[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adolescent-development\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adolescent-development":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,49,90,122,146,171,194,216,243,268],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100361428","reproductive-axis-maturation-in-the-early-post-menarchal-years-100361428",false,"NCT03986021","Reproductive Axis Maturation in the Early Post-Menarchal Years","Reproductive Axis Maturation in the Early Post-Menarchal Years: A Pilot Study","* Part 1 - Pre-menarche monitoring (\"holding pattern\"):\n\nInclusion Criteria:\n\n* Age 8-14.5 years old\n* Healthy weight, defined as having a body weight \\>85% of expected (EBW) and a body mass index (BMI) \\\u003C99th percentile\n* Some breast development\n* Pre-menarche\n\nExclusion Criteria:\n\n* Taking or planning to take medications that affect reproductive hormones in the next 2 to 3 years (e.g. birth control pills, biotin supplements).\n* Planning to move more than 60 miles from the CRU within the next 2 to 3 years\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* First-degree relative with polycystic ovarian syndrome, premature ovarian insufficiency, hypogonadotropic hypogonadism, or other pubertal development disorder\n* Excessive exercise (defined as running \\>20 miles per week or its equivalent)\n* Pregnancy\n\nPart 2 - Post-menarche cycle tracking:\n\nInclusion Criteria:\n\n* Age at menarche 10-14.5 years old\n* Healthy weight, defined as having a body weight \\>85% of expected (EBW) and a body mass index (BMI) \\\u003C99th percentile\n* Approximately \\\u003C 6 months post-menarchal (will typically have completed 4 or fewer menstrual cycles)\n* Biochemical criteria: normal thyroid hormone, prolactin, and testosterone levels\n\nExclusion Criteria:\n\n* Taking or planning to take medications that affect reproductive hormones in the next 2 to 3 years (e.g. birth control pills, biotin supplements).\n* Planning to move more than 60 miles from the CRU within the next 2 to 3 years\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* First-degree relative with polycystic ovarian syndrome, premature ovarian insufficiency, hypogonadotropic hypogonadism, or other pubertal development disorder\n* Excessive exercise (defined as running \\>20 miles per week or its equivalent)\n* Anemia (defined as hemoglobin \\\u003C12.0 g\u002Fdl)\n\n  --Participants with hemoglobin between 11.5 g\u002Fdl and 12.0 g\u002Fdl may still participate by providing dried blood spots, or no more than 18 ml of blood during any given interval.\n* Pregnancy\n\nPart 3 - Intensive monitoring of ovarian follicle growth\n\nInclusion Criteria:\n\n* Age at menarche 10-14.5 years old\n* Healthy weight, defined as having a body weight \\>85% of expected (EBW) and a body mass index (BMI) \\\u003C99th percentile\n* Within 1 year of menarche\n* Biochemical criteria: normal thyroid hormone, prolactin, and testosterone levels\n\nExclusion Criteria:\n\n* Taking or planning to take medications that affect reproductive hormones in the next 1-2 years (e.g. birth control pills, biotin supplements).\n* Planning to move more than 60 miles from the CRU within the next year\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* First-degree relative with polycystic ovarian syndrome, premature ovarian insufficiency, hypogonadotropic hypogonadism, or other pubertal development disorder\n* Excessive exercise (defined as running \\>20 miles per week or its equivalent)\n* Anemia (defined as hemoglobin \\\u003C12.0 g\u002Fdl)\n\n  --Participants with hemoglobin between 11.5 g\u002Fdl and 12.0 g\u002Fdl may still participate by providing dried blood spots, or no more than 18 ml of blood during any given interval.\n* Pregnancy\n\nPart 4 - Late Post-menarche cycle tracking:\n\nInclusion Criteria:\n\n* Age 11-17.5 years old\n* Approximately 2-5 years post-menarchal\n* Biochemical criteria: normal thyroid hormone and prolactin\n\nExclusion Criteria:\n\n* Taking or planning to take medications that affect reproductive hormones in the next 2 to 3 years (e.g. birth control pills, biotin supplements).\n* Planning to move more than 60 miles from the CRU within the next 6 months\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* Anemia (defined as hemoglobin \\\u003C12.0 g\u002Fdl)\n\n  --Participants with hemoglobin between 11.5 g\u002Fdl and 12.0 g\u002Fdl may still participate by providing dried blood spots, or no more than 18 ml of blood during any given interval.\n* Pregnancy\n\nAdolescent girls, at-risk daughters, or sisters of women with PCOS\n\nThe girls with mothers or sisters with PCOS group will complete the Screening Visit and Parts 1-3. The same inclusion and exclusion criteria apply for Parts 1, 2, and 3 as stated above except that these individuals must have a first-degree relative with PCOS and they can have high androgen levels, excess body hair, and severe acne at screening.\n\nWomen with known PCOS (activities for 8 weeks only)\n\nInclusion Criteria:\n\n* Age \\>=18-34 years old\n* PCOS diagnosis\n* at least 3-years post-menarchal with irregular menstrual cycles\n* Biochemical (blood) or clinical signs of high androgen levels\n\nExclusion Criteria:\n\n* Cannot be taking any medications that affect reproductive or metabolic hormones (e.g. birth control pill, biotin supplements, spironolactone, metformin).\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* Pregnancy\n\nHealthy control women (Activities x 2 menstrual cycles)\n\nInclusion Criteria:\n\n* Age \\>=18-34 years old\n* at least 3-years post-menarchal with regular menstrual cycles every 21-35 days\n\nExclusion Criteria:\n\n* Cannot be taking any medications that affect reproductive or metabolic hormones (e.g. birth control pill, biotin supplements, spironolactone, metformin).\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* PCOS diagnosis or first-degree relative with disorder\n* Pregnancy\n\nMothers of pediatric participants (Activities for 8 weeks \u002F 2 menstrual cycles)\n\nInclusion Criteria:\n\n* Age \\>=18-65 years old\n* Biological mother of A Girl's First Period participant\n\nExclusion Criteria:\n\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* Pregnancy",true,"FEMALE","8 Years","65 Years",{"count":21,"type":22},400,"ESTIMATED","OBSERVATIONAL","Background:\n\nMost adult women with irregular periods of unknown cause report symptoms dating back to early adolescence. This study aims to learn how girls' periods change in the 2 years after their first period. We are also looking at girls who may have a condition called PCOS. This will help researchers learn what healthy puberty looks like and how they can spot signs of hormone problems early on.\n\nObjective:\n\nTo learn how long it takes girls to develop regular menstrual cycles after their first period.\n\nEligibility:\n\nHealthy girls ages 8-14 who either (1) haven't had their first period but show signs of puberty, such as breast development and hair in the genital area; or (2) had their first period in the past 6 months\n\nGirls at risk for PCOS age 8-14 who have a mom or sister with PCOS\n\nGirls with irregular menstrual cycles age 11-17.5\n\nTo compare with the girls, we are looking at women \\>=18-34 years old with PCOS,\n\nHealthy women \\>= 18-34 years old without PCOS,\n\nand Mothers of pediatric participants age 18-65\n\nDesign:\n\nBoth parents or guardians must allow their daughter to participate. They must attend all study visits with her.\n\nParticipants will first be screened by phone. Those who qualify will be screened in person. They will have a physical exam. They will give blood and urine samples. They will have an ultrasound of their abdomen. They will fill out questionnaires. They will sit in a BOD POD for 6 minutes: This is an egg- shaped machine that takes body measurements. They have the option to provide DNA samples.\n\nParticipants will have sets of visits at home or at the clinic about every 6 months. The number of visits in each set will depend on their menstrual cycle. Then they will have a final visit. Visits will include repeats of the screening tests. There are additional parts that participants may choose to be involved in depending on how involved they want to be.\n\nAt home, participants will collect their urine daily to measure hormones. They will keep a diary of their periods.\n\nAdults: Women with known PCOS will complete the same Screening Visit as the girls and will collect dried urine specimens at home for 8 weeks;\n\nThe Healthy control women group will complete the same Screening Visit as the girls and collect dried urine specimens at home for 2 menstrual cycles;\n\nThe Mothers of pediatric participants group will complete a Screening Visit (informed consent, urine pregnancy test) and collect vaginal swab specimens at home for 2 menstrual cycles (approx. 8 weeks)....",[26,27,28,29],"Reproductive Physiological Processes","Pediatrics","Adolescent Health","Adolescent Development",[31,32,33,34,35],"Menarche","Adolescent","Physiology","Hormones","Natural History","RECRUITING","2026-07-01",{"date":39,"type":40},"2026-07-02","ACTUAL",{"date":42,"type":40},"2019-12-19",{"date":44,"type":22},"2029-07-01",{"name":46,"class":47},"National Institute of Environmental Health Sciences (NIEHS)","NIH",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":48},"100609281","emotichealth-promoting-adolescent-health-through-a-serious-game-100609281","NCT07212530","EmoTIChealth: Promoting Adolescent Health Through a Serious Game.","\"Promoting Health in Adolescents With and Without Chronic Diseases Through Emotional Development: Design and Implementation of a Serious Game Technology Platform (EmoTIChealth)\"","Inclusion Criteria:\n\n* Informed consent by parents\u002Fguardians and participants.\n* Aged between 12 and 16 years old\n\nExclusion Criteria:\n\n* No access to internet or new technologies\n* Not a Spanish speaker.","ALL","12 Years","16 Years",{"count":60,"type":22},600,"INTERVENTIONAL",[63],"NA","The intervention program targets adolescents between 12 and 16 years of age. The intervention program is designed for adolescents during a critical developmental stage marked by significant life transitions, where building strong personal resources and receiving psychological support is essential to foster socioemotional skills and overall well-being. The serious game aims to promote psycho-emotional health in the general adolescent population, supporting healthy development and preventing future emotional difficulties. At the same time, it incorporates specific modules for adolescents living with chronic conditions such as asthma, food allergy, type 1 diabetes, and allergic rhinitis, who may face additional risks of psychological challenges that can complicate treatment and prognosis. By combining universal health promotion with tailored support, the program addresses both the needs of healthy adolescents and those with chronic illnesses.\n\nThe platform integrates digital and technological tools for dynamic and personalized intervention. Artificial intelligence adapts activities and feedback to each participant's socio-demographic profile and evolving needs, this supports directly in participants' daily lives and natural environments, making the experience more relevant and impactful. The serious game, proven effective in engaging young people, goes beyond traditional psychoeducation by creating an interactive environment where adolescents develop socio-emotional competencies, resilience, and health-related knowledge. Through its six thematic areas, the game promotes overall well-being and healthy habits, while its condition-specific modules provide targeted guidance and coping strategies for asthma, food allergies, type 1 diabetes, and allergic rhinitis.",[66,67,68,69,29],"Type 1 Diabetes","Asthma","Allergic Rhinitis","Food Allergy",[66,67,68,71,72,73,74,75,76,77,78,79],"Food allergy","Serious Game","Technology platform","Psychological intervention","Adolescence","Quality of life","chronic organic illnesses","Socioemotional Education","Health Promotion","2026-05-12",{"date":82,"type":40},"2026-05-13",{"date":84,"type":40},"2025-12-01",{"date":86,"type":22},"2027-08-30",{"name":88,"class":89},"University of Valencia","OTHER",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":56,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":61,"phases":101,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":112,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":4},"100635550","the-effect-of-body-percussion-training-on-neuromotor-performance-attention-and-functionality-in-adolescents-with-mild-intellectual-disability-100635550","NCT07554144","The Effect of Body Percussion Training on Neuromotor Performance, Attention, and Functionality in Adolescents With Mild Intellectual Disability","The Effect of Body Percussion Training on Neuromotor Performance, Attention, and Functionality in Adolescents With Mild Intellectual Disability: A Randomized Controlled Study","Inclusion Criteria:\n\n* Being an adolescent aged 14-19 attending high school (e.g., special education high school)\n* Having been diagnosed with mild intellectual disability (IQ range according to relevant psychological assessment)\n* Having communication skills sufficient to understand simple commands and adapt to work\n* Being able to perform basic daily living activities (toilet hygiene and management, bladder\u002Fbowel management, eating, bathing, personal hygiene, dressing, functional mobility, etc.) independently or with minimal support, regardless of the level of disability\n* Signing an informed consent form with family consent and\u002For legal guardian consent\n\nExclusion Criteria:\n\n* Painful musculoskeletal\u002Forthopedic (rheumatic, etc.) problems that may prevent physical participation in rhythm-based body percussion training, restrict movement during training, and cause pain\n* Cardiovascular problems (arrhythmia, hypertension, etc.) that may prevent participants from attending training during the study period\n* Diagnosis of moderate or severe intellectual disability\n* Presence of additional diagnoses such as autism spectrum disorder, cerebral palsy, or developmental coordination disorder\n* Participation in a systematic physical therapy program other than rhythm or motor training\n* Conditions affecting motor performance due to medical or surgical treatment (within the last 6 months)\n* Severe auditory and visual deficits that hinder communication and the ability to imitate movements\n* Individuals who cannot attend regularly during the study period due to personal or family reasons\n* The family\u002Fadolescent's desire to withdraw from the study of their own accord","14 Years","19 Years",{"count":100,"type":22},25,[63],"The aim of this randomized controlled trial is to investigate the effects of group-based rhythm-based body percussion training on neuromotor performance, attention, and functionality in adolescents with mild intellectual disability.\n\nThe study will be conducted in individuals aged 14-18 years with mild intellectual disability using a two-arm, parallel-group, evaluator-blind design. Participants will be assigned to experimental and control groups using a simple randomization method.\n\nThe experimental group will receive structured body percussion training twice a week for 45 minutes over 8 weeks. This training consists of rhythmic patterns including clapping, knee tapping, chest tapping, finger snapping, and foot tapping, and will be presented as a progressively advancing program with metronome accompaniment.\n\nThe control group will receive passive music listening without intervention for the same duration and frequency.\n\nParticipants will be evaluated at two time points: before and after the intervention. Evaluation tools include: The tests cover neuromotor performance with the Minnesota Hand Skills Test and the Four Square Step Test, rhythm coordination with the Metronome Synchronization Test, attention with the Stroop Test, and functionality with the World Health Organization Disability Assessment Chart 2.0.",[104,105,29],"Mild Cognitive Impairment","Attention Impaired",[104,107,108,109,110,111],"attention","neuromotor performance","functionality","adolescents","body percussion training","NOT_YET_RECRUITING","2026-04-21",{"date":115,"type":40},"2026-04-28",{"date":117,"type":22},"2026-04-30",{"date":119,"type":22},"2026-07-03",{"name":121,"class":89},"Kutahya Health Sciences University",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":16,"sex":56,"minAge":97,"maxAge":98,"enrollmentInfo":130,"targetDuration":132,"studyType":23,"phases":4,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":48},"100630284","genesis-project-generating-evidence-on-the-needs-of-ecuadorian-adolescents-100630284","NCT07485673","GENESIS Project: Generating Evidence on the Needs of Ecuadorian Adolescents","Generating Evidence on the Needs of Ecuadorian Adolescents","GENESIS","Inclusion Criteria:\n\n* be between 14 and 19 years old\n\nExclusion Criteria:\n\n* have any disorder or treatment that contraindicated physical activity or that demanded special assistance\n* be under some pharmacological treatment;\n* not be authorized by parents, caregivers, or legal guardians to participate in the research project\n* do not agree to take part in the research project\n* for volunteering retirement.",{"count":131,"type":22},1450,"5 Years","Background: Adolescence is a period of intensified emotional responses and occurs when mental health disorders commonly develop since adolescents are learning how to deal with powerful emotions. Globally, 15% of adolescents experience a mental disorder like depression or anxiety. However, adolescent mental health goes beyond mental disorders. It is state of mental well-being that allows individuals to deal with stressors, recognize their abilities, develop their activities well, and participate in society, providing a holistic approach that highlights the interplay between psychological well-being and other aspects of life. Given this perspective, a Lifestyle Medicine (LM) approach based on a multi-component framework is needed for assessing adolescents' mental health. This study aims to evaluate adolescents' (aged 14-19) mental health, identify and mitigate the risks of developing any mental health disorder as well as formulate comprehensive interventions to promote and increase their emotional wellbeing. Methods: Cross-sectional and longitudinal studies will be performed. Adolescents from Quito, Ecuador will be recruited using a simple random sampling technique. The minimum sample size is 385; however, to increase the precision of the estimates, a target sample of approximately 1000 participants will be established. Main outcome measure will be mental health using social determinants of health and lifestyle medicine factors. Conclusion: This research project will evaluate adolescents' mental health through a holistic and multiapproach evaluation and interrelate social determinants of health and lifestyle medicine variables to propose and design multidisciplinary strategies and interventions to prevent and mitigate mental health outcomes in adolescents. Additionally, the results will be useful in informing public health authorities to evaluate or modify current policies",[29,135,136],"Mental Health Issue","Lifestyle Factors","2026-03-16",{"date":139,"type":40},"2026-03-20",{"date":141,"type":40},"2025-09-04",{"date":143,"type":22},"2030-08",{"name":145,"class":89},"Universidad de Especialidades Espiritu Santo",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":16,"sex":56,"minAge":153,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":61,"phases":157,"briefSummary":158,"conditions":159,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":48},"100596053","stress-trajectories-and-anhedonia-in-adolescence-research-study-100596053","NCT07040449","Stress Trajectories and Anhedonia in Adolescence Research Study","STAARS","Inclusion Criteria:\n\n* Age 13-15 years old at study entry\n* Ability to understand and sign an assent form\n* Meets study hearing and vision requirements\n\nExclusion Criteria:\n\n* Current use of antipsychotic medication\n* Current use of medications that would interfere with cardiovascular or endocrine assessments\n* Metal in the body or other MRI exclusion\n* Central nervous system disorder or brain injury that could confound brain imaging evaluations\n* Presence of a medical condition that would interfere with cardiovascular or endocrine assessments\n* Impaired intellectual functioning\n* Diagnosed with a neurodevelopmental disability","13 Years","15 Years",{"count":156,"type":22},192,[63],"This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) in adolescence. The goal of this project is to see if it is possible to combine these biological measures to describe different patterns of activity in the brain and body that adolescents may have in response to stress.\n\nThe main question this study aims to answer is whether different patterns of activity in the brain and body are related to whether adolescents develop anhedonia and how high or low levels of anhedonia are over time.\n\nThis study will enroll 192 adolescents who are between 13 and 15 years. Adolescents will complete tasks three times: at the beginning of the study, 10 months after that, and then 10 months after that. In total, they will be part of the study for 20 months. At each time, adolescents will complete surveys, provide samples of spit to measure hormones and provide pictures of their brain to measure brain activity, participate in mildly stressful tasks, and complete different activities that measure how they think. The investigators will also ask each adolescent's parent or legal guardian to answer some surveys about themselves and their child.",[160,161,29],"Anhedonia","Stress Response","2025-06-18",{"date":164,"type":40},"2025-06-27",{"date":166,"type":40},"2025-03-12",{"date":168,"type":22},"2030-02",{"name":170,"class":89},"University of North Carolina, Chapel Hill",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":16,"sex":56,"minAge":97,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":61,"phases":182,"briefSummary":183,"conditions":184,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":48},"100544495","monetary-incentive-delay-task-for-probing-reward-related-neural-processes-100544495","NCT06369623","Monetary Incentive Delay Task for Probing Reward-related Neural Processes","Neuromelanin MRI: A Tool for Non-invasive Investigation of Dopaminergic Abnormalities in Adolescent Substance Use","MID","Inclusion Criteria:\n\n* Males and females ages 14-17 years-old;\n* English-speaking for assent and interview completion;\n* Capacity to provide assent.\n* For parents, the inclusion criteria will be willing and capacity to provide parental permission\u002Fconsent.\n\nExclusion Criteria:\n\n* current (within 6 months) use of medication that may affect cerebral function\n* history of severe medical or neurological illness, including stroke or seizure;\n* history of head trauma with loss of consciousness;\n* presence of metal in the body;\n* pregnancy or breastfeeding;\n* recent drug or alcohol use determined by positive urine toxicology or breathalyzer (to validate self-report assessment of substance use history);\n* lifetime use of psychotropic or other medication that could likely influence dopamine function, namely stimulant medication or antipsychotic medication, except a subgroup of 25 youth with history of prescribed stimulant medication and a subgroup of 15 youth with history antipsychotic medication will be enrolled for comparison purposes.","17 Years",{"count":181,"type":22},300,[63],"150 males and 150 females ages 14-17 years-old will be enrolled in an observational, longitudinal study. There are three planned in-person visits: a baseline assessment, an 18-month follow-up, and a 36-month follow-up. The in-person visits will include assessment of substance use and other individual differences (e.g., reward function, psychiatric history), neuromelanin-sensitive MRI, as well as functional brain activation collected while the participant is at rest (resting-state fMRI) and while the participant completes a Monetary Incentive Delay task. Subjects will also be asked to complete past 90-day substance use assessments remotely every 90 days for 36 months.",[29],"2025-05-12",{"date":187,"type":40},"2025-05-15",{"date":189,"type":40},"2024-04-06",{"date":191,"type":22},"2028-11-30",{"name":193,"class":89},"Stony Brook University",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":16,"sex":56,"minAge":57,"maxAge":97,"enrollmentInfo":201,"targetDuration":4,"studyType":61,"phases":203,"briefSummary":204,"conditions":205,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":48},"100591188","adverse-adolescent-pathways-to-substance-use-100591188","NCT06977178","Adverse Adolescent Pathways to Substance Use","APSU","Inclusion Criteria:\n\n* Male or female\n* 12-14 years old,\n* Report symptoms of anxiety\n* Understand and sign an assent, and parents will sign a permission and a consent document in English\n* Meets study hearing and vision requirements\n* Substance use naïve\n\nExclusion Criteria:\n\n* Has any foreign metal objects or implants as determined by the safety questionnaires (e.g., bone screws, shunts or body piercing that can't be removed, etc.)\n* Has been diagnosed with psychosis or a severe emotional disturbance.\n* Has used alcohol, tobacco, or marijuana more than 3 times.\n* Is pregnant. Girls who self-report pregnancy may not participate in the stress evaluation or the MRI scan.\n* Is taking any medications that directly alter cardiovascular function (e.g., propranolol or other beta blockers).\n* Any current or lifetime treatment with antipsychotic medication.\n* Has had a head injury that resulted in a loss of consciousness for more than 5 minutes.\n* Is planning to get non-removable metal braces.\n* Impaired intellectual functioning (full-scale intelligence quotient \\\u003C70).\n* Past or current history of a clinically significant central nervous system that could confound brain imaging evaluations.",{"count":202,"type":22},180,[63],"Purpose: This 5-year R01 study will elucidate the role of maturational change across adolescence in neural connectivity and physiological stress responses in the relationship between anxiety and adverse pathways to substance use (APSU). Participants: Children (N=200) aged 12-14 with symptoms of anxiety and their legal caregiver will be recruited from clinical and community sources. Procedures: Youth participants will complete several questionnaires and interviews, undergo neuroimaging while performing cognitive tasks, and have their heart rate and skin conductance monitored during a mildly stressful task. Caregivers will complete several questionnaires.",[206,29,207],"Anxiety","Substance Use","2025-05-08",{"date":210,"type":40},"2025-05-18",{"date":212,"type":40},"2024-02-20",{"date":214,"type":22},"2030-06-30",{"name":170,"class":89},{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":223,"enrollmentInfo":224,"targetDuration":4,"studyType":61,"phases":226,"briefSummary":227,"conditions":228,"keywords":229,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":48},"100574476","inspiratory-and-expiratory-muscle-training-in-adolescent-volleyball-players-100574476","NCT06759779","Inspiratory and Expiratory Muscle Training in Adolescent Volleyball Players","Effects of Inspiratory and Expiratory Muscle Strength Training on Respiratory Functions and Performance in Adolescent Volleyball Players","Inclusion Criteria:\n\n* Athletes aged 12-18 who train at a submaximal level at least 3 days a week\n\nExclusion Criteria:\n\n* Adolescents with any history of chronic lung disease\n* unable to comply with the test and training\n* unwilling to participate in the study","18 Years",{"count":225,"type":22},26,[63],"This study will investigate the effects of inspiratory and expiratory muscle training on respiratory muscle strength, pulmonary function, and performance status in adolescent athletes",[29],[230,231,232,233],"pulmonary functions","muscle training","adolescent health","volleyball players","2025-01-07",{"date":236,"type":40},"2025-01-08",{"date":238,"type":40},"2023-07-01",{"date":240,"type":22},"2025-03-01",{"name":242,"class":89},"Gazi University",{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":16,"sex":56,"minAge":97,"maxAge":223,"enrollmentInfo":250,"targetDuration":4,"studyType":61,"phases":252,"briefSummary":253,"conditions":254,"keywords":256,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":48},"100552443","discovering-adolescents-talents-and-life-projects-as-a-key-factor-in-their-life-satisfaction-100552443","NCT06473155","Discovering Adolescents' Talents and Life Projects as a Key Factor in Their Life Satisfaction","GENIALADOLES","Inclusion Criteria:\n\n* Be a teenager between the ages of 14 and 18 (both included) and be in school.\n\nExclusion Criteria:\n\n* Diagnosis of mental disorder in the last year.\n* Active psychological or psychiatric treatment at the time of the investigation or less than 6 months before.\n* Suicidal ideation and\u002For self-harm.\n* Recently experienced bullying or intimidation (within the last 6 months).\n* Habitual consumption of drugs of abuse (chemical substances of various origins consumed for non-therapeutic purposes).\n* Insufficient level of proficiency in Spanish or Catalan.",{"count":251,"type":22},90,[63],"Recent data show a deterioration in the mental health of adolescents, with an increase in anxiety, depression, sleep disturbances, eating disorders, and a significant increase in suicides. Psychological distress may be related to the absence of a life project that provides motivation, satisfaction, and direction in their lives, and allows the formation of an integrated sense of personal identity, along with a projection of improvement in abilities. An intervention aimed at enhancing the life project of adolescents could increase their life satisfaction and, secondarily, improve their mental health. The goal of this clinical trial is to learn if a structured intervention oriented towards the discovery and development of personal talents can have a strong positive impact on the life satisfaction and mental health of adolescents.\n\nThe Spanish versions of the Satisfaction with Life Scale and Young Person-Clinical Outcomes in Routine Evaluation scales will be used to evaluate life satisfaction and psychological distress of participants before and after the intervention. In addition, the Geniotype questionnaire will be used to explore and enhance the participants' personal talents.\n\nThe full intervention comprises eight sessions based on Humanistic Integrative Psychotherapy (HIP). It includes one session with Explore Your Meanings (EYME), an immersive digital platform based on the repertory grid technique aimed to enhance the success of therapeutic work and improve personal capabilities.\n\nResearchers will compare the full intervention, with an intervention in which the Geniotype questionnaire is substituted by a somatic symptoms questionnaire (with no implications for the talents of the participant) to see if the Geniotype identification works to increase life satisfaction and reduce psychological distress. The control group will be a non-active waiting list.\n\nParticipants will attend eight weekly, one-hour sessions of a psychological intervention including Geniotype or a somatic symptoms questionnaire or remain in a waiting list for 2 months.",[255,29],"Healthy",[257,258],"adolescent","personal satisfaction","2024-11-15",{"date":261,"type":40},"2024-11-18",{"date":263,"type":40},"2024-11-05",{"date":265,"type":22},"2025-12-30",{"name":267,"class":89},"Centre Besai",{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":16,"sex":56,"minAge":4,"maxAge":58,"enrollmentInfo":276,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":277,"conditions":278,"keywords":286,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":307},"100479667","vulnerabilityresilience-factors-influencing-the-developmental-trajectories-and-adaptive-methods-of-children-and-adolescents-in-child-welfare-system-100479667","NCT05525962","Vulnerability\u002FResilience Factors Influencing the Developmental Trajectories and Adaptive Methods of Children and Adolescents in Child Welfare System.","Facteurs de vulnérabilité\u002Frésilience influençant Les Trajectoires développementales et Les modalités Adaptatives d'Enfants et d'Adolescents confiés à l'Aide Sociale à l'Enfance. Cohorte Primo-arrivants.","EvolASE-PEA","Inclusion Criteria:\n\n* Minor adressed to child protective services\n* Minor placed full time\n\nExclusion Criteria:\n\n* Non affiliation to social security system\n* Non accompanied minor\n* Minor and\u002For parfents not understanding french\n* Minor informed and refused participation\n* Parents or tutor having refused participation of their child",{"count":181,"type":22},"Assess the prevalence of medico-psychological characteristics at the time of placement (M0), their appearance \u002F disappearance and during the two years following placement (M12 and M24) by age group in children \u002F adolescents in Child Protective Services and placed full-time in the structures of Seine-Maritime and Eure as well as in nursery in Le Havre or Rouen",[279,280,281,29,282,283,284,285],"Behavior, Child","Child Development","Child Development Disorder","Adolescent Behavior","Child Mental Disorder","Child Behavior Disorders","Adolescent - Emotional Problem",[287,288,257,289,290,291,292,293,294,295,296,297],"child","preschool","psychiatry","psychology","Child Protective Services","social sciences","child protection","social services","psychiatric disorders","attachement","developmental trajectories","2024-04-08",{"date":300,"type":40},"2024-04-09",{"date":302,"type":40},"2022-09-29",{"date":304,"type":22},"2027-09-29",{"name":306,"class":89},"University Hospital, Rouen",5]