[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adductor-canal-block\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adductor-canal-block":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,69,92,121,146,173],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100600091","comparison-of-two-different-regional-anesthetic-methods-in-total-knee-arthroplasty-patients-100600091",false,"NCT07092982","Comparison of Two Different Regional Anesthetic Methods in Total Knee Arthroplasty Patients","Comparison of the Effects of Ultrasound-Guided Adductor Canal Block With iPACK (Space Between the Popliteal Artery and the Posterior Knee Capsule) Block Combination and Suprainguinal Fascia Iliaca Block on Postoperative Pain and Stress Response in Patients Undergoing Total Knee Arthroplasty","Inclusion Criteria:\n\n* Patients undergoing total knee arthroplasty\n* Patients aged 18-75\n* Patients with ASA I-II-III\n\nExclusion Criteria:\n\n* Coagulation disorders\n* Allergy to local anesthetics\n* Liver and renal failure\n* Alcohol and drug addiction\n* Cognitive dysfunction that may prevent pain assessment\n* Systemic or needle insertion site infection\n* Analgesic use for more than 3 months\n* Patient refusal to participate in the study\u002Frefusal to consent\n* Presence of a hematoma, hernia, neoplasm, etc. in the area where the block will be performed\n* Pre-existing neurological deficit\n* Patients with contraindications to nerve block","ALL","18 Years","75 Years",{"count":20,"type":21},52,"ESTIMATED","INTERVENTIONAL",[24],"NA","Total Knee Arthroplasty patients are among the orthopedic cases that experience severe postoperative pain. In these cases, pain must be controlled. If pain is not controlled, early mobilization cannot be achieved. This can result in delayed physical therapy, prolonged hospital stays, the development of nosocomial infections, and impaired cognitive function. All of these factors contribute to increased patient care costs. Multimodal analgesia methods are used to control this pain. One of these methods is peripheral nerve blocks. Peripheral nerve blocks provide pain control and reduce the likelihood of opioid use and related side effects such as nausea, vomiting, and constipation. Current studies recommend Adductor Canal Blocks and iPACK (space between the popliteal artery and the posterior knee capsule) blocks for Total Knee Arthroplasty patients. In addition, studies are also being conducted on the application of the Suprainguinal Fascia-Iliaca Block in Total Knee Arthroplasty patients. The differences in postoperative analgesic effects between these methods are a matter of interest. No study has been conducted comparing the effects of these two approaches, which are routinely applied in our clinic and comply with guidelines, on the postoperative stress response. Regional anesthesia provides adequate pain control and has a positive effect on the stress response. The investigators aim to see a similar effect in peripheral nerve blocks. Therefore, comparing the methods that mentioned will contribute to the literature. In this study, the effects of these two different approaches on postoperative stress response and analgesic efficacy will be compared in terms of patients' postoperative opioid consumption, pain at rest and with movement, time to first analgesic need and development of motor block. IL-6 and CRP values will be examined pre-operatively and post-operatively to measure the effects on the stress response.",[27,28,29],"Total Knee Arthroplasty","Ultrasound Guided Supra-inguinal Fascia Iliaca Block","Adductor Canal Block","RECRUITING","2026-03-31",{"date":33,"type":34},"2026-04-06","ACTUAL",{"date":36,"type":34},"2025-08-04",{"date":38,"type":21},"2026-07",{"name":40,"class":41},"SB Istanbul Education and Research Hospital","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100631895","adductor-canal-block-methods-in-bilateral-total-knee-arthroplasty-100631895","NCT07506629","Adductor Canal Block Methods in Bilateral Total Knee Arthroplasty","Comparison of Surgeon-Performed Intraoperative Adductor Canal Block and Ultrasound-Guided Anesthesiologist-Performed Block in Bilateral Total Knee Arthroplasty","Inclusion Criteria:\n\n* Adult patients aged 19 years or older\n* Patients scheduled for bilateral total knee arthroplasty\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate or inability to provide informed consent\n* Neurological or psychiatric conditions affecting cooperation (e.g., dementia, delirium)\n* Pre-existing neurological or anatomical abnormalities of the lower extremities\n* Chronic opioid use or opioid dependence\n* Coagulation disorders or contraindications to nerve block\n* Pregnancy\n* Cases in which ultrasound evaluation is technically not feasible","60 Years",{"count":52,"type":21},48,[24],"This study aims to compare the analgesic efficacy of surgeon-performed intraoperative adductor canal block (ACB) and ultrasound-guided anesthesiologist-performed ACB in patients undergoing bilateral total knee arthroplasty (TKA). In a prospective, randomized paired design, each patient will receive surgeon-performed ACB on one knee and anesthesiologist-performed ACB on the contralateral knee.\n\nThe primary outcome is postoperative pain measured using the Numeric Rating Scale (NRS), and the study is designed to evaluate the non-inferiority of surgeon-performed ACB. Secondary outcomes include opioid consumption, time to first ambulation, length of hospital stay, postoperative complications, and patient-reported outcome measures (PROMs).\n\nAdditionally, postoperative ultrasound evaluation will be performed to assess the distribution pattern of local anesthetic within the adductor canal, including cross-sectional area and longitudinal spread. This study is expected to provide evidence regarding the clinical effectiveness and technical accuracy of surgeon-performed ACB in comparison with the conventional ultrasound-guided technique.",[56,27,57,58,29],"Knee Osteoarthritis","Postoperative Pain","Peripheral Nerve Block","NOT_YET_RECRUITING","2026-03-26",{"date":62,"type":34},"2026-04-01",{"date":64,"type":21},"2026-05-01",{"date":66,"type":21},"2029-03-01",{"name":68,"class":41},"Yonsei University",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":42},"100514638","enhanced-recovery-after-major-surgery-and-chronic-pain-for-total-knee-arthroplasty-100514638","NCT05981105","Enhanced Recovery After Major Surgery and Chronic Pain for Total Knee Arthroplasty","Expanding the Peri-operative Surgical Home Model: ERAS TKR With a Transitional Pain Service (TeleTPS) - Continuous Adductor Canal Catheter Versus Adductor Canal Block for Total Knee Arthroplasty, a Randomized Double-blinded Controlled Trial.","Inclusion Criteria:\n\n* Patients with osteoarthritis scheduled for a primary total knee arthroplasty with a participating surgeon\n* Age 18 to 75 years\n* Planned use of regional anesthesia\n* Ability to follow study protocol\n* English speaking (secondary outcomes include questionnaires validated in English only)\n* Patients of participating surgeons: Drs. Mayman, Jerabek, Westrich, Su, Della Valle, Alexiades\n* Lives within one hour of the hospital\n* Has a smartphone\n\nExclusion Criteria:\n\n* Hepatic or renal insufficiency\n* Younger than 18 years old and older than 65\n* Patients undergoing general anesthesia\n* Allergy or intolerance to one of the study medications\n* BMI \\> 40\n* Diabetes\n* ASA of III,IV\n* Chronic gabapentin\u002Fpregabalin use (regular use for longer than 3 months)\n* PCS \\> 30\n* Chronic opioid use (taking opioids for longer than 3 months, or daily oral morphine equivalent of \\>5mg\u002Fday for one month)\n* Patients with severe valgus deformity or flexion contracture\n* Patients unable to follow home catheter instructions and unwilling to go home with an infusing catheter\n* Patients who have no home caregivers in the event if a catheter is to be sent home with the patient\n* Patients with planned stay at rehab facility",{"count":77,"type":21},64,[24],"The goal of this interventional clinical trial is to assess opioid consumption 24-48 hrs post anesthesia block among patients undergoing total knee arthroplasty. The main question it aims to answer is:\n\n1\\. Is there a difference in opioid consumption 24-48 hours post block administration among patients that receive an adductor canal catheter (ACC) versus adductor canal block (ACB)?\n\nParticipants will be:\n\n* Randomized to receive an adductor canal catheter (ACC) or a sham adductor canal catheter.\n* Asked to use the Diagnotes application to communicate with the pain doctor while the catheter is in place.\n* Follow up for up to 6 months post-operation. Researchers will compare the interventional group (ACC) to the control group (sham ACC + ACB) to see if there is difference in opioid consumption and chronic pain at 6 months post-operation.",[81,82,29,27],"Chronic Pain","Opioid Use","2026-01-14",{"date":85,"type":34},"2026-01-15",{"date":87,"type":34},"2023-06-12",{"date":89,"type":21},"2027-01-01",{"name":91,"class":41},"Hospital for Special Surgery, New York",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100617889","postoperative-analgesic-efficacy-between-adductor-canal-block--ipack-block-and-adductor-canal-block--genicular-nerve-block-in-total-knee-arthroplasty-100617889","NCT07324486","Postoperative Analgesic Efficacy Between Adductor Canal Block + IPACK Block and Adductor Canal Block + Genicular Nerve Block in Total Knee Arthroplasty","Comparison of Functional Outcomes and Postoperative Analgesic Efficacy Between Adductor Canal Block + IPACK Block and Adductor Canal Block + Genicular Nerve Block in Patients Undergoing Total Knee Arthroplasty","Inclusion Criteria:\n\n1. Patients scheduled for spinal anesthesia with TDA.\n2. Age ≥18.\n3. American Society of Anesthesiologists (ASA) physical status score I-III.\n4. Patients capable of providing informed consent.\n\nExclusion Criteria:\n\n1. Active infection at the injection site.\n2. Coagulopathy or systemic sepsis.\n3. Severe hypovolemia.\n4. Patients who refuse regional anesthesia.\n5. Known allergy to local anesthetics.\n6. Cognitive impairment or uncooperative patients.",{"count":100,"type":21},50,[24],"The aim of this study is to compare the postoperative analgesic efficacy and functional outcomes of the IPACK+Adductor Canal Block with the Genicular Nerve Block+Adductor Canal Block block in patients undergoing total knee arthroplasty (TKA). The primary objective (measurable) is to evaluate functional improvement using 6-Clicks scores, while secondary objectives include pain scores (Vas Score), opioid consumption, hospital stay duration, and patient satisfaction (Patient Satisfaction Index).\n\nIPACK : The infiltration between the popliteal artery and capsule of the knee",[27,29,104,105],"Genicular Nerves Block","IPACK Block Multimodal Analgesia",[107,108,109,110],"total knee arthroplasty","adductor canal block","genicular nerves block","IPACK","2025-12-30",{"date":113,"type":34},"2026-01-07",{"date":115,"type":21},"2025-12-15",{"date":117,"type":21},"2026-02-01",{"name":119,"class":120},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":131,"phases":4,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":143,"leadSponsor":144,"locationsCount":42},"100611977","adductor-canal-localization-in-living-and-cadaver-100611977","NCT07247591","Adductor Canal Localization in Living and Cadaver","Determination of Adductor Canal Location by USG Measurements and Cadaver Correlation","Inclusion Criteria:\n\nASA 1-2-3 patients\n\nBMI \\\u003C35\n\nAges 18-65\n\nThose willing to participate in the study\n\nExclusion Criteria:\n\nThose unwilling to participate in the study\n\nPregnant women\n\nBMI \\>35\n\nASA 4-5-6 patients","65 Years",{"count":130,"type":21},200,"OBSERVATIONAL","The aim of this study is to define the starting and ending points of the adductor canal in adductor canal block (ACB) applications through distance measurements relative to the anterior superior iliac spine (ASIS) and the adductor tubercle. These measurements are performed using ultrasound (USG) and correlated with cadaveric data.\n\nKey research questions addressed include:\n\n* Can the start and end points of the adductor canal be formulated along a line drawn between the ASIS and the adductor tubercle?\n* Is there a definable relationship between the block application site and anatomical landmarks such as the vastoadductor membrane (VAM), the apex of the femoral triangle, and other adjacent structures that facilitates localization?\n\nBy validating ultrasound measurements with cadaveric findings, the study aims to provide researchers with a more predictable and reliable method for determining the optimal site for adductor canal block administration.",[134,29],"Anatomy",[136,137,138],"ASIS","ADDUCTOR CANAL","BLOCK","2025-11-22",{"date":141,"type":34},"2025-11-25",{"date":141,"type":21},{"date":117,"type":21},{"name":145,"class":120},"Ankara Etlik City Hospital",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":16,"minAge":153,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":156,"briefSummary":157,"conditions":158,"keywords":161,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":4},"100600352","coupling-of-ipack-block-with-adductor-canal-block-versus-adductor-canal-block-alone-on-pain-functional-recovery-and-inflammatory-response-after-knee-replacement-100600352","NCT07096375","Coupling of IPACK Block With Adductor Canal Block Versus Adductor Canal Block Alone on Pain, Functional Recovery and Inflammatory Response After Knee Replacement","Competency of Coupling of IPACK Block With Adductor Canal Block Versus Adductor Canal Block Alone on Postoperative Pain, Functional Recovery and Inflammatory Response After Total Knee Replacement","Inclusion Criteria:\n\n* Patients undergoing total knee replacement.\n* ASA physical status I to III\n* Sex (males and females).\n* Age 20 - 70 years.\n\nExclusion Criteria:\n\n* Patients undergoing bilateral or revision total knee replacement.\n* ASA physical status more than III\n* Age less than 20 or older than 70\n* severe renal insufficiency ( Estimated Glomerular filtration rate eGFR \\\u003C 15 mL\u002Fmin\u002F1.73 m2 ).\n* history of arrhythmia or seizures.\n* Hypersensitivity to local anesthetics.\n* Preexisting peripheral neuropathy and prior vascular surgery on femoral vessels on operated site.\n* Infection near site of injection e.g. osteomyelitis, septic knee joint, etc.\n* Patient refusal or with difficulties in comprehending numeric pain rating scale (NRS) pain scores\n* Any contraindications for spinal anesthesia. (eg.: refusal of patients, coagulopathy, use of anticoagulants or antiplatelets...)","20 Years","70 Years",{"count":100,"type":21},[24],"The aim of this study is to compare the Competency of coupling of IPACK Block with Adductor Canal Block versus Adductor Canal Block Alone on Postoperative Pain after total knee replacement as well as Functional Recovery and Inflammatory Response and range of motion postoperatively.",[29,159,160],"Total Knee Replacement Surgery","Functional Recovery",[162,29,163],"IPACK block","Inflammatory Response","2025-07-24",{"date":166,"type":34},"2025-07-31",{"date":168,"type":21},"2025-09-20",{"date":170,"type":21},"2026-09-28",{"name":172,"class":41},"Ain Shams University",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":180,"targetDuration":4,"studyType":22,"phases":182,"briefSummary":183,"conditions":184,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":191,"leadSponsor":193,"locationsCount":42},"100580480","combined-intrathecal-dexmedetomidine-and-adductor-canal-block-for-analgesia-after-total-knee-arthroplasty-100580480","NCT06837844","Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty","Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 75 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-II.\n* Scheduled for total knee arthroplasty under spinal anesthesia.\n\nExclusion Criteria:\n\n* Patients with neurological or intellectual disability.\n* History of allergy to local anesthetics or dexmedetomidine .\n* Infection at the injection site.\n* Prolonged use of analgesic or sedative medications.\n* Coagulation abnormalities.\n* Pregnancy.\n* Obesity \\[body mass index (BMI) \\> 30 kg\u002Fm2\\].",{"count":181,"type":21},75,[24],"The aim of this work is to evaluate the effect of combined intrathecal dexmedetomidine and adductor canal block for analgesia after total knee arthroplasty (TKA).",[185,29,186,27],"Intrathecal Dexmedetomidine","Analgesia","2025-02-20",{"date":189,"type":34},"2025-02-21",{"date":187,"type":34},{"date":192,"type":21},"2025-08-01",{"name":194,"class":41},"Kafrelsheikh University"]