[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adolescent-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adolescent-health":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,49,85,115,143,165,200,233,260,290,326,361],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100361428","reproductive-axis-maturation-in-the-early-post-menarchal-years-100361428",false,"NCT03986021","Reproductive Axis Maturation in the Early Post-Menarchal Years","Reproductive Axis Maturation in the Early Post-Menarchal Years: A Pilot Study","* Part 1 - Pre-menarche monitoring (\"holding pattern\"):\n\nInclusion Criteria:\n\n* Age 8-14.5 years old\n* Healthy weight, defined as having a body weight \\>85% of expected (EBW) and a body mass index (BMI) \\\u003C99th percentile\n* Some breast development\n* Pre-menarche\n\nExclusion Criteria:\n\n* Taking or planning to take medications that affect reproductive hormones in the next 2 to 3 years (e.g. birth control pills, biotin supplements).\n* Planning to move more than 60 miles from the CRU within the next 2 to 3 years\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* First-degree relative with polycystic ovarian syndrome, premature ovarian insufficiency, hypogonadotropic hypogonadism, or other pubertal development disorder\n* Excessive exercise (defined as running \\>20 miles per week or its equivalent)\n* Pregnancy\n\nPart 2 - Post-menarche cycle tracking:\n\nInclusion Criteria:\n\n* Age at menarche 10-14.5 years old\n* Healthy weight, defined as having a body weight \\>85% of expected (EBW) and a body mass index (BMI) \\\u003C99th percentile\n* Approximately \\\u003C 6 months post-menarchal (will typically have completed 4 or fewer menstrual cycles)\n* Biochemical criteria: normal thyroid hormone, prolactin, and testosterone levels\n\nExclusion Criteria:\n\n* Taking or planning to take medications that affect reproductive hormones in the next 2 to 3 years (e.g. birth control pills, biotin supplements).\n* Planning to move more than 60 miles from the CRU within the next 2 to 3 years\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* First-degree relative with polycystic ovarian syndrome, premature ovarian insufficiency, hypogonadotropic hypogonadism, or other pubertal development disorder\n* Excessive exercise (defined as running \\>20 miles per week or its equivalent)\n* Anemia (defined as hemoglobin \\\u003C12.0 g\u002Fdl)\n\n  --Participants with hemoglobin between 11.5 g\u002Fdl and 12.0 g\u002Fdl may still participate by providing dried blood spots, or no more than 18 ml of blood during any given interval.\n* Pregnancy\n\nPart 3 - Intensive monitoring of ovarian follicle growth\n\nInclusion Criteria:\n\n* Age at menarche 10-14.5 years old\n* Healthy weight, defined as having a body weight \\>85% of expected (EBW) and a body mass index (BMI) \\\u003C99th percentile\n* Within 1 year of menarche\n* Biochemical criteria: normal thyroid hormone, prolactin, and testosterone levels\n\nExclusion Criteria:\n\n* Taking or planning to take medications that affect reproductive hormones in the next 1-2 years (e.g. birth control pills, biotin supplements).\n* Planning to move more than 60 miles from the CRU within the next year\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* First-degree relative with polycystic ovarian syndrome, premature ovarian insufficiency, hypogonadotropic hypogonadism, or other pubertal development disorder\n* Excessive exercise (defined as running \\>20 miles per week or its equivalent)\n* Anemia (defined as hemoglobin \\\u003C12.0 g\u002Fdl)\n\n  --Participants with hemoglobin between 11.5 g\u002Fdl and 12.0 g\u002Fdl may still participate by providing dried blood spots, or no more than 18 ml of blood during any given interval.\n* Pregnancy\n\nPart 4 - Late Post-menarche cycle tracking:\n\nInclusion Criteria:\n\n* Age 11-17.5 years old\n* Approximately 2-5 years post-menarchal\n* Biochemical criteria: normal thyroid hormone and prolactin\n\nExclusion Criteria:\n\n* Taking or planning to take medications that affect reproductive hormones in the next 2 to 3 years (e.g. birth control pills, biotin supplements).\n* Planning to move more than 60 miles from the CRU within the next 6 months\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* Anemia (defined as hemoglobin \\\u003C12.0 g\u002Fdl)\n\n  --Participants with hemoglobin between 11.5 g\u002Fdl and 12.0 g\u002Fdl may still participate by providing dried blood spots, or no more than 18 ml of blood during any given interval.\n* Pregnancy\n\nAdolescent girls, at-risk daughters, or sisters of women with PCOS\n\nThe girls with mothers or sisters with PCOS group will complete the Screening Visit and Parts 1-3. The same inclusion and exclusion criteria apply for Parts 1, 2, and 3 as stated above except that these individuals must have a first-degree relative with PCOS and they can have high androgen levels, excess body hair, and severe acne at screening.\n\nWomen with known PCOS (activities for 8 weeks only)\n\nInclusion Criteria:\n\n* Age \\>=18-34 years old\n* PCOS diagnosis\n* at least 3-years post-menarchal with irregular menstrual cycles\n* Biochemical (blood) or clinical signs of high androgen levels\n\nExclusion Criteria:\n\n* Cannot be taking any medications that affect reproductive or metabolic hormones (e.g. birth control pill, biotin supplements, spironolactone, metformin).\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* Pregnancy\n\nHealthy control women (Activities x 2 menstrual cycles)\n\nInclusion Criteria:\n\n* Age \\>=18-34 years old\n* at least 3-years post-menarchal with regular menstrual cycles every 21-35 days\n\nExclusion Criteria:\n\n* Cannot be taking any medications that affect reproductive or metabolic hormones (e.g. birth control pill, biotin supplements, spironolactone, metformin).\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* PCOS diagnosis or first-degree relative with disorder\n* Pregnancy\n\nMothers of pediatric participants (Activities for 8 weeks \u002F 2 menstrual cycles)\n\nInclusion Criteria:\n\n* Age \\>=18-65 years old\n* Biological mother of A Girl's First Period participant\n\nExclusion Criteria:\n\n* Chronic medical condition, including but not limited to diabetes mellitus, congenital adrenal hyperplasia, cystic fibrosis, sickle cell disease, inflammatory bowel disease, juvenile rheumatoid arthritis, and lupus.\n* Pregnancy",true,"FEMALE","8 Years","65 Years",{"count":21,"type":22},400,"ESTIMATED","OBSERVATIONAL","Background:\n\nMost adult women with irregular periods of unknown cause report symptoms dating back to early adolescence. This study aims to learn how girls' periods change in the 2 years after their first period. We are also looking at girls who may have a condition called PCOS. This will help researchers learn what healthy puberty looks like and how they can spot signs of hormone problems early on.\n\nObjective:\n\nTo learn how long it takes girls to develop regular menstrual cycles after their first period.\n\nEligibility:\n\nHealthy girls ages 8-14 who either (1) haven't had their first period but show signs of puberty, such as breast development and hair in the genital area; or (2) had their first period in the past 6 months\n\nGirls at risk for PCOS age 8-14 who have a mom or sister with PCOS\n\nGirls with irregular menstrual cycles age 11-17.5\n\nTo compare with the girls, we are looking at women \\>=18-34 years old with PCOS,\n\nHealthy women \\>= 18-34 years old without PCOS,\n\nand Mothers of pediatric participants age 18-65\n\nDesign:\n\nBoth parents or guardians must allow their daughter to participate. They must attend all study visits with her.\n\nParticipants will first be screened by phone. Those who qualify will be screened in person. They will have a physical exam. They will give blood and urine samples. They will have an ultrasound of their abdomen. They will fill out questionnaires. They will sit in a BOD POD for 6 minutes: This is an egg- shaped machine that takes body measurements. They have the option to provide DNA samples.\n\nParticipants will have sets of visits at home or at the clinic about every 6 months. The number of visits in each set will depend on their menstrual cycle. Then they will have a final visit. Visits will include repeats of the screening tests. There are additional parts that participants may choose to be involved in depending on how involved they want to be.\n\nAt home, participants will collect their urine daily to measure hormones. They will keep a diary of their periods.\n\nAdults: Women with known PCOS will complete the same Screening Visit as the girls and will collect dried urine specimens at home for 8 weeks;\n\nThe Healthy control women group will complete the same Screening Visit as the girls and collect dried urine specimens at home for 2 menstrual cycles;\n\nThe Mothers of pediatric participants group will complete a Screening Visit (informed consent, urine pregnancy test) and collect vaginal swab specimens at home for 2 menstrual cycles (approx. 8 weeks)....",[26,27,28,29],"Reproductive Physiological Processes","Pediatrics","Adolescent Health","Adolescent Development",[31,32,33,34,35],"Menarche","Adolescent","Physiology","Hormones","Natural History","RECRUITING","2026-07-01",{"date":39,"type":40},"2026-07-02","ACTUAL",{"date":42,"type":40},"2019-12-19",{"date":44,"type":22},"2029-07-01",{"name":46,"class":47},"National Institute of Environmental Health Sciences (NIEHS)","NIH",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":55,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":84},"100589498","youth-for-youth-mental-wellness-care-and-action-100589498","NCT06955195","Youth-for-Youth Mental Wellness Care and Action","Inclusion Criteria:\n\n* student in Hong Kong secondary school\n* Studying at Form 1 to Form 3 at the time of recruitment\n* Competence in comprehending written Chinese or English\n* Competence in speaking Cantonese or English\n* Written consent from students and their legal guardian\n\nExclusion Criteria:\n\n* Not studying at Form 1 to 3 in Hong Kong secondary school\n* Incompetence in comprehending written Chinese or English\n* Incompetence in speaking Cantonese or English\n* No written consent from students or their legal guardian","ALL",{"count":57,"type":22},18000,"INTERVENTIONAL",[60],"NA","This initiative aims to improve flourishing and quality of life of secondary school students, reduce mental distress (e.g., depression and suicidal ideation), enhance their understanding of mental health (e.g., mental health literacy) and help-seeking intention, and foster a supportive school environment (e.g., school climate-caring relationship, and sense of community). Also, this initiative aims to improve students' process of change in psychological (e.g., mattering, emotion regulation, empowerment) and social (e.g., trust belief) aspects and mental health awareness (e.g., mental health stigma). The feasibility, acceptability, and sustainability of the programme from multiple perspectives (e.g., students, student leaders, and stakeholders) will also be evaluated. In addition, the cost-effectiveness of delivering this programme (e.g., the incremental cost-effectiveness ratio (ICER)) among secondary schools in Hong Kong will be assessed.\n\nThe programme will be implemented among students in 130 local secondary schools over three academic years. The first is a pilot phase (Year 1), which 40 schools will implement the intervention and student participants will be evaluated at pre- (T0) and post-intervention (T1) using questionnaires. In this stage, participatory research will be conducted before and after the intervention among students, student leaders, and stakeholders in 20 pilot schools to co-design the intervention, ensuring the programme meet the actual wellness needs of youth. In following two academic years, an additional 90 schools will participate in a cluster randomized controlled trial (RCT) with a 1:1 ratio between intervention and waitlist control groups. Each year, 45 schools will implement the intervention. Summative evaluation will be conducted among RCT schools at T0 and T1, and 3-month follow-up (T2). Quantitative data be collected to assess the effectiveness of intervention, and qualitative data will provide understanding of students' and stakeholders' perspectives of the intervention implementation. Cost outcomes will include intervention costs and cost savings, calculated from the payer (i.e., JC\u002Fgovernment) perspective using administrative records or validated tools. The primary outcome of cost-effectiveness will be the quality-adjusted life-years (QALYs) of students. Cost of implementing the intervention program and QALYs will be used to evaluate the cost-effectiveness of the intervention, for example, estimate the incremental cost-effectiveness ratio (ICER).",[63,28,64,65,66],"Mental Well-being","Mental Health Literacy","School Difficulties Associated With Mental Health Problems","Mental Health Help-Seeking",[68,69,70,71,72,73],"MENTAL HEALTH","ADOLESCENT MENTAL HEALTH","SCHOOL CLIMATE ON MENTAL HEALTH","MENTAL HEALTH FRIENDLY CAMPUS","MENTAL HELP-SEEKING BEHAVIOR","MENTAL HEALTH LITERACY","2026-05-27",{"date":76,"type":40},"2026-05-29",{"date":78,"type":40},"2025-08-21",{"date":80,"type":22},"2027-12-31",{"name":82,"class":83},"Chinese University of Hong Kong","OTHER",2,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":16,"sex":55,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":58,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":48},"100637628","mest--a-school--based-health-literacy-intervention-trial-100637628","NCT07601815","MEST : A School- Based Health Literacy Intervention Trial","A Cluster- Randomized Controlled Trial Evaluating the MEST Work Strategy to Improve Health Literacy Among Upper Secondary School Students","Inclusion Criteria:\n\n* Students 16-24 years\n* Students enrolled in upper secondary school classes\n* Provided informed consent\n\nExclusion Criteria:\n\n\\- Students \\\u003C16 years and \\> 24 years","16 Years","24 Years",{"count":95,"type":22},1800,[60],"The purpose of this study is to evaluate the effectiveness of the MEST work strategy in upper secondary schools. MEST is a school based, health promoting intervention delivered by school health services and designed to strengthen students' health literacy and mental well being. The study assesses whether implementation of the MEST work strategy results in improved health literacy and mental well being compared with usual school health services.\n\nThis study is a cluster randomized superiority trial in which upper secondary schools are assigned either to an intervention group implementing the MEST work strategy or to a control group continuing with school health services as usual. Student reported outcomes are collected using digitally administered questionnaires during school hours at baseline, prior to initiation of the intervention, and at 4 and 9 months following intervention initiation (end of the school year).",[99,28],"Health Literacy",[101,102,103],"Health Promotion","School Health Services","Upper Secondary School","NOT_YET_RECRUITING","2026-05-18",{"date":107,"type":40},"2026-05-22",{"date":109,"type":22},"2026-08-17",{"date":111,"type":22},"2027-09-30",{"name":113,"class":114},"Norwegian Institute of Public Health","OTHER_GOV",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":16,"sex":17,"minAge":122,"maxAge":92,"enrollmentInfo":123,"targetDuration":4,"studyType":58,"phases":125,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":48},"100635543","hybrid-body-awareness-intervention-in-adolescent-girls-100635543","NCT07554053","HYBRID BODY AWARENESS INTERVENTION IN ADOLESCENT GIRLS","A RANDOMİZED CONTROLLED TRIAL","Inclusion Criteria:\n\n* Girls aged 11-16 years\n* Within 1-2 years after menarche\n* Able to participate in training and assessments\n* Written informed consent from participant and parent\u002Flegal guardian\n\nExclusion Criteria:\n\n* More than 2 years since menarche\n* Diagnosed psychiatric or gynecological disorder\n* Refusal to participate","11 Years",{"count":124,"type":22},180,[60],"Menstruation after menarche is a multidimensional experience affecting adolescents' quality of life, school attendance, and psychological adjustment. Educational and awareness-based interventions improve menstrual knowledge, attitudes, and coping behaviors; however, randomized controlled trials evaluating hybrid body awareness-based interventions are limited.\n\nThis study aims to evaluate the effect of a hybrid body awareness-based intervention on menstrual symptoms, menstrual attitudes, and self-regulation levels in post-menarche adolescent girls.",[128,28],"Menstruation",[32,128,130,131,132,133],"Body Awareness","Self-Regulation","Randomized Controlled Trial","Nursing","2026-04-27",{"date":136,"type":40},"2026-05-01",{"date":138,"type":22},"2026-05-15",{"date":140,"type":22},"2026-09-15",{"name":142,"class":83},"Kahramanmaras Sutcu Imam University",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":16,"sex":55,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":161,"leadSponsor":163,"locationsCount":4},"100634197","adolescent-rights-fulfilment-in-rural-assiut-egypt-100634197","NCT07536555","Adolescent Rights Fulfilment in Rural Assiut, Egypt","Fulfilment of Adolescent Rights in Health, Education, Protection and Community Participation in Beni Adi Village, Assiut Governorate, Egypt","ARBA","Inclusion Criteria:\n\n* Adolescents aged 15-19 years (both males and females)\n* Permanent residents of Beni Adi village, Manfalut district, Assiut Governorate\n* Willing and able to provide informed consent\u002Fassent to participate in the study\n* Able to communicate and respond to interview questions in Arabic\n\nExclusion Criteria:\n\n* Adolescents with severe cognitive impairment or mental health conditions that prevent meaningful participation in the interview\n* Temporary visitors or non-residents of Beni Adi village\n* Adolescents who decline to provide consent\u002Fassent\n* Adolescents who are severely ill or unavailable during the data collection period","15 Years","19 Years",{"count":154,"type":22},300,"This community-based cross-sectional study aims to assess the fulfilment of adolescent rights in health, education, protection, and community participation among adolescents aged 15-19 years living in Beni Adi village, a rural community in Assiut Governorate, Egypt.",[28],"2026-04-25",{"date":159,"type":40},"2026-04-30",{"date":37,"type":22},{"date":162,"type":22},"2026-12-15",{"name":164,"class":83},"Assiut University",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":16,"sex":55,"minAge":122,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":58,"phases":176,"briefSummary":177,"conditions":178,"keywords":183,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":48},"100608937","cultural-adaptation-validation-and-evaluation-of-the-programme-for-promotion-of-healthy-affective-sexual-behaviours-in-adolescents-iyg-100608937","NCT07208045","Cultural Adaptation, Validation, and Evaluation of the Programme for Promotion of Healthy Affective-Sexual Behaviours in Adolescents (IYG)","Es tu Juego: Decide Bien [It's Your Game: Keep It Real]. Cultural Adaptation, Validation, and Evaluation of the Programme for Promotion of Healthy Affective-Sexual Behaviours in Adolescents","IYG","Inclusion Criteria:\n\n* Adolescents aged between 11 and 14 years enrolled in compulsory secondary education (E.S.O).\n* Access to a computer and internet at their educational centre.\n\nExclusion Criteria:\n\n* Presence of linguistic, cognitive, or sensory barriers that prevent completion of the questionnaire\n* Participation in another programme aimed at preventing affective-sexual risk behaviours.","14 Years",{"count":175,"type":22},1200,[60],"The investigators are writing to inform participants about a study being carried out by a research group from the University of Granada and the University of Seville, in which the participant's son\u002Fdaughter is invited to participate. The study has been approved by the Provincial Research Ethics Committee of Granada under code 202499906944441.\n\nThe sole intention of the investigators is to ensure that participants receive correct and sufficient information to assess and decide whether or not to give consent for the child's participation in this study. The information sheet should be read carefully, and any questions may be addressed to the investigators.\n\nThe objective of the study is to culturally adapt the program It's Your Game: Keep it Real (IYG), which aims to prevent risky sexual and affective behaviors in adolescents. The IYG program consists of 12 lessons, each lasting 45 minutes. These lessons aim to help the child identify personal norms and boundaries regarding sexuality, recognize situations that might challenge these boundaries, and develop refusal skills to maintain them. The program also covers topics such as the characteristics of healthy and unhealthy relationships, friendships, anatomy and reproduction, the social, emotional, and physical consequences of sexual activity, the consequences of teenage pregnancy and STIs, condom and contraceptive use, and communication skills.\n\nThis adaptation will involve the child completing all 12 lessons (two lessons per week over a period of six weeks) that make up the IYG program, as well as filling out a series of questionnaires. These questionnaires will allow the investigators to assess the usability of the program in Spain (including ease of use, comprehension, acceptability, as well as aspects most liked and suggestions for improvement).\n\nParticipation is entirely VOLUNTARY AND ANONYMOUS, and consent may be withdrawn at any time, without providing any explanation and without this affecting the care the child will receive in any way.\n\nIn all cases, the CONFIDENTIALITY of the data collected will be maintained in accordance with the European Union General Data Protection Regulation (GDPR) 2016\u002F679 and the Spanish Organic Law on the Protection of Personal Data and Guarantee of Digital Rights (LOPD-GDD) 3\u002F2018, of December 5.\n\nRegarding the study results, these may be shared with the scientific community through presentations, conferences, and\u002For publications.\n\nThe investigators express appreciation in advance for cooperation in this study.",[179,180,181,28,182],"Sexual Behavior","Sexually Transmitted Disease (STD)","Condom Use","Cultural Adaptation",[184,185,186,187,188,189,190],"sexually behaviour","sex education","adolescents","health education","cultural adaptation","evidence-based prevention","school health","2025-09-28",{"date":193,"type":40},"2025-10-08",{"date":195,"type":22},"2025-10-01",{"date":197,"type":22},"2027-06-30",{"name":199,"class":83},"University of Seville",{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":55,"minAge":207,"maxAge":208,"enrollmentInfo":209,"targetDuration":4,"studyType":58,"phases":211,"briefSummary":212,"conditions":213,"keywords":218,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":48},"100566135","decision-support-intervention-of-minor-cancer-patients-and-their-parents-100566135","NCT06651242","Decision Support Intervention of Minor Cancer Patients and Their Parents","Effectiveness Evaluation on the Decision Preferences and Decision Support Intervention of Minor Cancer Patients and Their Parents","Inclusion Criteria:\n\n* Inclusion Criteria for Parents:\n\n  1. Age over 20 years.\n  2. Child under 20 years old, diagnosed with cancer by a doctor.\n  3. their child know her\u002Fhis cancer diagnosis.\n  4. Agree to have the child participate in family meeting and have ability to communicate in Mandarin or Taiwanese.\n* Inclusion Criteria for Minors:\n\n  1. Aged between 7 and 20 years, diagnosed with pediatrtic cancer.\n  2. Aware of their cancer diagnosis.\n  3. Able to express their thoughts to the researcher in Mandarin or Taiwanese.\n  4. Both the minor and their legal guardian consent to participate in the study.\n\nExclusion Criteria:\n\n1. Diagnosed with depression, and\u002For anxiety, and\u002For other mental disorders.\n2. Legal guardian is unwilling to inform the minor of their diagnosis.\n3. Minor is unwilling to share their thoughts with their parents.","7 Years","20 Years",{"count":210,"type":22},80,[60],"The purpose of this stuidy are: (1) to explore the information needs of parents having children with cancer when making treatment decisions; (2) to develop a Taiwan version of the Control Preferences Scale for decision support aids; (3) to implement and evaluate the effectiveness of involving minor cancer patients and their parents in treatment decision-making.",[214,28,215,216,217],"Pediatric Cancer","Decision Aids","Parents of Children With Cancer","Decision Making ,Shared",[219,220,221,222,223],"Minor Cancer","Parents","Decision Preferences","Decision Support","Intervention","2025-08-26",{"date":226,"type":40},"2025-08-28",{"date":228,"type":40},"2022-10-26",{"date":230,"type":22},"2027-07-31",{"name":232,"class":83},"Kaohsiung Medical University Chung-Ho Memorial Hospital",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":55,"minAge":241,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":58,"phases":245,"briefSummary":246,"conditions":247,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":4},"100548330","screening-and-support-for-youth-sasy-100548330","NCT06419595","Screening and Support for Youth (SASY)","Screening and Support for Youth","SASY","Inclusion Criteria:\n\n* 12 to 17 year old teens\n\nExclusion Criteria:\n\n* younger than 12 or older than 17","12 Years","17 Years",{"count":244,"type":22},220,[60],"To adapt the Screening and Support for Youth (SASY) intervention and approach to recruitment for racial, ethnic and linguistic diverse youth aged 12-17 in the Denver Health catchment area",[28,248,249,250],"Minority Health","Mental Health","Community Health Services","2025-06-23",{"date":253,"type":40},"2025-06-26",{"date":255,"type":22},"2026-11-01",{"date":257,"type":22},"2028-03-31",{"name":259,"class":83},"Cambridge Health Alliance",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":16,"sex":55,"minAge":151,"maxAge":242,"enrollmentInfo":268,"targetDuration":4,"studyType":58,"phases":269,"briefSummary":270,"conditions":271,"keywords":278,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":48},"100595994","empowering-knowledge-self-testing--resilience-through-innovative-methods-for-hiv-100595994","NCT07039682","Empowering Knowledge, Self-Testing & Resilience Through Innovative Methods for HIV","Developing a Digital-Based Education and Self-Screening Model to Improve Knowledge, Self-Awareness, and HIV Testing Coverage Among Adolescents","EKSTRIM","Inclusion Criteria:\n\n* Adolescents aged 15-17 years\n* Reside or attend school in the Yogyakarta area\n* Currently enrolled in one of the participating high schools\n* Able to read and understand Bahasa Indonesia\n* Own or have regular access to a smartphone or digital device with internet connectivity\n* Provide informed assent to participate in the study\n* Have obtained written parental or guardian consent\n\nExclusion Criteria:\n\n* Adolescents outside the 15-17 age range\n* Unable to access digital devices or internet independently\n* Previously diagnosed with HIV (as this study targets prevention and self-screening among untested adolescents)\n* Unwilling or unable to provide informed assent or whose parents\u002Fguardians do not provide consent\n* Currently participating in another HIV-related intervention study",{"count":21,"type":22},[60],"The goal of this study is to learn whether a digital tool can help improve HIV knowledge, self-awareness, and testing among adolescents in Yogyakarta, Indonesia. The tool includes online HIV education, a self-assessment for HIV risk, and access to trained peer educators for support. The study will also explore how comfortable and willing adolescents are to use this kind of digital health service.\n\nThe main questions the study aims to answer are:\n\n* Can this digital tool help adolescents better understand HIV and their personal risk?\n* Will more adolescents be willing to get tested for HIV after using the tool?\n* What factors affect whether adolescents accept and use digital HIV services?\n\nResearchers will compare two groups of high school students:\n\n* One group will use the digital tool for 6 weeks\n* The other group will receive standard HIV education (not through the tool)\n\nParticipants will:\n\n* Answer surveys before and after the 6-week period\n* Learn about HIV through videos and interactive content\n* Use the tool to assess their personal HIV risk\n* Receive support from trained peer educators (online)\n\nThe researchers hope this study will lead to new ways of using technology to improve HIV prevention and testing for young people.",[272,273,28,274,275,276,277],"Human Immunodeficiency Virus (HIV) Infection","HIV Prevention","Digital Education Interventions","Digital Health Intervention","Health Education","HIV Stigma",[279,280,187,281],"hiv prevention","adolescent health","digital intervention","2025-06-18",{"date":253,"type":40},{"date":285,"type":22},"2025-07-31",{"date":287,"type":22},"2025-12-31",{"name":289,"class":83},"Universitas Sebelas Maret",{"id":291,"slug":4,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":16,"sex":55,"minAge":122,"maxAge":4,"enrollmentInfo":297,"targetDuration":4,"studyType":58,"phases":299,"briefSummary":300,"conditions":301,"keywords":308,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":48},"100579291","NCT06822387","Health Without Barriers\u002FSalud Sin Barreras- Northern Colorado","Growing an Extension Network for Multisite Dissemination and Implementation of Intensive Health Behavior and Lifestyle Treatment","HWB\u002FSSB","Inclusion Criteria:\n\nAdolescent subjects\n\n* Between the ages 11-19 years old\n* Reside in Larimer County, Weld County, or the surrounding areas.\n\nParent\u002Fguardian subjects:\n\n* 18 years old or older\n* Are parents\u002Fguardians of an adolescent between the ages of 11-19\n* Reside in Larimer County, Weld County, or the surrounding areas\n\nFacilitators subjects\n\n* 18 years old or older\n* Reside in Larimer County, Weld County, or the surrounding areas\n* Are planning to or have facilitated HWB\n\nExclusion Criteria\n\nAdolescents subjects will not take part in the research activities if they have a medical and\u002For psychological\u002Fbehavioral condition that, in the opinion of the Colorado State University\u002FExtension program team, could interfere with safety for themselves or others or interfere with the capability of the participant or other participants to potentially benefit from the program (e.g., severe emotional-behavioral disturbance, inability to follow facilitator directions).\n\nParents\u002Fguardians will not take part in the research activities if they have a medical and\u002For psychological\u002Fbehavioral condition that, in the opinion of the Colorado State University\u002FExtension program team, could interfere with safety for themselves or others or interfere with the capability of their family or other participating families to potentially benefit from the program (e.g., using drugs or alcohol or under the use of drugs\u002Falcohol during program sessions, aggressive or inappropriate behavior toward other participants).\n\nThere is no exclusion for facilitator subjects.",{"count":298,"type":22},140,[60],"The overarching goal of this work is to address the limited access to evidence-based health behavior and lifestyle interventions for youth and families most impacted by preventable chronic diseases, including obesity and type 2 diabetes. In the current project, we implement a small single-arm pilot and feasibility trial of Health Without Barriers\u002FSalud Sin Barreras (HWB\u002FSSB), a culturally-adapted, whole-family intensive health behavior and lifestyle intervention to 11-19-year-old adolescents and their families living in Northern Colorado. Objectives are refining the HWB\u002FSSB community facilitator training, evaluating the feasibility and acceptability of HWB\u002FSSB implementation, and characterizing changes in health outcomes among adolescent participants.",[302,28,303,304,249,305,306,307],"Lifestyle Risk Reduction","Family Health","Cardio-metabolic Health","Wellness Program","Type 2 Diabetes","Obesity, Adolescent",[309,310,311,312,313,314,315,316],"Whole-family","Mindfulness","Wellness education","Nutrition","Physical Activity","Stress reduction","Health Without Barriers","Salud Sin Barreras","2025-04-29",{"date":319,"type":40},"2025-05-02",{"date":321,"type":40},"2025-04-07",{"date":323,"type":22},"2026-06-30",{"name":325,"class":83},"Colorado State University",{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":16,"sex":55,"minAge":334,"maxAge":4,"enrollmentInfo":335,"targetDuration":4,"studyType":58,"phases":337,"briefSummary":338,"conditions":339,"keywords":347,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":4},"100568625","hpv-vaccine-integrated-service-implementation-research-in-cameroon-100568625","NCT06683664","HPV Vaccine Integrated Service Implementation Research in Cameroon","Human Papillomavirus Vaccine Integrated Service Implementation Research in Cameroon","HPV-PASSREV","Inclusion Criteria:\n\n* Key informant identified by study and implementation teams (purposive sampling by key informant type)\n\nExclusion Criteria:\n\n* Does not provide written informed consent","21 Years",{"count":336,"type":22},40,[60],"The goal of this implementation research study is to understand whether a package of community-based interventions can increase access to and uptake of the human papillomavirus (HPV) vaccine among very young adolescent girls and boys in the North and Far North Regions of Cameroon. The main questions this study aims to answer are:\n\n* Can a package of community-based interventions increase delivery of routine HPV vaccination to boys and girls aged 9-13 in Cameroon's North and Far North Regions?\n* What is the acceptability, feasibility, cost, and potential for maintenance and scale of an integrated health intervention to deliver routine HPV vaccination in Cameroon?\n\nTo evaluate the effectiveness of the intervention, researchers will compare HPV vaccination within regions where the new intervention model is being implemented (intervention areas) to regions where the new routine HPV vaccination delivery model is not being implemented (comparison areas) for approximately 1 year before the new intervention model is implemented and for approximately 9 months after the start of implementation to compare changes over time and between intervention and comparison areas.\n\nThe study will evaluate the effect of the intervention on HPV vaccination delivery using routine health facility data.\n\nTo understand acceptability, feasibility, implementation, and potential for scale, the study will enroll participants including health officials and providers, adolescents girls receiving HPV vaccination and other services in intervention areas, and their parents\u002Fcaregivers. The study will be conducted in two phases, with the first phase focused on gathering formative data through interviews with key informants. This data will be used to inform the design of the intervention, which will be implemented and evaluated in phase 2. Only phase 1 of this study protocol has been currently approved.\n\nIn phase 1, key informant interview participants will be asked to participate in a an interview to discuss HPV vaccination services and their perspectives on how to integrate HPV vaccination within existing community-based and health facility structures and programs. Key informants will include government officials, health program implementers, representatives from non-government organizations working on HPV vaccine delivery, and healthcare providers, as well as community leaders including school and religious leaders.",[340,341,342,343,344,345,28,346],"Papillomavirus Vaccines","HPV Vaccinations","HPV Vaccines","HPV Vaccine Acceptability","HPV Vaccine Attitudes","HPV Vaccine Knowledge","Adolescent Health Services",[348,349,350,351],"Implementation Science","Cameroon","Implementation Research","Mixed Methods","2024-11-08",{"date":354,"type":40},"2024-11-12",{"date":356,"type":22},"2024-11",{"date":358,"type":22},"2025-12",{"name":360,"class":83},"Population Services International",{"id":362,"slug":363,"hasResults":11,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":367,"eligibilityCriteria":368,"healthyVolunteers":16,"sex":55,"minAge":369,"maxAge":4,"enrollmentInfo":370,"targetDuration":4,"studyType":58,"phases":372,"briefSummary":373,"conditions":374,"keywords":376,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":377,"lastUpdatePostDateStruct":378,"startDateStruct":380,"completionDateStruct":381,"leadSponsor":383,"locationsCount":4},"100567371","hpv-vaccine-integrated-service-implementation-research-in-ethiopia-100567371","NCT06667323","HPV Vaccine Integrated Service Implementation Research in Ethiopia","Human Papillomavirus Vaccine Integrated Service Implementation Study in Ethiopia (HPV-VISION)","HPV-VISION","Exclusion Criteria for key informant interviews\n\n\\- Does not provide informed consent\n\nInclusion Criteria for focus group discussions and in-depth interviews:\n\n* Girl: aged 9-14 years, female\n* Caregiver: Parent\u002Flegal guardian of eligible 9-14-year-old girl (above); 18 years of age or older\n\nExclusion Criteria:\n\n* Girl: Does not provide informed assent, including to audio-recording, Parent\u002Flegal guardian does not provide consent\n* Caregiver: Does not provide informed consent, including to audio-recording\n\nInclusion Criteria for exit interviews:\n\n* Girl accompanied by adult (18+) parent\u002Flegal guardian: Aged 9-14 years old; Female; Received a VYA health services supported by the program\\*, including HPV vaccination, on the date of recruitment\n* Girl accompanied by an\u002Fother adult(s) (18+): Aged 9-14 years old; Female; Received a VYA health services supported by the program\\*, including HPV vaccination, on the date of recruitment\n* Girl accompanied by an\u002Fother minor(s) only: Aged 9-14 years old; Female; Received a VYA health services supported by the program\\*, including HPV vaccination, on the date of recruitment\n* Girl completely unaccompanied: Aged 9-14 years old; Female; Received a VYA health services supported by the program\\*, including HPV vaccination, on the date of recruitment\n* Caregiver: Parent\u002Flegal guardian or caregiver of eligible 9-14-year-old girl (above); Accompanying eligible 9-14-year-old girl (above) during care\u002Fservice visit; 18 years of age or older\n\nExclusion Criteria:\n\n* Girl accompanied by adult (18+) parent\u002Flegal guardian: Does not provide informed assent; Parent\u002Flegal guardian does not provide consent; Requires urgent medical treatment or referral\n* Girl accompanied by an\u002Fother adult(s) (18+): • Does not provide informed assent; Caregiver does not provide permission; Requires urgent medical treatment or referral\n* Girl accompanied by an\u002Fother minor(s) only or completely unaccompanied: Does not provide informed assent; Requires urgent medical treatment or referral\n* Caregiver: Does not provide informed consent","9 Years",{"count":371,"type":22},1140,[60],"The goal of this implementation research study is to understand whether a package of community-based interventions can increase access to and uptake of the human papillomavirus (HPV) vaccine among very young adolescent girls in rural Ethiopia. The main questions this study aims to answer are:\n\n* Can a package of community-based interventions increase delivery of routine HPV vaccination to girls aged 9-14 in rural Ethiopia?\n* Is an intervention model that incorporates strategies that address gender norms and gender-specific barriers more effective at increasing delivery of routine HPV vaccination than a model that does not explicitly address gender?\n* What is the acceptability, feasibility, cost, and potential for maintenance and scale of an integrated health intervention to delivery routine HPV vaccination in rural Ethiopia?\n\nTo evaluate the effectiveness of the intervention, researchers will compare HPV vaccination within regions where the new intervention model is being implemented (intervention areas) to regions where the new routine HPV vaccination delivery model is not being implemented (comparison areas) for approximately 1 year before the new intervention model is implemented and for approximately 1 year after the start of implementation to compare changes over time and between intervention and comparison areas.\n\nThe study will evaluate the effect of the intervention on HPV vaccination delivery using routine health facility data.\n\nTo understand acceptability, feasibility, implementation, and potential for scale, the study will enroll participants including health officials and providers, adolescents girls receiving HPV vaccination and other services in intervention areas, and their parents\u002Fcaregivers.\n\nThese participants may be asked to participate in one or more of the following:\n\n* Completing a short questionnaire after receiving health services, including HPV vaccination, and their knowledge and attitudes towards HPV vaccination and experiences of care\n* Participating in an interview or a focus group discussion to discuss HPV vaccination services and the role of the intervention in delivering care",[340,342,343,344,341,345,28,346,375],"Integrated Community-based Intervention Package",[348,350],"2024-10-30",{"date":379,"type":40},"2024-10-31",{"date":379,"type":22},{"date":382,"type":22},"2026-03",{"name":360,"class":83}]