[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adenocarcinoma-of-ge-junction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adenocarcinoma-of-ge-junction":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100620135","phase-2-adebrelimab-plus-apatinib-combined-with-sox-regimen-as-conversion-therapy-for-gastric-cancer-100620135",false,"NCT07353684","Adebrelimab Plus Apatinib Combined With SOX Regimen as Conversion Therapy for Gastric Cancer","Phase II Clinical Study of Adebrelimab Plus Apatinib and SOX Regimen for Conversion Therapy of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma","Inclusion Criteria:\n\n* Age 18-75 years at the time of enrollment, with an estimated life expectancy of ≥ 3 months.\n* Histologically or cytologically confirmed gastric cancer or gastroesophageal junction cancer, predominantly adenocarcinoma.\n* Unresectable locally advanced gastric or gastroesophageal junction adenocarcinoma (Stage III or IV), as determined by the investigator based on CT, MRI, and\u002For PET-CT.\n* Disease with conversion (translational) therapeutic potential, as assessed by the investigator.\n* No prior anti-tumor treatment, including chemotherapy, radiotherapy, targeted therapy, immunotherapy, or other systemic anticancer therapies.\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.\n* Adequate hematologic function within 14 days prior to enrollment:\n\n  * White blood cell count ≥ 3.5 × 10⁹\u002FL.\n  * Absolute neutrophil count ≥ 1.5 × 10⁹\u002FL.\n  * Hemoglobin ≥ 90 g\u002FL (9.0 g\u002FdL).\n  * Platelet count ≥ 100 × 10⁹\u002FL.\n  * Adequate hepatic function within 14 days prior to enrollment:Total bilirubin ≤ 1.5 × upper limit of normal (ULN);ALT and AST ≤ 2.5 × ULN in patients without liver metastases;ALT and AST ≤ 5 × ULN in patients with liver metastases;Adequate renal function:Serum creatinine ≤ 1.5 × ULN;Women of childbearing potential must have a negative serum or urine pregnancy test within 7 days prior to enrollment and agree to use effective contraception during the study and for at least 12 weeks after the last dose.\n* Male participants must be surgically sterile or agree to use effective contraception during the study and for at least 12 weeks after the last dose\n* Ability to understand and willingness to sign a written informed consent form\n* Expected to comply with study procedures and follow-up requirements\n\nExclusion Criteria:\n\n* HER2-positive gastric or gastroesophageal junction adenocarcinoma.\n* Conditions that may significantly affect oral drug absorption, including inability to swallow, persistent nausea or vomiting, chronic diarrhea, or intestinal obstruction.\n* Known hypersensitivity or allergy to adebrelimab, apatinib, oxaliplatin, S-1 (tegafur\u002Fgimeracil\u002Foteracil), or any of their excipients.\n* History of severe allergic reactions to monoclonal antibodies.\n* Active autoimmune disease or autoimmune disorders requiring systemic treatment.\n* Congenital or acquired immunodeficiency.\n* Use of systemic immunosuppressive therapy within 14 days prior to the first dose of study treatment.\n* Administration of live attenuated vaccines within 4 weeks prior to the first dose or planned during the study period.\n* Severe infection within 4 weeks prior to initiation of study treatment.\n* History of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation.\n* Evidence of interstitial lung disease, including pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-induced pneumonitis, or severely impaired pulmonary function.\n* Uncontrolled hypertension despite at least 3 months of antihypertensive treatment.\n* Uncontrolled clinically significant cardiovascular disease.\n* High risk of severe bleeding, as judged by the investigator.\n* Peripheral neuropathy of Grade \\> 2 according to CTCAE.\n* Participation in another interventional clinical trial within 4 weeks prior to enrollment or within 5 half-lives of the investigational product, whichever is longer.\n* Any condition that, in the investigator's judgment, makes the participant unsuitable for study participation.","ALL","18 Years","75 Years",{"count":20,"type":21},49,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","This is a prospective, single-center, single-arm, open phase II clinical study. Forty-nine participants with pathologically or cytologically confirmed gastric cancer or gastroesophageal junction cancer are scheduled to be enrolled in this study. All participants will be treated with 2 to 8 cycles of adebrelimab, apatinib, oxaliplatin, and tigio before surgery. Participants will evaluate the treatment effect after every 2 cycles of medication. By the investigator assessment as an operable subject, apatinib was discontinued for one cycle. The adjuvant treatment will be determined by the investigators based on the participants' postoperative pathology results. Participants requiring adjuvant therapy, with a postoperative interval of at least 4 weeks, but not more than 10 weeks. When the resection standard isn't met for 8 cycles of treatment, the treatment is switched to a maintenance phase, which the subject treatment regimen is determined by the investigator. During the treatment period, participants will receive the study drugs on Day 1 of each 21-day cycle until evidence of disease progression or unacceptable toxicity.",[27,28,29],"Adebrelimab","Adenocarcinoma of GE Junction","Adenocarcinoma of Stomach",[31,32,33,34],"adebrelimab","Adenocarcinoma of GE junction","Adenocarcinoma of stomach","conversion therapy","RECRUITING","2026-04-21",{"date":38,"type":39},"2026-04-22","ACTUAL",{"date":41,"type":39},"2025-05-11",{"date":43,"type":21},"2028-05-31",{"name":45,"class":46},"Beijing Friendship Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":47},"100565792","early-phase-1-phase-iit-trial-of-sna014-100565792","NCT06646783","Phase IIT Trial of SNA014","Clinical Study of 68GA-labeled Claudin 18.2 Developer Combined with PET\u002FCT for Imaging of Gastric or Gastroesophageal Junction Adenocarcinoma and Pancreatic Cancer","Inclusion Criteria:\n\n* Age range of 18 to 75 years old (including boundary values);\n* Individuals with behavioral capacity who voluntarily participate in this clinical study and sign an informed consent form (ICF);\n* Diagnosed G\u002FGEJ adenocarcinoma and pancreatic cancer;\n* Gastroscopy\u002FCT\u002FMRI\u002FPET-CT examination results within the past month (if any);\n* Pathological test results and Claudin18.2 immunohistochemistry results within the past year (if available).\n\nExclusion Criteria:\n\n* Merge patients with other clearly diagnosed malignant tumors:\n* Uncontrolled severe infections or individuals with other serious illnesses;\n* Those with an expected survival period of less than or equal to three months;\n* Pregnant or lactating patients, as well as reproductive age patients who refuse to take appropriate contraceptive measures during this trial;\n* investigators determine that patients who are not suitable to participate in this study;",{"count":56,"type":21},28,[58],"EARLY_PHASE1","68Ga labeled Claudin 18.2 contrast agent combined with PET\u002FCT for gastric or gastroesophageal junction",[61,28,62],"Adenocarcinoma of the Stomach","Pancreatic Cancer Stage","NOT_YET_RECRUITING","2024-10-15",{"date":66,"type":39},"2024-10-17",{"date":68,"type":21},"2024-10-20",{"date":70,"type":21},"2025-11-20",{"name":72,"class":73},"SmartNuclide Biopharma","INDUSTRY"]