the optimal management strategy for immunosuppressors is not defined in kidney transplant recipients admitted to the ICU in those settings.\n\nMaintain a high level of immunosuppressive therapies may hinder the recovery from the acute critical condition. Furthermore, these treatments have a narrow therapeutic index; for instance, the management of calcineurin inhibitors is challenging in the ICU due to pharmacodynamic changes associated with the acute situation (distribution volume, organ failure) and the numerous potential drug interactions that carry inherent risks of overdose.\n\nthe investigators hypothesize that a reduction in the level of immunosuppressive treatments could promote recovery in kidney transplant recipients admitted to the ICU for septic shock and\u002For acute hypoxemic respiratory failure, without adversely affecting the risk of rejection or long-term renal prognosis.",[99,30,100,101],"Sepsis and Septic Shock","Kidney Transplant Recipients","Immunosuppressive Agents","2026-06-03",{"date":104,"type":44},"2026-06-05",{"date":106,"type":44},"2026-05-11",{"date":108,"type":22},"2029-06-01",{"name":110,"class":51},"University Hospital, Strasbourg, France",1,{"id":113,"slug":114,"hasResults":12,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":123,"briefSummary":124,"conditions":125,"keywords":126,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":111},"100633909","evaluation-of-perfusion-and-ventilation-distribution-in-children-a-pilot-study-100633909","NCT07532811","Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study.","Feasibility Study of the Evaluation of Perfusion and Ventilation Distribution in Children : a Pilot Study","PELUCHE 2","Inclusion Criteria:\n\n* patients \\\u003C 12 years hospitalized in pediatric intensive care\n* intubated, under conventional invasive mechanical ventilation and sedated\n* between 3 and 40 kg\n* with central venous access in the superior vena cava\n* consent signed by parents or legal guardians\n\nExclusion Criteria:\n\n* Patients with significant leaks \\> 20% around the endotracheal tube\n* Patients receiving spontaneous ventilation (inspiratory support, NIV, etc.)\n* Natremia \\> 150 mmol\u002FL at inclusion\n* Hyperchloremia ≥ 115 mmol\u002FL and\u002For hypokaliema ≤ 3 mmol\u002FL\n* Patients with intracranial hypertension\n* Patients with active bleeding or persistent hemodynamic instability despite amines\n* Patients with heart failure, uncorrected cyanotic heart disease, or a history of cardiac arrhythmia\n* Patients with contraindications to the use of the electrical impedance pulmonary tomography belt (skin lesions, burns, or recent thoracic surgery)\n* Conditions in which EIT data acquisition will be disrupted (chest dressings, pneumothorax, ECMO)\n* Patients with severe hypoxemia defined as FiO2 \\> 90% to maintain SpO2 \\> 88%\n* Individuals not affiliated with a social security system or beneficiaries of a similar system","12 Years",{"count":122,"type":22},20,[25],"Electrical impedance tomography (EIT) is a recent monitoring technique that provides information on regional ventilation distribution. Following the injection of a hypertonic saline bolus, EIT can also assess regional pulmonary perfusion distribution, allowing evaluation of the ventilation\u002Fperfusion (V\u002FQ) ratio.\n\nIn adults, protocols for assessing perfusion distribution require the injection of 10 mL of a 7.5% or 10% NaCl solution or sodium bicarbonate over a few seconds. Studies have reported good hemodynamic tolerance, adequate image quality, and no significant changes in serum sodium levels. However, this volume and sodium load are not appropriate for small children.\n\nTo date, no pediatric protocol exists for assessing pulmonary perfusion distribution and the ventilation\u002Fperfusion ratio using EIT. It is therefore proposed to conduct a pilot study to evaluate the feasibility of assessing pulmonary perfusion by EIT using a weight-adjusted bolus of hypertonic saline (NaCl or sodium bicarbonate).",[30],[127,128,129],"Electrical impedance tomography","Pediatric intensive care unit","Perfusion and ventilation distribution","2026-05-15",{"date":132,"type":44},"2026-05-19",{"date":134,"type":44},"2026-05-13",{"date":136,"type":22},"2028-08-13",{"name":138,"class":51},"Hospices Civils de Lyon",{"id":140,"slug":141,"hasResults":12,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":149,"conditions":150,"keywords":151,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":52},"100587937","waveform-capnography-compared-to-colorimetric-carbon-dioxide-detection-during-tracheal-intubation-of-critically-ill-adults-100587937","NCT06934876","Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults","Waveform Capnography and Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults","WAVE","Inclusion Criteria:\n\n1. Patient is located in a participating unit (ED or ICU)\n2. Patient is undergoing tracheal intubation.\n3. The clinician intends to use an exhaled CO2 detection device to confirm tracheal placement of the tube.\n\nExclusion Criteria:\n\n1. Patient is known to be a prisoner\n2. Patient is known to be \\\u003C 18 years old\n3. A responsible clinician has determined that sole use of either waveform capnography or colorimetric testing is required for optimal care of the patient.",{"count":148,"type":22},2092,"This study will compare the sensitivity and specificity of waveform capnography versus colorimetric carbon dioxide detection to identify tracheal placement of the endotracheal tube during intubation of critically ill adults.",[30],[152,153,154,155,156,157],"tracheal intubation","emergency intubation","waveform capnography","end-tidal CO2","exhaled carbon dioxide","colorimetric detection of exhaled carbon dioxide","2026-05-06",{"date":106,"type":44},{"date":161,"type":44},"2025-04-21",{"date":163,"type":22},"2027-01-01",{"name":165,"class":51},"Brian Driver",{"id":167,"slug":168,"hasResults":12,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":12,"sex":18,"minAge":174,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":181,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":52},"100603111","diaphragm-response-in-elderly-for-acute-monitoring-100603111","NCT07132268","Diaphragm Response in Elderly for Acute Monitoring","Using Diaphragmatic Ultrasound to Predict Acute Respiratory Distress (ARD) in Patients Aged 75 and Over Admitted to the Emergency Department for Acute Dyspnea : Prospective Multicenter Study.","DREAM","Inclusion Criteria:\n\n* Patients aged ≥ 75 years\n* Emergency admission for acute dyspnea\n* Requiring an emergency ultrsoung.\n\nExclusion Criteria:\n\n* Acute respiratory distress requiring immediate invasive or non-invasive ventilation\n* Respiratory rate ≥ 25 breaths\u002Fmin, and\u002For SpO2 ≤ 90% on room air, and\u002For PaO2 ≤ 60 mmHg\n* Known diaphragmatic paralysis\n* Patients with degenerative neuromuscular disease\n* State of shock: systolic blood pressure \\\u003C 90 mmHg and\u002For mean arterial pressure \\\u003C 65 mmHg and\u002For presence of skin mottling and\u002For CTR \\> 3s\n* Lactate levels \\> 2 mmol\u002FL\n* Hypercapnic respiratory acidosis (pH \\\u003C 7.38 and PaCO2 \\> 45 mmHg)\n* Dyspnea due to metabolic acidosis (e.g., diabetic ketoacidosis, renal failure)\n* Dyspnea of traumatic origin\n* Refusal to participate or inability to provide informed consent\n* Patients deprived of liberty\n* Patients under guardianship or curatorship","75 Years",{"count":176,"type":22},145,"Acute dyspnea is a common cause of emergency department admissions among elderly patients. Acute respiratory failure is often multifactorial and requires rapid and reliable evaluation. Currently, management relies on clinical, biological, and radiological assessments, but diaphragmatic ultrasound could provide an additional tool for real-time respiratory function evaluation. This study aims to integrate this non-invasive technology into the initial assessment of patients to improve care pathways. Hypothesis : Diaphragmatic ultrasound enables reliable assessment of respiratory function and can predict the need for mechanical ventilation.",[179,30,180],"Acute Dyspnea","Diaphragmatic Ultrasound","NOT_YET_RECRUITING","2026-05-05",{"date":158,"type":44},{"date":185,"type":22},"2026-06",{"date":187,"type":22},"2028-06",{"name":189,"class":190},"Centre Hospitalier de Bethune","NETWORK",{"id":192,"slug":193,"hasResults":12,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":200,"conditions":201,"keywords":202,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":84},"100614456","brain-lung-interaction-during-acute-respiratory-failure-100614456","NCT07279831","Brain-lung Interaction During Acute Respiratory Failure","Brain-lung Interactions in Patients Receiving High-flow Humidified Oxygen for de Novo Acute Hypoxemic Respiratory Failure","BrainFlow","Inclusion Criteria:\n\n* \\- Age ≥ 18 years\n* Admitted to the intensive care within the last 48 hours\n* De novo acute hypoxemic respiratory failure with an indication for high-flow nasal cannula (HFNC), defined by the combination of the following three criteria:\n\n  * Tachypnea \\> 25 breaths\u002Fmin or labored breathing\n  * PaO2 (partial pressure of oxygen ) \u002FFiO2 ( fraction of inspired oxygen ) ≤ 200 mmHg\n  * Unilateral or bilateral alveolar opacities on chest X-ray\n* Decision by the attending physician to initiate HFNC treatment\n* After information, the patient or next of kind did not refuse to participate (according to the French law, written informed consent is waived)\n\nExclusion Criteria:\n\n* \\- Exacerbation of an underlying chronic respiratory disease\n* Acute cardiogenic pulmonary edema indicating non-invasive ventilation (NIV)\n* Hypercapnia \\> 45 mmHg indicating NIV\n* Glasgow Coma Scale \\\u003C 13\n* Imminent intubation\n* Underlying central neurological disease likely to alter EEG signals\n* Pregnancy or breastfeeding\n* Lack of health insurance coverage\n* Patient under legal protection",{"count":7,"type":22},"Acute hypoxemic de novo respiratory failure (AHRF) is a common cause of admission to the intensive care unit (ICU). Its main cause is community-acquired pneumonia. Prevention of intubation relies, among other things, on high-flow nasal canulae (HFNC). However, approximately 40% of patients are intubated despite HFNC.\n\nOur team has developed measurements derived from electroencephalograms (EEG) and near-infrared spectroscopy (NIRS) that enable the study of brain-ventilation interactions. To date, these tools have been studied exclusively in intubated patients. the investigators now wish to study them in non-intubated patients.\n\nThe objective of this study is to investigate the relationship between the brain and lungs in adult patients admitted to the intensive care unit for acute hypoxemic respiratory failure and for whom the attending physician has decided to initiate HFNC.\n\nBefore and one hour after the introduction of HFNC, electroencephalogram (EEG), near-infrared spectroscopy (NIRS), and electromyogram (EMG) of the Scalen muscles will be collected.\n\nFrom these recordings, the following variables will be collected: 1) The density of the gamma (30-100 Hz), beta (13-30 Hz), alpha (8-12 Hz), theta (4-8 Hz), and delta (0.5-4 Hz) frequency spectrum of the EEG in each of the following right and left cortical regions: medial region of the prefrontal cortex, anterior region of the cingulate gyrus, posterior region of the cingulate gyrus, insula, somatosensory cortex, angular gyrus, lateral prefrontal cortex, and supplementary motor area; 2) Connectivity between these regions for each frequency spectrum; 3) Pre-inspiratory potential; 4) Rieman classifier; 5) Coherence and Granger causality between each frequency spectrum and the scalene muscles EMG.\n\nThese variables will be compared before and 1 hour after initiation of HFNC and between patients who will be intubated because of HFNC failure and those who will not.",[30],[203,204,205,206],"Acute respiratory failure","High flow nasal cannulae","Electroencephalogram","Near infrared spectroscopy","2026-04-27",{"date":209,"type":44},"2026-05-01",{"date":211,"type":44},"2026-04-22",{"date":213,"type":22},"2027-01-22",{"name":215,"class":51},"Assistance Publique - Hôpitaux de Paris",{"id":217,"slug":218,"hasResults":12,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":223,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":225,"conditions":226,"keywords":227,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":111},"100552925","a-clinical-study-for-developing-artificial-intelligenceai-based-clustering-model-for-personalized-medicine-in-acute-respiratory-failure-100552925","NCT06479421","A Clinical Study for Developing Artificial Intelligence(AI)-Based Clustering Model for Personalized Medicine in Acute Respiratory Failure","A Clinical Study for Developing AI-based Clustering Model for Personalized Medicine in Acute Respiratory Failure: Single Center, Prospective Cohort Study","\\# Inclusion Criteria:\n\n\\- Acute Respiratory Failure group\n\nAmong patients admitted to the internal medicine intensive care unit at Samsung Seoul Hospital, if all of the following conditions are met:\n\n1\\) Age 18 or older 2) Patients who require treatment with high flow nasal cannula (HFNC), non-invasive ventilation (NIV (BIPAP or CPAP)), or mechanical ventilation (MV) due to acute respiratory failure.\n\n\\- control group For comparative analysis, among patients admitted to the internal medicine intensive care unit at Samsung Seoul Hospital who meet all of the following conditions, they are registered as a control group with the consent of the subjects and undergo the same research procedure.\n\n1. Age 18 or older\n2. Patients who do not require high flow nasal cannula (HFNC), non-invasive ventilation (NIV (BIPAP or CPAP)), or mechanical ventilation (MV) treatment\n\n   * Exclusion Criteria:\n\nIf any of the following criteria applies, participants will not be permitted to participate in this clinical trial.\n\n1. Patients 48 hours after oxygen treatment (HFNC, NIV (BIPAP or CPAP), MV)\n2. Patients transferred from another hospital\n3. Patients with limitations in treatment",{"count":224,"type":22},250,"The investigators will prospectively collect clinical information to develop a clustering analysis model and confirm phenotype for patients with acute respiratory failure who admit to the intensive care unit and require oxygen supply beyond a high flow nasal cannula, and a control group without acute respiratory failure. and clinical characteristics and prognosis will be compared.",[30],[228,229],"phenotyping","clustering analysis","2026-04-23",{"date":232,"type":44},"2026-04-28",{"date":234,"type":44},"2023-08-14",{"date":236,"type":22},"2029-04-30",{"name":238,"class":51},"Samsung Medical Center",{"id":240,"slug":241,"hasResults":12,"nctId":242,"briefTitle":243,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":245,"targetDuration":247,"studyType":63,"phases":4,"briefSummary":248,"conditions":249,"keywords":253,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":111},"100634644","the-feasibility-of-pulmonary-perfusion-assessment-using-sodium-bicarbonate-contrast-with-electrical-impedance-tomography-a-prospective-pilot-study-100634644","NCT07542366","The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With Electrical Impedance Tomography: A Prospective Pilot Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Admitted to the intensive care unit (ICU)\n* Receiving invasive mechanical ventilation with controlled or assisted-controlled mode\n* Presence of a central venous catheter suitable for contrast bolus injection\n* Hemodynamically stable (no ongoing cardiopulmonary resuscitation; no uncontrolled shock judged by treating physician)\n* Expected to remain on mechanical ventilation for the duration of the EIT examination\n* Written informed consent obtained from the patient or legally authorized representative\n\nExclusion Criteria:\n\n* Known pregnancy\n* Known allergy, intolerance, or contraindication to sodium bicarbonate or hypertonic saline\n* Severe arrhythmia or unstable cardiovascular status in which small bolus injection is deemed unsafe by the treating physician\n* Uncontrolled agitation or conditions that preclude correct EIT belt placement (e.g., extensive chest wounds, large chest dressings, chest wall deformity that prevents belt use)\n* Implanted electronic devices or metallic implants in the thoracic area considered a contraindication to EIT by the manufacturer's instructions\n* End-stage disease with expected survival of only a few hours, in whom participation is not appropriate as judged by the treating physician\n* Participation in another interventional trial that, in the opinion of the investigator, could interfere with EIT measurements or safety assessment",{"count":246,"type":22},41,"28 Days","The goal of this observational pilot study is to learn if sodium bicarbonate can be used safely and effectively as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on mechanical ventilation. Electrical impedance tomography (EIT) is a bedside imaging method that uses a soft belt with small sensors around the chest to track changes in electrical signals related to breathing and blood flow.\n\nThe main questions are:\n\nDoes sodium bicarbonate create clear, readable lung blood flow images with EIT? Are these images similar in quality and pattern to images made with hypertonic saline (10% sodium chloride)? Is the short-term safety profile acceptable, including effects on blood pressure, heart rhythm, and blood tests?\n\nResearchers will compare two contrast agents within the same participant to see if image quality and lung blood flow patterns match:\n\nHypertonic saline (10% sodium chloride) Sodium bicarbonate (5%)\n\nParticipants will:\n\nHave an EIT belt placed around the chest during routine ICU care Pause the ventilator briefly during image capture to reduce motion Receive two small intravenous boluses through an existing central line, one of hypertonic saline and one of sodium bicarbonate, with time between doses Have routine monitoring of vital signs; blood gases and electrolytes may be checked per clinical care Be observed for any short-term side effects Findings from this study will show whether sodium bicarbonate is a practical and safe option for EIT-based lung blood flow assessment and will guide larger future studies.",[30,250,251,66,252],"Acute Respiratory Distress Syndrome (ARDS)","Pneumonia","Feasibility of Contrast-enhanced Electrical Impedance Tomography (EIT) for Pulmonary Perfusion Assessment in Mechanically Ventilated Adults",[254,255,256,257,258,259,260,261,262,263],"Electrical Impedance Tomography (EIT)","Pulmonary Perfusion","Contrast-Enhanced EIT","Sodium Bicarbonate Contrast","Hypertonic Saline (10% NaCl)","First-Pass Impedance Signal","Mechanical Ventilation","Intensive Care Unit (ICU)","Ventilation-Perfusion (V\u002FQ) Matching","Feasibility Study","2026-04-14",{"date":266,"type":44},"2026-04-21",{"date":268,"type":44},"2024-09-26",{"date":270,"type":22},"2026-09-25",{"name":272,"class":51},"First Affiliated Hospital of Wannan Medical College",{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":279,"targetDuration":4,"studyType":23,"phases":281,"briefSummary":282,"conditions":283,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":111},"100605875","comparison-of-two-spo2-targets-with-two-different-oximeters---impact-on-fio2-during-nasal-high-flow-oxygen-therapy-100605875","NCT07168213","Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy","Inclusion Criteria:\n\n* ≥ 18 years of age\n* Admiitted in intensive care unit\n* Presence of an arterial catheter\n* Ongoing on high flow nasal oxygen therapy with SpO2 between 88 and 100% with a FiO2 between 40 and 80% with the usual oximeter .\n\nExclusion Criteria:\n\n* No SpO2 signal with oximeter in use\n* False nails or nail polish\n* Methemoglobinemia \\>0.015 on last available arterial gas\n* Patient in isolation (multi-resistant bacteria, C-Difficile, SARS-CoV-2 ...)\n* Expected to use another respiratory support within two hour of inclusion (NIV or mechanical ventilation)",{"count":280,"type":22},30,[25],"Several factors can influence oxygenation monitoring and respiratory support through oxygen therapy: the type of oximeter used, skin pigmentation, and the oxygenation target. It is essential to have an accurate measurement of SpO2 in order to optimize the flow of oxygen or FiO2 administered to patients. The question arises as to the impact of these confounding factors on the FiO2 set during high-flow nasal oxygen therapy. The aim of the study is to evaluate the impact of the oxygenation target and the oximeter used on FiO2 in patients receiving high-flow nasal oxygen therapy.",[284,30,285,286],"Oxygen Delivery","High Flow Oxygen Therapy","Hypoxemic Acute Respiratory Failure","2026-03-05",{"date":289,"type":44},"2026-03-09",{"date":291,"type":44},"2025-10-21",{"date":293,"type":22},"2027-12",{"name":295,"class":51},"Laval University",{"id":297,"slug":298,"hasResults":12,"nctId":299,"briefTitle":300,"officialTitle":300,"acronym":301,"eligibilityCriteria":302,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":305,"conditions":306,"keywords":309,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":111},"100546920","investigating-dyadic-expectations-about-arf-survivorship-ideas-100546920","NCT06401239","Investigating Dyadic Expectations About ARF Survivorship (IDEAS)","IDEAS","Patient Inclusion Criteria:\n\n* ≥18 years old\n* Meets study definition of ARF:\n\n  * The study defines ARF as meeting 1 of the following 3:\n\n    1. Mechanical ventilation via an endotracheal tube ≥24 consecutive hours OR\n    2. Non-invasive ventilation (CPAP, BiPAP) ≥24 consecutive hours that is not for obstructive sleep apnea or other stable use OR\n    3. High flow nasal cannula with fraction of inspired oxygen (FIO2)≥.5 and flow rate ≥ litres per minute (LPM) for ≥24 consecutive hours.\n  * Occasional rest periods of ≤1 hour are not deducted from the calculation of consecutive hours. Patients who are intubated for mental status or airway obstruction are not eligible unless they have simultaneous ARF.\n* Survival to hospital discharge to home\n* Speaks or reads English or Spanish\n* Identifies an adult who is expected to act as a primary care partner for at least the next 6 months.\n\nPatient Exclusion Criteria:\n\n* Pre-existing cognitive impairment (IQ-CODE \\>3.6)\n* Residing in a medical institution at hospital discharge\n* Receiving hospice care or life expectancy \\\u003C6 months\n* Homelessness or recent history of psychosis\n\nCare Partner Inclusion Criteria:\n\n* ≥18 years old\n* Speaks or reads English or Spanish\n\nCare Partner Exclusion Criteria:\n\n* Pre-existing cognitive impairment (IQ-CODE \\>3.6)",{"count":304,"type":22},235,"The purpose of this observational study is to understand how adults who survive acute respiratory failure (ARF) and the people (usually family) who support ARF survivors after returning home think about the first 6 months of recovery. The study aims to find out if expectations about the recovery process after ARF are associated with mental health symptoms in both survivors and the survivor's care partners. Study participants will complete 3 surveys over 6 months. These surveys ask questions about participants' future expectations, feelings, and mood. Surveys can be completed online, over the phone, or on paper.",[30,307,308],"Caregiving Stress","Mental Health Issue",[310,311,312,313,314],"ARF survivor","Caregiver","ICU recovery","Dyadic coping","Dyadic self-efficacy","2026-02-03",{"date":317,"type":44},"2026-02-05",{"date":319,"type":44},"2024-07-23",{"date":321,"type":22},"2027-07",{"name":323,"class":51},"Johns Hopkins University",{"id":325,"slug":326,"hasResults":12,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":330,"eligibilityCriteria":331,"healthyVolunteers":12,"sex":18,"minAge":332,"maxAge":60,"enrollmentInfo":333,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":334,"conditions":335,"keywords":336,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":346},"100465964","study-on-ventilation-distribution-with-electrical-impedance-tomography-for-paediatric-respiratory-failure-100465964","NCT05347563","Study on Ventilation Distribution With Electrical Impedance Tomography for Paediatric Respiratory Failure","Study on Ventilation Distribution With Electrical Impedance Tomography for Paediatric Respiratory Failure: Impact of Intervention","PELUCHE1","Inclusion Criteria:\n\nGroupe A\n\n* children \\\u003C 18 years\n* Admitted to the PICU with acute respiratory failure\n* Monitoring with EIT\n* non opposition of parents or legal representative Groupe B\n* children \\\u003C 18 years\n* With general anesthesia and mechanical ventilation\n* Monitoring with EIT\n* non opposition of parents or legal representative\n\nExclusion Criteria:\n\n* Monitor not available\n* contra indication to the use of thoracic belt\n* Intraoperative period with use of electrocautery\n* Child not affiliated to a social security system and under protective measures legal","0 Years",{"count":224,"type":22},"Electrical impedance tomography (EIT) is a non-invasive, bedside monitoring technique that provides continuous, real-time information about the regional distribution of the ventilation.\n\nThere are very few data in children admitted to the PICU (pediatric intensive care unit) and the aim of the study is to describe the distribution of the ventilation in children with acute respiratory failure and to study the impact of the interventions in the PICU (change in ventilatory settings, change in position, suction, respiratory kinesiotherapy,…)",[30],[127,337,128],"Children","2026-01-21",{"date":340,"type":44},"2026-01-23",{"date":342,"type":44},"2022-06-18",{"date":344,"type":22},"2027-06",{"name":138,"class":51},4,{"id":348,"slug":349,"hasResults":12,"nctId":350,"briefTitle":351,"officialTitle":351,"acronym":352,"eligibilityCriteria":353,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":354,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":356,"conditions":357,"keywords":358,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":111},"100592127","coraline---correlation-between-physiological-and-clinical-variables-and-failure-of-non-invasive-respiratory-support-in-patients-with-acute-respiratory-failure-100592127","NCT06989385","CORALINE - Correlation Between Physiological and Clinical Variables and Failure of Non-Invasive Respiratory Support in Patients With Acute Respiratory Failure","CORALINE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Hospitalization in the Respiratory Medicine Unit at AOU Policlinico di Modena\n* Acute respiratory failure (hypoxemic and\u002For hypercapnic) with PaO₂\u002FFiO₂ \\\u003C 300 mmHg\n* Undergoing treatment with HFNO or NIV\n\nExclusion Criteria:\n\n* Immediate need for invasive ventilation upon admission\n* Known neuromuscular disease\n* Pregnancy\n* Lack of informed consent",{"count":355,"type":22},325,"This observational study aims to evaluate the relationship between clinical and physiological variables and the failure of non-invasive respiratory support (NIRS), including high-flow nasal oxygen (HFNO) and non-invasive ventilation (NIV), in patients with acute respiratory failure (ARF), both hypoxemic and\u002For hypercapnic. The study includes both retrospective and prospective components. Retrospective data will be collected from patient charts, while prospective data will be collected at defined time points during clinical care. The primary outcome is NIRS failure, defined as the need for orotracheal intubation. Secondary outcomes include in-hospital and 90-day mortality, ICU and hospital length of stay, and duration of non-invasive and invasive support.",[30],[203,359,360,361],"High flow nasal cannula","Non-invasive ventilation","Inspiratory effort","2026-01-19",{"date":364,"type":44},"2026-01-22",{"date":366,"type":44},"2024-11-01",{"date":368,"type":22},"2030-01-01",{"name":370,"class":51},"University of Modena and Reggio Emilia",{"id":372,"slug":373,"hasResults":12,"nctId":374,"briefTitle":375,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":377,"targetDuration":4,"studyType":23,"phases":379,"briefSummary":382,"conditions":383,"keywords":4,"overallStatus":181,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":4},"100620462","phase-1-early-inflammatory-immune-stratification-and-precision-glucocorticoid-intervention-in-acute-respiratory-failure-induced-by-community-acquired-pneumonia-100620462","NCT07357935","Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia","Inclusion Criteria:1. Age ≥ 18 years. 2. Admitted to the Intensive Care Unit (ICU) within 48 hours. 3. Meet diagnostic criteria for bacterial community-acquired pneumonia (CAP). 4. Meet at least one severity criterion: a) Receiving mechanical ventilation for acute respiratory failure with PEEP ≥ 5 cmH2O; OR b) On high-flow oxygen with FiO2 ≥ 0.5 and PaO2\u002FFiO2 ratio ≤ 250 mmHg; OR c) On a reservoir oxygen mask with PaO2 below the specified flow threshold (see protocol). 5. Signed informed consent.\n\n\\-\n\nExclusion Criteria: 1. Suspected aspiration pneumonia. 2. Invasive mechanical ventilation within 14 days prior to admission. 3. Diagnosis of hospital-acquired or ventilator-associated pneumonia (HAP\u002FVAP). 4. Positive for influenza virus, active tuberculosis, or fungal infection (except Pneumocystis jirovecii). 5. Active viral hepatitis or herpesvirus infection. 6. Hypersensitivity to glucocorticoids, or contraindications as judged by the investigator (e.g., severe concurrent infections, active gastrointestinal hemorrhage). 7. High-dose glucocorticoid therapy (\\>1 mg\u002Fkg\u002Fday prednisone equivalent) within 30 days for underlying disease. 8. Death within 24 hours of ICU admission. 9. Pregnancy or lactation. 10. Participation in other interventional studies or refusal to participate.\n\n\\-",{"count":378,"type":22},500,[380,381],"PHASE1","PHASE2","This is a prospective, multicenter, interventional cohort study aimed at constructing a high-quality, dynamic multimodal database for patients with acute respiratory failure caused by community-acquired pneumonia (CAP-ARF). The study focuses on bacterial CAP-ARF patients receiving standardized glucocorticoid therapy to investigate the heterogeneity of treatment responses under different etiologies and immune statuses. The goal is to provide a data foundation for precise immune stratification and identification of glucocorticoid-sensitive populations.",[30,384],"Community-Acquired Pneumonia","2026-01-14",{"date":364,"type":44},{"date":388,"type":22},"2026-02-01",{"date":390,"type":22},"2028-10-01",{"name":392,"class":51},"Qingyuan Zhan",{"id":394,"slug":395,"hasResults":12,"nctId":396,"briefTitle":397,"officialTitle":397,"acronym":4,"eligibilityCriteria":398,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":399,"enrollmentInfo":400,"targetDuration":402,"studyType":63,"phases":4,"briefSummary":403,"conditions":404,"keywords":415,"overallStatus":181,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":422,"leadSponsor":424,"locationsCount":4},"100619962","the-caribbean-registry-of-extracorporeal-membrane-oxygenation-ecmo-from-the-university-hospital-in-martinique-100619962","NCT07351435","The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique","Inclusion Criteria:\n\n* All consecutive patients implanted with a veno-venous extracorporeal membrane oxygenation device or extracorporeal membrane oxygenation device by the HeartTeam from the University Hospital of Martinique (UHM) from January 2010\n\nExclusion Criteria:\n\n* Patients with incomplete data (primary endpoint and less than 80% secondary study outcomes)","90 Years",{"count":401,"type":22},1200,"1 Year","The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana. All patients undergoing ECMO implantation will be prospectively registered.",[405,406,407,408,409,410,411,412,413,414,30],"Cardiogenic Shock","Malignant Arrhythmias","Ischemic or Valvular Heart Failure","Drepanocytosis and Thoracic Syndrome","Pulmonary Thromboembolisms","Sepsis","ARDS (Acute Respiratory Distress Syndrome)","Intoxication","Cardiac Arrest (CA)","Postcardiotomy Heart Failure",[416,417],"acute heart failure","respiratory insufficiency","2026-01-09",{"date":420,"type":44},"2026-01-20",{"date":388,"type":22},{"date":423,"type":22},"2033-06-30",{"name":425,"class":51},"University of Genova",{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":433,"targetDuration":4,"studyType":23,"phases":434,"briefSummary":435,"conditions":436,"keywords":438,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":84},"100589315","validation-study-of-the-emily-ai-device-in-acute-and-chronic-respiratory-failure-100589315","NCT06952816","Validation Study of the EMILY AI Device in Acute and Chronic Respiratory Failure","Functional, Clinical, and Predictive Validation Study of the EMILY AI Device in Patients With Acute and Chronic Respiratory Failure","Inclusion Criteria:\n\n* Men and women over 18 years of age.\n* Admitted to intermediate respiratory care unit with a diagnosis of acute respiratory failure for at least 8 hours.\n* Informed consent understood and signed.\n\nExclusion Criteria:\n\n* Hemodynamic instability.\n* Severe temperature changes.\n* Hemoglobinopathies, severe anemia, severe acidosis, or severe alkalosis.\n* Anatomical disturbances.\n* Pregnancy or breastfeeding.",{"count":122,"type":22},[25],"Currently, there is no holistic solution for patients with respiratory diseases that includes oxygenation and management of a patient with respiratory disease, combining dynamic and automatic O2 administration and the detection of clinical worsening, generating a diagnostic suspicion, a management proposal, and notifying the medical team.\n\nFor device validation, prospective studies will be conducted in patients in respiratory intermediate care units, conventional hospitalization, during physical activity in the hospital setting, and in an out-of-hospital setting. The device will be evaluated in terms of oxygenation efficacy, response time, patient safety, efficiency, versatility, clinical benefit, and adaptability.",[437,30],"Chronic Respiratory Failure",[439,440,441,442],"Respiratory failure","Hypoxia","Hyperxia","Oxigenotherapy","2026-01-08",{"date":418,"type":44},{"date":446,"type":44},"2025-04-23",{"date":448,"type":22},"2026-12-30",{"name":450,"class":451},"Aether Tech S.L.","INDUSTRY",{"id":453,"slug":454,"hasResults":12,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":460,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":461,"conditions":462,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":467,"completionDateStruct":469,"leadSponsor":471,"locationsCount":111},"100617927","acute-dyspnea-in-the-emergency-department-diagnostic-value-of-point-of-care-ultrasound-100617927","NCT07324980","Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound","Acute Dyspnea in the Emergency Department: Diagnostic Evaluation of Inferior Vena Cava Ultrasound Integrated With Multimodal Point-of-Care Ultrasound and Clinical Data","DYSP-ED-US","Inclusion Criteria:\n\n* Adults aged ≥18 years.\n* Presentation to the emergency department with acute dyspnea and acute respiratory failure, defined by at least one of the following:\n\n  * PaO₂ \\\u003C 60 mmHg on room air, or\n  * Oxygen saturation (SpO₂) \\\u003C 90% on room air, or\n  * PaO₂\u002FFiO₂ ratio \\\u003C 300.\n* Ability to provide written informed consent or eligibility for deferred consent according to local regulations.\n* Undergoing standard diagnostic evaluation including laboratory tests and chest imaging as part of routine clinical care.\n\nExclusion Criteria:\n\n* Refusal to provide informed consent (or consent by legal representative when applicable).\n* Inadequate ultrasound window or technically insufficient ultrasound assessment.\n* Acute respiratory failure secondary to chest trauma.\n* Cardiac arrest at presentation or during emergency department stabilization.\n* Requirement for invasive mechanical ventilation during initial stabilization in the emergency department.",{"count":62,"type":22},"Acute dyspnea is a common reason for emergency department (ED) admission and is frequently caused by acute heart failure with pulmonary edema. Rapid differentiation between cardiogenic and non-cardiogenic causes of dyspnea is essential to guide early treatment and risk stratification. However, no single gold standard exists for the assessment of venous congestion in the acute setting.\n\nThis prospective observational study aims to evaluate the diagnostic accuracy of respiratory variation in inferior vena cava (IVC) diameter measured by point-of-care ultrasound (POCUS) in identifying acute pulmonary edema in patients presenting to the ED with acute respiratory failure. In addition, the study investigates whether integration of IVC ultrasound with lung ultrasound, bedside cardiac ultrasound, and selected clinical and laboratory variables - such as hemoglobin and plasma protein changes - improves diagnostic performance and prognostic stratification.",[463,30,464],"Hydrostatic Pulmonary Edema","Dyspnea","2025-12-23",{"date":443,"type":44},{"date":468,"type":44},"2025-11-01",{"date":470,"type":22},"2028-11",{"name":472,"class":51},"Università degli Studi del Piemonte Orientale Amedeo Avogadro",{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":477,"acronym":478,"eligibilityCriteria":479,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":480,"enrollmentInfo":481,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":482,"conditions":483,"keywords":487,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":491,"lastUpdatePostDateStruct":492,"startDateStruct":494,"completionDateStruct":496,"leadSponsor":498,"locationsCount":84},"100573765","evaluating-the-safety-and-performance-of-the-minilung-petite-kit-in-neonatal-and-pediatric-patients-with-acute-respiratory-and-cardiac-failure-100573765","NCT06750536","Evaluating the Safety and Performance of the MiniLung Petite Kit in Neonatal and Pediatric Patients With Acute Respiratory and Cardiac Failure","PETIT","Inclusion criteria\n\n* Informed consent signed and dated by parents or legal representative and investigator\u002Fauthorized physician\n* Patients ≥2- ≤8 kg bodyweight to be treated with the MiniLung petite kit\n* Acute severe respiratory and\u002For cardiopulmonary failure with an ECMO indication\n\nExclusion criteria:\n\n* Participation in an interventional clinical study during the preceding 30 days that could interfere with the ECLS therapy\n* Previous participation in the same study\n* Prematurity (\\\u003C34 weeks gestational age)\n* Hypersensitivity to heparin or known history of heparin induced thrombocytopenia (HIT)\n* Impossibility of systemic anticoagulation","8 Months",{"count":122,"type":22},"This prospective observational study will evaluate the safety and performance of the MiniLung petite kit in neonatal and pediatric patients with acute respiratory and cardiac failure.\n\nThe main question it aims to answer is (study hypotheses):\n\nVeno-venous (VV) and veno-arterial (VA) Extracorporeal Membrane Oxygenation (ECMO) using the MiniLung petite kit is safe and improves gas exchange (oxygenation and CO2 removal) and hemodynamic stabilization in neonatal and pediatric patients with severe acute respiratory and\u002For cardiopulmonary failure within 24 hours compared to the treatment before VV or VA ECMO initiation and maintain a life-sustaining condition.",[484,485,30,486],"Extracorporeal Membrane Oxygenation Complication","Neonatal Aspiration Pneumonia","Acute Lung Injury",[488,489,490],"Extracorporeal Membrane Oxygenation","Neonatal and pediatric patients","MiniLung petite kit","2025-12-18",{"date":493,"type":44},"2025-12-24",{"date":495,"type":44},"2025-10-12",{"date":497,"type":22},"2026-12",{"name":499,"class":451},"Xenios AG",{"id":501,"slug":502,"hasResults":12,"nctId":503,"briefTitle":504,"officialTitle":505,"acronym":506,"eligibilityCriteria":507,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":508,"enrollmentInfo":509,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":511,"conditions":512,"keywords":513,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":111},"100583426","virtual-reality-in-icu---partner-100583426","NCT06876168","Virtual Reality in ICU - PARTNER","Virtual Reality in ICU (PARTNER) - A Research Study About Engaging in Strategies to Promote Relaxation, Improve Your Mood, and Stimulate Thinking in the Intensive Care Setting","VR-PARTNER","Inclusion Criteria:\n\n* Admitted to ICU at University of Kentucky for acute respiratory failure, sepsis or other\n\nExclusion Criteria:\n\n* Are less than 18 years of age\n* Have a pre-existing neurologic disorder\n* Have a pre-existing emotional or personality disorder\n* Have a history or active mental health disorder or disease\n* Experienced an acute neurologic event (e.g., stroke)\n* Are currently pregnant\n* Are a prisoner\n* Receiving hospice care\n* Have existing open wounds or pressure ulcers on head or neck","99 Years",{"count":510,"type":22},32,"This project is designed to have patients participate in a virtual environment with various tasks such as breathing exercises, games to help the brain, and techniques that promote relaxation while hospitalized in the Intensive Care Unit (ICU). The participation in research will last about 5 days and take about 15 to 45 minutes each day.",[30,410],[514,515,516,72],"virtual reality","intensive care unit","sepsis","2025-09-29",{"date":519,"type":44},"2025-10-03",{"date":521,"type":44},"2025-07-02",{"date":523,"type":22},"2026-09-30",{"name":525,"class":51},"Kirby Mayer",{"id":527,"slug":528,"hasResults":12,"nctId":529,"briefTitle":530,"officialTitle":531,"acronym":532,"eligibilityCriteria":533,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":399,"enrollmentInfo":534,"targetDuration":4,"studyType":23,"phases":536,"briefSummary":537,"conditions":538,"keywords":543,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":547,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":553,"locationsCount":555},"100540889","hyperangulated-vs-macintosh-blades-for-intubation-with-videolaryngoscopy-in-icu-100540889","NCT06322719","Hyperangulated vs Macintosh Blades for Intubation With Videolaryngoscopy in ICU","A Randomized Comparison Between the Hyperangulated vs. Macintosh Blades for First-attempt Intubation Success With Videolaryngoscopy in ICU Patients.","INVIBLADE","Inclusion Criteria:\n\n* Age 18 years or older.\n* Admitted to an Intensive Care Unit.\n* Need for tracheal intubation during the stay in the ICU.\n* The device to be used for intubation is a videolaryngoscope\n\nExclusion Criteria:\n\n* Pregnancy or lactation.\n* Emergent tracheal intubation that does not allow for the randomization of the procedure.\n* Need for tracheal intubation with a device other than the videolaryngoscope (fiberoptic bronchoscope, direct laryngoscopy, tracheostomy, etc.).\n* Tracheal intubation performed outside the ICU (Emergency Department, Hospital ward, etc.).",{"count":535,"type":22},1036,[25],"Tracheal intubation in the intensive care unit (ICU) is associated with high incidence of difficult intubation and complications. Videolaryngoscopes (VLs) devices have been proposed to improve airway management, and the use of VLs are recommended as first-line or after a first-attempt failure using direct laryngoscopy in ICU airway management algorithms. Although until relatively few years ago there were doubts about whether videolaryngoscopes had advantages over direct laryngoscopy for endotracheal intubation (ETI) in critically ill patients, two recent studies (DEVICE (1), INTUBATE (2)), and a Cochrane review (3) have confirmed that videolaryn should be used?, and what is the best blade? . There are two types of blades commonly used with videolaryngoscopes: the \"Macintosh\" blade with a slight curvature, and hyperangulated blades. The \"Macintosh\" blades have a lower angle of vision, but they have the advantage of being similar to the blades commonly used in direct laryngoscopy, making them easy to use for the person performing the ETI. Hyperangulated blades have a greater angle of vision, improving glottic visualization, especially in patients with an anterior glottis. However, the need to overcome this angulation could potentially hinder the passage of the endotracheal tube to the vocal cords. It is unknown if either blade has any advantage for intubating critically ill patients.",[30,539,540,541,542],"Intubation","Intubation; Difficult or Failed","Videolaryngoscopy","Intubation Complication",[544,152,545],"videolaryngoscopy","complication","2025-09-09",{"date":548,"type":44},"2025-09-15",{"date":550,"type":44},"2024-05-01",{"date":552,"type":22},"2026-06-01",{"name":554,"class":51},"Hospital Clinico Universitario de Santiago",29,{"id":557,"slug":558,"hasResults":12,"nctId":559,"briefTitle":560,"officialTitle":561,"acronym":562,"eligibilityCriteria":563,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":564,"targetDuration":4,"studyType":23,"phases":566,"briefSummary":567,"conditions":568,"keywords":571,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":574,"lastUpdatePostDateStruct":575,"startDateStruct":577,"completionDateStruct":579,"leadSponsor":581,"locationsCount":583},"100540625","phase-2-infusion-of-prostacyclin-vs-placebo-for-72-hours-in-mechanically-ventilated-patients-with-acute-respiratory-failure-100540625","NCT06319274","Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure","Efficacy and Safety of 72-hour Infusion of Prostacyclin (1 ng\u002Fkg\u002FMin) in Mechanically Ventilated Patients With Infectious Pulmonary Endotheliopathy - a Multicenter Randomized, Placebo-controlled, Blinded, Investigator-initiated Trial","COMBAT-ARF","Inclusion Criteria:\n\n* Adult intensive care patients (age ≥ 18 years)\n* Suspected pulmonary infection\n* Need for mechanical ventilation (\\\u003C 24 hours from time of screening)\n* soluble thrombomodulin (sTM) ≥ 4 ng\u002FmL in blood plasma\n\nExclusion Criteria:\n\n* Withdrawal from active therapy\n* Pregnancy (non-pregnancy confirmed by patient having a negative urine- or plasma Choriogonadotropin (hCG) or being postmenopausal defined as females at 60 years old or beyond or at the investigators discretion)\n* Septic shock according to the Sepsis 3 criteria AND a sTM\\> 10 ng\u002Fml\n* Known hypersensitivity to iloprost or to any of the other ingredients.\n* Previously included in this trial or a prostacyclin trial within 30 days\n* Life-threatening bleeding defined by the treating physician\n* Known severe heart failure (NYHA class IV)\n* Suspected acute coronary syndrome",{"count":565,"type":22},450,[381],"The purpose of this clinical trial is to investigate the efficacy and safety of continuous intravenous administration of low dose iloprost versus placebo for 72-hours, in 450 mechanically ventilated patients with infectious respiratory failure. The study hypothesis is that iloprost may be beneficial as an endothelial rescue treatment as it is anticipated to deactivate the endothelium and restore vascular integrity in patients suffering from respiratory failure caused by endothelial breakdown, ultimately improving survival.",[30,569,570],"Endothelial Dysfunction","Pulmonary Infection",[572,573],"Endotheliopathy","SHINE","2025-08-18",{"date":576,"type":44},"2025-08-22",{"date":578,"type":44},"2024-04-15",{"date":580,"type":22},"2027-09-30",{"name":582,"class":51},"Pär Johansson",5,{"id":585,"slug":586,"hasResults":12,"nctId":587,"briefTitle":588,"officialTitle":589,"acronym":4,"eligibilityCriteria":590,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":591,"targetDuration":4,"studyType":23,"phases":593,"briefSummary":594,"conditions":595,"keywords":596,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":600,"lastUpdatePostDateStruct":601,"startDateStruct":603,"completionDateStruct":605,"leadSponsor":607,"locationsCount":346},"100586206","continous-positive-airway-pressure-cpap-support-for-acute-hypoxemic-respiratory-failure-in-burkina-faso-100586206","NCT06912360","Continous Positive Airway Pressure (CPAP) Support for Acute Hypoxemic Respiratory Failure in Burkina Faso","Use of (Continous Positive Airway Pressure) CPAP in the Management of Acute Hypoxemic Respiratory Failure","Inclusion Criteria:\n\nAll patients aged 18 years and older will be included in the study if they meet at least one of the following criteria :\n\n* Acute respiratory distress, defined as dyspnea respiratory rate ≥ 25 cycles\u002Fmin\n* Hypoxemia, defined as the need for more 6 liters of oxygen to maintain an oxygen saturation (SpO2) of ≥ 92%. The fraction of inspired oxygen (FiO2) will be estimated using the 3% rule.\n\nExclusion Criteria:\n\nPatients with any of the following criteria will not be included in the study:\n\n* Pregnant or breastfeeding women\n* Persons deprived of their liberty\n* Exacerbation of asthma, chronic obstructive pulmonary disease, or another chronic respiratory disease\n* Moderate to large amount of unilateral or bilateral undrained pleural effusion\n* Contraindication to CPAP: patient refusal, undrained pneumothorax, chest injury, repeated or large vomiting, upper gastrointestinal bleeding, craniofacial trauma, severe upper airway obstruction, or tetraplegia in the initial phase\n* Cardiac arrest, severe arrhythmias, shock requiring the use of vasopressors (norepinephrine, adrenaline, dopamine)\n* Altered level of consciousness (Glasgow Coma Scale score \\\u003C 13), repeated seizures, or status epilepticus\n* Medical decision to limit treatment: no intubation, no admission to intensive care\n* Refusal to participate in the study or participation in another interventional study on respiratory distress or acute respiratory failure.",{"count":592,"type":22},240,[25],"Acute respiratory failure (ARF) is a frequent medical emergency, involving high costs for health organizations and patients who often require intensive care and respiratory assistance. According to an international study, 61% of hypoxemic patients in intensive care receive invasive ventilation \\[3\\]. Invasive mechanical ventilation is often unavailable in low-income countries and non-invasive ventilatory supports such as continuous positive airway pressure (CPAP) and high-flow oxygen therapy (HFO) were very useful during the COVID-19 pandemic. They reduced the rate of intubation and ICU admissions. In addition, CPAP can be used without a ventilator, no electricity is required. So, it could be a support of choice in low-income countries.\n\nUsed of Boussignac-type CPAP could potentially reduce the recourse to intubation in patients with acute hypoxemic respiratory failure in a context where access to invasive ventilation remains very limited.",[30],[597,598,599],"CPAP","Acute hypoxemic respiratory failure","Africa","2025-07-23",{"date":602,"type":44},"2025-07-28",{"date":604,"type":44},"2025-07-09",{"date":606,"type":22},"2026-02-20",{"name":608,"class":51},"Université NAZI BONI",{"id":610,"slug":611,"hasResults":12,"nctId":612,"briefTitle":613,"officialTitle":614,"acronym":615,"eligibilityCriteria":616,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":617,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":618,"conditions":619,"keywords":622,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":627,"lastUpdatePostDateStruct":628,"startDateStruct":630,"completionDateStruct":632,"leadSponsor":634,"locationsCount":111},"100567524","external-validation-of-the-bref-models-100567524","NCT06669312","External Validation of the BREF Models","External Validation of the BREF Models for Estimating the Breathing Effort During High-flow Oxygen Therapy","BREF2","Inclusion criteria:\n\n* adult (≥18 years of age) patients in the ICU\n* treated with high-flow oxygen delivered via nasal cannula\n* equipped with an esophageal balloon as per local clinical practice.\n\nExclusion criteria:\n\n* history of chronic lung disease\n* cardiogenic pulmonary edema\n* \\>96 hours from admission to the participating unit.",{"count":224,"type":22},"Introduction High-flow oxygen therapy is increasingly used to treat acute respiratory failure (ARF). It can reduce intubation rates without increasing mortality. Moreover, it is better tolerated than other non-invasive respiratory support therapies. However, patients with ARF often make strong breathing efforts, which may cause several harm. They can fatigue the respiratory muscles. They can increase whole-body oxygen consumption and carbon dioxide production. They can cause pulmonary edema. They might also injure the diaphragm and the lungs. For all these reasons, strong breathing efforts should be recognized and treated.\n\nDuring spontaneous breathing, inspiratory muscle contractions produce parallel deflections of the pleural and esophageal pressure (ΔPes), which reflect the magnitude of the effort. Unlike changes in pleural pressure, ΔPes can be easily measured at the bedside using a catheter similar to a typical nasogastric tube. In healthy subjects, ΔPes is only a few cmH2O during quiet breathing but \\>10-15 cmH2O during vigorous exercise or carbon dioxide inhalation. In patients with ARF, the upper limit for a \"safe\" ΔPes is unknown. Nonetheless, according to experts, breathing efforts with a ΔPes \\>10-15 cmH2O are probably too strong to be tolerated for a long time.\n\nHowever, esophageal manometry is not widely available. Estimating breathing efforts without it is complex, especially in non-intubated patients. Doctors mostly rely on their gestalt or overall impression. Therefore, it is unsurprising that they may disagree when rating their patients' breathing efforts or debating whether to proceed to intubation.\n\nThe investigators have recently developed two clinical prediction models for estimating the breathing effort of patients with ARF from a few variables readily available at the bedside. The first, \"linear\", model estimates the continuous value of ΔPes (in cmH2O) from the presence or absence of COVID-19, arterial base excess concentration (BEa) (in mmol\u002FL), respiratory rate (in bpm), the ratio of the arterial tension to the inspiratory fraction of oxygen (PaO2:FiO2) (in mmHg), and the product term between COVID-19 and PaO2:FiO2. The calibration slope was 1, and the adjusted R2 was 0.39. The second, \"logistic\", model estimates the probability of ΔPes being \\>10 cmH2O (dichotomous outcome) from BEa (in mmol\u002FL), respiratory rate (in bpm), and PaO2:FiO2 (in mmHg). When this model was tested on the same data set used to develop it (apparent performance), the area under the ROC curve (AUROC) was 0.79 (95% CI, 0.73-0.85). At internal validation (optimism-corrected performance), the AUROC was 0.76 (0.71-0.81). The investigators called these models BREF, which stands for BReathing EFfort, but also to the three main predictors: BEa (B), respiratory rate (RE), and PaO2:FiO2 (F).\n\nStudy aims The main goal of this study is to evaluate the BREF models' predictive performance in a new population. This process is known as \"external validation\". Additionally, there are two other secondary objectives. The investigators aim to update the BREF models by adding more variables unavailable in the development dataset (method \"extension\") and compare the accuracy of the BREF models with that of doctors who do not use them in assessing their patients' breathing efforts.\n\nStudy population\n\nInclusion criteria:\n\n* adult (≥18 years of age) patients in the ICU\n* treated with high-flow oxygen delivered via nasal cannula\n* equipped with an esophageal balloon as per local clinical practice.\n\nExclusion criteria:\n\n* history of chronic lung disease\n* cardiogenic pulmonary edema\n* \\>96 hours from admission to the participating unit.\n\nMethods First, participants will record all the variables needed to estimate ΔPes using the original version of the BREF models. These are the presence or absence of COVID-19, BEa, respiratory rate, PaO2:FiO2, and the product term between COVID-19 and PaO2:FiO2. Moreover, participants will record other variables that may help predict ΔPes based on scientific reasoning. Next, the attending doctor (blinded to the actual ΔPes) will assess the patient's breathing effort based on clinical judgment. Third, the actual ΔPes will be measured with esophageal manometry. Finally, the participants will record the type of respiratory support provided to the patient in the 72 hours following the study, the length of stay in the unit, and the vital status of the patient (dead or alive) at discharge from the unit.\n\nSample size calculation This study aims to enroll 250 patients in approximately two years.",[30,620,621],"Oxygen Inhalation Therapy","Respiratory Distress",[203,623,624,625,626],"High-flow oxygen therapy","Esophageal pressure","P-SILI","Breathing effort","2025-07-03",{"date":629,"type":44},"2025-07-04",{"date":631,"type":44},"2025-01-01",{"date":633,"type":22},"2027-01",{"name":635,"class":51},"Istituto Clinico Humanitas",{"id":637,"slug":638,"hasResults":12,"nctId":639,"briefTitle":640,"officialTitle":641,"acronym":642,"eligibilityCriteria":643,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":508,"enrollmentInfo":644,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":646,"conditions":647,"keywords":648,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":657,"completionDateStruct":659,"leadSponsor":661,"locationsCount":111},"100176521","improving-non-invasive-ventilation-100176521","NCT01571986","Improving Non-invasive Ventilation","Improving Non Invasive Ventilation","Improving NIV","Inclusion Criteria:\n\n* treatment with non-invasive ventilation\n* informed consent\n\nExclusion Criteria:\n\n* refusal of informed consent",{"count":645,"type":22},750,"A single center, observational, prospective study to improve knowledge about non-invasive ventilation, obtaining data about compliance, efficacy, imaging in patients who already receive non-invasive ventilation as standard of care.",[30],[649,72,650,651,652,653],"NIV","hypoxia","hypercapnia","non-invasive ventilation","hospital ward","2025-06-26",{"date":656,"type":44},"2025-07-01",{"date":658,"type":44},"2012-02",{"date":660,"type":22},"2026-05",{"name":662,"class":51},"Università Vita-Salute San Raffaele",{"id":664,"slug":665,"hasResults":12,"nctId":666,"briefTitle":667,"officialTitle":668,"acronym":669,"eligibilityCriteria":670,"healthyVolunteers":12,"sex":18,"minAge":60,"maxAge":671,"enrollmentInfo":672,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":673,"conditions":674,"keywords":676,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":679,"lastUpdatePostDateStruct":680,"startDateStruct":682,"completionDateStruct":684,"leadSponsor":686,"locationsCount":111},"100413642","inspiratory-effort-in-covid-19-100413642","NCT04666246","Inspiratory Effort in COVID-19","Inspiratory Effort Assessment in Patients With COVID-19 Pneumonia Undergoing Non Invasive Respiratory Support","PERSIA","Inclusion Criteria:\n\n* COVID-19\n* Acute respiratory failure undergoing non-invasive respiratory support\n\nExclusion Criteria:\n\n* Need for immediate endotracheal intubation\n* Chronic respiratory diseases","80 Years",{"count":5,"type":22},"This study aims at assessing esophageal pressure in patients with acute respiratory failure due to COVID-19 undergoing non invasive respiratory support.",[30,675],"Covid19",[203,624,677,678],"Non invasive respiratory support","COVID-19","2025-04-24",{"date":681,"type":44},"2025-04-25",{"date":683,"type":44},"2020-03-01",{"date":685,"type":22},"2030-02-01",{"name":370,"class":51}]