[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-respiratory-infections\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-respiratory-infections":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100558179","serum-vitamin-d-status-in-critically-ill-children-with-acute-respiratory-infections-100558179",false,"NCT06547749","Serum Vitamin D Status in Critically Ill Children With Acute Respiratory Infections","Assessment of Serum Vitamin D Status and Its Association With Disease Severity and Mortality Risk Among Critically Ill Children With Acute Respiratory Infections: A Cross-Sectional Study","VITD-ARI","Inclusion Criteria:\n\n* Children aged between 1 month and 12 years.\n* Admitted to the PICU with a primary diagnosis of acute respiratory infection.\n* Diagnosis confirmed by clinical symptoms and radiological evidence.\n\nExclusion Criteria:\n\n* Children with known chronic bone diseases or metabolic disorders.\n* Patients receiving vitamin D supplementation prior to admission.\n* Patients with chronic renal or hepatic failure.","ALL","1 Month","16 Years",{"count":21,"type":22},63,"ESTIMATED","OBSERVATIONAL","Acute respiratory infections (ARIs) are among the leading causes of hospitalization, morbidity, and mortality in children worldwide, particularly among critically ill patients admitted to pediatric intensive care units (PICUs). Vitamin D has an important role not only in bone metabolism but also in regulation of innate and adaptive immune responses, especially within the respiratory tract. Recent evidence suggests that vitamin D deficiency may be associated with increased susceptibility to respiratory infections, greater disease severity, prolonged hospitalization, and higher mortality rates in critically ill children.\n\nThis observational cross-sectional study aims to assess serum vitamin D status among critically ill children admitted to the PICU with acute respiratory infections and to evaluate the relationship between vitamin D levels, severity of respiratory illness, and risk of mortality. The study will include pediatric patients aged 1 month to 16 years admitted to the Pediatric Intensive Care Unit of Assiut University Children's Hospital.\n\nClinical evaluation and laboratory investigations, including serum 25-hydroxyvitamin D levels, serum calcium, and alkaline phosphatase, will be performed within the first 24 hours of admission. Severity of respiratory distress will be assessed using the Pediatric Respiratory Severity Score (PRESS), while mortality risk will be evaluated using the Pediatric Risk of Mortality Score (PRISM III).\n\nThe findings of this study may contribute to better understanding of the role of vitamin D in critically ill children with respiratory infections and may support future strategies for early risk assessment and improved clinical management in pediatric intensive care settings.",[26,27,28,29,30],"Acute Respiratory Infections","Critical Illness in Children","Vitamin D Deficiency","Pediatric Respiratory Infections","Respiratory Distress",[32,33,34,35,36,37,38,39,40,41],"25-hydroxyvitamin D","Vitamin D","Pediatric intensive care unit","PICU","Acute respiratory infection","Critically ill children","Pediatric respiratory severity score","Respiratory infection severity","Pediatric critical care","Mortality risk","NOT_YET_RECRUITING","2026-05-05",{"date":45,"type":46},"2026-05-08","ACTUAL",{"date":48,"type":22},"2026-06",{"date":50,"type":22},"2027-04",{"name":52,"class":53},"Assiut University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":63,"maxAge":4,"enrollmentInfo":64,"targetDuration":66,"studyType":23,"phases":4,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":54},"100614369","the-fever-clinic-acute-respiratory-cohort-100614369","NCT07278700","The Fever Clinic Acute Respiratory Cohort","The Fever Clinic Acute Respiratory Cohort (FACTS): A Prospective Real-World Cohort Study of Patients Presenting to Fever Clinics: Clinical Features, Laboratory and Radiographic Findings, and Long-Term Outcomes of Acute Respiratory Infections","FACTS","Inclusion Criteria:\n\n* Age ≥ 18 years (based on official identification document).\n* Presence of fever at the time of visit or within 24 hours prior to the visit, defined as a documented temperature of ≥37.3°C axillary\u002Ftympanic, ≥37.8°C orally, or ≥38.0°C rectally.\n* The primary cause of fever, as determined by the attending physician, is a respiratory tract infection.\n* Blood draw is required as part of standard clinical care.\n* Ability to comprehend the study's purpose, procedures, and potential risks, and willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Inability to provide independent informed consent due to impaired consciousness or other reasons.\n* Inability to comply with the study procedures.\n* Medical contraindications to blood sampling, such as severe coagulopathy (e.g., INR \\> 3.0, platelet count \\\u003C 50 × 10⁹\u002FL).\n* Diagnosed with a terminal illness (e.g., advanced malignancy, severe multiple organ failure) and a life expectancy of less than 3 months.","18 Years",{"count":65,"type":22},1000,"30 Days","This prospective cohort study aims to characterize the natural progression and outcomes of acute respiratory infections among patients presenting to fever clinics. At enrollment, patients' clinical symptoms, laboratory findings, and chest imaging data will be collected. Longitudinal follow-up will be conducted to evaluate disease progression, complications, and long-term outcomes.\n\nAs an observational study, no interventions are involved; all patients receive routine clinical management as directed by their attending physicians. This real-world study design enables the assessment of the natural course of acute respiratory infections and the identification of factors associated with clinical outcomes.",[26,69,70,71,72],"Febrile Illnesses","Community-acquired Pneumonia","Viral Respiratory Tract Infections","Influenza-like Illness",[74,75,76,77,78],"Respiratory Tract Infections","Fever","Community-Acquired Pneumonia","Anti-Bacterial Agents","Disease Progression","RECRUITING","2025-12-11",{"date":82,"type":46},"2025-12-12",{"date":84,"type":46},"2025-10-10",{"date":86,"type":22},"2028-10",{"name":88,"class":53},"Fudan University"]