[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-respiratory-tract-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-respiratory-tract-infection":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,65,87,112,144],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100644509","haiqu-hospital-air-quality-100644509",false,"NCT07670117","HAIQU (Hospital AIr QUality)","HAIQU (Hospital AIr QUality): Breathing Life Into Patient Care","HAIQU","Inclusion Criteria:\n\nTarget Group:\n\n* Mayo Clinic Staff working in ED with a minimum of .7 FTE in Midwest (MN and WI), Phoenix (AZ), or Jacksonville (FL) and patient contact.\n\nReference Group:\n\n* Mayo Clinic Staff working in primary care with a minimum of .7 FTE. in Rochester (MN), Phoenix (AZ), or Jacksonville (FL) and patient contact\n\nExclusion Criteria:\n\n* Any participant who does not meet either of the inclusion criteria.",true,"ALL","18 Years",{"count":21,"type":22},850,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this research is to assess whether integration of an aerosol biosensor and air quality risk assessment software that integrates into a building management system will improve indoor air quality metrics in hospital environments and reduces risk factors associated with respiratory disease transmission.",[28],"Acute Respiratory Tract Infection","NOT_YET_RECRUITING","2026-06-25",{"date":32,"type":33},"2026-06-29","ACTUAL",{"date":35,"type":22},"2026-10-01",{"date":37,"type":22},"2029-09-30",{"name":39,"class":40},"Mayo Clinic","OTHER",3,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":41},"100537814","a-long-term-observational-study-evaluating-the-presentation-and-management-of-acute-respiratory-tract-infections-in-primary-care-across-europe-100537814","NCT06282718","A Long-term Observational Study Evaluating the Presentation and Management of Acute Respiratory Tract Infections in Primary Care Across Europe","Perpetual Observational Study (POS) of Acute Respiratory Infections (ARI) in Primary Care Settings (PC) Across Europe","POS-ARI-PC","POS-ARI-PC AUDIT:\n\nInclusion Criteria:\n\nEligible patients will be of any age consulting (telephone, video, face-to-face) with a participating health care facility with:\n\n* Symptoms suggestive of an acute lower RTI with cough as predominant symptom and with illness duration less than 28 days, AND\u002FOR\n* Symptoms suggestive of an acute upper RTI with sore throat and\u002For coryza as predominant symptom and with illness duration of less than 14 days AND\u002FOR\n* Patients otherwise suspected of COVID-19, influenza or RSV.\n\nExclusion Criteria:\n\nPatients will not be eligible for if they have withdrawn their consent for anonymous data collection for research by their health care facility.\n\nPOS-ARI-PC CORE:\n\nInclusion criteria:\n\nEligible patients will be of any age consulting (telephone, video, face to face) with a participating primary health care facility with:\n\n* Symptoms suggestive of an acute lower respiratory infection with cough as the predominant symptom, with illness duration less than 28 days, AND\u002FOR\n* Symptoms suggestive of an acute upper respiratory infection with sore throat and\u002For coryza as the predominant symptom, with illness duration of less than 14 days AND\u002FOR\n* Other symptoms suggestive of COVID-19, Influenza, RSV AND\n* Participant or legal guardian(s) willing and able to provide informed consent and comply with study procedures\n\nExclusion criteria:\n\nPatients will not be eligible if:\n\n* According to the judgement of the recruiting clinician, they will not be able comply with study procedures, for example because they do not understand the language in which the study is being conducted locally (and have no one to help and translate for them); have a serious psychiatric disorder; or are terminally ill\n* Symptoms of presumed non-infective origin\n* Participant requires admission to hospital on the day of inclusion\n\nAdditional in\u002Fexclusion criteria might apply to embedded studies and will be described in the SSA or ISA.\n\nPOS-ARI-PC-001:\n\nSymptoms and Duration Symptoms suggestive of an acute lower RTI with new or increased cough as the predominant symptom, with illness duration ≤10 days; AND\u002FOR Symptoms suggestive of an acute upper RTI with sore throat and\u002For coryza as the predominant symptom, with illness duration ≤10 days;\n\nAge Aged 60 years and over OR Aged 50 to 59 years and have a long-term health condition which makes them eligible for the yearly influenza vaccination under the national influenza vaccination programme;\n\nConsent Willing and able to provide informed consent and have a swab taken.\n\nExclusion Criteria:\n\nAs per the POS-ARI-PC CORE Protocol, with one exception: patients needing hospitalisation can be recruited into the study if timing allows. Patients can provide a swab and decide not to participate in the follow-up procedures.",{"count":51,"type":22},2000,"OBSERVATIONAL","Acute respiratory infection (ARI) is the commonest reason for consulting in community care. Furthermore, new and re-emerging pathogens are often first noticed in primary care (PC). The POS-ARI-PC study is a long-term study, with the aim of describing the nature of ARI in adults and children presenting to PC across Europe. The POS-ARI-PC study will provide critically important data on the presentation and management of ARI, and build a research-ready infrastructure for studies related to the treatment, diagnosis, and prevention of ARI in primary care settings. Additional observational studies will be embedded and use the infrastructure developed in POS-ARI-PC.",[28],"RECRUITING","2026-04-09",{"date":58,"type":33},"2026-04-14",{"date":60,"type":33},"2024-02-22",{"date":62,"type":22},"2026-07",{"name":64,"class":40},"European Clinical Research Alliance for Infectious Diseases (ECRAID)",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":23,"phases":74,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100605185","pcot-for-outpatients-with-acute-respiratory-tract-infection-at-risk-of-severe-disease-in-primary-healthcare-100605185","NCT07159230","PCOT for Outpatients With Acute Respiratory Tract Infection at Risk of Severe Disease in Primary Healthcare","Point-of-care Multiplex PCR Test for Outpatients With Acute Respiratory Tract Infection at Risk of Severe Disease in Primary Healthcare: a Pragmatic Cluster-randomised Controlled Trial.","Inclusion Criteria:\n\n1. Onset time\\\u003C=7 days;\n2. First visit;\n3. Age\\>=18 years old;\n4. Patients with acute upper respiratory tract infection with severe high-risk factors, or patients with acute lower respiratory tract infection;\n5. The condition is allowed to be treated in an outpatient clinic;\n6. Signed informed consent.\n\nExclusion Criteria:\n\n1. The doctor judges that the disease is serious and requires hospitalization;\n2. New unclear consciousness;\n3. Respiratory rate\\>=30 beats\u002Fmin;\n4. Hypoxemia or respiratory failure;\n5. Heart rate\\> 125 beats\u002Fmin;\n6. Systolic blood pressure \\\u003C 90 or diastolic blood pressure \\\u003C 60 mmHg;\n7. Known active tuberculosis;\n8. Pregnant and lactating women;\n9. Have participated in this study within 90 days;",{"count":73,"type":22},16868,[25],"This study aims to evaluate the clinical value of point-of-care multiplex PCR testing (POCT) in guiding early diagnosis and target treatment for acute respiratory infections in primary healthcare settings.",[28],"2025-09-04",{"date":79,"type":33},"2025-09-08",{"date":81,"type":22},"2025-09-15",{"date":83,"type":22},"2028-01-31",{"name":85,"class":40},"Capital Medical University",1,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},"100501821","pos-ari-er-observational-study-of-acute-respiratory-infections-100501821","NCT05814237","POS-ARI-ER Observational Study of Acute Respiratory Infections","Perpetual Observational Study of Acute Respiratory Infections Presenting Via Emergency Rooms and Other Acute Hospital Care Settings","POS-ARI-ER","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Clinical suspicion of a new episode of acute respiratory tract infection, with onset in the last 10 days\n* Patient presents to an emergency room or secondary care setting\n* Informed consent is provided by patient or their legal representative\n\nExclusion Criteria:\n\n* Patient has been transferred from another hospital\n* Patient admitted to hospital for \\>2 days at the time of enrolment\n* Patient has been previously enrolled in the POS-ARI-ER study",{"count":96,"type":22},11750,"Acute respiratory infections (ARI) are one of the most frequent reasons for hospital admission and antibiotic use, and can be caused by a broad range of pathogens, including respiratory viruses with proven epidemic potential, e.g. influenza and coronaviruses. The POS-ARI-ER study will focus on describing the different routine diagnostic and therapeutic practices in the work-up and treatment of ARI, as well as clinical outcomes across the patient population. In addition, POS-ARI-ER aims to characterise both the adult patient population with ARI presenting to acute hospital settings in Europe, and the aetiology of ARI in these patients.",[99,28],"Acute Respiratory Infection",[101,102],"Infections","Communicable Diseases","2024-09-02",{"date":105,"type":33},"2024-09-19",{"date":107,"type":33},"2023-06-20",{"date":109,"type":22},"2026-02-28",{"name":64,"class":40},23,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":23,"phases":123,"briefSummary":125,"conditions":126,"keywords":127,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":4},"100560762","phase-4-tailoring-antibiotic-duration-for-respiratory-tract-infections-in-primary-care-100560762","NCT06581367","Tailoring Antibiotic Duration for Respiratory Tract Infections in Primary Care","Tailoring Antibiotic Duration for Respiratory Tract Infections in Primary Care: a Pragmatic Randomized Controlled Trial","STORM","Inclusion Criteria:\n\n* Either adults with a) acute cough (new cough or worsening of a previous cough) as the predominant symptom which the clinician believes to be a bacterial acute lower RTI, such as community-acquired pneumonia, acute bronchitis or acute chronic obstructive pulmonary disease (COPD) exacerbations, or b) an acute bacterial rhinosinusitis\n* Doctors deem beta-lactam therapy (given every eight hours for a minimum of seven days) is necessary\n\nExclusion Criteria:\n\n* RTIs different from a lower RTI or acute rhinosinusitis\n* Patients with suspected septicemia (quick Quick Sequential Organ Failure Assessment: respiratory rate ≥22 breaths\u002Fminute, systolic blood pressure \\\u003C100 mm Hg or altered mental status with a Glasgow score \\\u003C 5) ≥2\n* Patients with pneumonia and \\[Confusion, respiratory rate ≥30 breaths\u002Fminute, blood pressure \\\u003C 90\u002F60 mm Hg, or age \\>65 yr.\\] ≥1\n* Patients with very severe COPD (Forced Expiratory Volume in One Second \\\u003C30%)\n* Patients with COPD who have taken four or more antibiotic courses in the previous year, presence of significant bronchiectasis, and\u002For isolation of Pseudomonas in a previous sputum culture\n* Patients with reported allergy to beta-lactams\n* Patients who have taken an antibiotic in the previous two weeks\n* Patients who have been hospitalized in the last two weeks\n* A working diagnosis of a non-infective disorder, such as heart failure, pulmonary embolus, esophageal reflux\n* Immunocompromised patients, such as HIV infection, patients taking immunosuppressive treatment, antineoplastic therapy, or systemic corticosteroids\n* Currently participating in another clinical trial\n* Previously participated in the STORM study\n* Active neoplasia\n* Terminal illness\n* Institutionalized patient\n* Inability\u002Funable to understand and\u002For take part in the clinical trial","75 Years",{"count":122,"type":22},474,[124],"PHASE4","The rise of drug-resistant organisms and the need to minimize side effects calls for a new approach to antibiotic therapy duration. This study explores tailoring the length of antibiotic treatment to patient recovery, focusing on whether adjusting therapy based on when the patient feels better is as effective as completing the prescribed course for acute respiratory tract infections (RTIs). The investigators will enroll 474 outpatients aged 18-75 with acute RTIs across 25 Spanish healthcare centers. Patients will be randomized into two groups: one following standard full-course antibiotic therapy, and another receiving a tailored approach, where treatment may be shortened based on clinical assessments. The primary outcome is clinical efficacy at day 14. Secondary outcomes include antibiotic duration, complications, and quality of life.",[28],[128,129,130,131,132,133,134],"Antibacterial Agents Antimicrobial Resistance","Duration","Primary Health Care","Personalized Medicine","Drugs, Customized","Drug Resistance, Microbial","Patient-Centered Care","2024-08-30",{"date":137,"type":33},"2024-09-03",{"date":139,"type":22},"2025-10-01",{"date":141,"type":22},"2027-04-30",{"name":143,"class":40},"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":18,"minAge":151,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":23,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":4},"100337540","reducing-antibiotic-prescribing-in-family-practice-100337540","NCT03674775","Reducing Antibiotic Prescribing in Family Practice","Dialogue Around Respiratory Illness Treatment for Family Practice (DART -FP)","Inclusion Criteria:\n\n1. Children or adults with acute respiratory tract infections (ARTIs) defined as bacterial (acute otitis media \\[AOM\\], pharyngitis, and sinusitis) or viral (bronchitis and viral upper respiratory infection \\[URI\\]) based on their common etiologies.\n2. Seven months old and older\n\nExclusion Criteria:\n\n1\\. 0 - 6 months old","6 Months",{"count":153,"type":22},180,[25],"Antibiotic prescribing for childhood acute respiratory tract infections (ARTIs), including acute otitis media (AOM), pharyngitis, sinusitis, bronchitis, and upper respiratory infection (URI), is common in the United States (US). In the outpatient setting, more than 50% of children diagnosed with ARTIs receive antibiotic prescriptions. Considering that the estimated US prevalence of pediatric bacterial ARTIs is 27% (with the remainder of ARTIs caused by viruses) this represents a substantial degree of antibiotic overuse nationwide. Another troubling trend in antibiotic prescribing for ARTIs in children is the increased reliance on broad-spectrum, second-line agents for bacterial ARTIs. Unwarranted use of antibiotics, especially broad-spectrum agents, has been associated with increased resistance among several strains of bacteria that commonly cause ARTIs, posing risks to both individuals and communities.",[28],"2019-09-17",{"date":159,"type":33},"2019-09-19",{"date":161,"type":22},"2022-07",{"date":163,"type":22},"2026-06",{"name":165,"class":40},"Seattle Children's Hospital"]