[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-respiratory-syndrome-distress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-respiratory-syndrome-distress":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100617055","eit-guided-peep-optimization-in-trauma-and-postoperative-ards-100617055",false,"NCT07313644","EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS","Electrical Impedance Tomography-Guided Positive End-Expiratory Pressure Optimization in Patients With Trauma-Related and Postoperative Acute Respiratory Distress Syndrome","EIT-PEEP-SURG","Inclusion Criteria:\n\n* Mechanically ventilated surgical intensive care patients with trauma- or postoperative-associated moderate to severe ARDS, as defined by the 2023 Global Definition of ARDS.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>90 years.\n* Severe acute brain injury or acute stroke with Glasgow Coma Scale \\\u003C8.\n* Thoracic trauma with pneumothorax or pneumomediastinum.\n* End-stage diseases under palliative care (e.g., metastatic cancer, cirrhosis, end-stage renal disease).\n* Severe multiorgan failure with expected survival \\\u003C7 days.\n* Conditions requiring prolonged mechanical ventilation (e.g., Guillain-Barré syndrome, cervical spinal cord injury).\n* Contraindications to hypercapnia (e.g., elevated intracranial pressure, acute coronary syndrome).\n* Prior use of advanced respiratory therapies (e.g., ECMO, inhaled nitric oxide, prone positioning, high-frequency ventilation).\n* Pregnancy, breastfeeding, or skin lesions at electrode placement sites.\n* Implanted electrical devices interfering with EIT (e.g., pacemaker, ICD).\n* Known allergy to electrode materials.\n* Refusal to participate or concurrent enrollment in another study","ALL","18 Years","90 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery. Mechanical ventilation is essential for supportive care in this population, but may aggravate lung injury when suboptimal ventilatory settings are applied. Positive end-expiratory pressure (PEEP) is crucial for maintaining alveolar recruitment; however, optimal PEEP selection in trauma- or postoperative-associated ARDS remains uncertain. Electrical impedance tomography (EIT) enables bedside, real-time assessment of regional ventilation and may support optimal PEEP titration by balancing alveolar overdistension and collapse. This study compares EIT-guided PEEP optimization with the conventional low FiO₂-PEEP strategy in terms of oxygenation and respiratory mechanics in patients with moderate to severe ARDS following trauma or surgery.",[28,29,30,31],"Acute Respiratory Syndrome Distress","Positive End-Expiratory Pressure","Electrical Impedance Tomography","Trauma and Postoperative Pulmonary Insufficiency",[33,29,34,35,36,37],"Acute respiratory syndrome distress","electrical impedance tomography","Trauma and Postoperative","blood oxygenation","pulmonary mechanics","RECRUITING","2025-12-17",{"date":41,"type":42},"2026-01-02","ACTUAL",{"date":44,"type":42},"2025-03-15",{"date":46,"type":22},"2026-12-15",{"name":48,"class":49},"Nguyen Dang Thu","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":50},"100572430","the-impact-of-peep-guided-electrical-impedance-tomography-on-oxygenation-and-pulmonary-mechanics-in-moderate-to-severe-ards-100572430","NCT06733168","The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS","PEEP","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Intubated moderate and severe ARDS according to the New Global Definition (PaO2\u002FFiO2 ≤200 mmHg).\n* Used continuous sedation with or without paralysis.\n\nExclusion Criteria:\n\n* Presence of pneumothorax that is either undrained or newly occurred.\n* Unstable hemodynamics with a mean arterial pressure \\\u003C 60 mmHg and unresponsive to resuscitation measures, and\u002For heart rate \\\u003C 60 bpm.\n* Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application).\n* Pregnancy.\n* Severe neuromuscular disease.",{"count":59,"type":22},76,[25],"Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of ventilator-induced lung injury (VILI). Positive end-expiratory pressure (PEEP), a fundamental component of MV, is widely utilized in clinical practice; however, optimal PEEP selection for patients with moderate to severe ARDS remains a complex and unresolved challenge. Electrical impedance tomography (EIT), a bedside imaging modality that evaluates regional ventilation distribution, offers a means of individualizing PEEP settings in mechanically ventilated patients. By balancing the competing risks of alveolar overdistension and collapse, EIT facilitates precision in PEEP titration. This study compares the impact of EIT-guided PEEP selection versus the conventional low FiO2-PEEP table on blood oxygenation and pulmonary mechanics.",[28,29,63,64],"Mechanical Ventilation","Electrical Impedance Tomography (EIT)",[33,63,29,34,36,37],"2024-12-09",{"date":68,"type":42},"2024-12-13",{"date":70,"type":42},"2024-08-15",{"date":72,"type":22},"2026-12-30",{"name":74,"class":49},"Vietnam Military Medical University"]