[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adhesive-small-bowel-obstruction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adhesive-small-bowel-obstruction":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,73,109,136],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100599434","phase-4-comparison-of-outcomes-of-management-of-bowel-obstruction-100599434",false,"NCT07084441","Comparison of Outcomes of Management of Bowel Obstruction","COMBO","Inclusion Criteria:\n\n* Adults ≥18 years of age recruited from UWMC\n* Patients presenting to surgical services through the Emergency Department, diagnosis of SBO, consulted by surgeon, and an urgent or emergency operation is deemed not necessary by surgeon.\n* Diagnosis of aSBO is established by;\n\n  1. CT findings consistent with diagnosis of SBO; and\n  2. signs and symptoms consistent with SBO; and\n  3. Adhesions from prior abdominopelvic surgery are the likely cause of SBO (absence of incarcerated hernia, internal hernia, masses, fistula, stricture, volvulus, acute episode of inflammatory bowel disease (IBD) flare, etc.).\n* Ability to provide written or electronic informed consent in English and answer teach-back questions\n\nExclusion Criteria:\n\n* Signs and symptoms of peritonitis with emergency operation planned\n* Planned urgent operation within the next 12 hours\n* Allergy to dexamethasone\n* Surgery within prior 6 weeks\n* Unable or unwilling to return or be contacted for and\u002For complete research surveys\n* Currently incarcerated in a detention facility or in police custody (patients wearing a monitoring device can be enrolled) at baseline\u002Fscreening\n* Individuals with latent infections who have an increased risk of infection.","ALL","18 Years",{"count":19,"type":20},550,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The Comparison of Outcomes of Management of Bowel Obstruction (COMBO) trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.",[26],"Adhesive Small Bowel Obstruction",[28,29,30,31],"asbo","sbo","small bowel obstruction","dexamethasone","RECRUITING","2026-05-05",{"date":35,"type":36},"2026-05-07","ACTUAL",{"date":38,"type":36},"2026-02-03",{"date":40,"type":20},"2030-12",{"name":42,"class":43},"University of Washington","OTHER",4,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100619886","predictors-of-laparoscopy-conversion-in-adhesive-small-bowel-obstruction-100619886","NCT07350447","Predictors of Laparoscopy Conversion in Adhesive Small Bowel Obstruction","Predictors of Laparoscopy Conversion in the Treatment of Adhesive Small Bowel Obstruction","Inclusion Criteria:\n\n* patients underwent emergency and urgent surgery for acute adhesive intestinal obstruction\n* the surgery was performed laparoscopically\n* the surgery was initiated laparoscopically and completed via laparotomy\n\nExclusion Criteria:\n\n* acute adhesive intestinal obstruction in the hernial sac\n* pregnant in the third trimester\n* patients with severe cardiovascular or respiratory failure\n* patients with hemodynamic shock",{"count":53,"type":20},170,"OBSERVATIONAL","The goal of this observational study is to reveal predictors of unsuccessfull laparoscopic intervention in adult patients with adhesive small bowel obstruction. The main question it aims to answer is: are there any strong predictors of laparoscopy conversion in patients with small bowel obstruction, caused by intraabdominal adhesions.",[26],[58,59,60,61],"Adhesive small bowel obstruction","Ahesiolysis","Laparoscopic adhesiolysis","abdominal adhesions","NOT_YET_RECRUITING","2026-01-10",{"date":65,"type":36},"2026-01-20",{"date":67,"type":20},"2026-01-01",{"date":69,"type":20},"2026-05-31",{"name":71,"class":43},"Almazov National Medical Research Centre",7,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":83,"studyType":54,"phases":4,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100599014","adhesion-prevention-in-asbo-surgery-using-4dryfield-ph-100599014","NCT07078981","Adhesion Prevention in ASBO Surgery Using 4DryField® PH","Assessing Determinants of Headway in Evaluating Risk of Adhesion: the ADHERE Study","ADHERE","Inclusion Criteria:\n\nAge ≥ 18 years\n\n* Undergoing surgical treatment for adhesive small bowel obstruction (ASBO)\n* Ability and willingness to provide informed consent\n* Willingness to adhere to follow-up visits\n\nExclusion Criteria:\n\n* Presence of peritonitis\n* Intra-abdominal active malignancy\n* Pregnancy or breastfeeding",{"count":82,"type":20},189,"1 Year","Post-surgical adhesions occur in up to 90% of abdominal surgeries, often leading to complications like adhesive small bowel obstruction (ASBO) and chronic pain. They result from imbalanced healing processes influenced by growth factors, fibroblast activity, and genetic predispositions. While surgery can relieve ASBO, it frequently causes new adhesions, with recurrence rates up to 40%. Anti-adhesion barriers, such as the starch-based 4DryField® PH, form a temporary gel barrier to support healing. Though promising, its role in preventing ASBO recurrence is not well studied. This study evaluates whether intra-operative use of 4DryField® PH reduces ASBO recurrence over 12 months and compares perioperative outcomes in treated vs. untreated patients.",[26,86,87,88],"Postoperative Abdominal Adhesions","Bowel Obstruction","Abdominal Surgery Complications",[90,91,92,93,94,95,96,97,98,99],"adhesion","obstruction","acute abdomen","emergency surgery","4DryField","adhesiolysis","antiadhesion barrier","ASBO","abdominal surgery","peritoneal adhesion","2025-07-14",{"date":102,"type":36},"2025-07-22",{"date":104,"type":20},"2025-07-15",{"date":106,"type":20},"2027-07-15",{"name":108,"class":43},"Alessio Giordano",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":21,"phases":118,"briefSummary":120,"conditions":121,"keywords":122,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":135},"100575835","elective-adhesiolysis-vs-a-wait-and-see-policy-to-prevent-recurrences-after-conservative-treatment-of-adhesive-small-bowel-obstruction-100575835","NCT06777446","Elective Adhesiolysis vs. a Wait-and-see Policy to Prevent Recurrences After Conservative Treatment of Adhesive Small Bowel Obstruction","AWARE","Inclusion Criteria:\n\n* Adult patients aged 18 years and older who have recently recovered from aSBO by small bowel obstruction managed by conservative treatment.\n* Patients who have previously been operated (high a prior risk of adhesions) are required to have no signs of other causes of bowel obstruction on imaging studies (CT-scan).\n* Patients with no previous operation in history (low a prior risk of adhesions) are required to have typical signs for aSBO on imaging studies (abrupt change of bowel calibre, closed loop, or signs of torsion on vessels in the mesentery on CT-scan).\n\nExclusion Criteria:\n\n* Patient who are unfit for reoperation for surgical, anesthesiological or medical reasons as determined by multidisciplinary team assessment or pre-operative screening\n* Patients with active malignancy, reducing life expectancy\n* Pregnancy",{"count":117,"type":20},380,[119],"NA","Rationale: Adhesive small bowel obstruction (aSBO) is a frequent surgical emergency, associated with 3-8% hospital mortality and a high risk of recurrence (20% at two years of follow-up). ASBO can be treated conservatively or by emergency surgery. In the absence of bowel ischemia or strangulation, conservative treatment is often preferred, to avoid the excess morbidity and mortality from emergency surgery. Recent epidemiological studies, however, demonstrate a considerable higher recurrence risk of aSBO after conservative treatment that is associated with hospital readmissions and lower survival. Elective adhesiolysis following successful conservative treatment might reduce these long-term risks whilst avoiding the high complication rate of emergency surgery.\n\nObjective: The investigators aim to assess the efficacy of elective adhesiolysis following conservative treatment for aSBO as compared to the current state of the art (wait-and-see policy) to prevent long-term recurrence of aSBO. Further the investigators will evaluate quality of life, healthcare and societal costs.\n\nStudy design: Multicenter open-label randomized controlled trial, including 380 patients.\n\nStudy population: Adult patients who recovered from aSBO by conservative treatment. Patients that are inoperable for medical, anaesthesiological or surgical reasons are excluded. Intervention (if applicable): The intervention of investigation is elective adhesiolysis. Adhesiolysis is an abdominal procedure in which all adhesions are cut, and adhesion prevention applied to reduce the risk of adhesion reformation. The intervention is compared to wait-and-see policy (the current standard treatment)\n\nMain study parameters\u002Fendpoints: Primary outcome is recurrence, defined as readmission for obstructive systems with aetiology of adhesions confirmed by CT. The investigators hypothesize a 50% reduction in recurrence in the intervention arm. Secondary outcomes are morbidity from surgery, health-related quality of life (EQ5D), healthcare costs and societal costs (iMCQ and iPCQ)\n\nNature and extent of the burden and risks associated with participation, benefit and group relatedness:\n\nPatients in the intervention group are exposed to abdominal surgery, which is associated with a moderate risk of minor complications such as wound infection and haemorrhage, and a small risk of severe complications such as iatrogenic bowel injury. According to our hypothesis, a potential benefit is the reduction in the risk of recurrences. Recurrence of aSBO is associated with a risk of readmissions, reinterventions, and also increased long-term mortality.",[26],[123,124,125],"Tissue adhesions","Adhesiolysis","Surgery","2025-01-10",{"date":128,"type":36},"2025-01-15",{"date":130,"type":20},"2025-02",{"date":132,"type":20},"2034-02",{"name":134,"class":43},"Radboud University Medical Center",14,{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":21,"phases":145,"briefSummary":147,"conditions":148,"keywords":149,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":163},"100530095","phase-3-optimizing-treatment-of-adhesive-small-bowel-obstruction-100530095","NCT06182319","Optimizing Treatment of Adhesive Small Bowel Obstruction","The Use of Nasogastric Tubes And Water-Soluble Contrast In The Management Of Small Bowel Obstruction: A Feasibility Study","Inclusion Criteria:\n\n1. Male or female ≥18 years of age.\n2. Documentation of aSBO as evidenced by one or more clinical features meeting the following criteria: Nausea, emesis, abdominal pain, distended abdomen CT evidence of aSBO\n\nExclusion Criteria:\n\n1. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study.\n2. Presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or the quality of the data.\n3. Unstable angina or recent myocardial infarction (MI)\u002Fstroke within 6 months\n4. Nonadhesive SBO\n\n   1. Paralytic Ileus\n   2. Incarcerated hernia\n   3. Fecal impaction\n   4. Intra-abdominal malignancy Early aSBO within 4 weeks of a prior abdominal operation",{"count":144,"type":20},40,[146],"PHASE3","Small bowel obstruction (SBO) is one of the most common causes of serious gastrointestinal disease in the US. Adhesion-related SBO (aSBO) is usually treated by the placement of a nasogastric tube (NGT) to decompress the stomach, administration of intravenous (IV) fluids and observation by a surgical team.\n\nThe purpose of this feasibility study is to determine the potential for implementation of treatment protocols for aSBO and determine the feasibility of randomizing patients with aSBO to receive or not receive NGTs or water-soluble contrast (WSC). The investigators will also determine the ability to measure HRQOL as a main outcome for the treatment of aSBO. The studies outlined in this research program intend to address gaps in knowledge about how to determine who benefits from NGT placement, who can be managed without them, how to objectively determine when a bowel obstruction has resolved, how to reintroduce feeding to patients with aSBO, what criteria should be used for hospital discharge and what role cathartics such as WSC contrast have in the management of aSBO.\n\nThis feasibility study will enroll a limited number of patients (n=40) who will be followed for up to 30 days.",[26],[150,151,152,153],"nasogastric tube (NGT)","water-soluble contrast (WSC)","Adhesion-related SBO (aSBO)","Small bowel obstruction (SBO)","2024-05-07",{"date":156,"type":36},"2024-05-08",{"date":158,"type":36},"2024-01-01",{"date":160,"type":20},"2025-12-15",{"name":162,"class":43},"University of California, Los Angeles",1]