[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adolescent-cancer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adolescent-cancer":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,75,102,140],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100480731","exercise-in-adolescents-with-cancer-100480731",false,"NCT05539794","Exercise in Adolescents With Cancer","Exercise Intervention for Adolescents With Cancer (EXERCADOL): A Randomized Controlled Trial","EXERCADOL","Inclusion Criteria:\n\n* Newly diagnosed with a malignant extracranial tumour\n* Not having received any therapy--except surgery--at diagnosis\n* Adequate health status (Karnofsky\u002FEastern Cooperative Oncology Group scale score ≥50\u002F2)\n* To understand Spanish language and provide written informed consent.\n\nExclusion Criteria:\n\n* Life expectancy \\\u003C3 months\n* Comorbidity\u002Facute condition contraindicating exercise practice","ALL","12 Years","19 Years",{"count":21,"type":22},136,"ESTIMATED","INTERVENTIONAL",[25],"NA","The investigators will study the effects of an supevised exercise intervention along the duration of intensive treatment (neoadjuvant \\[solid tumours\\]\u002Fintense chemotherapy \\[leukemias\\], expected median duration 5-6 months) on several health-related variables. Participants will be recruited from 4 hospitals in Madrid (Spain). Inclusion criteria: male\u002Ffemale aged 12-19 years, newly diagnosed--or relapse of-- a malignant extracranial tumour; not having received any type of therapy--except surgery--at the time of diagnosis; adequate health status (Karnofsky\u002FEastern Cooperative Oncology Group scale score ≥50\u002F≤2); to understand Spanish language and to provide written informed consent. The investigators will recruit ≥136 participants and conduct a randomised controlled trial. The intervention group will follow a supervised concurrent exercise program from the start to the end of intensive treatment. The exercise intervention will be performed in the hospital gymnasium or in the patients' ward (during neutropenic phases), and will also include supervised online sessions. Additionally, the intervention group will perform include inspiratory muscle training. The following outcomes will be assessed at baseline (diagnosis), end of treatment, and at 3-month follow-up in all participants: echocardiography-determined left ventricular function (primary outcome); and other echocardiography-determined variables, cardiac biomarkers, blood pressure, blood lipids, body composition, physical activity levels, energy intake, cardiorespiratory fitness, muscle strength, functional mobility, health-related quality of life, cancer-related fatigue, clinical variables, and potential biological underpinnings of exercise multisystemic benefits (metabolic and inflammatory markers, plasma proteome, gut microbiome, and immune function).",[28],"Adolescent Cancer",[30,31,32],"cancer","lifestyle","cardiac function","RECRUITING","2026-05-28",{"date":36,"type":37},"2026-06-01","ACTUAL",{"date":39,"type":37},"2022-04-15",{"date":41,"type":22},"2026-12-31",{"name":43,"class":44},"Universidad Europea de Madrid","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100608029","comprehensive-care-for-aya-needs-assessment-survey-100608029","NCT07196241","Comprehensive Care for AYA: Needs Assessment Survey","Inclusion Criteria:\n\n* Individuals diagnosed with cancer between the ages of 15-39 per self-report. Participants may be enrolled at any age provided diagnosis was between ages 15-39.\n* Individuals who have received or are receiving cancer-directed treatment (chemotherapy, immunotherapy, surgery and\u002For radiation) at one of the participating centers per self-report.\n\nExclusion Criteria:\n\n* Severe emotional distress or anxiety that would limit compliance with study requirements per self-report.","15 Years",{"count":54,"type":22},300,"OBSERVATIONAL","The goal of this observational study is to assess gaps in education about exercise, sexual health, fertility, survivorship, financial issues, interpersonal relationships, and clinical trial participation among adolescents and young adults with cancer.\n\nParticipants will be asked to complete a series of questionnaires.",[58,59,28],"Cancer","Young Adult Cancer",[61,62,58,63,64,65],"Adolescent","Young Adult","AYA","Questionnaire","Needs assessment","2026-05-21",{"date":68,"type":37},"2026-05-26",{"date":70,"type":22},"2026-06",{"date":72,"type":22},"2026-10",{"name":74,"class":44},"Wake Forest University Health Sciences",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100610178","life-at-1004-an-immersive-social-virtual-reality-vr-education-tool-for-adolescent-and-young-adult-cancer-patients-and-caregivers-100610178","NCT07224204","Life at 100.4: An Immersive Social Virtual Reality (VR) Education Tool for Adolescent and Young Adult Cancer Patients and Caregivers","Life at 100.4: An Immersive Social Virtual Reality Education Tool for Adolescent and Young Adult Cancer Patients and Caregivers","Inclusion Criteria:\n\n* Newly diagnosed with a malignancy or bone marrow failure condition\n* Planned to receive chemotherapy and receive a central line\n\nExclusion Criteria:\n\n* Medical contraindication to virtual reality including head wounds and history of seizure with flashing lights\n* No plan to receive chemotherapy","13 Years","39 Years",{"count":85,"type":22},45,[25],"The purpose of this study is to design and Beta test the Life at 100.4, an immersive social virtual reality education tool, with an anticipated 5 patient-caregiver-provider triads.Patients at Yale Pediatric Hematology and Oncology with a new oncologic diagnosis and their caregivers will be eligible for enrollment. Investigators will determine the feasibility and acceptability of implementing Life at 100.4 using validated measures.",[58,28,59],[90,91],"Adolescent Cancer Patients and Caregivers","Young Adult Cancer Patients and Caregivers","2026-02-24",{"date":94,"type":37},"2026-02-25",{"date":96,"type":37},"2026-02-11",{"date":98,"type":22},"2027-04",{"name":100,"class":44},"Yale University",1,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":113,"conditions":114,"keywords":120,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":5},"100611871","caya-cancer-retrospective-cohort-study-100611871","NCT07246213","CAYA Cancer Retrospective Cohort Study","Improving Cancer Outcomes for Children, Adolescents, and Young Adults: A Multicenter Retrospective Cohort Study on Treatment Failure and Toxicity in Low- and Middle-Income Countries","Inclusion Criteria:\n\nSubjects must meet all the following criteria to be included in this registry:\n\n1. Participants must be willing and able to provide informed consent prior to enrollment in the registry.\n\n   1. For minors or individuals unable to provide informed consent, assent must be obtained along with consent from a legal guardian.\n   2. Note: Exemption applies to this criterion when waiver of informed consent\u002Fassent is granted by Institutional Review Board(IRB)\u002FIndependent Ethics Committee(IEC)\u002FCompetent Authorities(CAs).\n2. A confirmed diagnosis of any type of cancer within the 15 years prior to the site's activation date.\n3. Age 0 to 21 years at the time of diagnosis.\n4. Received substantial anti-cancer treatment at the participating center, including but not limited to:\n\n   1. Chemotherapy\n   2. Surgery\n   3. Radiation therapy\n   4. Immunotherapy\n5. Medical records are available and accessible for review\n\nExclusion Criteria:\n\n* Subjects meeting any of the following criteria will be excluded from this registry:\n\n  1. Patients who only visited the participating center for:\n\n     1. Consultation without subsequent primary anti-cancer treatment at the participating center\n     2. Pathology, radiology, or other diagnostic evaluations without treatment","0 Years","21 Years",{"count":112,"type":22},18000,"Despite advances in cancer treatment, significant disparities in outcomes persist between high-income countries (HICs) and low-and middle-income countries (LMICs). Around 80% of children with cancer live in LMICs, where they face challenges such as delayed diagnosis, misdiagnosis, comorbidities, distance to treatment, financial barriers, and limited access to risk-adapted therapies.\n\nAcute lymphoblastic leukemia(ALL)\u002Flymphoblastic lymphoma(LBL), for example, is one of the greatest success stories in pediatric oncology, however, such improvements are not evenly distributed worldwide, and the outcomes for leukemia patients are poorer in LMICs compared to HICs, primarily due to reduced access to quality healthcare.\n\nThis study aims to assess cancer treatment outcomes in LMICs, focusing on acute lymphoblastic leukemia\u002Flymphoblastic lymphoma. The findings will inform future studies to implement evidence-based interventions that improve care quality and reduce treatment failures through targeted strategies.",[115,116,59,28,117,118,119],"Acute Lymphoblastic Leukemia","Lymphoblastic Lymphoma","Childhood Cancers","Acute Lymphoblastic Leukemia (ALL)","Lymphoblastic Lymphoma (LBL)",[121,122,123,124,125,126,127,128,129,130],"Cancer outcomes","Low- and Middle-Income Countries (LMICs)","Childhood cancer","Adolescent and young adult cancer (CAYA)","Treatment failure","Therapy-related toxicities","Retrospective cohort","Leukemia outcomes","Oncology disparities","High-Income Countries (HICs)","2025-12-12",{"date":133,"type":37},"2025-12-19",{"date":135,"type":37},"2025-06-04",{"date":137,"type":22},"2028-12-04",{"name":139,"class":44},"Resonance, Inc.",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":23,"phases":150,"briefSummary":151,"conditions":152,"keywords":158,"overallStatus":165,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":101},"100610511","cesikids-trial-enhancing-psychological-resilience-in-adolescents-with-cancer-100610511","NCT07228533","CesiKids Trial: Enhancing Psychological Resilience in Adolescents With Cancer","Evaluation of the Effectiveness of a Nursing-Based Co-Design Intervention Program (CesiKids) to Enhance Psychological Resilience in Hospitalized Adolescents Diagnosed With Cancer: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Parents have provided informed consent after receiving information,\n* The child has given assent to participate after being informed,\n* The child is between 12 and 18 years of age,\n* The child has been diagnosed with cancer and is currently receiving inpatient treatment,\n* The child is undergoing chemotherapy and\u002For radiotherapy,\n* The child is able to use a computer and\u002For smartphone,\n* The child can understand and speak Turkish.\n\nExclusion Criteria:\n\n* Receiving hematopoietic stem cell transplantation treatment,\n* Having developed a relapse after remission,\n* Experiencing communication difficulties (e.g., intellectual disability, visual impairment, etc.),\n* Having a psychiatric diagnosis made by a psychiatrist,\n* Having experienced a significant life event affecting psychological well-being within the past four weeks (e.g., death, divorce, etc.).","18 Years",{"count":149,"type":22},36,[25],"This study will develop and evaluate a mobile-based co-design intervention (CesiKids) to enhance psychosocial resilience in hospitalized adolescents aged 12-18 diagnosed with cancer. The program will be created using Bronfenbrenner's Ecological Systems Theory and designed in collaboration with nurses, recovered adolescents, and parents. A randomized controlled design will be used. The intervention group will participate in a four-week structured program, while the control group will receive standard care. Psychosocial resilience and coping outcomes will be assessed at baseline, post-intervention, and follow-up. This research aims to offer an evidence-based, scalable model to support resilience among adolescents with cancer in clinical settings.",[153,28,154,155,156,157],"Resilience, Psychological","Mobile Application","Pediatric Cancer","Pediatric Nursing","Coping",[61,159,160,161,162,163,164],"Resilience","Coping skills","Neoplasms","Pediatric nursing","Mobile application","Psychosocial intervention","NOT_YET_RECRUITING","2025-11-13",{"date":168,"type":37},"2025-11-14",{"date":170,"type":22},"2025-11",{"date":172,"type":22},"2027-06",{"name":174,"class":44},"Eskisehir Osmangazi University"]