[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adherence-patient\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adherence-patient":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,83,112,136],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":25,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644193","impact-of-changing-the-appearance-of-oral-antineoplastics-on-adherence-and-continuity-of-treatment-patient-reported-health-outcomes-and-patient-experience-of-care-100644193",false,"NCT07664683","Impact of Changing the Appearance of Oral Antineoplastics on Adherence and Continuity of Treatment, Patient-reported Health Outcomes, and Patient Experience of Care","Objective 1:\n\nInclusion criteria:\n\nANEOs included in the pharmacotherapeutic guide of the three hospitals for two years of follow-up (June 2025-2027) will be included.\n\nObjectives 2-5:\n\nInclusion criteria:\n\n* Patients on treatment for at least 6 months with one of the following ANEOs will be included: capecitabine (L01BC06) (not used as adjuvant in short cycles), imatinib (L01EA01), everolimus (L04AA18), abiraterone (L02BX03) and lenalidomide (L04AX04), at the time of a change in their usual treatment (from brand to generic or between two generics).\n* Patients on treatment with ANEOs who meet the established criteria and who change their treatment from brand to generic or from one generic to another generic during the study period may also be included.\n\nExclusion criteria:\n\n* Individuals who collect medication for others and those who are institutionalised will be excluded.\n* Patients who have been admitted to hospital in the last 4 weeks are also excluded, due to the increased control of their medication.\n\nObjective 2( Qualitative analysis)\n\n\\- Spanish Patient Forum","ALL","18 Years",{"count":18,"type":19},334,"ESTIMATED","OBSERVATIONAL","Oral chemotherapy is a convenient and flexible option for cancer treatment that can improve patients quality of life and increase adherence to treatment compared to traditional intravenous chemotherapy. However, since patients are responsible for taking the medication, there can be issues with continuity and adherence. Like other medications, generics of existing oral chemotherapy have emerged, which help reduce costs and improve access to this therapy. These generics contribute to a more sustainable healthcare system, so it is necessary to implement effective strategies for their adoption.\n\nAlthough generic treatments have been shown to be just as effective as the original drug, there is no regulation requiring the pill to have the same shape and color as the original (what we refer to as appearance). Additionally, the packaging of the treatment is different as it is specific to each brand. Therefore, a patient on a specific treatment may switch from the original medication to a generic or from one generic to another, which may have a different appearance in both the pill and the packaging.\n\nIt has been observed that these changes can lead to medication errors or a loss of patient confidence, resulting in decreased continuity and adherence to treatment. These issues have been seen with other medications for chronic diseases but have not been studied in cancer patients to date. In these patients, despite the nature of the disease suggesting they would be adherent to treatment, previous studies have shown that this is not the case, with only about 70% of patients being adherent. This lack of adherence affects treatment efficacy, increases the risk of disease relapse, and therefore negatively impacts patient s quality of life and survival while also increasing costs.\n\nTherefore, this study focuses on evaluating whether these changes in pill appearance and\u002For packaging impact treatment continuity and adherence, as well as other relevant patient outcomes and their experience with the healthcare received. Additionally, we want to analyze whether there are patient variables (such as health literacy, age, or clinical variables) that influence the impact of these changes. Given the differences in adherence between men and women, it is essential to conduct these analyses separately for both genders.\n\nThe results obtained from this study will contribute to the development of educational strategies for managing oral chemotherapy by patients and healthcare professionals. Additionally, new evidence will be generated to allow decision-makers to establish policies, either by choosing treatments with the least change in appearance or by regulating the appearance of treatments. All of this will contribute to greater treatment effectiveness, improved patient quality of life, and a lower rate of disease recurrence.",[23,24],"Adherence, Patient","Cancer",[26,27,28,29,30,31],"adherence","patient care","PROMS","PREMS","oral antineoplastic drug","appearance","RECRUITING","2026-06-16",{"date":35,"type":36},"2026-06-24","ACTUAL",{"date":38,"type":36},"2025-12-08",{"date":40,"type":19},"2027-06-29",{"name":42,"class":43},"Universidad Miguel Hernandez de Elche","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":15,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":44},"100486356","leveraging-technology-to-improve-medication-adherence-in-youth-with-kidney-or-liver-transplant-100486356","NCT05613010","Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant","Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients: A Micro-Randomized Trial","Inclusion Criteria:\n\n* Adolescents and young adults (13-25 years old) who underwent kidney or liver transplantation at least 6 months prior to enrollment\n* Currently prescribed tacrolimus or sirolimus.\n\nExclusion Criteria:\n\n* Currently receiving dialysis\n* Hospitalized for duration of study\n* Significant developmental or cognitive delay\n* No access to a mobile device that supports text messaging\n* Decline to use electronic pill box to monitor daily medication adherence\n* Non-English speaking\n* If a participant meets inclusion criteria, enrolls in the study, and experiences graft failure potentially leading to dialysis in the case of kidney transplant recipients, the participant will be given the option to continue in the study if they remain on tacrolimus or sirolimus.","13 Years","25 Years",{"count":55,"type":19},65,"INTERVENTIONAL",[58],"NA","Can the investigators create an effective way to improve adherence to immunosuppressant medication and reduce rejection, graft loss, and death in adolescents and young adults who have undergone kidney or liver transplantation? The investigators' mobile technology intervention uses real-time electronic pillbox-assessed dose timing and text message prompts to address antirejection medication nonadherence when nonadherence is detected.",[61,62,63,23,64],"Transplant;Failure,Kidney","Transplant; Failure, Liver","Adherence, Medication","Adherence, Treatment",[66,67,68,69,70,71,72,73],"kidney transplant","liver transplant","medication adherence","medication nonadherence","compliance","mobile health","mobile phone","technology","2026-04-09",{"date":76,"type":36},"2026-04-13",{"date":78,"type":36},"2024-03-19",{"date":80,"type":19},"2026-11-30",{"name":82,"class":43},"Johns Hopkins University",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":92,"conditions":93,"keywords":101,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":44},"100613051","adherence-to-home-based-exercises-in-musculoskeletal-disorders-100613051","NCT07261553","Adherence to Home-Based Exercises in Musculoskeletal Disorders","Adherence to Home-Based Exercise Programs Among Patients With Musculoskeletal Disorders and Its Influencing Factors","Inclusion criteria:\n\n* Be 18 years of age or older\n* To have a musculoskeletal disease (degenerative, neurological or orthopedic)\n* To be given a home exercise program\n* To have cognitive and language functions to communicate, to be a volunteer\n\nExclusion criteria:\n\n* Those with major psychiatric illness\n* Those with cognitive dysfunction\n* Those with communication disorders, reluctant\u002Freluctant to participate\n* Those with any condition other than a primary degenerative, orthopedic, or neurological disease that could significantly affect exercise adherence, including musculoskeletal or systemic disorders (e.g., severe anemia, heart failure, respiratory failure, uncontrolled diabetes, inflammatory rheumatic disease, recent fractures, or active infections).",{"count":91,"type":19},252,"Home exercise program is recommended by physicians to patients and their relatives to do at home and It is a treatment option in which the physician describes how to do it. Home workout program to be completed at home to complement and reinforce their program in the clinic It is a personalized set of therapeutic exercises that are taught. There are factors that can change exercise compliance; There are some reasons why some patients adhere to the prescribed home exercise program and others do not.\n\nAdherence to home exercises is a major issue in rehabilitation and the reasons for this are multifactorial; It includes both psychological and specific conditions factors that vary between each individual and these conditions should be taken into account by clinicians in designing personalized exercise programs.\n\nHome exercise programs constitute a fundamental component of rehabilitation and are widely prescribed by physicians support therapeutic gains beyond the clinical environment. These individualized programs aim to maintain functional improvements, reduce symptoms, and promote self-management among individuals with musculoskeletal disorders. Although adherence to home-based exercises is recognized as a key determinant of rehabilitation outcomes, non-adherence remains a persistent challenge. Despite growing emphasis on the importance of exercise compliance, the existing literature provides relatively limited and insufficient evidence regarding the factors that influence adherence across different musculoskeletal conditions, including degenerative, orthopedic, and neurological disorders.\n\nAddressing this gap, the present prospective longitudinal cohort study aims to evaluate adherence to individualized home-based exercise programs among patients with diverse musculoskeletal conditions and to determine whether adherence behaviors differ across diagnostic groups. In addition, the study seeks to identify demographic, clinical, psychosocial, and functional factors associated with exercise compliance. By integrating structured clinical evaluations with validated outcome measures, this study aims not only to clarify the determinants of exercise adherence but also to contribute to the development of more effective, condition-specific strategies to enhance sustained engagement in home-based rehabilitation.",[94,64,95,96,23,97,98,99,100],"Exercise Training","Musculoskeletal Disease","Rehabilitation Exercise","Home Exercise Program","Stroke","Orthopedic Operations","Degeneration of Spine and Osteoarticular",[97,26,96,95,23],"2026-03-21",{"date":104,"type":36},"2026-03-25",{"date":106,"type":36},"2024-12-30",{"date":108,"type":19},"2026-05-15",{"name":110,"class":111},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":15,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":56,"phases":122,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":44},"100465087","custom-non-invasive-ventilation-masks-in-children-100465087","NCT05336136","Custom Non-invasive Ventilation Masks in Children","Inclusion Criteria:\n\n* Children between 8-12 years of age\n* Followed clinically by the Non-invasive ventilation clinic at the Stollery Children's Hospital\n* Established on non-invasive ventilation as part of their treatment plan.\n\nExclusion Criteria:\n\n* Children with developmental or physical disabilities that would prevent their successful completion of the study protocol (e.g., non-verbal, unable to follow 3-step commands, unalbe to lie still for 20 min).\n* Children whose parent\u002Fguardian are unable to provide consent because of an inability to read the study documents in english.","8 Years","12 Years",{"count":121,"type":19},15,[58],"One significant challenge to non-invasive ventilation (NIV) use in children is finding masks to fit a wide range of growing shapes and sizes. While the technology has improved with development of masks specifically for children, the range of options remains limited. Given the smaller size relative to adults, craniofacial abnormalities and craniofacial differences are more likely to compromise mask fit for children. A poor mask fit is uncomfortable, alters delivery of airway pressure, and, in some children, leads to failure of NIV and the need for surgical insertion of an airway in the neck to deliver positive airway pressure through a tracheostomy. This makes expanding the technology to deliver NIV vital and custom NIV masks an exciting solution.In this study, this study will enroll children who are established on long-term NIV with at least some use within 3 months of starting this therapy but who have non-optimal adherence. After consenting to participate and completing demographic and health questionnaire, participants will undergo a facial scan using stereophotogrammetry. This scan will be imported into a computer-aided design software to create a NIV mask customized to the individual face. The steps of mask testing will include: i) Bench testing to compare the leak and comfort parameters of the current commercial mask used by the participant to the custom mask: ii) Efficacy of treatment as measured by polysomonography iii) NIV compliance from machine downloads; iv) Questionnaires to assess the subjective comfort, fit, and adverse events Finally, participants and their parents\u002Fguardian will be asked which mask they prefer and why.",[125,126,23],"Noninvasive Ventilation","Child, Only","2026-03-13",{"date":129,"type":36},"2026-03-16",{"date":131,"type":36},"2023-12-15",{"date":133,"type":19},"2026-06",{"name":135,"class":43},"University of Alberta",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":144,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":56,"phases":147,"briefSummary":148,"conditions":149,"keywords":159,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":44},"100417487","health-enhancing-adapted-physical-activity-program-at-mon-stade-100417487","NCT04716322","Health-Enhancing Adapted Physical Activity Program at \"Mon Stade\"","Study of the Determinants Associated With Sustained Changes in Physical Activity Behaviors, and Their Effects on the Prevention and Treatment of Chronic Diseases, in Individuals Enrolled in an Adapted Physical Activity Program","SESAME","Inclusion Criteria:\n\n* Male or female\n* 18 years of age or older\n* Speaking and understanding French\n* Affected by a chronic pathology according to a predefined list (LTI, obesity, HTA, COPD, COVID-19 with persistent symptoms)\n* Carrier of a writing APA prescription\n* Able to come to \"Mon Stade\" twice a week for their APA sessions following the 16-week health-adapted PA program;\n* Signature of the information and consent form.\n\nExclusion Criteria:\n\n\\- Women whose pregnancy is known",true,{"count":146,"type":19},2024,[58],"Introduction: Regular practice of exercise or physical activity (PA) is a recognized intervention as a determinant of good health acquisition, maintenance, or recovery for a large number of chronic pathologies. Nevertheless, few studies have evaluated adherence to an initial health-adapted PA (APA) program, and persistence of active behavior over the time in individuals with a chronic disease.\n\nThe aim of the study is to determine the brakes and levers associated with motivation and long-term compliance. In addition, the investigators aim to evaluate the cost-effectiveness of such program in term of care consumption. Finally, the investigators complete their interest for APA prescription from practitioners agreeing to enroll their patients in the present study.\n\nMethod: The investigators perform a prospective monocentric cohort, of 2024 patients affected of a chronic disease or long-term illness (LTI), enrolled from 2021 to 2024 (4 years, 506 per year), for a 16-week APA program, and followed 5 years with an annual fitness and habits of life and care consumption evaluation.",[150,151,23,152,153,154,155,156,157,158],"Exercise Therapy","Behavior and Behavior Mechanisms","Lifestyle, Sedentary","Life Style","Life Style, Healthy","Cost-Benefit Analysis","Prescriptions","Physical Activity","Adapted Physical Activity",[158,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,157,178,179,180,181,182,183,184],"Active Live Habits","Adherence","Aerobic Capacity","Behavior","Body Composition","Budget Impact Analysis","Cardiorespiratory Fitness","Care Consumption","Chronic Disease","DEXA scan","Exercise","Health-Adapted Physical Activity","Health-Enhancing","Life-Style","Long-Term Illness","Medico-Economic","Motivation","Perceived Barriers","Physical Fitness","Prescription","Prevention","Psycho-social","Quality Of Life","Questionnaire","VO 2 measurement","2022-04-06",{"date":187,"type":36},"2022-04-07",{"date":189,"type":36},"2021-01-28",{"date":191,"type":19},"2030-12-31",{"name":193,"class":43},"Mon Stade Sports Medicine Centre"]