[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adaptation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adaptation":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,52,79,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100624481","resistance-training-adaptations-and-caffeine-intake-100624481",false,"NCT07410195","Resistance Training Adaptations and Caffeine Intake","Study of Different Caffeine Supplementation Strategies on Resistance Training-Induced Adaptations","Inclusion Criteria:\n\n* Male sex and age between 18-30 years\n* No history of caffeine use or very low habitual intake (\\\u003C50 mg\u002Fday)\n* No participation in a regular resistance training program in the past 6 months\n* Body mass index (BMI) between 18.5-30 kg\u002Fm2\n* Willingness to attend all training and testing sessions regularly\n* Provision of written informed consent after being fully informed about the study\n\nExclusion Criteria:\n\n* Presence of cardiovascular, metabolic, renal, hepatic, or other serious chronic diseases\n* Diagnosed psychiatric disorders or severe caffeine intolerance\u002Fallergy\n* Use of medications affecting caffeine metabolism or muscle anabolism (e.g., beta-blockers, antidepressants, anabolic steroids)\n* Musculoskeletal injuries that prevent safe resistance training\n* Smoking or alcohol consumption at levels that could affect study outcomes\n* Concurrent participation in another exercise intervention study\n* Inability to tolerate DXA scanning, blood sampling, or D2O ingestion procedures",true,"MALE","18 Years","30 Years",{"count":21,"type":22},180,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized, double-blind, placebo-controlled crossover trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 180 caffeine-naive, inactive young adult males. Participants will undergo two 4-week supervised resistance training programs separated by a 2-week washout\u002Fcrossover period. The three caffeine strategies are: (1) constant daily low-moderate dosing (3 mg\u002Fkg\u002Fday), (2) gradually escalating dose (3 to 6 mg\u002Fkg across weeks), and (3) training-day-only caffeine (3 mg\u002Fkg\u002Fday). Primary outcomes include non-invasive measures of integrated anabolism and hypertrophy (D2O-derived plasma proteomic fractional synthesis rate, DXA muscle volume) and strength metrics. Secondary outcomes include hormonal responses (insulin, cortisol, testosterone, IGF-1), sleep\u002Frecovery parameters, and adverse effects.",[28,29,30,31],"Muscle Hypotrophy","Exercise Performance","Muscle Strength","Adaptation",[33,34,35,36,37,38],"Caffeine","Resistance Training","Muscle Adaptation","Supplementation","Strength Training","Hypertrophy","NOT_YET_RECRUITING","2026-02-07",{"date":42,"type":43},"2026-02-13","ACTUAL",{"date":45,"type":22},"2026-02-20",{"date":47,"type":22},"2026-04-20",{"name":49,"class":50},"Istanbul University - Cerrahpasa","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":16,"sex":59,"minAge":4,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":51},"100616276","preparation-for-sports-retirement-study-protocol-100616276","NCT07303504","Preparation for Sports Retirement: Study Protocol","Preparation for Sports Retirement: Protocol for a Psychoeducational Program in a Randomized Controlled Trial","Inclusion Criteria:\n\n* Participants will be included if they are within the critical transition period, defined as:\n\nFive years prior to sports retirement, when the first signs of preparation and emotional anticipation begin.\n\nFive years after retirement, the stage in which identity, psychological, and professional adaptation processes are consolidated.\n\nThis interval reflects the progressive nature of adaptation to sports retirement.\n\nExclusion Criteria:\n\n* Athletes presenting any of the following conditions will be excluded from the study:\n\nSignificant literacy difficulties or relevant deficits in linguistic comprehension that prevent adequate participation in the psychoeducational sessions or the completion of assessment instruments.\n\nSevere unstabilized medical or psychological conditions that may interfere with the normal development of the program (e.g., untreated severe depressive episodes, limiting neurological disorders).\n\nFailure to meet the inclusion criteria, specifically not being within the five-year period prior to or after sports retirement or failing to verify high-performance sports experience.\n\nRefusal to sign the informed consent or lack of availability to regularly attend the program sessions.","ALL",{"count":61,"type":22},26,[25],"Background: This article presents the protocol for a randomised controlled trial designed to develop and evaluate a psychoeducational intervention aimed at preparing high-performance athletes for the challenges and opportunities presented by the transition to retirement from sport. The protocol was developed through a literature review and consultations with experts in sports psychology and career transition.\n\nMethods: The study will be conducted at the Faculty of Psychology of the University of Salamanca (Spain). High-performance athletes aged 30 or older who are close to retirement or who have retired in the last five years will be recruited. Participants will be randomly assigned to two groups: the intervention group, which will undergo a psychoeducational programme consisting of 12 sessions over 3 months; and the control group, which will receive a minimum educational programme of one session. All participants will complete initial and final assessments, as well as a 3-month follow-up, collecting sociodemographic data and applying various psychological, social and health assessment instruments.\n\nDiscussion: This protocol describes a comprehensive psychoeducational intervention aimed at improving quality of life and attitudes towards retirement from sport, increasing life satisfaction, psychological flexibility, perceived social support, general health, self-efficacy and self-regulation, and reducing negative stereotypes associated with the end of a sporting career. The evidence generated will guide future interventions, policies, and educational programmes to promote a healthy, active, and satisfying transition to the post-sport stage.",[65,66,67,31,68,69],"Sport Retirement","Psychoeducation","Retirement","Psychosocial Factors","Psychology","2025-12-26",{"date":72,"type":43},"2025-12-31",{"date":74,"type":22},"2026-02-01",{"date":76,"type":22},"2027-05-01",{"name":78,"class":50},"University of Salamanca",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":16,"sex":59,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":51},"100558816","investigating-the-effects-of-transcranial-direct-current-stimulation-to-different-brain-regions-on-ankle-tracking-motor-learning-motor-adaptation-and-brain-connectivity-in-healthy-middle-aged-and-older-adults-and-patients-with-subcortical-stroke-100558816","NCT06556043","Investigating the Effects of Transcranial Direct Current Stimulation to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke","Investigating the Effects of Transcranial Direct Current Stimulation (tDCS) to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke","tDCS","Inclusion Criteria: Part 1: healthy middle-aged and older adults\n\n1. age between 40 and 80 years old\n2. intact cognitive function (MMSE ≧ 27)\n3. normal ankle dorsiflexor and plantarflexor strength (manual muscle strength testing= 5) and passive range of motion (ankle dorsiflexion ≧10 degrees; ankle plantarflexion ≧ 45 degrees)\n4. corrected far vision ≥ 0.8 (Landolt C test) and uncorrected near vision ≥ 0.04 (Comprehensive Color Blindness Checklist)\n\nExclusion Criteria: Part 1: healthy middle-aged and older adults\n\n1. having any contraindications for MRI or tDCS;\n2. serious or uncontrolled systematic diseases;\n3. symptoms or history of neurological diseases, including transient ischemic attack, stroke, epilepsy, history of abnormal electroencephalogram (EEG), meningitis, encephalitis, brain tumors, brain surgery, and sensory disorders, etc.;\n4. severe musculoskeletal problems that would affect lower limb functions;\n5. visual spatial perception disorders and hearing loss;\n6. color blindness;\n7. depression and psychiatric disorders;\n8. use of any medication that could affect the central nervous system function;\n9. drug, substance, or alcohol addiction;\n10. those participating in research involving invasive or non-invasive brain stimulation;\n11. those deemed unsuitable for MRI or tDCS after evaluation by the attending physician;\n12. those affiliated with any research-conducting institution.\n\nInclusion Criteria: Part 2: patients with chronic subcortical stroke\n\n1. aged between 40 and 80 years old;\n2. intact cognitive function (MMSE ≥ 27);\n3. first-ever onset of subcortical stroke occurring at least 3 months prior to enrollment, with brain lesions involving unilateral subcortical regions only;\n4. hemiplegic or hemiparetic;\n5. no spatial neglect;\n6. able to actively perform at least 5 degrees of ankle dorsiflexion and 10 degrees of ankle plantarflexion with the affected ankle;\n7. no excessive spasticity;\n8. no severe contracture (passive range of motion ≥ 10 degrees for ankle dorsiflexion and ≥ 20 degrees for ankle plantarflexion) in the affected leg;\n9. mild-to moderate disability;\n10. can walk independently or under supervision without assistance;\n11. corrected far vision ≥ 0.8 (Landolt C test) and uncorrected near vision ≥ 0.04 (Comprehensive Color Blindness Checklist.)\n\nExclusion Criteria: Part 2: patients with chronic subcortical stroke The exclusion criteria will be the same as those listed for healthy participants described in Part 1 except for items (3) and (4). Item (3) will be changed to \"(3a) symptoms or history of other neurological diseases, including epilepsy, history of abnormal EEG, meningitis, encephalitis, brain tumors, brain surgery, and sensory disorders, etc.\" and item (4) will be changed to \"(4a) severe musculoskeletal problems of the non-hemiparetic limbs that would affect mobility functions\".","40 Years","80 Years",{"count":90,"type":22},120,[25],"Ankle control is essential to safe over-ground navigation for humans. Middle- aged and older adults and patients with stroke whose ankle control is poor often lose their balance or fall. Transcranial direct current stimulation (tDCS) is an emerging non-invasive brain stimulation technology that has great potential to be applied to neurorehabilitation; however, the optimization of its applications still needs further studies. The aims of this project are to compare the effects of anodal tDCS (AtDCS) applied to the primary motor cortex (M1) contralateral to the moving leg (cM1), posterior parietal cortex (PPC) contralateral to the moving leg (cPPC), and cerebellar cortex (CBM) ipsilateral to the moving leg (iCBM) on motor learning, motor adaptation, and brain connectivity in healthy middle-aged and older adults and hemiparetic patients with chronic subcortical stroke.",[94,95,96,31,97,98,99],"Transcranial Direct Current Stimulation","Ankle","Motor Learning","Brain Structure","Brain Connectivity","Stroke","RECRUITING","2024-08-15",{"date":103,"type":43},"2024-08-19",{"date":105,"type":43},"2024-07-09",{"date":107,"type":22},"2026-07-31",{"name":109,"class":50},"National Taiwan University Hospital",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":16,"sex":59,"minAge":117,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":130,"locationsCount":51},"100557060","psycho-educational-intervention-programme-for-comprehensive-preparation-for-retirement-study-protocol-100557060","NCT06533202","Psycho-educational Intervention Programme for Comprehensive Preparation for Retirement: Study Protocol","Study Protocol for a Randomised Controlled Trial: Effect of a Psycho-educational Intervention Programme for Comprehensive Preparation for Retirement and the New Phase of Life","Inclusion Criteria:\n\n* Be retired or nearing retirement (within 5 years)\n* Be 60 years of age or older\n* Voluntarily sign the consent form to participate\n* Complete the initial assessment\n\nExclusion Criteria:\n\n* No evidence of literacy difficulties or a significant deficit in language comprehension\n* Not meet any of the inclusion criteria.","60 Years",{"count":61,"type":22},[25],"Background: The transition to retirement can be a challenging event, necessitating the adjustment of new routines, roles and expectations. Such modifications have the potential to impact the individual's quality of life and psychosocial well-being. t is of the utmost importance to develop intervention programmes that prepare people for retirement, with the objective of facilitating a positive and healthy transition.\n\nMethods: A parallel randomised controlled clinical trial with two arms will be conducted. The study will be conducted at the Faculty of Psychology of the University of Salamanca (USAL) in Spain. The study will recruit individuals aged 60 years or older who are already retired or who will retire within the next five years. The participants will be divided into two groups: the intervention group (IG), which will undergo a comprehensive psychoeducational intervention programme, and the control group (CG), which will engage in a controlled follow-up. The programme will comprise 12 sessions over a period of three months. All participants will be assessed at the outset and conclusion of the study, as well as after three months, during which time data regarding their socio-demographic characteristics and responses to the following scales will be collected: The World Health Organization Quality of Life Measure - Brief Version (WHOQOL-BREF), the Retirement Attitudes Scale (EAJ), the Satisfaction With Life Scale (SWLS), the Questionnaire of Stereotypes towards Old Age (CENVE), the Acceptance and Action Questionnaire-II (AAQ-II), the MOS Questionnaire of Perceived Social Support (MOS), the General Health Questionnaire (GHQ), the Generalised Self-Efficacy Scale (EAG) and the Self-Regulation Scale (EAR).\n\nDiscussion: The objective of this study is to enhance the comprehension and implementation of intervention programmes in anticipation of retirement and the subsequent phase of life. To this end, a comprehensive psychoeducational intervention is proposed, with the aim of improving quality of life and attitudes towards retirement, increasing life satisfaction, psychological flexibility, perceived social support and general health, self-efficacy and self-regulation, and reducing stereotypes about ageing. The programme is designed to equip individuals with the skills and knowledge to navigate the challenges and opportunities associated with the transition to retirement.",[122,31,68,69,123,67],"Aging","Older People","2024-07-29",{"date":126,"type":43},"2024-08-01",{"date":128,"type":22},"2024-09-09",{"date":72,"type":22},{"name":78,"class":50}]