[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-type-a-aortic-dissection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-type-a-aortic-dissection":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100637545","ai-guided-intensified-follow-up-after-surgery-for-acute-type-a-aortic-dissection-100637545",false,"NCT07623213","AI-Guided Intensified Follow-up After Surgery for Acute Type A Aortic Dissection","Artificial Intelligence Multimodal Prediction Model-Guided Intensified Follow-up Strategy for 1-Year Outcomes After Surgery for Acute Type A Aortic Dissection: A Multicenter Randomized Controlled Trial","AIMS-ATAAD-FU","Inclusion Criteria:\n\n* 1\\. Age 18 years or older. 2. Acute Stanford type A aortic dissection confirmed by CTA, intraoperative findings, or medical records.\n\n  3\\. Underwent open surgical repair or open repair combined with endovascular\u002Fhybrid repair.\n\n  4\\. Postoperative condition is stable and the patient is planned for discharge or has entered early post-discharge follow-up.\n\n  5\\. Core baseline data required for AI model operation are available, including at least one eligible preoperative or postoperative CTA imaging dataset.\n\n  6\\. Able to complete telephone, outpatient, or inpatient follow-up and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* 1\\. Predominantly chronic type A dissection, traumatic dissection, or iatrogenic dissection, if the investigator judges the patient unsuitable for this follow-up strategy study.\n\n  2\\. Did not undergo surgical repair, received only palliative treatment, or did not meet postoperative randomization conditions.\n\n  3\\. Expected inability to complete 12-month follow-up, no stable contact information, or inability to obtain outpatient, telephone, or inpatient follow-up data.\n\n  4\\. Severe missing baseline data preventing generation of the AI risk report. 5. Concurrent participation in another interventional study that may substantially affect postoperative follow-up intensity or the primary outcome.\n\n  6\\. Any other condition that, in the investigator's judgment, makes the patient unsuitable for participation.","ALL","18 Years",{"count":20,"type":21},1314,"ESTIMATED","INTERVENTIONAL",[24],"NA","This multicenter, prospective, randomized controlled trial will evaluate whether an artificial intelligence (AI) multimodal prediction model-guided intensified follow-up strategy improves 1-year outcomes after surgery for acute Stanford type A aortic dissection. Eligible adult patients who have undergone open surgical repair or open plus endovascular\u002Fhybrid repair and are clinically stable to enter the postoperative follow-up phase will be randomized 1:1 to usual postoperative follow-up or AI-guided intensified follow-up. The AI-guided arm will receive usual follow-up plus an AI-generated risk stratification report for 1-year mortality and adverse aortic remodeling. Higher-risk patients may receive more frequent follow-up, prioritized CTA review, multidisciplinary assessment, and targeted management reminders. The primary outcome is all-cause mortality through postoperative day 365. Key secondary outcomes include aortic reintervention, adverse aortic remodeling, and ICU readmission within 1 year.",[27,28,29],"Acute Type A Aortic Dissection","Stanford Type A Aortic Dissection","Postoperative Aortic Dissection Follow-up",[31,32,33,34,35,36,37,38],"Acute type A aortic dissection","ATAAD","randomized controlled trial","artificial intelligence","multimodal prediction model","intensified follow-up","aortic reintervention","adverse aortic remodeling","NOT_YET_RECRUITING","2026-05-29",{"date":42,"type":43},"2026-06-03","ACTUAL",{"date":45,"type":21},"2026-12-01",{"date":47,"type":21},"2029-12-01",{"name":49,"class":50},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100604518","arch-clamping-technique-under-mild-hypothermia-in-treating-with-acute-type-a-aortic-dissection-100604518","NCT07150559","Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection","Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection: Study Protocol for a Multicenter, Three-arm, Open-label, Randomized, Parallel-controlled Trial","AHEAD","Inclusion Criteria:\n\n1. Aortic CTA confirmed as ATAAD according to the 2022 ACC\u002FAHA Guideline for the Diagnosis and Management of Aortic Disease;\n2. Adult patients (18-70 years) weighing 50-120 kg;\n3. Time interval between the onset of symptoms and operation is less than 14 days;\n4. Indications for total aortic arch replacement are available;\n5. Signed informed consent and availability for follow-up.\n\nExclusion Criteria:\n\n1. History of chronic renal failure, hepatocirrhosis, and hepatic insufficiency;\n2. Severe gastrointestinal complications of non-aortic dissection, such as mesenteric ischemia, gastrointestinal bleeding, hepatopancreaticobiliary dysfunction, and intestinal obstruction;\n3. History of severe cerebral infarction (with cerebral infarction sequels);\n4. Preoperative intubation or unconsciousness;\n5. Inflammatory aortic diseases, such as Takayasu arteritis and Behçet's disease, etc;\n6. History of infectious aortic diseases;\n7. History of cardiac and aortic surgery;\n8. History of malignancy or previous radiotherapy;\n9. Pregnant or feeding women, or anyone planning to reproduce during the test period;\n10. Without an informed consent signature;\n11. Participating in any other clinical trial;\n12. Having other causes not eligible for operation.","70 Years",{"count":61,"type":21},306,[24],"The study is a multicenter, three-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 306 participants diagnosed with acute type A aortic dissection (ATAAD) from 7 hospitals in China. All patients receive total arch replacement (TAR) combined with frozen elephant trunk (FET) implantation and are randomized to Group 1 (arch-clamping technique under mild hypothermia), Group 2 (arch-clamping technique under moderate hypothermia) and Group 3 (Sun's procedure using bilateral antegrade cerebral perfusion) in the ratio of 1:1:1. After a 1-year follow-up, the validity and safety of the mild hypothermic arch-clamping technique for ATAAD was evaluated via the incidence of major adverse events including death, renal replacement therapy, stroke, and paraplegia, as well as times of circulatory arrest, cardiopulmonary bypass, and mechanical ventilation, and length of ICU stay.",[27,65,66,67,68],"Hypothermia","Total Aortic Arch Replacement","Frozen Elephant Trunk","Bilateral Antegrade Cerebral Perfusion","RECRUITING","2026-04-02",{"date":72,"type":43},"2026-04-06",{"date":74,"type":43},"2026-02-03",{"date":76,"type":21},"2028-02-28",{"name":78,"class":50},"Beijing Anzhen Hospital",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":18,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":4,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":79},"100587545","a-prediction-model-of-prolonged-mechanical-ventilation-following-acute-type-a-aortic-dissection-surgery-100587545","NCT06929780","A Prediction Model of Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery","Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery: Risk Factor Analysis, Impact on Clinical Outcomes and Development of Prediction Model","Inclusion Criteria:\n\n* Age ≥18 years;\n* Diagnosis of acute type A aortic dissection (ATAAD) confirmed by computed tomography angiography and echocardiography;\n* Patients who underwent aortic surgery requiring cardiopulmonary bypass (CPB), were admitted to the surgical intensive care unit (SICU), and received mechanical ventilation.\n\nExclusion Criteria:\n\n* Reintubation;\n* Intraoperative death or failure to survive beyond 72 hours postoperatively;\n* Pregnancy;\n* Severe comorbidities (e.g., lung cancer);\n* Missing critical outcome data (e.g., short-term mortality, mechanical ventilation duration, reintubation).",{"count":88,"type":21},1400,"OBSERVATIONAL","The goal of this observational study is to develop and validate a predictive model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery.\n\nThe main questions it aims to answer are:\n\n1. To validate the predictive performance of the model for PMV after ATAAD surgery\n2. To assess the proportion of PMV among patients undergoing ATAAD surgery\n3. To evaluate the ICU length of stay and operative mortality in patients with PMV following ATAAD surgery",[27],[31,93,94],"Prolonged mechanical ventilation","mechanical ventilation time","2025-04-08",{"date":97,"type":43},"2025-04-16",{"date":99,"type":21},"2025-04-10",{"date":101,"type":21},"2025-09-30",{"name":103,"class":50},"China-Japan Friendship Hospital"]