[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"addiction-alcohol\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:addiction-alcohol":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,66,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100408499","efficiency-of-prevention-program-dedicated-to-addictive-behaviors-preventure-of-vulnerable-teenagers-100408499",false,"NCT04599270","Efficiency of Prevention Program Dedicated to Addictive Behaviors (PREVENTURE) of Vulnerable Teenagers","PREVADO","Inclusion Criteria:\n\n* Aged between 14 and 17 years old\n* Patient consulting in one of the participating centres or referred by a school doctor\n* Patient who has had at least one previous experience with alcohol (at least 1 standard unit of alcohol, once in their lifetime)\n* Having access to an internet network and a computer, tablet or telephone\n* Written and informed consent of the parents and the teenager\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Moderate to Severe Adolescent Substance Use Disorders (other than smoking)\n* Decompensated current psychiatric disorders in adolescents\n* Already followed for severe use disorders and\u002For severe psychiatric disorders\n* Nonunderstanding of the french language","ALL","14 Years","17 Years",{"count":20,"type":21},700,"ESTIMATED","INTERVENTIONAL",[24],"NA","At the age of 17, in Brittany, 94.9% of adolescents have experimented alcohol consumption 78.1% within a month and 25.5% report repeated episodes of Intensive Punctual Alcohol. Among the potential explanatory factors of this worrying epidemiology, social and cultural factors induce a social valuation of alcohol consumption and drunkenness. There are also individual vulnerability factors, particularly important in adolescence between experimentation and the transition to regular use or even to alcohol use disorders. Despite the extent of the damage, there is currently little reliable data on effective primary prevention strategies for dealing with addictive behavior. Many prevention programs target age range in school settings, to delay or reduce use of psychoactive substances.\n\nA meta-analysis on the impact of this prevention programs in school settings, concluded that most interventions are associated with no or little impact with respect to the goal of reducing psychoactive substances with teenagers.\n\nAmong existing programs, \"PREVENTURE\" has been evaluated in 5 trials with high-risk teenagers identified in schools settings, in different countries (Canada, Europe). The results show a clear and robust effect on reducing alcohol consumption. This program has not been tested outside the school setting and a recent review mention the need to make this program more accessible by targeting vulnerable groups and studying the impact of this program on this population.\n\nThe PREVADO study is a prospective, controlled, randomised, open-label study. After inclusion, the adolescent completes the questionnaire SURPS (Substance Use Risk Profile Scale).\n\nThe SURPS is self-report questionnaire that assesses four well-validated personality risk factors for substance misuse (Impulsivity, Sensation Seeking, Anxiety Sensitivity, and Hopelessness). There is a 23-item to which adolescents are asked to respond using a 4-point Likert scale ranging from \"strongly agree\" to \"strongly disagree\" : Hopelessness (7 items), Anxiety Sensitivity (5 items), Impulsivity (5 items), and Sensation Seeking (6 items).\n\nAdolescents will be randomized into 2 groups (stratification on the 4 predominant risk personality types from the SURPS (Substance Use Risk Profile Scale) and on the recruitment modality) :\n\n* Intervention group : teenagers follow the \"PREVENTURE\" program and routine cares\n* Control group : teenagers follow routine cares",[27,28],"Addiction, Alcohol","Addiction, Substance","RECRUITING","2026-06-08",{"date":32,"type":33},"2026-06-10","ACTUAL",{"date":35,"type":33},"2021-10-01",{"date":37,"type":21},"2027-10-01",{"name":39,"class":40},"University Hospital, Brest","OTHER",5,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100476948","evaluation-of-the-implementation-of-a-parenting-program-in-parents-with-children-aged-4-to-12-years-and-one-parent-with-an-alcohol-use-disorders-100476948","NCT05490589","Evaluation of the Implementation of a Parenting Program in Parents With Children Aged 4 to 12 Years and One Parent With an Alcohol Use Disorders","APPROCHILD","Inclusion Criteria :\n\n* Major subject (age \\> 18 years)\n* Patient with a child between 4 and 12 years old\n* Patient living with his\u002Fher child permanently or partially\n* Patient or his\u002F her spouse with an alcohol use disorder (at least 3 of the 11 DSM 5 criteria for alcohol use disorder in the past 12 months)\n* Written and informed consent\n\nExclusion Criteria :\n\n* Minor subject (age \\\u003C 18 years)\n* Acute, unstabilized psychiatric disorder impairing judgment\n* Incapacity or refusal to give consent\n* Subject under judicial protection or family habilitation\n* Subject deprived of liberty by judicial or administrative decision, under guardianship or curatorship ;\n* Non comprehension of the French language","18 Years",{"count":51,"type":21},90,[24],"Alcohol use disorders are a major public health problem in Europe. The average prevalence of Alcohol Use Disorders (AUD) in the general population is 7.5%, although there are large variations between countries. According to the literature, 20 to 30% of children have parents with problematic alcohol use. Public health authorities are alarmed by the precociousness of alcohol consumption in the youngest age and by the prevalence of alcohol consumption in adolescence. One of the well-established risk factors for alcohol use and abuse is having a parent with AUD. Compared with people growing up without any parent with AUD, the relative risk of suffering negative life events in childhood is 2 to 13 times higher if one or both parents have alcohol use disorders. A family history of Alcohol Use Disorders is predictive of earlier alcohol, tobacco, or cannabis use in adolescence, but it is also associated with a higher risk of developing substance use disorders.",[27],[56],"Alcohol dependance","2025-12-16",{"date":59,"type":33},"2025-12-22",{"date":61,"type":33},"2024-02-22",{"date":63,"type":21},"2027-08-22",{"name":39,"class":40},1,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":78,"conditions":79,"keywords":86,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100524217","neurobehavioral-profiles-of-adaptive-stress-responses-in-individuals-with-alcohol-use-disorder-100524217","NCT06105853","Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder","Towards Neurobehavioral Profiles and Models of Adaptive Stress Responses and Resilience in Individuals With Alcohol Use Disorder","A03","Inclusion criteria are:\n\n* age between 16 and 65 years\n* meeting at least 2 criteria of an alcohol use disorder according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5), yet without the need for a therapeutic intervention\n* fluency in German\n* able to understand the study procedures and give informed consent\n* willingness to use a study smartphone\n\nExclusion criteria are:\n\n* current use of drugs or medications that interact with the central nervous system or the glucocorticoid system\n* contraindications for magnetic resonance imaging\n* medical history of bipolar disorder, psychotic disorder, schizophrenia or schizophrenic spectrum disorder, or substance use disorder other than alcohol, nicotine, or cannabis\n* medical history of severe head injury or other severe central nervous system disorders or other severe somatic disorders (e.g. liver cirrhosis)\n* pregnancy","65 Years",{"count":76,"type":21},100,[24],"The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder. The main questions the projects aims to answer are:\n\nWhat are the neurobehavioral underpinnings of adaptive stress responses and resilience to repeated stress exposure with regards to:\n\n* alcohol craving?\n* alcohol use?\n* their modulation by prior stress exposure, social interactions, coping strategies and individual health behavior?\n\nParticipants will:\n\n* be exposed to an established experimental stress-induction protocol, the Trier Social Stress Test\n* be exposed to their favorite drink in a bar lab environment\n* be assessed using fMRI to determine their neural alcohol cue reactivity, response inhibition, and emotion processing\n* conduct an ambulatory phase to assess stressors, alcohol craving, substance use and details on social interactions, health behavior and coping strategies using ecological momentary assessment tools.",[80,81,82,83,84,27,85],"Alcohol Use Disorder","Stress Reaction","Social Stress","Craving","Relapse","Risk Behavior",[87,88,89,90,91,92,93,94],"stress","resilience","craving","sensitization","habituation","cortisol","ecological momentary assessment","alcohol use disorder","2025-04-28",{"date":97,"type":33},"2025-04-29",{"date":99,"type":33},"2023-12-01",{"date":101,"type":21},"2027-06-30",{"name":103,"class":40},"Central Institute of Mental Health, Mannheim",2,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":123,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":65},"100467042","acceptability-of-simultaneous-screening-for-viral-hepatitis-b-c-and-hiv-among-drug-users-in-non-conventional-structures-100467042","NCT05361603","Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Structures","Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Facilities \"Outside the Walls\" Using the Dual Screening Method TROD (Rapid Diagnostic Tests) and FibroScan","SCANVIR","Inclusion Criteria:\n\n* Adult 18 and over\n* Patient frequenting an unconventional structure \"outside the walls\" or referred by a professional in the care sector\n* Patient who agreed to participate to the research\n\nExclusion Criteria:\n\n* Patient doesn't agree to participate to the research",true,{"count":115,"type":21},1500,"OBSERVATIONAL","The principle is to propose dedicated monthly screening days bringing together the health personnel involved (hepatologist, addictologist, nurse in charge of the program, addictology nurse and social worker) and to propose appropriate management for each situation assessed.",[119,120,27,121,122],"Hepatitis C","Transmission, Intravenous Drug Abuser","Addiction Opiate","Hepatitis C Virus Infection, Response to Therapy of",[124,125,126,127,128,129,130],"hepatitis C","Elimination","HBV","HIV","PWID","Addiction","Care structure","2022-05-03",{"date":133,"type":33},"2022-05-04",{"date":135,"type":33},"2017-05-24",{"date":137,"type":21},"2030-02-14",{"name":139,"class":40},"University Hospital, Limoges"]