[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-uncomplicated-appendicitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-uncomplicated-appendicitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100639074","phase-3-efficacy-of-non-operative-treatment-with-amoxicillinclavulanic-acid-versus-surgical-treatment-in-acute-uncomplicated-appendicitis-in-children-100639074",false,"NCT07587450","Efficacy of Non Operative Treatment With Amoxicillin\u002FClavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children","Efficacy of Non Operative Treatment With Amoxicillin\u002FClavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children: a Prospective Multicenter Randomized Controlled Non-inferiority Trial With Cost Utility Analysis","NACAC","Inclusion Criteria:\n\n* Age from 5 to \\\u003C15 years-old\n* Diagnosis of first episode of acute uncomplicated appendicitis confirming the diagnosis:\n* an increase in the calibre of the appendix, measured at more than 6 mm in diameter and non-compressibility\n* free fluid, echogenic fat, regional hyperemia\n* performed in hospital or reviewed by local radiologist investigators if performed outpatient.\n* Surgery expected within 24 hours after diagnosis\n* Parental good understanding of the monitoring French instructions\n* Free and informed consent, signed by both holders of parental authority\u002Flegal representative, with the accord of the minor patient.\n* Affiliation to the health insurance plan\n\nExclusion Criteria:\n\n* Ultrasound or CT scan showing one or several stercoliths, a plastron, an abscess or peritonitis\n* Non-visualization of the appendix at ultrasound or CT scan\n* Situations contraindicating surgery or anesthesia (patient for whom surgery and anesthesia would pose a life-threatening risk)\n* Patients who have already received antibiotic therapy for acute appendicitis\n* Known immunodepression, ongoing immunosuppressive treatment, diabetes\n* Severe hematologic disorders (such as bone marrow failure, blood clotting disorders)\n* History of proved allergy to Penicillin\n\n  * History of proved allergy to amoxicillin and\u002For clavulanic acid\n  * History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. a cephalosporin, carbapenem or monobactam).\n  * History of jaundice\u002Fhepatic impairment due to amoxicillin\u002Fclavulanic acid\n  * History of allergy to any of the excipients listed in section 6.1 of each SmPC.\n* On going antibiotherapy : previous antibiotherapy have to be stopped at least 48h before inclusion\n* Parental refusal of research protocol\n* Impossibility of home follow-up after discharge from hospital\n* Pregnancy\u002F breastfeeding\n* Simultaneously participation in another research study involving medicinal products\n* Mental state rendering the person giving consent incapable of understanding the trial\n* Parents being a relative of the investigator or a relative of someone from the team directly involved in the trial, including assistant doctors, pharmacists, nurses, and trial coordinators\n* Renal insufficiency with creatinine clearance \\\u003C 30mL\u002Fmin\n* Presence of an appendicolith","ALL","5 Years","14 Years",{"count":21,"type":22},724,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","The majority of children with uncomplicated acute appendicitis may be considered for either a non-operative or an operative management. The antibiotic-first strategy appears effective as an initial treatment in 97% of children with uncomplicated AA (recurrence rate 14%), with Non Operative Treatment (NOT) also leading to less morbidity, fewer disability days, and lower costs than surgery. In this trial, the investigators will compare children randomised in a surgery group with children randomised in a NOT group (antibiotic strategy group). Children have 2 on-site visits (including surgery) in the first 12 days with recording of clinical datas and questionnaires, a phone visit at month 1, month 6, month 12 to collect concomitant treatment, Adverse Event (AE) and complications and parental questionnaires at the end of the study. A Cost-Utility analysis will be performed from the healthcare payer's perspective. The time horizon of the medico economic analysis was one year.",[28],"Acute Uncomplicated Appendicitis",[30,31,32],"surgery","antibiotics therapy","medico - economic analysis","NOT_YET_RECRUITING","2026-05-19",{"date":36,"type":37},"2026-05-22","ACTUAL",{"date":39,"type":22},"2026-09-01",{"date":41,"type":22},"2034-09-01",{"name":43,"class":44},"University Hospital, Toulouse","OTHER",10,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":59,"conditions":60,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100610653","direct-visualization-erat-versus-laparoscopic-appendectomy-in-adults-with-acute-uncomplicated-appendicitis-100610653","NCT07230379","Direct Visualization ERAT Versus Laparoscopic Appendectomy in Adults With Acute Uncomplicated Appendicitis","Direct Visualization Endoscopic Retrograde Appendicitis Therapy (ERAT) Versus Laparoscopic Appendectomy (LA) for Acute Uncomplicated Appendicitis in Adults (E-APPEND): An Open-Label, Multicenter, Randomized Controlled Non-Inferiority Trial","E-APPEND","Inclusion Criteria:\n\n1. Age ≥ 18 years.\n2. Diagnosis of first-episode acute uncomplicated appendicitis (AUA) confirmed by CT scan of the lower abdomen. AUA is defined as acute appendicitis without evidence of abscess, perforation, gangrene, or tumor.\n3. Provision of written informed consent.\n\nExclusion Criteria:\n\n1. Complicated appendicitis, defined as acute appendicitis with perforation, gangrene, periappendiceal abscess or phlegmon, generalized peritonitis, or radiologic evidence of extraluminal appendicolith, extraluminal air, periappendiceal fat stranding, or appendiceal mass.\n2. Severe intestinal adhesions or bowel obstruction.\n3. Intolerance or contraindication to bowel preparation or colonoscopy (e.g., intestinal perforation or bowel obstruction).\n4. Poor general condition precluding tolerance of abdominal surgery.\n5. Abdominal pain caused by other diseases as confirmed by CT or other diagnostic examinations, including inflammatory bowel disease, urinary tract disease, or gynecological disease.\n6. Pregnancy.\n7. Severe dysfunction of major organ systems, including but not limited to cardiac, pulmonary, renal, hepatic, or hematologic systems.\n8. Current enrollment in another clinical trial.\n9. Any condition that may prevent the participant from completing all study requirements.","18 Years",{"count":56,"type":22},376,[58],"NA","This study compares two ways of treating acute uncomplicated appendicitis, which is a mild form of appendicitis. In the Direct Visualization ERAT group, participants will receive Endoscopic Retrograde Appendicitis Therapy (ERAT). This is a minimally invasive, non-surgical treatment that uses a flexible endoscope passed through the colon to reach the appendix, clear the blockage, and drain the infection. In the Surgery group, participants will undergo Laparoscopic Appendectomy (LA), which is the current standard surgical treatment to remove the appendix. The purpose of this study is to determine whether ERAT is as safe and effective as standard surgery for treating uncomplicated appendicitis.\n\nBefore treatment, each participant will have a CT scan of the lower abdomen with contrast to confirm uncomplicated appendicitis and to rule out any signs of more serious infection. Participants will then be randomly assigned to either the ERAT group or the surgery group, and they will be informed of which treatment they will receive. Regardless of the group, all participants will receive the same supportive care, including pain relief, close monitoring, and a single dose of antibiotics before treatment. After the procedure, participants will stay in the hospital for at least 24 hours for observation. Follow-up will include an outpatient visit at 2 weeks, and telephone follow-ups at 1 month, 3 months, 6 months, and 1 year to monitor recovery and ensure that appendicitis does not recur.",[28],[62,63,64,65,66],"ERAT","Endoscopic retrograde appendicitis therapy","Appendicitis","LA","Laparoscopic appendectomy","2025-11-13",{"date":69,"type":37},"2025-11-17",{"date":71,"type":22},"2025-11",{"date":73,"type":22},"2027-11",{"name":75,"class":44},"Changhai Hospital",14]