[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adolescent-idiopathic-scoliosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adolescent-idiopathic-scoliosis":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,50,86,114,141,167,192,213,239,262,290,326,347,372,395,417,439,458,481,499,521,545,567,581,601],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":21,"enrollmentInfo":22,"targetDuration":4,"studyType":25,"phases":26,"briefSummary":28,"conditions":29,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100519373","kids-with-iron-deficiency-and-scoliosis-100519373",false,"NCT06042699","Kids With Iron Deficiency and Scoliosis","Kids With Iron Deficiency and Scoliosis (KIDS) Study","KIDS","Inclusion Criteria:\n\n1. 10-26 years old;\n2. diagnosis of scoliosis or kyphosis;\n3. self-reported ability to swallow a tablet;\n4. spinal fusion procedure planned approximately 6 to 24 weeks from an orthopedic surgical clinic visit at which patient agrees to phlebotomy for screening blood work;\n5. serum ferritin less than or equal to 25 µg\u002FL.\n\nExclusion Criteria:\n\n1. taking or planning to take iron-containing supplement on patient's own volition, and not willing to stop for duration of study;\n2. taking or planning to take iron-containing supplement as prescribed or recommended under the care of a physician;\n3. Hg \\\u003C10mg\u002FdL if post-menarchal, Hg \\\u003C 11 if premenarchal or male\n4. C-reactive protein \\> 10 mg\u002FL\n5. receiving nutritional support by report in the medical chart;\n6. self-reported history of hypersensitivity reaction to iron-containing supplements;\n7. self-reported history of or suspected non-iron deficient hematologic disorder;\n8. self-reported history of iron overloaded state such as hereditary hemochromatosis or hemosiderosis;\n9. objection to receiving red blood cell transfusions;\n10. current pregnancy (by self-report);\n11. prisoners;\n12. patient or parent decides against study participation.",true,"ALL","10 Years","26 Years",{"count":23,"type":24},275,"ESTIMATED","INTERVENTIONAL",[27],"NA","This study is a randomized controlled trial of preoperative oral iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in adolescents undergoing scoliosis surgery.\n\nResearch Question(s)\u002FHypothesis(es):\n\nPrimary\n\n* Iron supplementation will reduce the incidence of perioperative RBC transfusion in iron deficient scoliosis patients undergoing spinal fusion.\n\nSecondary\n\n* Iron supplementation will reduce postoperative neurocognitive functional declines in iron deficient scoliosis patients undergoing spinal fusion.\n* Iron supplementation will improve patient-reported physical functioning in iron deficient scoliosis patients undergoing spinal fusion.",[30,31,32,33,34,35,36],"Adolescent Idiopathic Scoliosis","Neuromuscular Scoliosis","Perioperative\u002FPostoperative Complications","Iron Deficiencies","Anemia","Spinal Fusion","Postoperative Cognitive Dysfunction","RECRUITING","2026-06-25",{"date":40,"type":41},"2026-06-26","ACTUAL",{"date":43,"type":41},"2024-01-11",{"date":45,"type":24},"2028-02-01",{"name":47,"class":48},"Columbia University","OTHER",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":18,"sex":19,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":61,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100444723","advanced-spinal-innovations-with-robotics-and-enabling-technology-registry-100444723","NCT05071144","Advanced SPinal Innovations With Robotics and Enabling Technology Registry","ASPIRE","Inclusion Criteria:\n\n* Diagnosis of a spine deformity\n* Scheduled for surgery using robotics and navigation and\u002For patient-specific rods\n* Up to and including 21 years of age\n* Speak and read English or Spanish\n\nExclusion Criteria:\n\n• None","0 Years","21 Years",{"count":60,"type":24},700,"5 Years","OBSERVATIONAL","Creation of a pediatric robotic spine surgery registry will allow for data collection and analysis on the coupled use of robotics and navigation, as well as patient-specific rods in pediatric spine deformity surgery across participating study institutions. Eventually, an educational and informative framework for this technology will be established.",[65,66,30,67,68,31],"Spine Deformity","Idiopathic Scoliosis","Spondylolisthesis","Congenital Scoliosis",[70,71,72,73,74,75],"Pediatric","Spine","Surgery","Registry","Robotic","Navigation","2026-06-18",{"date":78,"type":41},"2026-06-22",{"date":80,"type":41},"2021-12-13",{"date":82,"type":24},"2031-12",{"name":84,"class":48},"Boston Children's Hospital",10,{"id":87,"slug":88,"hasResults":12,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":12,"sex":19,"minAge":93,"maxAge":58,"enrollmentInfo":94,"targetDuration":4,"studyType":25,"phases":96,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":4},"100643545","the-use-of-a-comfort-tote-to-improve-recovery-in-pediatric-and-adolescent-patients-after-surgery-100643545","NCT07632833","The Use of a Comfort Tote to Improve Recovery in Pediatric and Adolescent Patients After Surgery","The Use of the Comfort Tote Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis: a Randomized Controlled Trial Pilot Study","Inclusion Criteria:\n\n* Patients of all genders, racial, and ethnic groups aged between 10 and 21 that have had been diagnosed with AIS requiring surgical correction with PSF.\n* Patients must be scheduled to undergo PSF at Morgan Stanley Children's Hospital of NYP.\n* The patients and their parent(s)\u002Flegal guardian(s) must also provide informed consent, for those under 18 years old.\n* The patient population will include mental health conditions such as anxiety and\u002For depression and all surgery levels.\n\nExclusion Criteria:\n\n* Patients who have had growing rods and revisions, those who have local or systemic infections, those with anemia, cardiovascular diseases, or osteoporosis, and patients with severe medical comorbidities such as neurological or developmental condition that precludes engagement with the Comfort Tote\n* Patients with two or more chronic conditions (excluding AIS)","12 Years",{"count":95,"type":24},50,[27],"The goal of this clinical trial is to learn if the use of Comfort Tote can treat pain and anxiety in adolescents with idiopathic scoliosis undergoing posterior spinal fusion. The study aims to answer two questions:\n\n1. To characterize the effectiveness and determine the impact of integrative therapy interventions of the Comfort Tote use in reducing self-reported pain, anxiety, and stress among pediatric patients with AIS undergoing PSF. By comparing self-reported pain, anxiety, and stress scores, as well as documented Morphine Milligram Equivalents (MMEs) and Numeric Rating Scale (NRS) pain scores, between patients using non-therapeutic and therapeutic Comfort Totes.\n2. To evaluate the impact of an educational video on the use of the Comfort Tote. This will assess whether the inclusion of instructional content enhances understanding and application of the Comfort Tote, thereby improving patient outcomes in pain management, anxiety reduction, and overall satisfaction with care. It is hypothesized that the therapeutic Comfort Tote intervention with the educational video will provide the highest patient satisfaction and greater tote usage, with decreased patient pain, stress, and anxiety levels. The findings from this pilot study will provide crucial insights into establishing a new standard of care for pediatric patients undergoing PSF and potentially provide baseline data for use in larger, multicenter randomized controlled trials.",[30,99,100,101],"Postoperative Pain, Acute","Postoperative Nausea and Vomiting","Anxiety",[103,104],"Posterior spinal fusion","Integrative therapy","NOT_YET_RECRUITING","2026-06-02",{"date":108,"type":41},"2026-06-08",{"date":110,"type":24},"2026-06-15",{"date":112,"type":24},"2028-06-30",{"name":47,"class":48},{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":25,"phases":124,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":49},"100636141","phase-3-the-effect-of-erector-spinae-plane-block-espb-on-pediatric-pain-management-following-posterior-spinal-fusion-psf-surgery-100636141","NCT07561827","The Effect of Erector Spinae Plane Block (ESPB) on Pediatric Pain Management Following Posterior Spinal Fusion (PSF) Surgery","ESPB","Inclusion Criteria:\n\n* Diagnosis of Adolescent Idiopathic Scoliosis (AIS) or neuromuscular scoliosis\n* Undergoing Posterior Spinal Fusion (PSF) Surgery\n\nExclusion Criteria:\n\n* Patients with forms of scoliosis other than AIS or NM Scoliosis.\n* Patients undergoing a spinal deformity correction surgery other than Posterior Spinal Fusion Surgery\n* Allergy or other contraindication to erector spinae plane block (ESPB) with Ropivacaine patients who are taking pre-operative opioids","18 Years",{"count":123,"type":24},42,[125],"PHASE3","This study is being done to better understand the efficacy of an erector spinae plane block (ESPB) in pain management for children with Adolescent Idiopathic Scoliosis or Neuromuscular Scoliosis undergoing Posterior Spinal Fusion surgery. The study team is trying to find out if receiving the ESPB leads to less pain and less need for pain medication after surgery.\n\nThe ESPB involves an injection of a local anesthetic, ropivacaine, into your child's back muscles to help block pain signals.",[128,31,30],"Adolescent Idiopathic Scoliosis (AIS)",[130,131],"posterior spinal fusion","pain management","2026-04-24",{"date":134,"type":41},"2026-05-01",{"date":136,"type":41},"2025-06-06",{"date":138,"type":24},"2027-01-26",{"name":140,"class":48},"University of California, San Francisco",{"id":142,"slug":143,"hasResults":12,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":12,"sex":148,"minAge":149,"maxAge":150,"enrollmentInfo":151,"targetDuration":4,"studyType":25,"phases":153,"briefSummary":154,"conditions":155,"keywords":156,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":49},"100308230","brace-monitoring-for-adolescent-idiopathic-scoliosis-ais-100308230","NCT03292601","Brace Monitoring for Adolescent Idiopathic Scoliosis (AIS)","Effect of Feedback and Monitoring on Patient Compliance With Spinal Orthoses for Scoliosis Treatment","Inclusion Criteria:\n\n* Diagnosis of Adolescent Idiopathic Scoliosis (AIS)\n* Sanders skeletal stage 4 or earlier\n* Clinician-recommended Rigo bracing\n* Patient receiving brace treatment\n\nExclusion Criteria:\n\n\\- Prior spine surgery","FEMALE","8 Years","17 Years",{"count":152,"type":24},87,[27],"The overall aim of the study is to utilize a novel device and smartphone application in order to improve measurement of patient compliance with at-home bracing for scoliosis as well as create a more accurate assessment of brace fit via continuous and objective measures of tension. These ground-breaking metrics will provide analyzable data to more accurately reflect and predict actual patient compliance as well as allow for further exploration of how to increase compliance, and thus, efficacy of bracing; it will additionally allow both physicians and patients to have a more reliable measure for brace fit by providing them with continuous data of fit via tension, and provide built-in feedback mechanisms to the patient to ensure proper tightness of the brace.\n\nAdditionally, the study will investigate whether providing the wearer's own brace-wear compliance information directly to the patient and their caregiver(s) via the mobile app will further improve rates of compliance as compared to those who do not receive the same feedback mechanism.",[30],[157,158],"Spinal Orthosis","Spinal Brace","2026-03-30",{"date":161,"type":41},"2026-04-03",{"date":163,"type":41},"2017-10-18",{"date":165,"type":24},"2027-02",{"name":47,"class":48},{"id":168,"slug":169,"hasResults":12,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":121,"enrollmentInfo":174,"targetDuration":4,"studyType":25,"phases":175,"briefSummary":176,"conditions":177,"keywords":178,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":4},"100630059","diaphragm-mobilization-in-adolescent-idiopathic-scoliosis-100630059","NCT07482748","Diaphragm Mobilization in Adolescent Idiopathic Scoliosis","Effect of Diaphragm Mobilization Added to the Schroth Best Practice Program in Adolescent Idiopathic Scoliosis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adolescents aged between 10 and 18 years\n* Diagnosis of adolescent idiopathic scoliosis\n* Cobb angle ≥ 10°\n* Ability to participate in exercise sessions\n* Written informed consent from the participant and their parent or legal guardian\n\nExclusion Criteria:\n\n* Non-idiopathic scoliosis (e.g., neuromuscular, congenital, or syndromic scoliosis)\n* Presence of congenital anomalies affecting the musculoskeletal system\n* Previous scoliosis treatment within the last 6 months\n* Participation in another physiotherapy or rehabilitation program during the study period\n* Current use of a scoliosis brace\n* History of spinal surgery\n* Presence of neurological, rheumatological, or cardiopulmonary diseases that may affect participation in the intervention\n* Cognitive impairment, communication disorders, or any condition that may limit the ability to follow instructions or complete assessments",{"count":123,"type":24},[27],"Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity that can affect posture, trunk movement, and respiratory function. Changes in the shape of the rib cage may influence diaphragm function and breathing mechanics in individuals with scoliosis. The Schroth Best Practice (SBP) exercise program is commonly used in the conservative treatment of scoliosis and focuses on posture correction and scoliosis-specific exercises. However, the additional benefits of manual diaphragm mobilization combined with this exercise program are not well known.\n\nThe aim of this randomized controlled trial is to investigate the effect of diaphragm mobilization added to the Schroth Best Practice program in adolescents with idiopathic scoliosis. Participants will be randomly assigned to two groups: one group will perform the SBP exercise program alone, and the other group will receive SBP exercises combined with diaphragm mobilization. The intervention will be performed three times per week for six weeks.\n\nAssessments will be conducted at baseline, at the end of the 6-week intervention, and at a 12-week follow-up. Outcomes will include respiratory function measured by spirometry, trunk rotation, thoracic mobility, trunk flexibility, quality of life, and body image. The results of this study may help determine whether adding diaphragm mobilization to scoliosis-specific exercise programs improves clinical outcomes in adolescents with idiopathic scoliosis.",[30],[30,179,180,181,182],"Diaphragm Mobilization","Scoliosis-Specific Exercise","Respiratory Function","Physiotherapy","2026-03-16",{"date":185,"type":41},"2026-03-19",{"date":187,"type":24},"2026-03-15",{"date":189,"type":24},"2027-01",{"name":191,"class":48},"Marmara University",{"id":193,"slug":194,"hasResults":12,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":198,"eligibilityCriteria":199,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":25,"phases":202,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":211,"locationsCount":49},"100420960","3d-dynamic-and-mechanically-informed-decision-making-in-ais-100420960","NCT04761549","3D, Dynamic and Mechanically-informed Decision Making in AIS","Identification of Key Parameters to Initiate the Shift Towards 3D, Dynamic and Mechanically-informed Decision Making in Adolescent Idiopathic Scoliosis","3D-AIS","Inclusion Criteria:\n\n* Patient diagnosed with Adolescent Idiopathic Scoliosis\n* 10-35 years old\n* Patient is scheduled to be surgically treated by vertebral body tethering (VBT) or selective fusion at UZ Leuven\n* Informed consent obtained: also from parent\u002Fguardian in case of minors\n\nExclusion Criteria:\n\n* Patient has undergone a fusion or VBT procedure before\n* Patient has a severe underlying illness which might influence the outcome of the surgery\n* Making it reasonable for the investigator to exclude the patient",{"count":201,"type":24},100,[27],"Adolescent Idiopathic Scoliosis (AIS) is a growth defect of the spine that primarily occurs in prepubertal children between the age of 10 to 14 years, affecting approximately 3% of these otherwise normal children. AIS has been associated with problems related to posture, load-related back pain, as well as aesthetic problems, e.g. the induced asymmetry of the shoulder. Therefore, early diagnosis followed by the appropriate treatment is vital to prevent further curve progression of AIS and minimize the health-related complications of these patients.\n\nThe current treatment recommendation to stop curve progression for an immature patient with a scoliosis curve between 25 and 40 degrees is to wear a brace. If the curve in the skeletally immature patient is not responding to the brace treatment, dynamic scoliosis correction by vertebral body tethering can be considered when there is still some growth potential left. State-of-the-art guidelines for the selection of fusion levels are currently mainly based on two-dimensional (2D) static radiographic parameters (such as, the Cobb angle and Shoulder balance) and a qualitative assessment of 2D bending or traction radiographs. Several classification systems and algorithms that are based on the 2D static radiographic (X-ray) parameters exist to assist surgeons in determining the appropriate levels to be instrumented. Despite this wide range of classification systems and detailed guidelines available in the literature, spinal fusion does not always yield satisfying 2D radiographic clinical outcome, with revision rates ranging from 3.9% to 22%.\n\nOverall, the surgeon is presently not provided with 3D dynamic and mechanical information regarding the deformity of the AIS to guide the decision-making. Obtaining this vital 3D dynamic information regarding the curvature and mechanical behavior of the spine will allow the surgeon to make an evidence-based and well-informed decisions in the treatment of the AIS patient. Consequently, realizing these objectives has the potential to improve patient satisfaction, reduce the postoperative complications and accordingly reduce socio-economic costs associated with AIS treatment. Recent advances in the use of subject specific musculoskeletal models will form the basis to realize this shift from 2D to 3D dynamic in AIS care.",[30],"2026-03-06",{"date":207,"type":41},"2026-03-09",{"date":209,"type":41},"2021-01-19",{"date":189,"type":24},{"name":212,"class":48},"Universitaire Ziekenhuizen KU Leuven",{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":25,"phases":223,"briefSummary":225,"conditions":226,"keywords":227,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":49},"100357534","phase-4-dysport--as-an-adjunctive-treatment-to-bracing-in-the-management-of-adolescent-idiopathic-scoliosis-100357534","NCT03935295","Dysport ® as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis","Dysport ® (abobotulinumtoxinA) as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis","Inclusion criteria:\n\n* Clinically determined idiopathic nature of scoliosis\n* Age 10-16 years\n* Risser stage 0,1,or 2\n* major curve of 20°-40°\n* curve apex caudal to T7 vertebra\n* ability to adhere to bracing protocol\n* Botulinum toxin naïve or previously treated greater than 6 months prior to study entry\n\nExclusion criteria:\n\n* Diagnosis of congenital scoliosis, neuromuscular scoliosis, or other \"reason\" for scoliosis - Previous surgery at any segment of the spine\n* Current need for surgery at any level of the spine\n* Treatment with any drug known to interfere with neuromuscular function\n* Any other medical condition, laboratory or diagnostic procedure finding that might preclude administration of BTX\n* Ongoing infection at the injection sites\n* Diagnosis as either resistant or sensitive to botulinum toxin treatment of any type or to any components of the BTX formulation\n* Cow milk protein allergy","16 Years",{"count":222,"type":24},90,[224],"PHASE4","This study evaluates the combined effect of botulinum toxin A (administered as Dysport® (Ipsen Pharmaceuticals)) and bracing in children with adolescent idiopathic scoliosis. Two thirds of patients will be treated with Dysport® and bracing, while the remaining patients will be treated with placebo and bracing.",[30],[228,229],"AIS","adolescent idiopathic scoliosis","2025-12-05",{"date":232,"type":41},"2025-12-09",{"date":234,"type":41},"2020-09-03",{"date":236,"type":24},"2026-12-31",{"name":238,"class":48},"Johns Hopkins University",{"id":240,"slug":241,"hasResults":12,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":220,"enrollmentInfo":246,"targetDuration":4,"studyType":25,"phases":247,"briefSummary":248,"conditions":249,"keywords":250,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":49},"100611864","mri-guided-dynamic-support-system-for-scoliosis-correction-100611864","NCT07246122","MRI-Guided Dynamic Support System for Scoliosis Correction","MRI-Guided Dynamic Support System for Scoliosis Correction (MRI-DSS)","Inclusion Criteria:\n\n* Age: 10-16 years\n* Diagnosis: Adolescent idiopathic scoliosis (Cobb angle 10-25°)\n* No prior spinal surgery or other orthopedic conditions\n* Able to provide informed consent\n* Risser sign 0-5\n\nExclusion Criteria:\n\n* Age \\\u003C10 or \\>16 years\n* Cobb angle \\\u003C10° or \\>25°\n* History of spinal surgery or other spine disorders\n* Contraindications to MRI",{"count":85,"type":24},[27],"This prospective pilot study evaluates the feasibility and effectiveness of an MRI-guided dynamic support system (MRI-DSS) for rapid, quantitative correction of adolescent idiopathic scoliosis (AIS). The system uses MRI-compatible air padding supports and programmable pneumatic control to apply and adjust corrective forces in real time. AIS patients underwent MRI-guided bracing, with Cobb angles and biomechanical parameters measured at each pressure level.",[30],[251,252],"MRI","Scoliosis","2025-11-20",{"date":255,"type":41},"2025-11-24",{"date":257,"type":41},"2023-07-27",{"date":259,"type":24},"2027-12-31",{"name":261,"class":48},"Chinese University of Hong Kong",{"id":263,"slug":264,"hasResults":12,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":4,"eligibilityCriteria":268,"healthyVolunteers":12,"sex":148,"minAge":269,"maxAge":150,"enrollmentInfo":270,"targetDuration":4,"studyType":25,"phases":272,"briefSummary":273,"conditions":274,"keywords":275,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":49},"100536241","interest-of-adapted-physical-activity-by-tele-rehabilitation-in-chronic-pathology---idiopathic-scoliosis-in-adolescents-100536241","NCT06262269","Interest of Adapted Physical Activity by Tele-rehabilitation in Chronic Pathology - Idiopathic Scoliosis in Adolescents","Interest of Adapted Physical Activity by Tele-rehabilitation in Chronic Pathology - Application to Idiopathic Scoliosis in Adolescents","Inclusion Criteria:\n\n* Affiliated to a social security system\n* Having signed the consent after clear and fair information adapted to her age\n* Obtained signed consent from at least 1 of the 2 parents or holders of parental authority, after clear and fair information\n* Subject presenting an AIS defined by the existence of a three-dimensional deformity three-dimensional deformity of the spine associating a frontal deviation measured by by the frontal radiographic angle of Cobb which must be at least 15°, but less than 40°, and a vertebral rotation attested by the presence of a presence of at least 5° of gibbosity on Bunnel's scoliometer.\n* Subject with front and side radiographs of the total spine, according to the EOS EOS technique, under load, less than 3 months old\n* Risser test \\\u003C 4\u002F5 (EOS radiographs less than 3 months old)\n* Subject not practicing any regular extracurricular physical activity (including regular (regular = at least 1 hour per week), for at least 6 months.\n* Internet connection at home allowing tele-rehabilitation in a dedicated a dedicated room for the time of the session with a free surface of minimum 4m² on the floor, without any obstacle up to the ceiling.\n* Compatibility with the technical requirements: access to a screen screen (computer or laptop, tablet...), with a minimum size of 8 inches (diagonal of 8 inches (diagonal of 20 cm), with an integrated or connected HD webcam connected, and a good quality sound, screen placed on a stable surface surface with a minimum height of 75cm and enough distance to see the to perceive from the camera the whole working area (4m²).\n\nExclusion Criteria: (One criterion is sufficient for non-inclusion)\n\n* Subject with secondary scoliosis: neurological, orthopedic, malformative...\n* Placement of a corset or rehabilitation for less than 3 months\n* BMI ≤15 or ≥ 30\n* Partial or total medical contraindication of any kind to the sports practice (examples: heart disease, unbalanced diabetes, juvenile polyarthritis, chronic painful joint pathology limiting physical performance, osteochondrosis of growth type Osgood-Schlater, Sever, Sinding-Larsen, osteochondritis, surgical sequelae limiting physical performance...)\n* Inability to undergo the medical follow-up of the trial for psychological social or geographical reasons.","13 Years",{"count":271,"type":24},70,[27],"This study is a randomised controlled trial designed to compare two adapted physical activity treatments for adolescent idiopathic scoliosis (AIS). The main hypotheses it aims to address are as follows:\n\n* Treatment with a HIIT (High-Intensity Interval Training) type training program via tele-rehabilitation, supervised by an adapted physical activity teacher, is effective in AIS.\n* A 12-week physical activity program maintains this efficacy over the long term. To test this hypothesis, Two groups of adolescents will be evaluated: a first group made up of non-athletic adolescents suffering from Idiopathic Scoliosis who will benefit from a tele-rehabilitation (physical activity sessions at home supervised by a teacher in adapted physical activities by video). A second group, control, also made up of non-athletic adolescents suffering from Idiopathic Scoliosis who will benefit from a self-program at home consisting of exercises specific to their scoliosis.",[30],[276,277,278,279,280],"Adapted physical activity","Telerehabilitation","Physical condition","Hiit","Exercise booklet","2025-09-30",{"date":283,"type":41},"2025-10-03",{"date":285,"type":41},"2022-09-21",{"date":287,"type":24},"2026-12",{"name":289,"class":48},"Association des Paralysees de France (APF)",{"id":291,"slug":292,"hasResults":12,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":12,"sex":19,"minAge":93,"maxAge":297,"enrollmentInfo":298,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":299,"conditions":300,"keywords":301,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":49},"100607339","assessment-of-respiratory-parameters-aerobic-capacity-and-sleep-quality-in-thoracic-ais-100607339","NCT07187271","Assessment of Respiratory Parameters, Aerobic Capacity and Sleep Quality in Thoracic AIS","Comparison of Respiratory Parameters, Aerobic Capacity, and Sleep Quality in Individuals With Thoracic Adolescent Idiopathic Scoliosis","Inclusion Criteria:\n\nIndividuals with a Cobb angle greater than 10 degrees Adolescents aged 12-20 years diagnosed with thoracic Adolescent Idiopathic Scoliosis, classified as T-type or TL-type according to ISST classification Patients currently undergoing brace treatment\n\nExclusion Criteria:\n\nIndividuals with a history of spinal surgery Individuals with neurological disorders Individuals with a diagnosed psychiatric disorder Pregnant individuals Individuals who do not provide consent to participate in the study","20 Years",{"count":5,"type":24},"This study aims to compare respiratory parameters -including pulmonary function and respiratory muscle strength-as well as aerobic capacity and sleep quality in individuals with thoracic adolescent idiopathic scoliosis. Participants will be categorized according to the ISST classification into T-type and TL-type curvature patterns. The study will evaluate differences between these groups using standardized clinical assessments.",[30],[228,302,303,304,305,306,307,308,309,310,311,312,313,314,315,316],"ISST classification","Thoracic AIS","Thoracolumbar AIS","Cobb angle","Angle of Trunk Rotation (ATR)","Pulmonary function test","FEV1","FVC","Respiratory muscle strength","MIP (Maximal Inspiratory Pressure)","MEP (Maximal Expiratory Pressure)","Aerobic capacity","Incremental Shuttle Walk Test (ISWT)","PUKİ (Pittsburgh Sleep Quality Index)","SAQ (Scoliosis Appearance Questionnaire)","2025-09-19",{"date":319,"type":41},"2025-09-22",{"date":321,"type":24},"2025-10-05",{"date":323,"type":24},"2025-12-15",{"name":325,"class":48},"Uskudar University",{"id":327,"slug":328,"hasResults":12,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":121,"enrollmentInfo":333,"targetDuration":4,"studyType":25,"phases":334,"briefSummary":335,"conditions":336,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":346},"100533375","schroth-and-pilates-exercises-in-idiopathic-adolescent-scoliosis-100533375","NCT06224998","Schroth and Pilates Exercises in Idiopathic Adolescent Scoliosis","Comparison of the Effects of Schroth and Pilates Exercises on Respiratory Functions, Functional Capacity, Balance, Spine Structure and Quality of Life in Idiopathic Adolescent Scoliosis","Inclusion Criteria:\n\n* having a Cobb angle between 10 and 25 degrees\n* age between 10-18 years\n\nExclusion Criteria:\n\n* Presence of secondary scoliosis (congenital, muscular and neurological scoliosis)\n* Presence of any cardiovascular and pulmonary disease that will prevent respiratory functions\n* Having a history of thoracic surgery\n* Use of assistive devices\n* Presence of a secondary orthopedic problem",{"count":5,"type":24},[27],"Adolescent idiopathic scoliosis (AIS) is a common anomaly that is frequently seen in prepubertal growth and is characterized by deviation and rotation of the spine, causing high level of disability. Pubertal development and asymmetrical load distribution increase the progression of the deformity. Affecting the spinal structure and its movement can affect the structures and cause problems in many areas such as pain, balance, respiration, mental health and quality of life. AIS can cause functional disability by causing deterioration in chest wall mechanics, weakness in respiratory muscles and limitation of functional capacity. As the disease progresses, prolonged hypoinflation and atelectasis lead to irreversible atrophy of the lungs and further reduction in lung volume. Displacement and\u002For compression of the heart due to thoracic deformity may not allow for the required increase in stroke volume during exercise. In severe cases, patients are at risk of developing pulmonary hypertension due to chronic respiratory failure and chronic atelectasis, chronic hypoxemia, chronic hypercapnia. In addition, muscle atrophy and muscle weakness in AIS are thought to cause muscle imbalances and loss of balance.\n\nExercise is the most appropriate treatment for low and moderate AIS cases due to its low cost and low risk of complications. Exercises prevent the development of many problems by controlling the severity of curvature and preventing the progression of curvature. It is thought that scoliosis exercises\n\ncan delay or even prevent surgery and reduce the duration or degree of brace, especially in patients with low-to-moderate curvature during growth. One of these exercise approaches, the Schroth technique, is primarily based on isometric muscle contraction exercises that aim to rotate, lengthen and stabilize the spine. The core component of the Schroth method is autocorrection, defined as the patient's ability to reduce spinal deformity through active postural realignment of the spine in three dimensions.\n\nAnother frequently used exercise method, Pilates exercise training improves flexibility and overall physical health by emphasizing the coordination of movements associated with strength, posture, and breathing. However, the effects of these exercises in reducing curvature and related problems are controversial in the literature. Therefore, in this study, we aimed to investigate the effects of Schroth and pilates exercises on respiratory functions, functional capacity, balance, spine structure and quality of life in adolescents with idiopathic scoliosis.\n\nThirty patients aged 10 to 18 years, with a Cobb angle between 10 and 25 degrees, will be included in the study. The subjects will be randomly divided into two groups; Schroth exercises will be applied to one group and pilates exercises will be applied to another group. All participants will participate in exercise sessions of 60 minutes a day, 3 days a week, for 8 weeks. Each participant will receive a total of 24 sessions of exercise therapy under the supervision of a physiotherapist. In this study, exercises that activate the muscle groups responsible for maintaining the correct posture and correcting the curvature will be selected for practice. Within the study, axial trunk rotation with a scoliometer, respiratory functions and respiratory muscle strength measurement with spirometry, functional capacity with the 6-minute walking test, balance with the Tecnobody balance measuring device, quality of life with Scoliosis will be assessed by the Research Society-22 Quality of Life Questionnaire. The results obtained from the study are of great importance as they will help to determine the effects of Schroth and pilates exercises on spinal deformity and the treatment of related problems in patients with AIS and to establish appropriate programs for the prevention and treatment of these problems.",[30],"2025-06-18",{"date":339,"type":41},"2025-06-24",{"date":341,"type":41},"2023-11-01",{"date":343,"type":24},"2025-08",{"name":345,"class":48},"Izmir Katip Celebi University",2,{"id":348,"slug":349,"hasResults":12,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":12,"sex":19,"minAge":93,"maxAge":354,"enrollmentInfo":355,"targetDuration":4,"studyType":25,"phases":357,"briefSummary":358,"conditions":359,"keywords":360,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":49},"100505385","minimally-invasive-surgery-vs-standard-posterior-approach-in-the-treatment-of-developmental-idiopathic-scoliosis-100505385","NCT05860673","Minimally Invasive Surgery vs Standard Posterior Approach in the Treatment of Developmental Idiopathic Scoliosis","Minimally Invasive Surgery vs Standard Posterior Approach in the Treatment of Developmental Idiopathic Scoliosis: Randomized Trial.","Inclusion Criteria:\n\n1. Patients with AIS\n2. Age between 12 and 25 years;\n3. Site of scoliotic curve: thoracic and\u002For lumbar;\n4. Preoperative radiographic range of the main scoliotic curve between 40° and 70° according to Cobb;\n5. Ability and consent of patients\u002Fparents to actively participate in the study and clinical follow-up.\n\nExclusion Criteria:\n\n1. Patients already treated surgically for scoliosis;\n2. Site of the scoliotic curve: cervical;\n3. Patients with scoliosis other than adolescent idiopathic scoliosis;\n4. Patients who do not fall within the described parameters;\n5. Unbalanced sagittal profile;\n6. Patients unable to consent or perform follow-ups.\n7. Pregnant women.","25 Years",{"count":356,"type":24},126,[27],"This is a randomized trial with 1:1 allocation. The aim of the study is to evaluate clinical and radiographic outcomes in patients with developmental age idiopathic scoliosis treated with mini invasive scoliosis surgery (MIS) technique versus posterior spinal fusion (PSF) technique through clinical and radiographic evaluations.",[30],[130,361,30,362],"mini invasive scoliosis surgery","randomized trial","2025-06-03",{"date":365,"type":41},"2025-06-04",{"date":367,"type":41},"2023-07-15",{"date":369,"type":24},"2032-06",{"name":371,"class":48},"Istituto Ortopedico Rizzoli",{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":378,"eligibilityCriteria":379,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":380,"enrollmentInfo":381,"targetDuration":4,"studyType":25,"phases":383,"briefSummary":384,"conditions":385,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":346},"100568367","preoperative-carbohydrate-drink-in-adolescent-idiopathic-scoliosis-surgery-the-impact-on-safety-and-enhanced-recovery-100568367","NCT06680297","Preoperative Carbohydrate Drink in Adolescent Idiopathic Scoliosis Surgery: the Impact on Safety and Enhanced Recovery","A Pilot Study on Preoperative Carbohydrate Loading in Adolescent Idiopathic Scoliosis Surgery: the Impact on Safety and Enhanced Recovery","CARBO-AIS","Inclusion Criteria:\n\n* Patient diagnosed with idiopathic scoliosis undergoing single-staged posterior spinal fusion\n* Age between 10 to 19 years old\n* ASA 1 \\& 2\n\nExclusion Criteria:\n\n* Patient diagnosed with diabetes mellitus (either type I or type II)\n* Patient with intellectual disability\n* American Society of Anesthesiologists (ASA) class 3 and above\n* Significant risk of aspiration (diagnosed with hiatal hernia, presence of GERD, BMI \\> 35 kg\u002Fm2 , poor GCS, swallowing abnormality, gastrointestinal abnormality)","19 Years",{"count":382,"type":24},60,[27],"The goal of this interventional study is to learn if carbohydrates loading improves overall outcome in adolescent patient undergoing scoliosis curgery\n\nThe main questions of the study are as follows:\n\n1. Does carbohydrates loading improves gastrointestinal related problems such as improvement in return of bowel function measured by first passage of flatus, reduce constipation by patient's time to first bowel opening and reduce incidence of post post operative nausea and vommiting\n2. Does carbohydrates loading reduces length of hospital stay and patient's overall condition in term of anxiety, thirst and hunger\n3. Does carbohydrates loading affects gastric residual volume by measuring residual gastric volume with ultrasound",[30],"2025-05-06",{"date":388,"type":41},"2025-05-11",{"date":390,"type":41},"2024-11-12",{"date":392,"type":24},"2025-12-31",{"name":394,"class":48},"University of Malaya",{"id":396,"slug":397,"hasResults":12,"nctId":398,"briefTitle":399,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":12,"sex":19,"minAge":149,"maxAge":121,"enrollmentInfo":401,"targetDuration":4,"studyType":25,"phases":402,"briefSummary":403,"conditions":404,"keywords":405,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":4},"100579539","detecting-and-monitoring-scoliosis-without-radiography-standard-radiographic-monitoring-program-versus-self-screening-with-momentum-spinetm-100579539","NCT06825611","Detecting and Monitoring Scoliosis Without Radiography: Standard Radiographic Monitoring Program Versus Self-Screening with Momentum SpineTM","Inclusion Criteria:\n\n* Children between the ages of 8-18 years of age\n* Confirmed radiographic diagnosis of adolescent idiopathic scoliosis\n* No history of spinal\u002F chest surgery.\n* Participants who have had spine x-rays ±1 week as baseline visit at CHLA will be included in the study.\n* Participants who have identifiable markings such as tattoos or birthmarks can be included in the study, though their markings will be covered with tape.\n\nExclusion Criteria:\n\n* Participants who have had x-rays in a brace will not be included.\n* Participants who have had an x-ray from another institution will not be included in the study. X-rays from out of community are typically done with a different and lower quality machine then the one at our institution. Additionally, we do not have consent from outside institutions to use their x-rays for research purposes.\n* Participants with a confirmed pregnancy will not be included. Pregnancy status will be self-reported by participants.\n* Participants with the existence of a second deformity which may affect topographic assessment will be excluded (e.g. Limb length discrepancy greater than 2cm).\n* Families who do not speak English and Spanish will be unable to participate as the application is only available in English and Spanish at this time.\n* Families who do not have access to their own compatible personal smart phone device will be unable to participate in the study.",{"count":201,"type":24},[27],"The goal of this clinical trial is for the Momentum SpineTM application to accurately detect scoliosis progression, including accuracy, margin of error, sensitivity, specificity, AUC, and overall agreement with radiographs in 8-18 year olds with adolescent idiopathic scoliosis. The main question it aims to answer \\[is\u002Fare\\]:\n\n* Based on previous data it is hypothesize that Momentum SpineTM imaging software will be able to accurately detect scoliosis progression (\\>= 7 degrees), including accuracy, margin of error, sensitivity, specificity, AUC, and overall agreement with radiographs.\n* Based on the above hypothesis that Momentum SpineTM is able to accurately detect scoliosis and curve progression (\\>= 7 degrees).\n* It is hypothesized there will be indications for accelerated clinical visits based on at home detection of progression, and that these visits will be accurate and necessary.\n* It is hypothesized that there will be a proportion of standard care visits that are deemed unnecessary, and that the application is able to accurately predict these visits.\n\nParticipants will:\n\n* Use Momentum SpineTM assessment from home to perform body scans at 1-month intervals on personal device and during the clinical visit.\n* Received monthly scans that will be evaluated by the provider using the application.\n* Receive additional scans as warranted.\n* Complete net promoter score (NPS) within the application following completion of a body scan.\n* Complete a patient satisfaction survey following 6 months of application usage.",[30],[406,407],"spinal curve monitoring","Scoliosis mobile application","2025-03-03",{"date":410,"type":41},"2025-03-04",{"date":412,"type":24},"2025-03-15",{"date":414,"type":24},"2027-08-15",{"name":416,"class":48},"Children's Hospital Los Angeles",{"id":418,"slug":419,"hasResults":12,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":4,"eligibilityCriteria":423,"healthyVolunteers":12,"sex":19,"minAge":424,"maxAge":121,"enrollmentInfo":425,"targetDuration":4,"studyType":25,"phases":426,"briefSummary":427,"conditions":428,"keywords":429,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":49},"100517861","phase-4-postoperative-steroid-use-in-adolescent-idiopathic-scoliosis-and-neuromuscular-scoliosis-patients-100517861","NCT06023043","Postoperative Steroid Use in Adolescent Idiopathic Scoliosis and Neuromuscular Scoliosis Patients","A Randomized Trial of Postoperative Steroid Use Following Posterior Spinal Fusion in 100-subject Adolescent Idiopathic Scoliosis (AIS) and Neuromuscular Scoliosis (NMS)","Inclusion Criteria:\n\nParticipants must meet all of the inclusion criteria to participate in this study:\n\n• Patients aged 9-18 years who are scheduled to undergo posterior spinal fusion to treat AIS or NMS\n\nExclusion Criteria:\n\nPatients will be excluded if any of the following criteria are met at baseline:\n\n* Prior instrumentation or spine surgery\n* Conditions associated with increased wound healing issues such as spina bifida\n* Non AIS or NMS patients\n* Not undergoing PSF\n* Outside the ages of 9-18\n* Allergies to the steroids and\u002For their ingredients\n* Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements\n* Inability or unwillingness of individual or legal guardian\u002Frepresentative to give written informed consent.","9 Years",{"count":201,"type":24},[224],"The goal of this randomized clinical trial is to compare the immediate use of steroids after surgery for accelerated discharge in adolescent idiopathic scoliosis and neuromuscular scoliosis after a posterior spinal fusion.\n\nThe main question it aims to answer are:\n\n* What are the effects of using steroids immediately after surgery in decreasing opioid use and helping early mobilization(movement)?\n* Does post-operative steroid use affect the incidence of wound complications and are there any long-term impacts on scar formation?\n\nParticipants will:\n\n* Fill out a Patient-Reported Outcomes Measurement Information System (PROMIS) survey specifically for pain interference and physical activity observing health related quality of life at enrollment, 3 months, 1 year, and 2 years\n* Have clinical photos of their incision at 3 months, 1 year, and 2 years\n\n  * Their photos will be assessed using the stony book scar evaluation scale\n* For treatment of their scoliosis, patients will undergo a posterior spinal fusion (PSF) per standard of care, however whether the participant receives or does not receive steroids is what the investigators are trying to understand.\n* Researchers will compare no immediate postoperative steroid (NS) to the group with immediate postoperative steroid (WS) group to see if there are changes in opioid use, wound complications, scar formation, and facilitation in early mobilization.",[31,30],[430,431,252],"Steroid","Dexamethasone",{"date":433,"type":41},"2025-03-05",{"date":435,"type":24},"2025-11-01",{"date":437,"type":24},"2028-12-31",{"name":416,"class":48},{"id":440,"slug":441,"hasResults":12,"nctId":442,"briefTitle":443,"officialTitle":444,"acronym":4,"eligibilityCriteria":445,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":121,"enrollmentInfo":446,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":448,"conditions":449,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":456,"locationsCount":49},"100574348","central-motor-mechanisms-in-ais-via-hd-semg-eeg-and-neuromuscular-coupling-analysis-100574348","NCT06758115","Central Motor Mechanisms in AIS Via HD-sEMG, EEG and Neuromuscular Coupling Analysis","Study on the Central Motor Regulation Mechanism in Adolescent Idiopathic Scoliosis (AIS) Patients Based on HD-sEMG, EEG, and Neuromuscular Coupling Analysis","Inclusion Criteria:\n\n1. Patients aged ≥10 years;\n2. Risser sign grade 0-3;\n3. Cobb angle between 10° and 40°;\n4. No prior treatment;\n5. Female patients within 1 year after menarche or before menstruation;\n6. The patient's guardian signs the informed consent form for treatment.\n\nExclusion Criteria:\n\n1. Those who do not meet the diagnostic criteria for AIS or inclusion criteria;\n2. Patients with severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney, and hematopoietic system disorders, or those with mental illnesses;\n3. Patients with thrombocytopenia, coagulation disorders, or a tendency to bleed;\n4. Patients who are afraid of the treatment and cannot tolerate it;\n5. Those who have already received other treatments that may affect the study's outcome measures.",{"count":447,"type":24},40,"1. Verifying the Motor Control Effects of Spinal Manipulation on AIS Using outpatient and inpatient AIS patients from our department as the study subjects, standardized spinal manipulation treatment is applied. The efficacy is evaluated through a combination of clinical outcome measures, HD-EMG for paraspinal muscle function assessment, and Pro-Kin balance system for trunk stability analysis. This establishes an AIS efficacy platform to further clarify the effectiveness of spinal manipulation in motor control regulation of AIS.\n2. Investigating the Central Motor Network's Response to Spinal Manipulation in AIS Utilizing high-density sEMG-EEG technology, synchronized brain and muscle electrical signals are collected before and after treatment. By employing a neuromuscular synchronization and coupling analysis approach that integrates linear and nonlinear methods, the characteristic indices of information interaction between the central system and muscles are identified. This further explores the motor control and response characteristics of the muscle-cortex network to spinal manipulation in AIS.",[30],"2024-12-26",{"date":452,"type":41},"2025-01-03",{"date":454,"type":41},"2024-01-01",{"date":236,"type":24},{"name":457,"class":48},"The First Affiliated Hospital of Zhejiang Chinese Medical University",{"id":459,"slug":460,"hasResults":12,"nctId":461,"briefTitle":462,"officialTitle":463,"acronym":4,"eligibilityCriteria":464,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":121,"enrollmentInfo":465,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":466,"conditions":467,"keywords":468,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":477,"leadSponsor":479,"locationsCount":346},"100371512","determining-best-indications-for-bracing-for-adolescent-idiopathic-scoliosis-100371512","NCT04117334","Determining Best Indications for Bracing for Adolescent Idiopathic Scoliosis","Determining the Best Indications for Initiating Brace Treatment for Adolescent Idiopathic Scoliosis","Inclusion Criteria:\n\n* Patients who are diagnosed with adolescent idiopathic scoliosis and are seen in the first setting with remaining growth potential (Risser 0-2), and are prescribed with either underarm (Boston) or Milwaukee bracing\n\nExclusion Criteria:\n\n* Patients whose diagnosis is not adolescent idiopathic scoliosis, unable to comply with study follow-up and refused consent for study",{"count":60,"type":24},"This is a prospective study for Investigating the cost-effectiveness of current bracing protocols for adolescent idiopathic scoliosis (AIS). It is hypothesized that aggressive management of adolescent idiopathic scoliosis (AIS) including early bracing at mild curve magnitudes and surgery at 40 degrees is more cost-effective while maintaining similar health quality of life. Scoliosis Research Society 22-item and EuroQol- 5 dimension questionnaires and direct\u002Findirect medical costs will be utilized for the cost-effectiveness analysis and health related quality of life assessment. The findings of this study have the potential to improve decision-making and revolutionize care of AIS patients in Hong Kong and globally. Clinicians will be able to utilize our results to provide the best and most cost-effective timing for initiating brace treatment.",[30],[469,470,471],"Bracing","Cost-effectiveness","Adolescent idiopathic scoliosis","2024-12-05",{"date":474,"type":41},"2024-12-06",{"date":476,"type":41},"2016-12-01",{"date":478,"type":24},"2026-03-31",{"name":480,"class":48},"The University of Hong Kong",{"id":482,"slug":483,"hasResults":12,"nctId":484,"briefTitle":485,"officialTitle":486,"acronym":4,"eligibilityCriteria":487,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":121,"enrollmentInfo":488,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":490,"conditions":491,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":492,"lastUpdatePostDateStruct":493,"startDateStruct":494,"completionDateStruct":496,"leadSponsor":498,"locationsCount":49},"100571232","3d-depth-camera-based-assessment-of-adolescent-idiopathic-scoliosisusing-a-depth-camera-100571232","NCT06717568","3D Depth Camera-Based Assessment of Adolescent Idiopathic ScoliosisUsing a Depth Camera","Assessment of Adolescent Idiopathic Scoliosis Based on 3D Imaging Technology Using a Depth Camera","Inclusion Criteria:\n\n(1) Adolescents aged 10-18 years, diagnosed with adolescent idiopathic scoliosis (AIS) with a Cobb angle ≥10°; (2) No history of spinal surgery or other corrective treatments; (3) Able to undergo short-term inpatient treatment (5 days) and comply with study procedures.\n\nExclusion Criteria:\n\n(1) Patients with congenital, neuromuscular, or other secondary scoliosis; (2) Presence of major comorbidities affecting spinal structure or muscle tone (e.g., spinal cord injury, muscular dystrophy); (3) Patients unable to complete standardized assessment procedures.",{"count":489,"type":24},80,"Adolescent Idiopathic Scoliosis (AIS) is a common spinal deformity affecting adolescent health, and early diagnosis and accurate assessment are crucial for preventing disease progression. Traditional assessment indicators, such as the trunk rotation angle (ATR) and Cobb angle, rely on clinical examinations and X-ray imaging, which have certain limitations, including radiation exposure and insufficient sensitivity. The Back Height Difference (BHD), as a quantitative measure of the back surface morphology, may reflect the degree of trunk deformity caused by scoliosis.\n\nThe use of the Kinect v2 depth camera to capture three-dimensional point cloud data of the back provides a high-precision, radiation-free assessment method.",[30],"2024-11-30",{"date":472,"type":41},{"date":495,"type":41},"2022-01-01",{"date":497,"type":24},"2024-12-31",{"name":457,"class":48},{"id":500,"slug":501,"hasResults":12,"nctId":502,"briefTitle":503,"officialTitle":504,"acronym":505,"eligibilityCriteria":506,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":58,"enrollmentInfo":507,"targetDuration":4,"studyType":25,"phases":508,"briefSummary":509,"conditions":510,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":511,"lastUpdatePostDateStruct":512,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":518,"locationsCount":346},"100468445","posterior-column-spinal-osteotomies-in-the-treatment-of-adolescent-idiopathic-scoliosis-100468445","NCT05379868","Posterior Column Spinal Osteotomies in the Treatment of Adolescent Idiopathic Scoliosis","Posterior Column Spinal Osteotomies in the Treatment of Adolescent Idiopathic Scoliosis. A Randomized Clinical Trial","ASPO","Inclusion Criteria:\n\n* Adolescent idiopathic scoliosis (Lenke 1 to 4)\n* Age at surgery between 10 and 21 years\n* Cobb angle of 45 degrees or more\n* Posterior spinal fusion\n\nExclusion Criteria:\n\n* Anteroposterior surgery\n* Vertebral column resection\n* Smoking\n* Diabetes mellitus\n* Bleeding disorder",{"count":222,"type":24},[27],"Background: Posterior column osteotomies (PCO) are routinely used to facilitate curve correction in surgical treatment of adolescent idiopathic scoliosis (AIS). Data regarding routine use of PCO is controversial, with conflicting data for coronal and sagittal plane correction and clinical benefit. Use of PCO has not been studied in the surgical treatment of AIS in a prospective randomized clinical trial.\n\nStudy Design: A randomized, multicenter clinical trial on children and adolescents undergoing posterior spinal fusion for idiopathic scoliosis using pedicle screw instrumentation. Sixty consecutive adolescents will be randomized into PCO or no PCO group after surgical exposure of the spine in 1:1 ratio.\n\nAims and Hypothesis: To compare PCO vs. no PCO groups for the correction of coronal and sagittal plane curve in children undergoing posterior spinal fusion for AIS. The investigators hypothesize that the correction of coronal curve and hypokyphosis will be better in PCO group without increasing blood loss or complications.\n\nInclusion criteria: Adolescents (aged 10 to 21 years of age) undergoing corrective surgery for idiopathic scoliosis using pedicle screw technique.\n\nExclusion criteria: Coagulation disorder, smoking, unwilling to consent, vertebral column resection, need for anteroposterior surgery.\n\nMain outcome parameters: Primary outcome is the radiographic correction (Coronal and sagittal plane). Secondary outcomes include health-related quality of life (Scoliosis Research Society 24 outcome questionnaire), postoperative pain, rib hump, operative time, blood loss, hospital stay, and complications.\n\nEthical aspects: Ethical committee approval will be obtained. An informed consent will be obtained from all children and their parents.\n\nTime schedule and budget: This study has ethical committee approval.There will be no extra costs as all information gathered will be part of normal surgical treatment of AIS. A part-time research nurse has been hired to take care of data collection into the database.",[30],"2024-11-27",{"date":513,"type":41},"2024-12-03",{"date":515,"type":41},"2022-06-01",{"date":517,"type":24},"2029-06-01",{"name":519,"class":520},"Turku University Hospital","OTHER_GOV",{"id":522,"slug":523,"hasResults":12,"nctId":524,"briefTitle":525,"officialTitle":526,"acronym":4,"eligibilityCriteria":527,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":121,"enrollmentInfo":528,"targetDuration":4,"studyType":25,"phases":530,"briefSummary":531,"conditions":532,"keywords":533,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":536,"lastUpdatePostDateStruct":537,"startDateStruct":539,"completionDateStruct":541,"leadSponsor":543,"locationsCount":49},"100537564","clinical-effectiveness-of-intervertebral-disc-release-in-treating-lenke-5-adolescent-idiopathic-scoliosis-100537564","NCT06279468","Clinical Effectiveness of Intervertebral Disc Release in Treating Lenke 5 Adolescent Idiopathic Scoliosis","Clinical Effectiveness of Intervertebral Disc Release in Treating Lenke 5 Adolescent Idiopathic Scoliosis (INDIRECT)","Inclusion Criteria:\n\n* Between the ages of 10 and 18\n* American Society of Anesthesiologists (ASA) physical statusclassification of I-II\n* Lenke 5 type adolescent idiopathic scoliosis\n\nExclusion Criteria:\n\n* A history of previous corrective surgery\n* With sharp, angulated short-segmental scoliosis\n* With congenital scoliosis requiring 3-column osteotomy",{"count":529,"type":24},132,[27],"Adolescent idiopathic scoliosis (AIS) poses challenges in achieving optimal three-dimensional correction. While posterior fusion with pedicle screws has shown success, osteotomy techniques, such as Ponte osteotomy, have further improved outcomes. However, residual vertebral rotation remains a concern, impacting long-term complications. Intervertebral disc release (IDR) presents a potential solution to enhance derotation and reduce fusion levels, particularly in Lenke Type 5 AIS. This prospective randomized controlled trial aims to evaluate the clinical effectiveness of IDR in treating Lenke 5 AIS, comparing it to Ponte osteotomy. The study focuses on axial vertebral rotation correction, coronal curve improvement, blood loss, hospital stay, and adverse events. Participants aged 10-18 with Lenke 5 AIS will undergo either IDR or Ponte osteotomy, randomly assigned. Outcome measures include axial rotation correction rate, radiographic parameters, and clinical assessments. A total of 132 participants will be recruited. The IDR technique, through posterior disc removal, presents a promising approach to optimize derotation in Lenke 5 AIS. While offering potential advantages, challenges like limited working space and bleeding risks require careful consideration. The study's findings aim to provide robust clinical evidence, enhancing treatment strategies for Lenke 5 AIS and offering innovative approaches for AIS as a whole.",[30],[534,471,535],"Intervertebral disc release","Derotation","2024-10-17",{"date":538,"type":41},"2024-10-21",{"date":540,"type":41},"2024-09-01",{"date":542,"type":24},"2026-09-01",{"name":544,"class":48},"Peking Union Medical College Hospital",{"id":546,"slug":547,"hasResults":12,"nctId":548,"briefTitle":549,"officialTitle":550,"acronym":4,"eligibilityCriteria":551,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":552,"enrollmentInfo":553,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":555,"conditions":556,"keywords":557,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":565,"locationsCount":49},"100340769","dynamic-pressure-monitoring-system-for-orthotic-treatment-of-scoliosis-100340769","NCT03716843","Dynamic Pressure Monitoring System for Orthotic Treatment of Scoliosis","Design of a Dynamic Pressure Monitoring System for Orthotic Treatment of Scoliosis","Inclusion Criteria:\n\n* Teenagers diagnosed with adolescent idiopathic scoliosis\n* Cobb's angle between 25 to 45 degrees\n* Immature skeletons (Risser grade 0-2)\n* Types of scoliosis are classified by the Lenke classification system\n* Have received rigid brace treatment\n\nExclusion Criteria:\n\n* Contraindications for x-ray exposure\n* Diagnosis of other musculoskeletal or developmental illness that might be responsible for the spinal curvature\n* History of previous surgical treatment for AIS\n* Contraindications for pulmonary and\u002F or exercise tests\n* Psychiatric disorders\n* Recent trauma\n* Recent traumatic (emotional) event","15 Years",{"count":554,"type":24},20,"Adolescent idiopathic scoliosis (AIS) involves three-dimensional spinal deformity in children aged between 10 and 16. Traditional braces modify the natural dynamics and thus the mechanical behaviour of the scoliotic spine through external constraints. Patients usually develop pressure ulcers and skin irritation when prescribed brace treatment for 18-23 hours per day. The excessive pressure, unknown pressure distribution and pressure shifting between the human body and the brace causes the effects of brace treatment to be unpredictable. Dynamic pressure monitoring system will be developed based on the body landmarks of scoliotic patients and critical areas where active pressure is applied by the brace. The overall pressure distribution and dynamic pressure between the body and the thoraco-lumbo-sacral orthosis (TLSO) rigid brace will be measured. The efficacy of the brace design will be evaluated, and the maximum compressive stresses that patients can endure on different body parts without pressure injury can be computed.",[30],[558],"Dynamic Pressure Monitoring","2024-10-16",{"date":561,"type":41},"2024-10-18",{"date":563,"type":41},"2022-01-02",{"date":259,"type":24},{"name":566,"class":48},"The Hong Kong Polytechnic University",{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":487,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":121,"enrollmentInfo":573,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":574,"conditions":575,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":576,"lastUpdatePostDateStruct":577,"startDateStruct":578,"completionDateStruct":579,"leadSponsor":580,"locationsCount":49},"100565509","3d-imaging-assessment-of-scoliosis-back-height-difference-vs-trunk-rotation-angle-100565509","NCT06643104","3D Imaging Assessment of Scoliosis: Back Height Difference vs. Trunk Rotation Angle","Assessment of Adolescent Idiopathic Scoliosis Based on 3D Imaging With Depth Cameras: A Comparative Study of Back Height Difference and Angle of Trunk Rotation",{"count":489,"type":24},"This study focuses on adolescents with idiopathic scoliosis, employing 3D imaging technology with depth cameras to measure back height difference (BHD) and angle of trunk rotation (ATR) before and after conventional treatments such as massage, exercise therapy, and bracing. Statistical analyses are conducted to verify the correlation between BHD and ATR and to assess the sensitivity of BHD in evaluating short-term treatment effectiveness.",[30],"2024-10-13",{"date":559,"type":41},{"date":495,"type":41},{"date":497,"type":24},{"name":457,"class":48},{"id":582,"slug":583,"hasResults":12,"nctId":584,"briefTitle":585,"officialTitle":586,"acronym":4,"eligibilityCriteria":587,"healthyVolunteers":12,"sex":148,"minAge":20,"maxAge":269,"enrollmentInfo":588,"targetDuration":4,"studyType":25,"phases":589,"briefSummary":590,"conditions":591,"keywords":592,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":594,"lastUpdatePostDateStruct":595,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":600,"locationsCount":49},"100499959","trials-of-intelligent-nighttime-brace-with-smart-padding-to-treat-of-adolescent-idiopathic-scoliosis-100499959","NCT05790031","Trials of Intelligent Nighttime Brace With Smart Padding to Treat of Adolescent Idiopathic Scoliosis","Development of Intelligent Nighttime Brace With Smart Padding to Treat of Adolescent Idiopathic Scoliosis","Inclusion Criteria:\n\n1. between the ages of 10-13,\n2. scoliosis with a Cobb angle larger between 10 -25 degrees;\n3. No prior treatment\n4. Pre-menarche or post- menarche by no more than 1 year\n5. Ability to read and understand English or Chinese\n6. Physical and mental ability to adhere to intelligent nighttime braces protocol\n\nExclusion Criteria:\n\n1. History of previous surgical or orthotic treatment for AIS\n2. Diagnosis of other musculoskeletal or developmental illness that might be responsible for the spinal curvature\n3. Contraindications for pulmonary and\u002F or exercise tests\n4. Psychiatric disorders\n5. Recent trauma",{"count":85,"type":24},[27],"Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity usually associated with intervertebral rotation that takes place during adolescence. Generally, bracing treatment is a common option for scoliosis patients. Non-surgical treatment for scoliosis patients is to offer a conservative solution to treat their condition and encourage a higher degree of compliance by avoiding interference with their daily life activities. Therefore, intelligent nighttime braces have been developed to solve this issue, which are intended to be worn for inhibiting the advancement of spinal deformity during sleeping hours. However, its efficacy is still controversial. Intelligent nighttime brace with a specialized design for teenagers with scoliosis is limited and most part of them are lack of mobility and lack of control over corrective forces on particular regions of the vertebra. A scientific approach should be used to design and develop intelligent nighttime brace as a treatment option for adolescents with early scoliosis.",[30],[593],"Scoliosis, Bracing Treatment","2024-10-09",{"date":596,"type":41},"2024-10-15",{"date":598,"type":41},"2023-09-01",{"date":437,"type":24},{"name":566,"class":48},{"id":602,"slug":603,"hasResults":12,"nctId":604,"briefTitle":605,"officialTitle":606,"acronym":607,"eligibilityCriteria":608,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":150,"enrollmentInfo":609,"targetDuration":4,"studyType":25,"phases":611,"briefSummary":612,"conditions":613,"keywords":614,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":621,"lastUpdatePostDateStruct":622,"startDateStruct":624,"completionDateStruct":626,"leadSponsor":627,"locationsCount":49},"100396385","non-fusion-surgery-in-adolescent-idiopathic-scoliosis-patients-100396385","NCT04441411","Non Fusion Surgery in Adolescent Idiopathic Scoliosis Patients","Non Fusion Surgery in Adolescent Idiopathic Scoliosis Patients Using the Nemost-AIS System","NEMOST-AIS","Inclusion Criteria:\n\n* Adolescent idiopathic scoliosis ;\n* Primary Cobb angle greater than 30°;\n* Failed non-operative treatment defined as progression of the curve greater than 5° per year at any time;\n* Skeletally immature (Risser grade\\* ≤2 and Skeletal age of hand and wrist X-rays ≤14y);\n* In girl, either pre-menarchal or post-menarchal by no more than 1 year;\n* Age over 10 years;\n* Non rigid curve;\n* All Lenke type;\n* No previous spine surgery.\n\nExclusion Criteria:\n\n* Non-idiopathic scoliosis: musculoskeletal or neurologic conditions responsible for cause of the spine curvature (i.e. neuromuscular, congenital or syndromic scoliosis);\n* History of previous spine surgery;\n* Risser sign \\>2;\n* Disease or deformity likely to affect the stability of the device (i.e. inadequate anatomy of pedicles, trauma or tumor in fixation region, severe osteoporosis, bone destruction or poor bone quality);\n* Non-reductible scoliosis;\n* Known allergy or intolerance to one of the device material;\n* Acute or chronic infections, local or systemic;\n* Absence or insufficience of covering tissues;\n* Pathological obesity.",{"count":610,"type":24},18,[27],"The primary objective of the study is to monitor the effectiveness of a minimal invasive non-fusion double rod bipolar posterior spinal implant (Nemost growing domino) to correct the scoliotic curve in growing patients suffering from progressive adolescent idiopathic scoliosis (AIS) who have failed conservative treatment.",[30],[615,616,617,618,619,620],"scoliosis","nonfusion","surgery","fusionless","idiopathic","adolescent","2024-07-29",{"date":623,"type":41},"2024-07-30",{"date":625,"type":41},"2020-06-01",{"date":437,"type":24},{"name":628,"class":48},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)"]