[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adherence\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adherence":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,48,81,105,143,167,188,214,241,274,301,331,359],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100635623","a-study-of-multiple-micronutrient-supplementation-mms-to-increase-adherence-with-digital-technology-100635623",false,"NCT07555093","A Study of Multiple Micronutrient Supplementation (MMS) to Increase Adherence With Digital Technology","A Randomized Controlled Trial in Lombok: Assessing Factors Influencing Acceptance and Adherence to Multiple Micronutrient Supplementation (MMS) Using Digital Tools","SMART-MMS","Inclusion Criteria:\n\n* Pregnant women up to 32 weeks\n* Pregnant women stay in the site at least during the study period\n\nExclusion Criteria:\n\n* Lost to follow up\n* Moving to another area\n* Death\n* Abortus\n* Stillbirth",true,"FEMALE","14 Years",{"count":21,"type":22},10012,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this randomized clinical trial is to learn whether a digital health intervention can improve adherence to Multiple Micronutrient Supplementation (MMS) among pregnant women in Lombok Island. The study also aims to understand how individual characteristics, socio-economic factors, maternal health status, and antenatal care services influence adherence to MMS.\n\nThe main questions it aims to answer are:\n\n1. Does a digitally supported intervention increase adherence to MMS compared to standard care?\n2. Does the type of MMS packaging (bottle vs. blister) affect adherence?\n3. In the second stage, does adding calcium supplementation affect adherence to MMS?\n\nResearchers will compare four groups to see if digital support and packaging type improve MMS adherence:\n\n1. Standard care with MMS in bottles\n2. Standard care with MMS in blister packs\n3. Digital intervention with MMS in bottles\n4. Digital intervention with MMS in blister packs\n\nApproximately 10,012 pregnant women will be randomly assigned to one of these four groups using a 2×2 factorial design.\n\nParticipants will:\n\n1. Receive MMS through either bottle or blister packaging\n2. Receive either standard care or a digital health intervention (such as reminders or digital support tools)\n3. Attend routine antenatal care services\n4. Be followed throughout pregnancy, delivery, and up to 42 days after childbirth\n\nIn the second stage of the study, participants from community health posts (Posyandu) will also receive calcium supplementation in addition to MMS. Additional 900 pregnant women will be enrolled from the same Puskesmas areas participating in the MMS study to evaluate the addition of calcium supplementation. These participants will be recruited outside of the main MMS cohort and will be equally distributed across the four study arms. This stage aims to assess whether adding calcium supplementation influences adherence to MMS among pregnant women.\n\nParticipants will be monitored during pregnancy, at delivery, and during the postnatal care period up to 42 days after birth.\n\nThis study represents an early implementation of Multiple Micronutrient Supplementation (MMS) in Lombok Island, where MMS is not yet routinely available through government programs. Only selected primary healthcare centers (Puskesmas) that are randomized into the study will provide MMS to eligible participants. While the government has begun introducing MMS in other areas, it has not yet been implemented in Lombok.\n\nThe digital health intervention will only be provided to pregnant women who agree to participate in the study and provide informed consent. All participants will continue to receive standard antenatal care (ANC) services in accordance with existing government programs.\n\nThis study is also integrated with the ongoing distribution of iron and folic acid supplementation (TTD) in Lombok. Pregnant women who do not consent to participate in the study or do not receive MMS will continue to receive TTD as part of routine care outside of the study.",[28,29],"Pregnancy","Adherence",[31,28,32,33,34],"MMS","Digitalization","adherence","Antenatal Care","RECRUITING","2026-06-30",{"date":38,"type":39},"2026-07-01","ACTUAL",{"date":41,"type":39},"2026-06-13",{"date":43,"type":22},"2027-06",{"name":45,"class":46},"Summit Institute for Development, Indonesia","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":17,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":77,"leadSponsor":79,"locationsCount":47},"100616740","mediterranean-diet-uptake-and-nutrition-on-child-health-inflammation-and-early-life-symbiosis-munchies-study-100616740","NCT07309536","Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES) Study","Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES): A Randomized Controlled Trial","MUNCHIES","Inclusion Criteria:\n\n* Parent is ≥19 years of age.\n* Carried a singleton pregnancy.\n* Delivered at term (≥37 weeks gestation).\n* Delivered vaginally or by cesarean section.\n* Infant was born with a birth weight between 2,500 g and 4,500 g.\n* Toddler is between 24 and 36 months of age at enrollment.\n* Parent is able to communicate in English.\n* Parent is willing to adhere to the Mediterranean diet for their toddler for 3 weeks.\n* Parent is willing to participate in a nutrition education program for 3 months.\n* Parent is willing to complete all measurements and provide a stool sample from their toddler.\n\nExclusion Criteria:\n\n* Toddler has food allergies or dietary restrictions (e.g., gluten-free) that make it difficult to follow a Mediterranean diet.\n* Toddler is at high risk for food allergies (e.g., strong family history of multiple food allergies common to the Mediterranean diet).\n* Toddler is already following a Mediterranean diet.\n* Toddler has had recent or active consumption of antibiotics, probiotics, or prebiotic drops.\n* Toddler has an active acute illness, such as fever, diarrhea, or constipation.\n* Toddler was born with a congenital illness or malformation that could affect diet, inflammation, gut health, or body composition.\n* Toddler is currently breastfeeding, formula-feeding, or combination feeding.","ALL","24 Months","36 Months",{"count":60,"type":22},40,[25],"Toddlerhood (ages 2-3) is a critical window when the gut microbiome is still developing and eating habits are being established. Yet, many Canadian toddlers eat diets high in sugar and salt, which may affect long-term health. This study will test whether a MED diet can improve dietary inflammation, gut health, and body composition in toddlers and whether a tailored nutrition education program for parents can help families maintain healthy eating patterns.\n\nIn this study, toddlers will be randomly assigned to a 3-week MED diet or their usual diet. Families in the MED diet group will receive free meal boxes for the 3 weeks, plus guidance from a nutrition researcher through a structured education program. The standard diet group will continue their regular diet with general nutrition advice. Researchers will collect dietary information, body composition assessments, and stool samples to measure gut microbiome composition and metabolites.\n\nThis first study of a controlled diet intervention in toddlers, combining behavioral support, high-quality food provision, and advanced gut microbiome analysis, will help understand how early diet shapes lifelong eating habits and health, guiding public health strategies and precision nutrition approaches to prevent chronic disease from early life.",[64,65,29,66,67],"Gut Microbiome","Body Composition","Metabolites","Inflammation",[69,70,71,67],"Dietary patterns","Gastrointestinal microbiome","Body composition","NOT_YET_RECRUITING","2026-05-11",{"date":75,"type":39},"2026-05-12",{"date":38,"type":22},{"date":78,"type":22},"2027-11-01",{"name":80,"class":46},"University of New Brunswick",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":56,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":47},"100638218","support-system-design-for-adolescent-scoliosis-orthosis-wear-100638218","NCT07574229","Support System Design for Adolescent Scoliosis Orthosis Wear","A Product System Intervention Study on Improving Wear Compliance and Psychological Motivation for Adolescent Idiopathic Scoliosis Patients Based on Sensory Monitoring and Interactive Feedback","Eligibility Criteria\n\nInclusion Criteria:\n\nClinical diagnosis of Adolescent Idiopathic Scoliosis (AIS).\n\nCurrent orthotic treatment with a prescription for a spinal brace (e.g., Boston, Milwaukee, or similar corrective braces).\n\nBetween 10 and 18 years of age at the time of enrollment.\n\nAbility to read, understand, and complete the Intrinsic Motivation Inventory (IMI) and other study-related questionnaires.\n\nAccess to a stable home environment with Wi-Fi or local network connectivity for the interactive desktop terminal.\n\nWillingness of the participant to provide assent and the legal guardian to provide written informed consent.\n\nExclusion Criteria:\n\nSecondary scoliosis caused by neuromuscular, congenital, or syndromic conditions (e.g., cerebral palsy or Marfan syndrome).\n\nScheduled spinal surgery within the planned study period.\n\nSevere skin allergies or chronic dermatological conditions at the brace contact sites that might be aggravated by sensor integration.\n\nPrevious participation in similar digital intervention studies for scoliosis management.\n\nDiagnosed cognitive impairments or severe psychological disorders that may interfere with accurate reporting or regular use of the product system.","10 Years","18 Years",{"count":91,"type":22},18,[25],"This study focuses on improving the daily lives and treatment outcomes of teenagers diagnosed with Adolescent Idiopathic Scoliosis (AIS). For many young patients, wearing a corrective brace for 20+ hours a day is physically uncomfortable and psychologically challenging, leading to low compliance and emotional distress.The investigators have developed an integrated \"Product System\" designed to transform the bracing experience from a burdensome task into a guided, supportive journey. This system consists of three main components:Smart Sensing: Discrete, thin-film pressure sensors are integrated into the existing brace to monitor real-time wear time and fit quality without compromising comfort.Interactive Desktop Terminal: A dedicated device for the home that uses \"narrative-driven\" feedback (themed around a journey called \"The Spine's Path\"). Instead of cold medical data, it provides intuitive progress visualizations and rewards to keep participants engaged.Mobile Support App: A tool for both participants and parents to track long-term trends, access educational resources, and facilitate communication with healthcare providers.The Goal of the Study The primary objective is to evaluate how this digital intervention affects a participant's \"Intrinsic Motivation\"-the internal drive to adhere to treatment. By focusing on three psychological dimensions-Interest\u002FEnjoyment, Perceived Competence, and Pressure\u002FTension-the investigators aim to determine if interactive feedback can reduce the \"medical feel\" of the brace and help teenagers feel more in control of the recovery.What Participation Involves Participants will use the product system during the daily routine in home and school environments. The investigators will collect objective data (brace usage hours) and subjective data (through the Intrinsic Motivation Inventory\u002FIMI scale) to measure changes in behavior and mental well-being.Benefits for Families and ProvidersFor Participants: A more engaging, less stressful way to manage the condition and see real-time progress.For Families: Reduced friction regarding brace-wearing and better visibility into the participant's treatment status.For Healthcare Providers: Access to accurate, objective data on participant compliance, allowing for more personalized and effective clinical adjustments.",[95,29],"Adolescent Idiopathic Scoliosis (AIS)","2026-05-03",{"date":98,"type":39},"2026-05-07",{"date":100,"type":39},"2026-02-01",{"date":102,"type":22},"2026-10-01",{"name":104,"class":46},"Shanghai Jiao Tong University School of Medicine",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":56,"minAge":89,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":115,"conditions":116,"keywords":120,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":47},"100635630","stick2it---understanding-why-people-do-or-do-not-stick-with-exercise-treatment-for-achilles-tendinopathy-100635630","NCT07555184","STICK2IT - Understanding Why People Do or Do Not Stick With Exercise Treatment for Achilles Tendinopathy","STICK2IT: Identifying and Prioritising Determinants of Adherence to Progressive Tendon-Loading Exercise in People With Achilles Tendinopathy","Inclusion Criteria:\n\n* • Adults aged 18 years or over with lived experience of Achilles tendinopathy (AT).\n\n  * Gender representation: A purposive sample including men and women, with inclusion of non-binary participants where self-identified, aiming for broad gender representation rather than fixed quotas.\n  * Ethnic and cultural diversity: Purposive sampling will seek representation from diverse ethnic and cultural backgrounds, informed by local population demographics and service user profiles.\n  * Socioeconomic diversity: Participants will be recruited across high, mid, and low socioeconomic deprivation groups, defined using postcode-derived Index of Multiple Deprivation (IMD) tertiles (lower, middle, upper thirds of national IMD distribution). Recruitment will aim for representation across all three IMD categories rather than predefined percentages.\n\nExclusion Criteria:\n\n* • Under 18 years of age\n\n  * Inability to confirm previous AT through either ELHT electronic medical records or through discussion with CI\n  * Individuals whose Achilles symptoms are due to a different primary pathology (e.g., Rheumatological, Achilles Rupture)\n  * Unable to provide informed consent\n  * Unable or unwilling to be audio-recorded.",{"count":113,"type":22},30,"OBSERVATIONAL","Achilles tendinopathy is a common condition that causes pain and stiffness in the tendon at the back of the ankle. It can make walking, exercise, work, and everyday activities difficult. The main recommended treatment is a programme of progressive tendon-loading exercises, usually supported by an NHS physiotherapist. These exercises can help improve pain and function, but many people find them hard to continue over time. This means that, even though the treatment can work well, some people do not get the full benefit because they are unable to keep up with the exercise programme as advised.\n\nPeople with Achilles tendinopathy often describe worries about making the tendon worse, uncertainty about whether pain during exercise is safe, low confidence, slow progress, and difficulty fitting exercises into daily life. These challenges may be even greater for people from underserved groups, including those living with long-term health conditions, financial pressures, language barriers, or other forms of disadvantage. At present, there is limited research exploring these experiences in a structured way, especially in routine NHS care.\n\nThe aim of this study is to understand what helps or makes it harder for people to stick with NHS-prescribed progressive tendon-loading exercises for Achilles tendinopathy. The study will focus particularly on the experiences of people who may be at higher risk of poor outcomes or reduced access to support.\n\nUp to 30 adults with experience of Achilles tendinopathy and previous NHS physiotherapy treatment will take part in a one-to-one interview. Interviews will last up to 45 minutes and can take place in person, online, or by telephone, depending on what suits the participant best. Participants will be asked about their experiences of living with Achilles tendon pain, being given exercise treatment, and trying to follow that treatment in everyday life.\n\nThe information from these interviews will be analysed to identify the main barriers and supports affecting exercise adherence. The findings will be used to build a clearer understanding of the behavioural factors that influence whether people are able to continue with treatment. This will help inform the future development of a targeted support approach to improve adherence to exercise-based rehabilitation for Achilles tendinopathy in NHS practice.\n\nThe long-term goal of the study is to help make treatment more effective, more personalised, and more suitable for people from a wide range of backgrounds, including those whose needs are often overlooked in research and healthcare design.",[117,118,29,119],"Achilles Tendinopathy (AT)","Musculoskeletal Diseases or Conditions","Behaviour Change",[121,122,123,124,125,126,127,128,129,130,131,132,133],"Achilles tendinopathy","Theoretical Domains Framework","Qualitative","Adherence to prescribed exercise","Tendon loading exercise","Musculoskeletal physiotherapy","Behaviour change","Underserved populations","Health inequalities","Multimorbidity","Socioeconomic deprivation","Semi-structured interviews","thematic analysis","2026-04-21",{"date":136,"type":39},"2026-04-29",{"date":138,"type":22},"2026-05-01",{"date":140,"type":22},"2027-05-01",{"name":142,"class":46},"East Lancashire Hospitals NHS Trust",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":56,"minAge":150,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":23,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":47},"100624859","improving-ldl-c-levels-through-temporal-self-regulation-theory-based-personality-tailored-health-messages-100624859","NCT07415109","Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages","Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages: A Three-Arm Randomized Controlled Trial","Inclusion Criteria:\n\n* New participants of RESET who have given consent to be contacted for future studies\n* ≥21 years old\n\nExclusion Criteria:\n\n* are not able to read, write or communicate in English","21 Years","65 Years",{"count":153,"type":22},3000,[25],"The study is meant to run parallel to the larger study, RESET. The goal of this study is to to evaluate the effectiveness of a once-off general and personality-tailored text message on GP consultation among RESET participants identified to have high LDL-C. The main question it aims to answer is:\n\nWill participants exposed to personality tailored advice have a higher adherence to GP consultation compared to the participants in the control group?\n\nResearchers will compare a personalized message to a general message (with no personalization according to patients personality type) and control group to see if the messages increase adherence.\n\nParticipants are required to complete two questionnaires: one before and one after they receive their RESET results.",[29,157],"Preventive Health Services","2026-04-07",{"date":160,"type":39},"2026-04-13",{"date":162,"type":39},"2025-11-25",{"date":164,"type":22},"2028-11",{"name":166,"class":46},"National University Health System, Singapore",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":17,"sex":56,"minAge":89,"maxAge":4,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":181,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":47},"100586767","promoting-adherence-to-chemotherapy-handling-guidelines-among-oncology-nurses-100586767","NCT06919653","Promoting Adherence to Chemotherapy Handling Guidelines Among Oncology Nurses","Inclusion Criteria:\n\n* being at least 18 years old\n* able to read and speak English\n* working as an oncology nurse for at least 3 months\n* handling chemotherapy drugs at work\n\nExclusion Criteria:\n\n* None",{"count":174,"type":22},60,[25],"Chemotherapy exposure is a serious occupational hazard affecting oncology nurses. Oncology nurses' adherence to chemotherapy handling guidelines is essential to prevent their exposure to chemotherapy. The goal of this research is to develop, validate, and pilot test an intervention \"Workplace program to Improve Safe Handling of hazardous drugs\" (WISH), to promote adherence to chemotherapy handling guidelines among oncology nurses. The WISH intervention includes two components: an educational component and debriefing sessions on chemotherapy exposure incidents. First, the research team will use a mixed-methods approach to develop an online educational component on chemotherapy safety, establish the content validity of the educational content based on experts' evaluation, and establish the face validity of the educational content by conducting three qualitative focus group with oncology nurses (n=4-6 nurses per group) or individual interviews. Next, the research team will test the feasibility and acceptability of the intervention using a pilot randomized controlled trial with two groups of oncology nurses, an intervention group (n= 30) and a control group (n=30). We will obtain quantitative and qualitative measures of the intervention feasibility and acceptability. The output is an intervention program targeted to train nurses on safe chemotherapy handling guidelines. Findings will be disseminated through peer-reviewed publications and presentations. The intermediate outcome is the adoption of the intervention program by healthcare institutions to train nurses on chemotherapy handling guidelines. The end outcome is promoting adherence to chemotherapy handling guidelines among oncology nurses.",[178,179,180,29],"Chemotherapy Exposure","Handling Guidelines","Oncology Nurse",{"date":160,"type":39},{"date":183,"type":22},"2026-06",{"date":185,"type":22},"2027-08",{"name":187,"class":46},"University of Cincinnati",{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":17,"sex":56,"minAge":196,"maxAge":4,"enrollmentInfo":197,"targetDuration":4,"studyType":23,"phases":199,"briefSummary":200,"conditions":201,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":210,"leadSponsor":212,"locationsCount":47},"100631273","virtual-assistant-for-exercise-adherence-in-older-adults-100631273","NCT07498530","Virtual Assistant for Exercise Adherence in Older ADULTS","Application of a Virtual Assistant to Enhance Exercise Adherence in Older Adults","AGE-BOT","Inclusion Criteria:\n\n* Adults aged 60 years or older.\n* Community-dwelling individuals capable of participating in an exercise program.\n* Ability to complete 60-minute exercise sessions, three times per week during the 12-week intervention.\n* Experimental group (BOT Group): Participants willing to use a smartphone\u002Ftablet and interact with the virtual assistant.\n* Control group (Municipal Exercise Group): Individuals already enrolled in the municipal program Enguera se saludable.\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Medical contraindications to physical exercise, as determined by clinical judgment (e.g., uncontrolled cardiovascular, respiratory, or metabolic conditions).\n* Severe cognitive impairment or neurological conditions that limit the ability to follow instructions or safely perform the exercise program.\n* Severe mobility limitations preventing participation in structured exercise (e.g., inability to walk independently with or without aid).\n* Acute musculoskeletal injuries or recent surgeries that contraindicate exercise participation.\n* Individuals currently participating in another structured exercise program that would interfere with the study interventions (other than Enguera se saludable for the control group).\n* Inability or unwillingness to comply with the requirements of the study (frequency, duration, assessments).\n* For the BOT group: lack of access to a device compatible with the virtual assistant or inability\u002Funwillingness to use it.","59 Years",{"count":198,"type":22},70,[25],"This study will evaluate the effectiveness of a virtual assistant-guided exercise program to improve adherence in older adults. In a nonrandomized controlled clinical trial, the experimental group will complete a 12-week, home-based program (60-minute sessions, 3 times per week) supported by a virtual assistant (BOT). The control group will comprise community-dwelling older adults already engaged in the municipal program Enguera se saludable, which delivers an in-person exercise program of comparable frequency and duration. The primary outcome is exercise adherence, defined as the proportion of prescribed sessions completed. Secondary outcomes include muscle strength, balance, functional capacity, health-related quality of life, and the user experience and usability of the virtual assistant.",[202,203,29,204,205],"Older Adult","Exercise","Prevention","New Technologies","2026-03-25",{"date":208,"type":39},"2026-03-27",{"date":100,"type":39},{"date":211,"type":22},"2026-12-31",{"name":213,"class":46},"University of Valencia",{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":220,"eligibilityCriteria":221,"healthyVolunteers":17,"sex":18,"minAge":89,"maxAge":222,"enrollmentInfo":223,"targetDuration":4,"studyType":23,"phases":225,"briefSummary":226,"conditions":227,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":47},"100578372","reducing-anemia-among-preconception-women-in-nepal-through-a-group-norm-and-micronutrient-supplementation-intervention-100578372","NCT06810440","Reducing Anemia Among Preconception Women in Nepal Through a Group Norm and Micronutrient Supplementation Intervention","Reducing Anemia Among Young Preconception Women in Nepal Through a Group Household Norm and Micronutrient Supplementation Intervention","Sumadhur","Inclusion Criteria:\n\n* the newly married couple having been married in the last four months\n* women being under 25 years old\n* never pregnant and not currently pregnant\n* co-residing with the mother-in-law in a household as defined by sharing meals together.\n* all triad-household members must also be willing to participate\n* husbands must not be planning to migrate in the next 6 months.\n\nExclusion Criteria:\n\n* Over 25, under 18 years old\n* Currently or ever pregnant\n* married more than 4 months before\n* not co-residing\n* not being willing to participate.\n* do not consent to blood-draws\n* women who are severely anemic (hemoglobin \\\u003C 8.0 g\u002FdL) at baseline based on hemoglobin via Hemocue assessment of a fingerprick blood sample at the time of enrollment","25 Years",{"count":224,"type":22},2100,[25],"Preconception micronutrient status (including anemia) is a critical determinant of maternal, newborn, and child health that remains undervalued in Nepal. However, providing micronutrient supplements (MMS) alone is not enough. In the Nepali context, the gap between marriage and the first birth is short and newly married women have the lowest household status. Addressing the intersectional barriers to health for newly married women, including inequitable gender norms and women's empowerment, household relationships, nutrition knowledge and practices-is essential for improving maternal and infant outcomes in Nepal. To mitigate the community, household, and individual factors resulting in poor nutrition, the team developed and pilot-tested an educational group intervention (Sumadhur, meaning \"Best Relationship\") for newly married women, husbands, and mothers-in-law triads. Sumadhur aims to provide information on nutrition and women's health, address inequitable gender norms and practices, strengthen household relationships and communication, and improve the household status of newly married women. The pilot study of Sumadhur brought triads of several households together for 16 interrelated sessions over four-months. Findings suggest that participants (N=90) found the intervention to be highly feasible and acceptable and nutritional norms and practices improved.\n\nWe propose to test the effectiveness of Sumadhur on maternal health and nutrition outcomes using a 2-arm cluster RCT (cRCT). The intervention participants will receive the Sumadhur group intervention and will be provided MMS directly at group sessions. In control villages who do not receive the Sumadhur group intervention, we will facilitate access to MMS at primary health centers. We will randomize 70 villages to each arm (with one group per village). Each village has one group of five women (total of 700 women). Newly married women, their husbands and mothers-in-laws (total=2,100), will be followed four times for 18 months post-intervention through surveys, hemoglobin tests and blood draws (women only). The specific aims are to estimate the effectiveness of Sumadhur on women's anemia and micronutrient status, including the cost-benefit of the intervention (Aim 1); explore the impact on intermediate outcomes such as gender norms, household relationships and eating practices and characterize the individual and household-level mechanisms of impact (Aim 2); understand triadic experiences and impact over time of Sumadhur (Aim 3).\n\nAccomplishing these aims will provide evidence for how to improve micronutrient and anemia status among women before they become pregnant-thereby ensuring that women are not deficient in the critical early phases of pregnancy. These findings will also advance the field by testing novel approaches (household and community level behavior and norm change intervention) that, when combined with supplements, may lead to better adherence, uptake, and, ultimately, health outcomes, and have additional longer-term benefits.",[228,229,29,230,231],"Anemia, Iron-Deficiency","Nutritional Deficiencies","Norms, Social","Knowledge, Attitudes, Practice","2026-03-24",{"date":234,"type":39},"2026-03-30",{"date":236,"type":39},"2025-10-08",{"date":238,"type":22},"2029-04-01",{"name":240,"class":46},"University of California, San Francisco",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":17,"sex":18,"minAge":89,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":114,"phases":4,"briefSummary":251,"conditions":252,"keywords":258,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":272,"locationsCount":47},"100623758","assessing-health-system-readiness-for-scaling-antenatal-mms-in-cambodia-100623758","NCT07400796","Assessing Health System Readiness for Scaling Antenatal MMS in Cambodia","Assessing Health System Readiness for Scaling Antenatal MMS in Cambodia: A Mixed-Methods Assessment","TIPS-Cambodia","For the cohort of pregnant individuals consuming MMS:\n\nInclusion Criteria:\n\n* Current pregnant\n* At least 18 years of age\n* Have attended at least one ANC visit at a health center or hospital in Takeo during the study period\n* Can provide a functioning phone number for follow-up contact\n* Willingness to participate and provide consent\n\nExclusion Criteria:\n\n* Individuals with diagnosed anemia who require iron and folic acid (IFA) supplementation instead of MMS\n* Individuals unable to communicate via telephone,;(3) individuals who withdraw consent at any point",{"count":250,"type":22},710,"Malnutrition among pregnant women in low- and middle-income countries (LMICs) can cause micronutrient deficiencies that result in adverse maternal and neonatal health outcomes. The World Health Organization has recently recommended antenatal multiple micronutrient supplementation (MMS) that includes iron and folic acid (IFA) to improve maternal and neonatal health outcomes. MMS likely provides additional antenatal benefits over IFA supplementation alone. The Cambodian government, in partnership with Helen Keller International, is piloting MMS implementation in Takeo Province, which will inform nationwide scale-up of MMS.\n\nStudy Purpose: The Takeo implementation must be evaluated to understand context-specific implementation of MMS and health system readiness for scale-up. This study assesses system readiness through four domains from the Intervention Scalability Assessment Tool (ISAT): (1) fidelity and adaptation, (2) reach and acceptability, (3) delivery setting and workforce capacity, and (4) implementation infrastructure.\n\nPopulation: The pilot involves transitioning to MMS from IFA across all 86 health centers, all 6 referral hospitals, and the provincial hospital in Takeo province. This study includes pregnant women receiving antenatal care, antenatal healthcare providers and facilities, and hospital managers in Takeo. The study also includes national governing bodies for MMS delivery.\n\nMethods: This mixed-methods study uses ISAT as a framework for developing data collection methods. Sampling strategies emphasize urban and rural representation across all operational districts in Takeo and diverse stakeholder perspectives at multiple levels of the health system. Data collection includes:\n\n* 12 focus group discussions (FGDs) with health center providers to assess provider adherence to MMS delivery guidelines, perspectives on the transition to MMS, and additional resources needed for MMS delivery\n* Workload assessment surveys at FGDs to quantify any burden on providers and resource gaps to deliver MMS\n* MMS stockout monitoring at 18 health centers and 7 hospitals to assess supply chain reliability\n* 15 key informant interviews with hospital managers to assess perspectives on the integration of MMS into antenatal services and facility readiness for MMS delivery\n* Phone surveys with 630 pregnant women to assess acceptability and adherence to MMS at 90- and 180-days after MMS distribution\n* One FGD with national-level stakeholders to assess national-level readiness, economic planning, and resource planning for sustainable MMS implementation and scale-up\n* Rapid economic evaluation to estimate the cost of nationwide scale-up Potential Impact: This study will generate insights into real-world implementation of MMS in Cambodia. It will identify context-specific adaptations, implementation gaps, and resource planning frameworks needed for nationwide scale-up of MMS. Successful scale-up is anticipated to improve maternal and neonatal health in Cambodia. Findings can also be used to guide other LMICs seeking to transition to and sustainably implement MMS.",[253,28,254,255,256,257,29],"Anemia","Micronutrients","Supplement","Health Systems","Supply Chain Vulnerabilities",[259,260,261,262,263,264,265],"anemia","nutrition","micronutrient","supplement","dietary supplement","Cambodia","policy","2026-02-12",{"date":268,"type":39},"2026-02-17",{"date":270,"type":39},"2025-12-01",{"date":36,"type":22},{"name":273,"class":46},"University of British Columbia",{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":17,"sex":56,"minAge":89,"maxAge":281,"enrollmentInfo":282,"targetDuration":4,"studyType":23,"phases":284,"briefSummary":285,"conditions":286,"keywords":288,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":47},"100405278","effort-based-decision-making-and-cpap-adherence-100405278","NCT04557293","Effort-based Decision-making and CPAP Adherence","Effort-based Decision-making as a Possible Predictor of Poor Adherence to CPAP Treatment in Obstructive Sleep Apnea","Inclusion Criteria:\n\n* Age ≥ 18\n* AHI±15\n\nExclusion Criteria:\n\n* BMI ≥ 35 Kg\u002Fm2\n* MMSE \\\u003C24\n* Complex sleep apnoea\n* Sleep disorder\n* Psychiatric disorder","80 Years",{"count":283,"type":22},64,[25],"Obstructive sleep apnoea is the most common sleep disorder in general population, and is often associated with cognitive deficit, mood disorders, hypertension, diabetes mellitus, excessive daytime somnolence, nicturia and an increased cardiovascular and metabolic risk. The gold standard of treatment is Continuous Positive Airway Pressure (CPAP), but the adherence is often poor. The aim of our study is to investigate the effort based-decision making in patients with OSA, pre and post CPAP treatment, as a possible cause of poor adherence.",[287,29],"Obstructive Sleep Apnea",[289,290,291,33],"apnoea","effort based decision making","rehabilitation","2025-11-14",{"date":294,"type":39},"2025-11-18",{"date":296,"type":39},"2021-03-10",{"date":298,"type":22},"2026-04-30",{"name":300,"class":46},"Istituti Clinici Scientifici Maugeri SpA",{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":307,"eligibilityCriteria":308,"healthyVolunteers":11,"sex":56,"minAge":89,"maxAge":4,"enrollmentInfo":309,"targetDuration":4,"studyType":23,"phases":311,"briefSummary":312,"conditions":313,"keywords":319,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":330},"100590724","nurse-led-telehealth-for-gout-100590724","NCT06971146","Nurse-Led Telehealth for Gout","Health Literacy-Based, Nurse-Led Telehealth Support for Gout Self-Management: the Danish Randomized GOUTCONNECT Trial","GoutConnect","Inclusion Criteria:\n\n* ≥18 years old\n* Fulfills ACR\u002FEULAR 2015 Gout Classification Criteria\n* Estimated Glomerular Filtration Rate (e-GFR) \\>30 ml\u002Fmin\n* Prescribed Allopurinol or Adenuric, and achieved two consecutive serum urate levels of two consecutive serum urate levels of ≤0.30 mmol\u002Fl for patients with tophi and ≤0.36 mmol\u002FL for patients without tophi\n* Have sufficient Danish reading and writing skills to understand information and complete questionnaires.\n\nExclusion Criteria:\n\n• Cognitively impaired, unable to understand or provide informed consent.",{"count":310,"type":22},200,[25],"The aim of this clinical trial is to evaluate whether nurse-led telehealth support helps individuals with gout better manage their condition and adhere to urate-lowering medication after discharge from a rheumatology clinic.\n\nEligible patients will be recruited from five rheumatology departments in the Central Denmark Region after achieving two consecutive target serum urate levels-below 0.36 mmol\u002FL, or below 0.30 mmol\u002FL for patients with tophi.\n\nParticipants will be adults with gout who meet specific medical criteria, are taking medications such as allopurinol or Adenuric, and are able to read and write Danish.\n\nParticipants will be randomly assigned to one of two groups:\n\n* Intervention group: nurse-led telehealth support.\n* Control group: usual care with follow-up by their general practitioner.\n\nThe primary goal is to support patients in maintaining healthy uric acid levels after 52 weeks.\n\nParticipants in the nurse-led group have the option to choose from four support options:\n\nI1: App-Based Support - an app provides information and reminders. I2: Letter Reminders - messages are sent via digital or postal mail. I3: Text Reminders - SMS messages are sent every three months. I4: Phone Support - nurses call three times a year to check in.",[314,315,316,317,318,29],"Health Literacy","Gout Arthritis","Gout Initiating Urate-loweringUrate-lowering Therapy","Telehealth","Digital Health",[320],"self-managment","2025-09-17",{"date":323,"type":39},"2025-09-18",{"date":325,"type":22},"2025-10-01",{"date":327,"type":22},"2027-08-01",{"name":329,"class":46},"University of Aarhus",5,{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":337,"eligibilityCriteria":338,"healthyVolunteers":17,"sex":56,"minAge":88,"maxAge":4,"enrollmentInfo":339,"targetDuration":4,"studyType":23,"phases":341,"briefSummary":342,"conditions":343,"keywords":345,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":356,"locationsCount":47},"100573604","enhancing-prevention-of-injuries-in-community-youth-and-adult-amateur-football-players-100573604","NCT06748443","Enhancing Prevention of Injuries in Community Youth and Adult Amateur Football Players","Enhancing Prevention of Injuries in Community (EPIC) Youth and Adult Amateur Football Players - Design of a Type 3 Hybrid Implementation-effectiveness Cluster Randomised Controlled Trial","EPIC","Inclusion Criteria:\n\n* Male and female, youth and adult amateur football teams\n* Teams participating in series for players 10 years or older\n* Teams with scheduled training at least twice per week during the season\n* All eligible players in the team are invited to participate, regardless of whether they have an injury or not at study start\n\nExclusion Criteria:\n\n* Players with long-term injuries not planning to take part in match play in the 2025 season",{"count":340,"type":22},1600,[25],"This is a type 3 hybrid cluster randomised controlled trial, where implementation of the intervention is the primary outcome and preventive effectiveness is the secondary outcome.\n\nThe overall purpose of this study is to evaluate the added value of implementation support on the use and preventive effectiveness of the injury prevention exercise programme Knee Control+ in male and female, youth and adult amateur football teams.\n\nResearch questions\n\n1. Does use and injury preventive effect of Knee Control+ differ between teams randomised to an intervention group receiving additional support for Knee Control+ use and teams randomised to a control group with standard access to digital Knee Control+ programme material?\n2. Does coach self-efficacy to use Knee Control+, player motivation and player training dosage differ between the intervention and control groups?\n3. What are the mediators and moderators that influence use of Knee Control+?\n4. How well do the intervention and control groups adhere to Knee Control+ recommended use and is there an association between adherence and preventive efficacy?\n5. How are different components of the support material used by the intervention group teams, and how is the implementation support perceived by administrators, coaches and players in the clubs (end-users) and by fitness coaches who educate coaches about the programme (intervention deliverers)?\n6. How do coaches perceive their engagement to lead Knee Control+ training with their players and has this changed after having used the implementation support material?\n\nFootball teams will be randomised before the 2025 season to an intervention group receiving additional support for the implementation of Knee Control+ or to a control group without this support. All teams will have access to digital programme material via the Swedish Football Association.\n\nData on implementation of Knee Control+ and injuries (players only) will be collected weekly (coaches) and monthly (players) throughout the season using web-based questionnaires. Behavioural outcomes: for coaches self-efficacy, action and coping planning and perceived support from the club, and for players autonomous motivation, basic psychological needs and basic need support, will also be analysed.",[344,29],"Injury Prevention in Sports",[346,347,33,348,349],"amateur sports","injury prevention exercise programme","co-design","support for coaches","2025-04-24",{"date":352,"type":39},"2025-04-27",{"date":354,"type":39},"2025-03-25",{"date":183,"type":22},{"name":357,"class":358},"Linkoeping University","OTHER_GOV",{"id":360,"slug":361,"hasResults":11,"nctId":362,"briefTitle":363,"officialTitle":364,"acronym":365,"eligibilityCriteria":366,"healthyVolunteers":11,"sex":56,"minAge":89,"maxAge":281,"enrollmentInfo":367,"targetDuration":4,"studyType":23,"phases":369,"briefSummary":370,"conditions":371,"keywords":375,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":389,"leadSponsor":391,"locationsCount":47},"100580169","application-of-intelligent-care-systems-in-radiation-therapy-enhancing-patient-safety-and-reducing-anxiety-through-system-optimization-and-real-time-blood-data-monitoring-100580169","NCT06833801","Application of Intelligent Care Systems in Radiation Therapy: Enhancing Patient Safety and Reducing Anxiety Through System Optimization and Real-Time Blood Data Monitoring","Application of Intelligent Care Systems in Radiation Therapy: Enhancing Patient Safety and Reducing Anxiety Through System Optimization, Enhanced Education Strategies, and Real-Time Blood Data Monitoring","ICS-RT","Inclusion Criteria:\n\n* Patients undergoing radiation therapy combined with chemotherapy.\n* Age ≥ 18 years.\n* Ability to understand and comply with the study protocol.\n* Willing to participate in the study and provide informed consent.\n\nExclusion Criteria:\n\n* Patients with severe cognitive impairment or intellectual disability, affecting their ability to understand or follow study procedures.\n* Patients unwilling to complete study questionnaires.\n* Any mental health condition (e.g., major depressive disorder, severe anxiety disorder) that could interfere with participation.\n* Patients with conditions requiring immediate intervention that would make study participation impractical.",{"count":368,"type":22},100,[25],"This study aims to evaluate the impact of an intelligent care system on radiation therapy patients, focusing on real-time blood data monitoring, optimized patient education, and internal alert systems. The goal is to enhance patient safety, improve treatment adherence, and reduce anxiety by integrating an alert function into the hospital's existing system.\n\nKey interventions include:\n\nReal-time blood monitoring alerts: Healthcare providers will receive automatic notifications of abnormal blood test results to ensure timely intervention.\n\nOptimized patient education materials: Clearer guidance will help patients proactively communicate blood test needs and manage their health during radiation therapy.\n\nInternal reminders: Visual signs and alerts in treatment areas will reinforce patient awareness and engagement.\n\nThe study will compare patients receiving these interventions with those under standard care, assessing treatment compliance, anxiety levels, and clinical outcomes over a 12-month period.",[372,373,374,29],"Radiation Therapy","Chemoradiotherapy","Anxiety",[372,376,377,378,379,380,381,382,383,384],"Intelligent Care System","Real-Time Blood Data Monitoring","Patient Safety","Oncology Treatment Compliance","Cancer Treatment Anxiety","Clinical Decision Support System","Health Education in Radiation Oncology","Automated Blood Test Alerts","Supportive Care in Cancer Patients","2025-02-18",{"date":387,"type":39},"2025-02-20",{"date":387,"type":22},{"date":390,"type":22},"2025-12-31",{"name":392,"class":46},"Chung Shan Medical University"]