[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adherence-treatment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adherence-treatment":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,46,83,123,147,178,211,251,278,304,334],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100595431","implementing-depression-and-adherence-treatment-100595431",false,"NCT07032363","Implementing Depression and Adherence Treatment","Implementing Depression and Adherence Treatment in South Africa HIV Care","Inclusion Criteria for Clinics (the primary \"participants\"):\n\n* Clinics are eligible if they provide HIV primary care via the City of Cape Town (CoCT) Department of Health\n* Clinics will be assigned to the study upon notice of funding and before start up.\n\nInclusion Criteria for Patient-level Outcomes:\n\nAlthough the unit of randomization is at the clinic level, the study will be looking at adult patient level data at each clinic. All patients engaged in care at one of the 10 primary care\u002FHIV treatment clinics in the study will be included if they:\n\n* Are 18 years of age or older and\n* Have a detectable HIV viral load (operationalized as the lower limit of detection on the standard test is used at the local clinic), or presumed detectable viral load per clinic standards\n* Screen in for depression via the PHQ (following detection standards set in clinics)\n\nExclusion Criteria:\n\n-Children below the age of 18 will not be included in the proposed study for adults.","ALL","18 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to compare a core set and enhanced set of implementation strategies in increasing the reach of evidence-based treatments to patients with HIV and depression. The main questions it aims to answer are:\n\nWhat proportion of patients start an evidence-based treatment for depression (reach)? What percentage of patients show clinical improvement in depression and what percentage attain viral undetectability within one year (effectiveness)?\n\nResearchers will compare high and low reach clinics to further inform tailored implementation strategies for uptake and maintenance.\n\nClinics will be randomized into one of two study arms: core versus enhanced strategies. In both arms, core strategies will be utilized. Enhanced clinics will also receive more resource-intensive training.",[26,27,28,29],"Depression","HIV","Adherence, Treatment","AIDS",[31,27,32],"implementation science","depression","RECRUITING","2026-06-22",{"date":36,"type":37},"2026-06-24","ACTUAL",{"date":39,"type":37},"2026-05-20",{"date":41,"type":20},"2030-05",{"name":43,"class":44},"University of Miami","OTHER",3,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100486356","leveraging-technology-to-improve-medication-adherence-in-youth-with-kidney-or-liver-transplant-100486356","NCT05613010","Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant","Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients: A Micro-Randomized Trial","Inclusion Criteria:\n\n* Adolescents and young adults (13-25 years old) who underwent kidney or liver transplantation at least 6 months prior to enrollment\n* Currently prescribed tacrolimus or sirolimus.\n\nExclusion Criteria:\n\n* Currently receiving dialysis\n* Hospitalized for duration of study\n* Significant developmental or cognitive delay\n* No access to a mobile device that supports text messaging\n* Decline to use electronic pill box to monitor daily medication adherence\n* Non-English speaking\n* If a participant meets inclusion criteria, enrolls in the study, and experiences graft failure potentially leading to dialysis in the case of kidney transplant recipients, the participant will be given the option to continue in the study if they remain on tacrolimus or sirolimus.","13 Years","25 Years",{"count":56,"type":20},65,[23],"Can the investigators create an effective way to improve adherence to immunosuppressant medication and reduce rejection, graft loss, and death in adolescents and young adults who have undergone kidney or liver transplantation? The investigators' mobile technology intervention uses real-time electronic pillbox-assessed dose timing and text message prompts to address antirejection medication nonadherence when nonadherence is detected.",[60,61,62,63,28],"Transplant;Failure,Kidney","Transplant; Failure, Liver","Adherence, Medication","Adherence, Patient",[65,66,67,68,69,70,71,72],"kidney transplant","liver transplant","medication adherence","medication nonadherence","compliance","mobile health","mobile phone","technology","2026-04-09",{"date":75,"type":37},"2026-04-13",{"date":77,"type":37},"2024-03-19",{"date":79,"type":20},"2026-11-30",{"name":81,"class":44},"Johns Hopkins University",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":89,"minAge":17,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":92,"briefSummary":93,"conditions":94,"keywords":108,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":82},"100577203","efficacy-of-physical-therapy-treatment-in-endometriosis-and-its-relationship-to-adherence-rates-100577203","NCT06795243","Efficacy of Physical Therapy Treatment in Endometriosis and Its Relationship to Adherence Rates.","Inclusion Criteria:\n\n* Adult women (over 18 years of age) diagnosed with endometriosis.\n* Women with the capacity to carry out a therapeutic program based on muscular exercise.\n* Women with the capacity to understand the requirements of the study.\n\nExclusion Criteria:\n\n* Women undergoing fertility and\u002For assisted reproduction treatment.\n* Pregnant women.","FEMALE",{"count":91,"type":20},32,[23],"The main objective of this study is to know if the application of both therapies, neuroscience pain education plus therapeutic exercise will modify pain, catastrophizing and quality of life in endometriosis.",[95,96,97,98,99,100,101,102,103,104,105,28,106,107],"Endometriosis","Endometriosis Related Pain","Endometriosis, Pain","Endometriosis-related Pain","Pain","Pain Intensity Assessment","Pain Management","Pain, Chronic Disease","Pain Score","Therapeutic Exercise","Exercise Adherence","Treatment Adherence and Compliance","Quality of Life",[95,96,97,99,100,101,109,110,111,112,28,106,113],"Pain, chronic disease","pain score","therapeutic exercise","exercise adherence","Quality of life","2026-03-30",{"date":116,"type":37},"2026-04-06",{"date":118,"type":37},"2025-05-01",{"date":120,"type":20},"2026-07-01",{"name":122,"class":44},"University of Seville",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":21,"phases":132,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":137,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":4},"100631809","early-phase-1-visualization-of-the-effects-of-guideline-directed-medical-therapy-gdmt-on-improving-adherence-and-quality-of-life-in-heart-failure-with-reduced-ejection-fraction-hfref-100631809","NCT07505511","Visualization of the Effects of Guideline-directed Medical Therapy (GDMT) on Improving Adherence and Quality of Life in Heart Failure With Reduced Ejection Fraction (HFrEF)","VISUALIZE-PRO","Inclusion Criteria:\n\n* Age ≥18 years\n* Diagnosis of heart failure with reduced ejection fraction (HFrEF) (left ventricular ejection fraction ≤40%)\n* Indication for guideline-directed medical therapy (GDMT) for heart failure\n* Stable clinical condition at the time of enrollment\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Acute decompensated heart failure requiring immediate hospitalization\n* Severe cognitive impairment or inability to understand study-related information\n* Life expectancy \\\u003C6 months due to non-cardiac comorbidities\n* Participation in another interventional clinical trial that may interfere with this study\n* Contraindications to prescribed heart failure medications\n* Any condition that, in the investigator's judgment, precludes safe participation in the study",{"count":131,"type":20},100,[133],"EARLY_PHASE1","Heart failure with reduced ejection fraction (HFrEF) remains a major public health challenge with substantial morbidity and mortality despite the availability of effective guideline-directed medical therapy (GDMT). Although four major drug classes have been shown to significantly improve survival and reduce hospitalizations, real-world implementation remains suboptimal. In addition to underutilization by healthcare providers, poor medication adherence among patients-reported to range between 29% and 63%-represents a critical barrier to achieving optimal therapeutic benefit.\n\nThe Visualize-Pro study is a prospective, exploratory pilot study designed to evaluate a simple, patient-centered intervention aimed at improving medication adherence in patients with HFrEF. The intervention consists of patient-friendly graphical visualizations illustrating the survival benefits and risk reduction associated with optimal heart failure therapy. These materials are designed to enhance patient understanding, motivation, and engagement with prescribed treatments.\n\nTo objectively assess medication adherence, this study incorporates therapeutic drug monitoring (TDM) as a gold standard method, in addition to established patient-reported outcome measures such as quality of life and adherence questionnaires. Blood samples will be collected at predefined study visits, and drug levels (or their metabolites) will be analyzed in collaboration with a specialized laboratory to quantify adherence.\n\nParticipants will be followed over a predefined study period with serial assessments at scheduled visits.\n\nThe primary objective is to evaluate the feasibility and preliminary effectiveness of the intervention in improving medication adherence. Secondary objectives include assessing changes in patient-reported outcomes and exploring associations between adherence and clinical parameters.\n\nAs a pilot study, the results are intended to inform the design of a future large-scale, multicenter trial. Ultimately, this approach aims to provide a scalable and low-threshold strategy to improve adherence to life-saving therapies in heart failure, thereby contributing to reduced morbidity and mortality in this high-risk population.",[62,28,136],"Heart Failure","NOT_YET_RECRUITING","2026-03-29",{"date":140,"type":37},"2026-04-01",{"date":142,"type":20},"2026-03-01",{"date":144,"type":20},"2028-03-01",{"name":146,"class":44},"University of Giessen",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":154,"targetDuration":4,"studyType":156,"phases":4,"briefSummary":157,"conditions":158,"keywords":166,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":82},"100613051","adherence-to-home-based-exercises-in-musculoskeletal-disorders-100613051","NCT07261553","Adherence to Home-Based Exercises in Musculoskeletal Disorders","Adherence to Home-Based Exercise Programs Among Patients With Musculoskeletal Disorders and Its Influencing Factors","Inclusion criteria:\n\n* Be 18 years of age or older\n* To have a musculoskeletal disease (degenerative, neurological or orthopedic)\n* To be given a home exercise program\n* To have cognitive and language functions to communicate, to be a volunteer\n\nExclusion criteria:\n\n* Those with major psychiatric illness\n* Those with cognitive dysfunction\n* Those with communication disorders, reluctant\u002Freluctant to participate\n* Those with any condition other than a primary degenerative, orthopedic, or neurological disease that could significantly affect exercise adherence, including musculoskeletal or systemic disorders (e.g., severe anemia, heart failure, respiratory failure, uncontrolled diabetes, inflammatory rheumatic disease, recent fractures, or active infections).",{"count":155,"type":20},252,"OBSERVATIONAL","Home exercise program is recommended by physicians to patients and their relatives to do at home and It is a treatment option in which the physician describes how to do it. Home workout program to be completed at home to complement and reinforce their program in the clinic It is a personalized set of therapeutic exercises that are taught. There are factors that can change exercise compliance; There are some reasons why some patients adhere to the prescribed home exercise program and others do not.\n\nAdherence to home exercises is a major issue in rehabilitation and the reasons for this are multifactorial; It includes both psychological and specific conditions factors that vary between each individual and these conditions should be taken into account by clinicians in designing personalized exercise programs.\n\nHome exercise programs constitute a fundamental component of rehabilitation and are widely prescribed by physicians support therapeutic gains beyond the clinical environment. These individualized programs aim to maintain functional improvements, reduce symptoms, and promote self-management among individuals with musculoskeletal disorders. Although adherence to home-based exercises is recognized as a key determinant of rehabilitation outcomes, non-adherence remains a persistent challenge. Despite growing emphasis on the importance of exercise compliance, the existing literature provides relatively limited and insufficient evidence regarding the factors that influence adherence across different musculoskeletal conditions, including degenerative, orthopedic, and neurological disorders.\n\nAddressing this gap, the present prospective longitudinal cohort study aims to evaluate adherence to individualized home-based exercise programs among patients with diverse musculoskeletal conditions and to determine whether adherence behaviors differ across diagnostic groups. In addition, the study seeks to identify demographic, clinical, psychosocial, and functional factors associated with exercise compliance. By integrating structured clinical evaluations with validated outcome measures, this study aims not only to clarify the determinants of exercise adherence but also to contribute to the development of more effective, condition-specific strategies to enhance sustained engagement in home-based rehabilitation.",[159,28,160,161,63,162,163,164,165],"Exercise Training","Musculoskeletal Disease","Rehabilitation Exercise","Home Exercise Program","Stroke","Orthopedic Operations","Degeneration of Spine and Osteoarticular",[162,167,161,160,63],"adherence","2026-03-21",{"date":170,"type":37},"2026-03-25",{"date":172,"type":37},"2024-12-30",{"date":174,"type":20},"2026-05-15",{"name":176,"class":177},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":21,"phases":188,"briefSummary":189,"conditions":190,"keywords":197,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":45},"100605436","attach-in-denmark-a-feasibility-randomized-controlled-trial-100605436","NCT07162493","ATTACH in Denmark: A Feasibility Randomized Controlled Trial","Attachment and Child Health (ATTACH) Added to Treatment As Usual Versus Treatment As Usual Alone for Parents With Psychosocial Problems: A Feasibility Randomized Controlled Trial","AiD","Inclusion criteria\n\n* Child aged 0 - 5.7 years at enrollment.\n* Speaks Danish or English sufficiently to take part in assessments and intervention without an interpreter.\n* Both parents provide consent in case of shared child custody. Parents experience psycho-social problems that have resulted in referral to the family treatment center on the basis of legislation from the Danish Child Act (\"Barnets Lov\"), under the following Sections defining support needs: Section 29: Family counselling: Includes open access to family counselling as an early preventive effort. In this context, the counselling may involve referring the family to other departments within the municipality or to other relevant authorities that can provide the appropriate guidance and support. Section 30: Early preventive intervention: Includes a variety of approaches, such as consultancy services and participation in network or discussion groups to address and prevent challenges faced by the family at an early stage. Section 32: Supportive interventions: May be initiated on the basis of a preliminary assessment or a child welfare investigation pursuant to Sections 19 and 20 of the Child Act, or concurrently with the completion of such an assessment or investigation. Support may include practical, pedagogical, or other types of support in the home; appointment of a permanent contact person for the entire family; family therapy or individual treatment for the child or young person; family placement involving residential care in a foster family, an approved child and youth residential facility, or a housing facility; supportive placement in a foster family or in an approved child and youth residential facility; other forms of assistance aimed at providing counseling, treatment, and practical and pedagogical support.\n* Parents who have their child in out-of-home placement \u002Ffoster care (with or without consent).\n* Parental psychosocial problems such as (but are not limited to) mental health problems, cognitive difficulties, substance abuse, poverty, social isolation, adverse childhood experiences, functional or somatic disorders, criminal involvement, domestic violence, having a child with emotional regulation difficulties, having a child with developmental problems, having a child with functional or somatic problems, having a child with internalizing or externalizing problems.\n\nExclusion Criteria:\n\n* Child is older than 5.7 years at enrollment.\n* Parent does not speak Danish or English sufficiently to take part in assessments and intervention without an interpreter.\n* Consent cannot be obtained from both parents in case of shared child custody.\n* The parent is known to move to a different municipality within 5 months from randomization.",{"count":187,"type":20},52,[23],"The goal of this feasibility randomized controlled pilot trial is to learn whether the trial can be done as planned, and to investigate if the 10-session parenting program \"ATTACH(TM) increases mentalizing skills (the ability to reflect on thoughts and feelings) in parents of children between 0-5 years of age, who are receiving support for psychosocial problems in their municipal family treatment center.\n\nThe main questions the trial aims to answer are:\n\n* How many eligible parents agree to participate in the random allocation to treatment?\n* How many parents allocated to receive \"ATTACH(TM) will have completed the program 5 months after allocation (at least 7 out of 10 sessions)?\n* How many parents complete the data collection 5 months after allocation on the primary exploratory clinical outcome, i.e., parental mentalizing skills?\n* Do parents who received the ATTACH(TM) program show more increase in their mentalizing skills, compared to parents, who did not receive treatment with ATTACH(TM)?\n\nResearchers will compare ATTACH, added to Treatment as Usual, with Treatment as Usual without ATTACH in three municipal family treatment centers located in the Capital Region of Denmark.\n\nParticipants will:\n\n1. Take part in baseline data collection with a survey, video observation of parent-child interaction, and an interview assessing mentalizing skills.\n2. Be randomly allocated to receive treatment in their local family center with or without ATTACH.\n3. Take part in data collection 5 months after being allocated to either group, as well as participate in an interview about their experiences with the treatment they received.\n4. After one year, the research group will follow up on the current treatment\u002Fsupport needs of the families, who were allocated to either group.",[191,192,28,193,194,195,196],"Mentalization","Recruitment of Participants","Drop Out","Parenting Intervention","Vulnerable Families","Feasibility Studies",[198,199,200,201],"parenting","mentalizing","intervention","feasibility","2025-09-17",{"date":204,"type":37},"2025-09-23",{"date":206,"type":37},"2025-09-01",{"date":208,"type":20},"2027-12-31",{"name":210,"class":44},"Johanne Smith-Nielsen",{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":219,"sex":89,"minAge":17,"maxAge":4,"enrollmentInfo":220,"targetDuration":4,"studyType":21,"phases":222,"briefSummary":223,"conditions":224,"keywords":234,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":82},"100592937","enhanced-mentor-mother-strategy-for-pregnant-and-postpartum-women-living-with-hiv-100592937","NCT06999928","Enhanced Mentor Mother Strategy for Pregnant and Postpartum Women Living With HIV","Pilot Implementation-Effectiveness Study of an Enhanced Mentor Mother Strategy","PIE-eMMs","Inclusion Criteria:\n\n* Pregnant and postpartum women living with HIV (and their infants born during the study)\n* ≥18 years of age\n* Enrolled in PMTCT services at BFSDH\n* Able to understand and provide informed consent in English or Kiswahili\n\nExclusion Criteria:\n\n* Women who are not pregnant or postpartum\n* \\\u003C18 years of age\n* Not enrolled in PMTCT services at BFSDH\n* Unable to understand and provide informed consent in English or Kiswahili\n* Cognitive impairment that would interfere with ability to participate in the study",true,{"count":221,"type":20},200,[23],"Mentor Mothers (MMs) are peer supporters who help pregnant and postpartum women living with HIV (WLHIV) as they receive prevention of mother-to-child transmission of HIV (PMTCT) services in resource-limited settings like Kenya. Differentiated service delivery (DSD) is a care model that tailors services based on clients' needs, helping to improve both the quality and efficiency of care.\n\nThis hybrid implementation-effectiveness study will test whether an enhanced MM strategy that uses DSD can be successfully carried out and improve health outcomes for mothers and infants. The study will take place at Burnt Forest Sub-District Hospital (BFSDH) in Kenya.\n\nResearchers will ask:\n\n* Can the enhanced MM strategy be delivered as planned and accepted by patients and staff?\n* Does the strategy improve clinical outcomes like keeping mothers in PMTCT care, achieving HIV viral suppression, completing infant HIV testing, and preventing HIV transmission to infants? Researchers will compare health outcomes before and after the strategy is introduced at BFSDH, and also compare outcomes at other similar clinics that continue with standard MM services.\n\nWomen who choose to participate will meet with a MM during their routine antenatal and postnatal clinic visits. They will be offered the enhanced MM support, but can choose to receive standard care if they prefer.",[225,226,227,28,228,229,230,231,232,233],"Hiv","Transmission Vertical","Viremia","Stigmatization","Socioeconomic Adversity","Health Care Utilization","Health Care Acceptability","Peer Group","Mothers",[235,236,237,238,239,240,241],"prevention of mother-to-child transmission","retention","implementation","mentor mothers","differentiated service delivery","maternal-child health","Kenya","2025-07-14",{"date":244,"type":37},"2025-07-15",{"date":246,"type":37},"2025-07-10",{"date":248,"type":20},"2026-10-12",{"name":250,"class":44},"Indiana University",{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":255,"acronym":4,"eligibilityCriteria":256,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":21,"phases":260,"briefSummary":261,"conditions":262,"keywords":265,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":82},"100553565","efficacy-of-a-home-based-stretching-program-on-fibromyalgia-symptoms-a-randomised-controlled-trial-100553565","NCT06487741","Efficacy of a Home-based Stretching Program on Fibromyalgia Symptoms: a Randomised Controlled Trial","Inclusion Criteria:\n\n* individuals diagnosed with fibromyalgia in accordance with the ACR 2016 diagnostic criteria.\n* individuals diagnosed with chronic non-malignant pain or individuals diagnosed with chronic widespread pain (including fibromyalgia syndrome) are also included when they meet the ACR 2016 diagnostic criteria.\n\nExclusion Criteria:\n\n* Non-controlled systemic disorders (such as hypertension, diabetes and coronary insufficiency),\n* neurological conditions that impair alertness or comprehension, musculoskeletal conditions that could compromise assessments (such as nerve root compression or knee joint inflammation),\n* relevant joint disorders (such as severe arthritis, arthroplasty of the hip or knee, and rheumatoid arthritis),\n* recent changes in therapy for fibromyalgia (i.e., within four weeks of baseline).","60 Years",{"count":259,"type":20},58,[23],"This randomised controlled trial will examine the clinical efficacy of a six-week, novel, home-based stretching programme compared to usual care on the effect of symptoms experienced by patients with fibromyalgia.",[263,264,28],"Fibromyalgia","Stretch",[263,266,267,268],"Stretching exercises","Home-based","Adherence","2025-02-12",{"date":271,"type":37},"2025-02-17",{"date":273,"type":37},"2024-10-31",{"date":275,"type":20},"2026-08-30",{"name":277,"class":44},"University College of Northern Denmark",{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":282,"acronym":4,"eligibilityCriteria":283,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":284,"targetDuration":4,"studyType":21,"phases":286,"briefSummary":287,"conditions":288,"keywords":292,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":82},"100525019","impact-of-the-implementation-of-a-telemedicine-program-on-patients-diagnosed-with-asthma-100525019","NCT06116292","Impact of the Implementation of a Telemedicine Program on Patients Diagnosed with Asthma","Inclusion Criteria:\n\n* Age ≥18 years with a diagnosis of asthma based on GEMA 5.2 2022.\n* Patients seen in the pulmonology service of the center.\n* Patients who have not previously received asthma education.\n* Capable of giving signed informed consent.\n\nExclusion Criteria:\n\n* Patient who does not have a mobile device with Android or IOS system.\n* Lack of minimum technological knowledge for the use of the application (ESTOI).\n* People who are participating or have participated in a clinical trial in the last 6 months.\n* Patients diagnosed with other respiratory diseases except for obstructive sleep apnea (OSA), Asthma-COPD overlap syndrome (ACOS).\n* Patients with palliative or severe chronic illnesses that limit their life expectancy.",{"count":285,"type":20},108,[23],"Introduction: Asthma is one of the most common chronic respiratory diseases worldwide. Despite the extensive knowledge of the condition and available therapeutic options, severe asthmatic patients have poor disease control in 50% of cases.\n\nObjective: To assess the impact of implementing a mobile application (ESTOI) in patients diagnosed with asthma on disease control, treatment adherence, and perceived quality of life.\n\nMethodology: A 52-week randomized clinical trial involving asthma patients receiving care at a highly specialized hospital in Spain. A total of 108 patients will be included and divided into two groups. The intervention group will receive more comprehensive monitoring than usual, including access to the ESTOI application. The Asthma Control Test (ACT) questionnaire will be used as the primary assessment variable. Other variables to be studied include the Inhaler Adherence Test (TAI), the number of exacerbations, peak expiratory flow, exhaled nitric oxide examination, hospital anxiety and depression scale, asthma quality of life questionnaire, forced spirometry parameters (FVC, FEV1, and reversibility), and analytical parameters (eosinophilia and IgE).",[289,290,28,107,291],"Asthma","Telemedicine","Control",[289,290,293,294,28],"Asthma Control","Quality of Live","2024-10-20",{"date":297,"type":37},"2024-10-22",{"date":299,"type":37},"2024-01-01",{"date":301,"type":20},"2026-12-31",{"name":303,"class":44},"Hospital Universitari de Bellvitge",{"id":305,"slug":306,"hasResults":11,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":310,"eligibilityCriteria":311,"healthyVolunteers":219,"sex":89,"minAge":17,"maxAge":4,"enrollmentInfo":312,"targetDuration":4,"studyType":21,"phases":314,"briefSummary":315,"conditions":316,"keywords":321,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":329,"completionDateStruct":330,"leadSponsor":332,"locationsCount":82},"100530507","a-nutrition-and-exercise-lifestyle-intervention-program-participant-choice-approach-100530507","NCT06187675","A Nutrition and Exercise Lifestyle Intervention Program Participant Choice Approach","A Participant Choice Approach to Improve Adherence and Investigate Pregnancy Outcomes to Lifestyle Interventions","NELIP","Inclusion Criteria:\n\n* between 12 to 18 weeks of pregnancy\n* a singleton fetus\n* medically screened with the Get Active Questionnaire for Pregnancy to determine eligibility for participation in the exercise component\n\nExclusion Criteria:\n\n* inability to walk\n* serious medical problems\n* high blood pressure\n* uncontrolled chest pain\n* uncontrolled symptomatic lung disease\n* diabetes before pregnancy\n* a history of recreational substance use disorder\n* any contraindication to exercise\n* enrolled in another clinical trial.",{"count":313,"type":20},120,[23],"Interventions that target excessive gestational weight gain (EGWG) with nutrition and exercise behavior change struggle with low program adherence. The investigators recently examined adherence in a randomized controlled trial to a previously established lifestyle program called the Nutrition and Exercise Lifestyle Intervention Program (NELIP) and found that those individuals with high adherence to the program were more likely to prevent EGWG. Perhaps offering participants a choice to intervention strategies may improve adherence. The current research question is: What impact does participant choice have on adherence to the introduction of nutrition and exercise components during 3 intervention strategies offered to pregnant individuals compared to no choice and does choice maintain pregnancy health outcomes? The strategies are: Group A - introducing both the nutrition and exercise components simultaneous at baseline (12-18 weeks of pregnancy) that is followed to delivery (NELIP); Group B - introducing the nutrition component first and then at 25 weeks adding the exercise component; or Group C - starting with the exercise component first, followed with introducing the nutrition component at 25 weeks. Both Groups B and C follow the full NELIP from 25 weeks to delivery (final intervention measures will occur at 34-36 weeks gestation). Follow-up will occur at birth (6-18 hours), 2, 6 and 12 months post delivery.",[317,318,28,319,320],"Lifestyle, Healthy","Pregnancy Related","Nutrition, Healthy","Weight Gain, Maternal",[322,323,324,325,167],"pregnancy","lifestyle","nutrition","exercise","2024-03-01",{"date":328,"type":37},"2024-03-05",{"date":299,"type":37},{"date":331,"type":20},"2029-11",{"name":333,"class":44},"Western University, Canada",{"id":335,"slug":336,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":340,"eligibilityCriteria":341,"healthyVolunteers":11,"sex":16,"minAge":342,"maxAge":343,"enrollmentInfo":344,"targetDuration":4,"studyType":156,"phases":4,"briefSummary":345,"conditions":346,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":357,"locationsCount":359},"100518423","clinical-outcomes-from-treatment-and-evaluation-of-obstructive-sleep-apnoea-in-children-with-down-syndrome-100518423","NCT06030349","Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome","Real World Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea Syndrome in Children With Down Syndrome","REFRESHED","Inclusion Criteria:\n\n* Individuals with a confirmed diagnosis of Down Syndrome where a clinical decision has been made to initiate respiratory support with non-invasive ventilation.\n* Obstructive Apnoea Hypopnoea Index \\> 2 episodes\u002Fhour or where sleep disordered breathing symptoms occur in combination with an Apnoea Hypopnoea Index \\> 1 episode\u002Fhr. - English language proficiency.\n* Age ≥ 4 months at the commencement of therapy.\n\nExclusion Criteria:\n\n* Individuals not willing to comply with study procedures or assessments.\n* Individuals for whom ventilatory support devices are already prescribed and those with artificial airways.\n* Individuals on clinical trials of investigational support therapies.","6 Months","16 Years",{"count":221,"type":20},"The goal of this observational study is to learn about the use of non-invasive ventilation for treatment of obstructive sleep apnoea syndrome in children with Down Syndrome. The main questions it aims to answer are:\n\n* What is the impact of non-invasive ventilation on sleep behaviours and quality of life?\n* What barriers are faced by children and their families in establishing tolerance to non-invasive ventilation?\n\nParticipants will be asked to complete questionnaires before and after starting treatment. Researchers will compare this data with the results of sleep studies and non-invasive ventilator downloads recorded as part of standard medical care. A sub-group of up to 20 participants will be invited to take part in 45-60 minute interviews exploring expectations, experiences and barriers encountered during non-invasive ventilation therapy.",[347,348,107,349,28],"Obstructive Sleep Apnea","Down Syndrome","Behavior","2024-02-09",{"date":352,"type":37},"2024-02-12",{"date":354,"type":37},"2022-11-28",{"date":356,"type":20},"2027-12-28",{"name":358,"class":177},"Children's Health Ireland",6]