[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-spinal-cord-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-spinal-cord-injury":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,43,81,102,129,150,176,200,223],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100472038","phase-1-spinal-cord-injury-neuroprotection-with-glyburide-100472038",false,"NCT05426681","Spinal Cord Injury Neuroprotection With Glyburide","Spinal Cord Injury Neuroprotection With Glyburide (SCING): Pilot Study: An Open-Label Prospective Evaluation of the Feasibility, Safety, Pharmacokinetics, and Preliminary Efficacy of Oral Glyburide (DiaBeta) in Patients With Acute Traumatic Spinal Cord Injury","SCING","Inclusion Criteria:\n\n* No life threatening injuries resulting from the traumatic accident\n* No evidence of sepsis\n* Acute cervical or thoracic SCI with ASIA Impairment Scale Grade A, B, or C od admission.\n* Non-penetrating SCI at neurologic level from C2 to C8 or T1 to T12\n\nExclusion Criteria:\n\n* Unconsciousness or other mental impairment that prevents neurological assessment within the first 8 hours\n* Acute SCI with ASIA Impairment Scale grade D or E\n* Currently involved in another non-observational SCI research study or receiving another investigational drug\n* History of hypersensitivity to sulfonylureas, in particular glyburide, or any of its components\n* Any condition likely to result in the patient's death within the next 12 months\n* Severe renal disorder from the patient's history (e.g. dialysis) or baseline eGFR of \\\u003C 30 mL\u002Fmin\u002F1.73 m2\n* Known severe liver disease, or ALT \\> 3 times upper limit of normal or bilirubin\n* Blood glucose \\\u003C55 mg\u002FdL at enrollment or immediately prior to administration of DiaBeta, or a clinically significant history of hypoglycemia\n* Acute ST elevation myocardial infarction, and\u002For acute decompensated heart failure, and\u002For QTc \\> 520 ms, and\u002For known history of cardiac arrest (PEA, VT, VF, asystole), and\u002For admission for an acute coronary syndrome, myocardial infarction, or coronary intervention (percutaneous coronary intervention or coronary artery surgery) within the past 3 months\n* Known G6PD enzyme deficiency",true,"ALL","18 Years","80 Years",{"count":22,"type":23},12,"ESTIMATED","INTERVENTIONAL",[26],"PHASE1","To assess the safety and efficacy of using oral Glyburide (Diabeta) as a neuroprotective agent in patients with acute cervical or thoracic traumatic spinal cord injury.",[29],"Acute Spinal Cord Injury","RECRUITING","2026-02-10",{"date":33,"type":34},"2026-02-13","ACTUAL",{"date":36,"type":34},"2022-07-07",{"date":38,"type":23},"2028-05",{"name":40,"class":41},"Francis Farhadi","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":24,"phases":53,"briefSummary":55,"conditions":56,"keywords":66,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":42},"100495499","spinal-cord-transcutaneous-stimulation-effect-on-blood-pressure-in-acute-spinal-cord-injury-sci-100495499","NCT05731986","Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)","Neuromodulation of Blood Pressure Using Transcutaneous Spinal Stimulation in Individuals With an Acute Spinal Cord Injury - A Safety, Feasibility and Efficacy Study","SCI","Inclusion Criteria:\n\n* 7-30 days after injury\n* Injury level ≥T2 (thoracic level)\n* American Spinal Injury Association Impairment Scale (AIS) A-C\n* Exhibits at least one of the following hypotensive symptoms:\n\n  1. Baseline hypotension - resting supine or seated SBP \\\u003C 90mmHg;\n  2. SBP drop ≥ 20 mmHg within 5 minutes of assuming seated position;\n  3. Symptoms of orthostasis with a drop of SBP (\\\u003C90mmHg) from supine to sitting.\n\nExclusion Criteria:\n\n* Current illness (e.g., a recent diagnosis of a deep vein thrombosis (DVT) or pulmonary embolism (PE), a pressure injury that might interfere with the intervention, etc.) or infection\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* Initiated on new cardiac medications within the past 5 days\n* Insufficient mental capacity to understand and independently provide consent\n* Pregnancy\n* Cancer\n* Deemed unsuitable by study physician","75 Years",{"count":22,"type":23},[54],"NA","The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury). Blood pressure instability, specifically orthostatic hypotension (a drop in blood pressure when moving lying flat on your back to an upright position), appears early after the injury and often significantly interferes with participation in the critical rehabilitation time period.\n\nThe main questions it aims to answer are:\n\n1. Can optimal spinal stimulation increase blood pressure and resolve orthostatic symptoms (such as dizziness and nausea) when individuals undergo an orthostatic provocation (a sit-up test)? Optimal stimulation and sham stimulation (which is similar to a placebo treatment) will be compared.\n2. What are the various spinal sites and stimulation parameters that can be used to increase and stabilize blood pressure to the normal range of 110-120 mmHg?\n\nParticipants will undergo orthostatic tests (lying on a bed that starts out flat and then moved into an upright seated position by raising the head of bed by 90° and dropping the base of the bed by 90° from the knee) with optimal and sham stimulation, and their blood pressure measurements will be evaluated and compared.",[57,58,59,60,61,62,63,64,29,65],"Spinal Cord Injuries","Spinal Cord Diseases","Trauma, Nervous System","Nervous System Diseases","Central Nervous System Diseases","Hypotension","Orthostatic Hypotension","Cardiovascular Diseases","Blood Pressure",[67,68,63,65,69,70,62,71],"Transcutaneous Spinal Cord Stimulation","Spinal stimulation","Neuromodulation","Acute spinal cord injury","Acute inpatient rehabilitation","2025-08-29",{"date":74,"type":34},"2025-09-02",{"date":76,"type":34},"2023-12-01",{"date":78,"type":23},"2026-08",{"name":80,"class":41},"Kessler Foundation",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":24,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":42},"100496520","the-use-of-functional-electrical-stimulation-in-conjunction-with-respiratory-muscle-training-to-improve-unaided-cough-in-individuals-with-acute-spinal-cord-injury-100496520","NCT05745298","The Use of Functional Electrical Stimulation in Conjunction With Respiratory Muscle Training to Improve Unaided Cough in Individuals With Acute Spinal Cord Injury","AFES and RMT","Inclusion Criteria:\n\n1. Traumatic and atraumatic C2- T12 Spinal cord injury (AIS A, B, and C motor incomplete and complete injuries) currently admitted to inpatient rehabilitation with an injury date \\\u003C 12 months prior to enrollment\n2. Positive response to electrical stimulation through a palpable contraction\n3. Fluent in written and spoken English\n\nExclusion Criteria:\n\n1. Individuals who do not meet inclusion criteria\n2. Prisoners\n3. Concurrent traumatic brain injury determined by Rancho level of cognitive functioning \\\u003C VI\n4. Individuals with open tracheostomy\n5. Persons with pacemakers\n6. Pregnant women\n7. Persons with epilepsy\n8. Open wounds or metal implants at site of electrode placement\n9. Unresponsive to functional electrical stimulation\n10. Current diagnosis or history of thoraco-abdomino-pelvic cancer",{"count":89,"type":23},50,[54],"The overall objective of this study is to improve unaided cough with abdominal and latissimus dorsi functional electrical stimulation in conjunction with respiratory muscle training in individuals with acute spinal cord injuries.",[29],"2025-07-03",{"date":95,"type":34},"2025-07-09",{"date":97,"type":34},"2023-07-21",{"date":99,"type":23},"2027-09-21",{"name":101,"class":41},"University of Miami",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":51,"enrollmentInfo":109,"targetDuration":4,"studyType":24,"phases":111,"briefSummary":113,"conditions":114,"keywords":115,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":128},"100366680","phase-2-pmz-1620-sovateltide-in-patients-of-acute-spinal-cord-injury-100366680","NCT04054414","PMZ-1620 (Sovateltide) in Patients of Acute Spinal Cord Injury","A Prospective, Multicentric, Randomized, Double Blind, Saline Controlled Phase II Clinical Study to Compare the Safety and Efficacy of PMZ-1620 Therapy Along With Standard Supportive Care in Patients of Acute Spinal Cord Injury","Inclusion Criteria:\n\n1. Adult males or females aged between 18 and 75 years inclusive\n2. Able to give consent for participation on their own or through their Legally Acceptable Representative (LAR)\n3. Able to cooperate in the completion of a standardized neurological examination by ISNCSCI standards (excludes patients who are on ventilator)\n4. ISNCSCI Impairment Scale Grade \"B,\" \"C\" or \"D\" based upon first ISNCSCI evaluation after arrival to the hospital is classified as motor or sensory incomplete\n5. Willing and able to comply with the study Protocol\n6. Women must be of non-childbearing potential or surgically sterile or willing to use adequate birth control; men who are sexually active will also be required to use adequate birth control\n7. Able to receive the Investigational Drug within 48 hours of injury\n8. Neurological Level of Injury between C5-C8, T1-T12, L1-L5 and S1-S5 based upon first ISNCSCI evaluation after arrival to the hospital\n9. Patient with incomplete\u002Fpartial damage\u002Ftransaction as shown by CT or MRI scan\n10. Patients with any other chronic conditions, who are stable with appropriate treatment\n\nExclusion Criteria:\n\n1. Previous history related to spinal cord disease\n2. Patient on ventilator or requires ventilator\n3. Patient with pathological fracture of vertebral column\n4. Impairment Scale Grade \"A\" based upon first ISNCSCI assessment and classified as complete injury\n5. One or more upper extremity muscle groups un-testable during baseline ISNCSCI examination\n6. Concomitant head injury with a clinically significant abnormality on a head CT (head CT required only for patients suspected to have a brain injury at the discretion of the investigator)\n7. Females who are breastfeeding or have a positive urine pregnancy test\n8. Body mass index (BMI) of ≥35 kg\u002Fm2 at screening\n9. Known immunodeficiency, including human immunodeficiency virus, or use of immunosuppressive or cancer chemotherapeutic drugs\n10. Patient having rheumatoid arthritis\n11. The participant has a clinically significant cardiovascular disorder or an abnormal electrocardiogram (ECG) at the discretion of the investigator\n12. Pre-existent neurologic disorder which would preclude accurate evaluation and follow-up (i.e. Alzheimer's disease, Parkinson's disease, any psychiatric disorder with hallucinations\u002Fdelusions\u002Fschizophrenia)\n13. Patients who are currently participating in a clinical trial with an investigational drug or investigational device\n14. Patients who, in the opinion of the investigator, are otherwise unsuitable for this study",{"count":110,"type":23},40,[112],"PHASE2","This was a prospective, multicentric, randomized, double blind, parallel, saline controlled Phase II clinical study to compare the safety and efficacy of PMZ-1620 (INN: Sovateltide) therapy along with standard supportive care in patients of acute spinal cord injury.",[29],[116,117],"Endothelin","Neurogenesis","2025-07-01",{"date":120,"type":34},"2025-07-04",{"date":122,"type":34},"2019-01-10",{"date":124,"type":23},"2026-07",{"name":126,"class":127},"Pharmazz, Inc.","INDUSTRY",5,{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":24,"phases":137,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":42},"100566409","phase-4-contrast-enhanced-ultrasound-in-the-treatment-of-acute-spinal-cord-injury-100566409","NCT06654804","Contrast-enhanced Ultrasound in the Treatment of Acute Spinal Cord Injury","Contrast-Enhanced Ultrasound Biomarker for Prognostication and Guidance of Surgical Treatment in Acute Traumatic Spinal Cord Injury","Inclusion Criteria:\n\n* 18 years of age minimum\n* Acute spinal cord injury fpr less than 24 hours\n* Injury ranging from mild spinal cord injury where motor function is preserved (AIS A) to complete injury where there is no motor or sensory function below the leel of the injury (AIS D)\n* Medically stable to undergo routine dorsal decompression, spinal realignment\n* and stabilizing with segmental instrumentation\n\nExclusion Criteria:\n\n* Younger than 18 years old\n* Neurological lower extremity exam missing or intact\n* Traumatic head injury with a Glasgow score of 11 or lower\n* Cord injury level caudal to T10 (thoracic spine level 10)\n* A known sensitivity to lipid microsphere or its components, such as polyethylene glycol (PEG)\n* A history of anaphylactoid reactions from ultrasound enhancing agents\n* A known history of cardiopulmonary conditions\n* Cardiac shunt",{"count":89,"type":23},[138],"PHASE4","Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal cord tissue and decreased spinal cord blood flow at the site of injury. The combination of increased pressure and decreased blood flow causes vascular hypoperfusion of the spinal cord and exacerbates the severity of injury. This is also referred to as secondary injury. Thus, knowledge of spinal cord hypoperfusion would allow the treating physician to optimize the hemodynamic condition of the patient with acute spinal cord injury and potentially improve functional outcomes.",[29],"2025-04-23",{"date":143,"type":34},"2025-04-27",{"date":145,"type":34},"2023-09-28",{"date":147,"type":23},"2027-09-15",{"name":149,"class":41},"University of Washington",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":24,"phases":159,"briefSummary":160,"conditions":161,"keywords":162,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":42},"100462703","tscs-for-acute-sci-100462703","NCT05305118","TSCS for Acute SCI","Safety, Feasibility, and Efficacy of Transcutaneous Spinal Cord Stimulation on Stabilizing Blood Pressure for Acute Inpatients With Spinal Cord Injury","Inclusion Criteria:\n\n* All newly injured patients with SCI who are sequentially admitted during the 42-month recruitment period\n* Meet the following Model Systems entry criteria with evidence of BP instability\n* Exhibit one or more of the following: Resting hypotension - systolic BP ≤ 110 mmHg for males or ≤ 100 mmHg for females; OH - fall in systolic BP ≥ 20 mmHg and\u002For a fall in diastolic BP ≥ 10 mmHg within 10 minutes of assuming an upright position; BP instability - fluctuation in systolic BP ≥ 20 mmHg and\u002For fluctuation in diastolic BP ≥ 10 mmHg within a single day during routine activities in the AIR setting.\n* Have trouble with your blood pressure as determined by your doctor.\n* Participants must be between the ages of 18-89 years old, experienced a spinal cord injury (SCI) within the past 30 days to 6 months, have sustained a SCI with temporary or permanent loss of sensory and\u002For motor function, and are an inpatient for acute SCI rehabilitation therapy at Mount Sinai.\n* You are not dependent on a ventilator at this time.\n* You do not have a history of implanted pacemaker\u002Fdefibrillator or significant coronary artery disease.\n\nExclusion Criteria:\n\n* Implanted brain\u002Fspine\u002Fnerve stimulators, cochlear implants, cardiac pacemaker\u002Fdefibrillator, or intracardiac lines\n* Open skin lesions on or near the electrode placement sites (neck, upper back)\n* Significant coronary artery or cardiac conduction disease\n* Recent history of myocardial infarction\n* Insufficient mental capacity to understand and independently provide consent\n* Pregnancy\n* Cancer\n* Deemed unsuitable by study physician\n\nAs part of the feasibility assessment, the study team will document demographic and injury characteristics of eligible patients who refuse enrollment, as well as reasons for ineligibility among those who do not meet entrance criteria.","89 Years",{"count":89,"type":23},[54],"This project will focus on a novel approach to stabilizing blood pressure (BP) during inpatient rehabilitation after acute SCI. After SCI, people have unstable blood pressure, ranging from too low (orthostatic hypotension) to too high (autonomic dysreflexia). Unstable BP often interferes with performing effective physical rehabilitation after SCI. A critical need exists for the identification of safe, practical and effective treatment options that stabilize BP after traumatic SCI. Transcutaneous Spinal Cord Stimulation (TSCS) has several advantages over pharmacological approaches: (1) does not exacerbate polypharmacy, (2) can be activated\u002Fdeactivated rapidly, and (3) can be applied in synergy with physical exercise. The study team is asking the key question: \"What if applying TSCS earlier after injury could prevent the development of BP instability?\" To facilitate adoption of TSCS for widespread clinical use, the study team plans to map and develop a parameter configuration that will result in an easy to follow algorithm to maximize individual benefits, while minimizing the burden on healthcare professionals. This project will provide the foundational evidence to support the feasible and safe application of TSCS in the newly injured population, thereby overcoming barriers to engagement in prescribed inpatient rehabilitation regimens that are imposed by BP instability.",[29,65,62],[67,69,163,164,165,166],"Spinal Cord Stimulation","Blood Pressure Disorders","Cerebral Blood Flow Velocity","Acute Inpatient Rehabilitation","2025-04-11",{"date":169,"type":34},"2025-04-16",{"date":171,"type":34},"2022-01-01",{"date":173,"type":23},"2027-10-01",{"name":175,"class":41},"Icahn School of Medicine at Mount Sinai",{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":180,"acronym":181,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":183,"enrollmentInfo":184,"targetDuration":4,"studyType":24,"phases":186,"briefSummary":187,"conditions":188,"keywords":191,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":197,"leadSponsor":199,"locationsCount":42},"100550837","early-intervention-for-information-processing-speed-deficits-in-acute-sci-a-pilot-study-100550837","NCT06452264","Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study","SCI-IQ","Inclusion Criteria:\n\n* 18-65 years old\n* recent traumatic SCI (approximately 6 months post-injury)\n\nExclusion Criteria:\n\n* no other significant neurological, psychiatric or substance use history\n* no significantly impairing visual disturbance","65 Years",{"count":185,"type":23},20,[54],"This study seeks to conduct a pilot study to test whether a cognitive training program can improve processing speed abilities in individuals with acute traumatic spinal cord injury.",[57,189,190,29],"Cognitive Dysfunction","Cognitive Impairment",[192],"processing speed","2024-06-19",{"date":195,"type":34},"2024-06-21",{"date":193,"type":34},{"date":198,"type":23},"2024-11-30",{"name":80,"class":41},{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":181,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":24,"phases":210,"briefSummary":211,"conditions":212,"keywords":213,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":222},"100534412","a-pilot-rct-to-improve-cognitive-processing-speed-in-acute-sci-100534412","NCT06238492","A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI","Intervening Quickly: A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI","Inclusion Criteria:\n\n* 18-59 years old\n* recent traumatic SCI (approximately 6 months post-injury)\n\nExclusion Criteria:\n\n* no other significant neurological, psychiatric or substance use history\n* no significantly impairing visual disturbance","59 Years",{"count":209,"type":23},24,[54],"This study seeks conduct a pilot study to test whether a cognitive training program can improve processing speed abilities in individuals with acute traumatic spinal cord injury.",[57,189,190,29],[192],"2024-06-04",{"date":216,"type":34},"2024-06-06",{"date":218,"type":34},"2024-04-01",{"date":220,"type":23},"2025-10-31",{"name":80,"class":41},3,{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":155,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":18,"minAge":229,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":24,"phases":232,"briefSummary":233,"conditions":234,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":240,"leadSponsor":242,"locationsCount":42},"100516136","safety-feasibility-and-efficacy-of-tscs-on-stabilizing-blood-pressure-for-acute-inpatients-with-sci-100516136","NCT06000592","Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI","Inclusion Criteria:\n\n* Newly injured patients with traumatic SCI\n* Admitted to Acute Inpatient Rehabilitation at Mount Sinai\n* Within one year of SCI\n* Seated hypotension (systolic BP ≤ 110 mmHg for males or ≤ 100 mmHg for females)\n* Orthostatic hypotension (fall in systolic BP ≥ 20 mmHg and\u002For a fall in diastolic BP ≥ 10 mmHg within 10 minutes of assuming an upright position)\n* Daily fluctuation in systolic BP ≥ 20 mmHg and\u002For fluctuation in diastolic BP ≥ 10 mmHg\n* At least 14 years old\n\nExclusion Criteria:\n\n* Implanted brain\u002Fspine\u002Fnerve stimulators\n* Cochlear implants\n* Cardiac pacemaker\u002Fdefibrillator, or intracardiac lines\n* Open skin lesions on or near the electrode placement sites (neck, upper back)\n* Significant coronary artery or cardiac conduction disease\n* Recent history of myocardial infarction\n* Insufficient mental capacity to understand and independently provide consent\n* Pregnancy\n* Cancer\n* Deemed unsuitable by study physician","14 Years","100 Years",{"count":89,"type":23},[54],"Current forms of pharmacologic and non-pharmacologic treatments for hypotension and orthostatic hypotension (OH) remain inadequate during acute inpatient rehabilitation (AIR) following a traumatic spinal cord injury (SCI). A critical need exists for the identification of safe, practical, and effective treatment options that stabilize blood pressure (BP) after traumatic SCI. Recent published evidence suggests that transcutaneous Spinal Cord Stimulation (TSCS) can be used to raise seated BP, and mitigate the falls in BP during orthostatic repositioning in individuals with chronic SCI. This site-specific project will focus on the use of TSCS to stabilizing seated BP and mitigate the fall in BP during orthostatic repositioning during AIR following traumatic SCI.",[29,57,69,235,163,236,65,164],"Traumatic Spinal Cord Injury","SCI - Spinal Cord Injury",{"date":238,"type":34},"2024-04-02",{"date":171,"type":34},{"date":241,"type":23},"2026-10-01",{"name":243,"class":244},"Jill M. Wecht, Ed.D.","FED"]