[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"acute-uncomplicated-diverticulitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:acute-uncomplicated-diverticulitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100639711","phase-4-non-antibiotic-management-in-acute-uncomplicated-diverticulitis-100639711",false,"NCT07625267","Non-antibiotic Management in Acute Uncomplicated Diverticulitis","Non-antibiotic Management in Acute Uncomplicated Diverticulitis: Randomized Open Label-controlled Trial","NAMAD","Inclusion Criteria:\n\n* Left-sided diverticulitis, primary or recurrent\n* Signs of diverticulitis on CT-confirmed Hinchey (0 or 1a based on CT final report)\n* White Blood Cell (WBC) count \\\u003C15,000mm\\^3\n* Controlled symptoms in the ED (i.e., Pain score \\\u003C5 on VAS scale, tolerating PO intake, no fever)\n\nExclusion Criteria:\n\n* Signs of complicated diverticulitis on CT with abscess, fistula, free air, Micro perforation, or signs of other diagnosis on CT Abdomen and pelvis\n* Inflammatory bowel disease\n* American Society for Anesthesiologists (ASA) physical status classification of \\>=3\n* Immunocompromised patient; (i.e., haematological malignancies, AIDS patients with low CD4+ counts, transplantation, chemotherapy, splenectomy, long-term corticosteroid use and genetic disorders such as severe combined immunodeficiency\n* Pregnancy\n* Ongoing antibiotic therapy or in the previous 2 weeks\n* High fever, affected general condition, peritonitis or sepsis\n* Subjects who do not have the capacity to consent","ALL","18 Years","80 Years",{"count":21,"type":22},556,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Diverticulitis is a common condition that causes swelling and pain in part of the colon (the large intestine). Doctors classify it as \"mild\" when there are no serious complications.\n\nFor many years, doctors in the United States have treated mild diverticulitis with antibiotics. New studies from Europe suggest that many people with mild diverticulitis may not need antibiotics and can get better with just pain medicines. But this approach has not been tested in the United States, where antibiotics are still the standard treatment.\n\nThe goal of this clinical trial is to find out if people with mild diverticulitis can be safely treated at home without antibiotics. The main questions it aims to answer are:\n\n* Are people treated without antibiotics admitted to the hospital more often than people treated with antibiotics?\n* Do people treated without antibiotics have more emergency room visits, worsening of their disease, or need for surgery?\n\nResearchers will compare two groups of people who come to the emergency department with mild diverticulitis to see if treatment without antibiotics is as safe as treatment with antibiotics.\n\nParticipants will:\n\n* Be sent home with pain medicines (ibuprofen and acetaminophen) only, or with pain medicines plus an antibiotic taken by mouth for 7 days\n* Follow a liquid diet and slowly return to normal food as they feel better\n* Come back to clinic for a check-up at 1 to 2 weeks\n* Answer phone calls about their health at 4 weeks, 3 months, and 6 months",[28],"Acute Uncomplicated Diverticulitis",[30,31,32,33,34],"Diverticulitis, Colonic","Anti-Bacterial Agents","Outpatients","Watchful Waiting","Acute Disease","NOT_YET_RECRUITING","2026-05-26",{"date":38,"type":39},"2026-06-04","ACTUAL",{"date":41,"type":22},"2026-07-01",{"date":43,"type":22},"2028-06-30",{"name":45,"class":46},"Montefiore Medical Center","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100630781","phase-2-aplaud-trial-antibiotics-vs-placebo-for-acute-uncomplicated-diverticulitis-100630781","NCT07492134","APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)","Comparing Placebo Versus Antibiotics for Acute Uncomplicated Diverticulitis","Inclusion Criteria:\n\n* Patients presenting to the emergency department with left-sided uncomplicated diverticulitis\n* Radiologic score (moderate diverticulitis per Ambrosetti classification)\n* Age 18-90\n* Access to a smartphone with internet access.\n\nExclusion Criteria:\n\n* Complicated diverticulitis (abscess, free air, peritonitis)- severe diverticulitis by Ambrosetti classification\n* Diverticulitis other than left colon\n* Contraindication to use of study medication (ie advanced renal failure or allergy to all antibiotics used in the study)\n* Concurrent cancer diagnosis\n* Concurrent IBD Diagnosis\n* Any other disease process with life expectancy \\\u003C 6 months\n* Concurrent chronic pain diagnosis.\n* Women in pregnancy or breastfeeding\n* Antibiotic treatment for any reason in the last 3 weeks\n* Diagnosis of prior episode of acute diverticulitis in the past 3 months\n* Significant comorbidities: diabetes mellitus with organic involvement (retinopathy, angiopathy, nephropathy), emergency assistance for a cardiogenic event in the last 3 months (acute myocardial infarction, angina, heart failure), decompensation of chronic liver disease in the last 3 months (Child ≥ B) and end-stage renal disease.\n* Immunodepression: the absence, and immunodepression is the presence, of any of the following: active neoplastic disease, hematologic malignancy, human immunodeficiency virus long-term corticosteroid treatment, immunosuppressant therapy (20mg pred (or equivalent) for \\>2 weeks), transplant, splenectomy and genetic immunodeficiency\n* Previous colectomy\n* Patients with dementia, memory disorders or other cognitive impairment that would impact their ability to provide informed consent or otherwise participate in the trial","90 Years",{"count":57,"type":22},100,[59],"PHASE2","The goal of this clinical trial is to determine whether antibiotics improve recovery from acute uncomplicated diverticulitis (AUD) in racially and ethnically diverse United States clinical practice. The main questions it seeks to answer are:\n\n* What is the feasibility for completing a subsequent definitive efficacy trial of antibiotics vs. placebo to treat AUD?\n* What are the needs for successful recruitment of racial and ethnic subgroups?\n* What are the effects of a placebo compared to antibiotics for AUD on a range of key patient-centric efficacy and safety endpoints?\n* How do such effects differ by race and ethnicity? Researchers will compare a placebo to antibiotics to see if AUD can be treated without using antibiotics.\n\nParticipants will:\n\n* Take two antibiotics or a matching placebo every day for 10 days\n* Receive analgesia, gastric protection, diet modifications, and a follow-up\n* Submit daily photos of pills to the study team to verify adherence",[28],[63,64,65],"Acute uncomplicated diverticulitis","Antibiotic stewardship","Antimicrobial resistance","2026-04-15",{"date":68,"type":39},"2026-04-21",{"date":70,"type":22},"2026-04-01",{"date":72,"type":22},"2028-10-01",{"name":74,"class":46},"Vanderbilt University Medical Center"]