[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adolescents\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adolescents":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,46,80,110,139,164,190,228,264,288,320,351,372],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100574602","phase-2-a-prospective-single-arm-clinical-study-of-liposomal-mitoxantrone-combination-regimen-in-the-treatment-of-relapsed-and-refractory-solid-tumors-in-children-adolescents-and-young-adults-100574602",false,"NCT06761417","A Prospective, Single-arm Clinical Study of Liposomal Mitoxantrone Combination Regimen in the Treatment of Relapsed and Refractory Solid Tumors in Children, Adolescents and Young Adults","Main inclusion Criteria:\n\n1. The patient fully understands this study, voluntarily participates and signs the informed consent form (ICF).\n2. Age: children (6 - 12 years old), adolescents (13 - 18 years old) and young adults (19 - 24 years old) (CAYA). The expected survival time is \\> 3 months.\n3. Diagnosed with relapsed and refractory solid tumors by histopathology, and it is one of the following subtypes: (1) bone and soft tissue tumors; (2) neuroblastoma; (3) other types of solid tumors that the investigator deems eligible for enrollment.\n4. There must be measurable tumor lesions by CT, enhanced CT, PET\u002FCT or MRI.\n5. Karnofsky score \\> 50; ECOG score ≤ 2.\n6. Bone marrow function: neutrophil count \\> 1.5 × 10⁹\u002FL, platelet count \\> 75 × 10⁹\u002FL, hemoglobin ≥ 80 g\u002FL.\n7. Liver and kidney function: serum creatinine ≤ 1.5 times the upper limit of normal value; AST and ALT \\\u003C 2.5 times the upper limit of normal value (for patients with liver invasion \\\u003C 5 times the upper limit of normal value); total bilirubin \\\u003C 1.5 times the upper limit of normal value (for patients with liver invasion \\\u003C 3 times the upper limit of normal value).\n8. No history of myocardial infarction, unstable angina, severe unstable ventricular arrhythmia or any other arrhythmia requiring treatment, no history of clinically severe pericardial disease, or no electrocardiogram evidence of acute ischemic or active conduction system abnormality within 6 months before recruitment.\n\nMain exclusion Criteria:\n\n1. Patients with known hypersensitivity to any component of the study drugs.\n2. Patients with other malignant tumors that are not under control (except for basal cell carcinoma of the skin, in-situ breast\u002Fcervical cancer, and other malignant tumors that have been effectively controlled without treatment in the past five years).\n3. Pregnant, lactating women and women of childbearing age who are unwilling to take contraceptive measures.\n4. Other situations judged by the investigator as not suitable for participating in this study.","ALL","6 Years","24 Years",{"count":19,"type":20},49,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","The aim of this clinical study is to determine the efficacy and safety of the liposomal mitoxantrone combination regimen in treating relapsed and refractory solid tumors among children, adolescents, and young adults. The key questions it intends to address are:\n\nCan the liposomal mitoxantrone combination regimen improve the objective response rate (ORR) compared to historical data? What are the adverse events associated with this combination regimen? Researchers will administer the liposomal mitoxantrone combination regimen (including capecitabine and anlotinib with specific dosing regimens) to the participants and closely monitor their conditions.\n\nParticipants will:\n\nReceive the treatment regimen for 4 - 6 cycles, with each cycle lasting 21 days Undergo regular checkups and tests during the treatment period and follow-up period as per the protocol.\n\nHave their tumor status, blood parameters, and other relevant indicators measured to evaluate the treatment effect and safety.",[26,27,28],"Solid Tumors","Children","Adolescents",[30,31,32],"Mitoxantrone liposomes","Solid tumor","Children and adolescents","RECRUITING","2026-05-06",{"date":36,"type":37},"2026-05-07","ACTUAL",{"date":39,"type":37},"2025-01-24",{"date":41,"type":20},"2028-02-01",{"name":43,"class":44},"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100586865","child-bipolar-network-ketogenic-diet-approach-to-bipolar-disorder-in-adolescents-100586865","NCT06920940","Child Bipolar Network Ketogenic Diet Approach to Bipolar Disorder in Adolescents","CBN Keto","Inclusion Criteria:\n\n* Youth must be ages 12 to 21 years old and speak English\n* Youth must be appropriate for outpatient treatment (i.e., not a danger to self or others; not acutely psychotic, suicidal or manic; not in need of partial or full hospitalization)\n* Youth must have a current BSD (bipolar I, II per DSM-5 criteria (Association, 2013) or other specified BSD by the University of Pittsburgh diagnostic criteria (Birmaher et al., 2006). The Pittsburgh other specified BSD criteria require recurrent and distinct 1-3 day periods (minimum 4 hours\u002Fday) in which there has been abnormally elevated, expansive, or irritable mood plus two (three, if irritable mood only) symptoms of mania that caused a change in functioning and totaled at least 4 days in the child's lifetime\n* Active symptoms: In the 2 weeks prior to study intake, participants must have had weekly depression Psychiatric Status Ratings (PSRs) of 3 (moderate) or higher (using the 1-6 depression severity scales from the Adolescent Longitudinal Follow-up Evaluation, or A-LIFE); or an interview-based Children's Depression Rating Scale, Revised (CDRS-R) score covering the prior 2 weeks of \\> 20. Youth may also enter with mixed symptoms (e.g., simultaneous elevations of \\> 3 on the PSR depression and hypomania scales, with Young Mania Rating Scale scores of 12 or higher), without meeting criteria for a full manic episode in the past month.\n* Participants must continue to meet the study's active symptom criteria when beginning the phase II keto \"ramp-up\" phase: a depression PSR rating of 3 or higher over the prior 2 weeks, and a CDRS-R score covering the prior 2 weeks of \\> 20.\n* Youth\u002Fparents must be willing to participate in evaluation and medication management sessions with a study psychiatrist and the study dietitian for assessment of the diet and side effects.\n* Youth under 18 years old must have at least one English-speaking parent or other caregiving family member consenting to participate in the study and available for consultation if needed\n* Youth and (for minors) all parents\u002Flegal guardians with health care decision making rights must express willingness to have the youth be in the study and try the keto therapy, assuming that the youth is eligible. The team must ascertain that the participating minor's youth\u002Fcaregiver is likely to make a strong effort to adhere to the study's protocol.\n\nExclusion Criteria:\n\nThe youth must not have any of the following needs or conditions for which the keto diet may be contraindicated:\n\n* pregnancy or breastfeeding\n* underweight (BMI below 18.5) or wasting syndrome (e.g., anorexia cachexia)\n* current or history of anorexia nervosa\n* current disordered eating (bulimia or binge eating disorder)\n* autism spectrum disorder diagnosis level 2 or greater (more than mild)\n* cardiac issues, including history of arrhythmia, or cardiovascular or cerebrovascular disease\n* type I and type II diabetes\n* history of seizures\u002Fepilepsy\n* history of stroke or cancer\n* unstable respiratory condition\n* severe gastroesophageal reflux (GERD; painful\u002Fimpairing despite prescription medication)\n* substance use disorder (with an exception for mild cannabis or nicotine use disorders)\n* history of kidney stones\u002Fdisease\n* diseases involving the pancreas, liver, gallbladder or thyroid, including Von Gierke's glycogen storage disease\n* Condition with high cholesterol of triglycerides will prompt physician review of eligibility (LDL\\>190 or triglycerides\\>500)\n* genetic metabolic disorders: either porphyria (impacting the body's ability to make hemoglobin) or fatty acid oxidation disorder (FAOD)\n* rare conditions of defective ketone production or breakdown (carnitine deficiency, carnitine palmitoyl-transferase deficiency, carnitine-acylcarnitine translocase deficiency, mitochondrial fatty acid β-oxidation disorders, Succinyl-CoA:3-ketoacid CoA transferase deficiency (SCOT), or pyruvate carboxylase deficiency)\n* youth must not be taking SGLT-2 inhibitors (e.g., canagliflozin), insulin, or sulfonylureas (to avoid hypogycemia), or Antihypertensive medication (e.g., lisinopril\u002FACE Angiotensin inhibitors ending in \"pril\", ARB Angiotensin II receptor blockers, spironolactone\u002FAldactone, Thiazide-type diuretics)","12 Years","21 Years",{"count":56,"type":20},80,[58],"NA","The present study is an open trial of ketogenic diets for adolescents and young adults (ages 12-21 yrs) in the depressive or mixed phases of bipolar disorder (BD). The investigators aim to determine whether combining standard of care pharmacological treatment for bipolar spectrum disorders with a 16-week ketogenic diet is well-tolerated and associated with improvements in depression, inflammatory and metabolic indicators, and executive functioning over the study period.\n\nThe experimental treatment in this study is a 16-week full ketogenic diet. Four study sites (UCLA, U Cincinnati, U Colorado and U Pittsburgh) will recruit 80 total youth (20 each) from bipolar specialty clinics. All youth eligible for the ketogenic therapy will be provided with the ketogenic diet and standard of care pharmacological treatment. During the diet therapy youth will be seen by a study child\u002Fadolescent psychiatrist at least once a month (and more frequently when needed), with the psychiatrist recommending and providing side effects monitoring and pharmacotherapy as clinically indicated.\n\nThe youth and caregivers will also meet with an expert dietitian who will coach all youth on maintaining the ketogenic diet (low carbs, high fats, medium protein) and making sure the child is tolerating the diet and getting enough liquid and nutrients, following the practice guidelines of the International Ketogenic Diet Study Group for treating youth. All youth and involved caregivers will also be provided will at least one motivational enhancement session to support them in goal setting and completion of the study elements.\n\nThroughout the study the investigators will assess metabolic (e.g., blood ketones, HOMA-IR) and inflammatory indicators (e.g., C-reactive protein), both for safety reasons and to assess correlates of symptomatic change. Independent evaluators will assess youth every month regarding their symptoms (depression, mania, anxiety, psychosis), psychosocial functioning, and quality of life.\n\nThe investigators anticipate that the pilot will transpire over 24 months and be an important step toward establishing feasibility and acceptability of ketogenic therapy for this population, not only in terms of diet administration and compliance but also for obtaining symptomatic, metabolic and inflammatory measurements.",[61,62,63,64,28],"Bipolar Disorder (BD)","Bipolar Disorder NOS","Bipolar Disorder I or II","Bipolar Spectrum Disorder",[66,67,68,69],"ketogenic","treatment","diet","keto","2026-04-17",{"date":72,"type":37},"2026-04-22",{"date":74,"type":37},"2025-03-19",{"date":76,"type":20},"2027-03-19",{"name":78,"class":44},"University of California, Los Angeles",4,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":21,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":45},"100620869","effect-of-core-stabilization-exercises-versus-traditional-rehabilitation-in-adolescent-with-idiopathic-scoliosis-100620869","NCT07363226","Effect of Core Stabilization Exercises Versus Traditional Rehabilitation in Adolescent With Idiopathic Scoliosis","Efficacy of Two Different Exercises Approach: Core Stabilization Exercises Versus Traditional Rehabilitation on Adolescent Idiopathic Scoliosis-A Single Blind Randomized Control Trial","AIS","Inclusion Criteria:\n\n* Female adolescents aged 11-18 years\n* Diagnosed with idiopathic scoliosis\n* Cobb's angle between 10° and 40°\n* Referred to physiotherapy\n\nExclusion Criteria:\n\n* Congenital, neuromuscular, or secondary scoliosis\n* Previous spine surgery or spinal correction\n* Presence of rheumatologic, renal, cardiovascular, pulmonary, or vestibular disorders\n* Inability to follow verbal instructions","FEMALE","11 Years","18 Years",{"count":92,"type":20},60,[58],"This study aims to compare the effectiveness of core stabilization exercises versus traditional rehabilitation exercises in adolescents with idiopathic scoliosis. Participants are assigned to one of two intervention groups: a core stabilization exercise program or a traditional rehabilitation program. The study evaluates the impact of both interventions on spinal stability, posture, and functional outcomes. The results of this study may help identify more effective rehabilitation approaches for managing adolescent idiopathic scoliosis.",[96,97,98,28],"Adolescence Idiopathic Scoliosis","Core Stabilization Exercise","Traditional Rehabilitation","NOT_YET_RECRUITING","2026-01-24",{"date":102,"type":37},"2026-01-27",{"date":104,"type":20},"2026-02",{"date":106,"type":20},"2026-12",{"name":108,"class":109},"Armed Forces Hospitals, Southern Region, Saudi Arabia","OTHER_GOV",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":90,"enrollmentInfo":118,"targetDuration":4,"studyType":21,"phases":120,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":45},"100620954","omega-3-fatty-acids-neuroendocrine-and-attention-deficit-hyperactivity-disorder-omneadhd-100620954","NCT07364331","Omega-3 Fatty Acids, Neuroendocrine and Attention Deficit Hyperactivity Disorder (OMNeADHD)","Omega- 3 Fatty Acids, Neuroendocrine and Attention Deficit Hyperactivity Disorder With (OMNeADHD) A Double Blind Randomized Controlled Trial of High Dose Omega- 3 Fatty Acids in Children and Adolescents With ADHD With Omega- 3 Deficiency.","OMNeADHD","Inclusion Criteria:\n\n1. DSM-5 diagnosis of ADHD\n2. Did not have any changes of ADHD treatment (pharmacological\u002Fpsychological) within 4 weeks of entering the trial.\n3. SNAP-IV inattention subscale \\>=12, or hyperactivity subscale \\>=12, or inattention+ hyperactivity subscales \\>=24\n\nExclusion Criteria:\n\n1. IQ\\\u003C80\n2. Allergic to omega-3\n3. Physical disorders: thyroid function, cancer\n4. Psychiatric comorbidity: SUD, psychotic disorders, bipolar disorder, major depressive disorder",{"count":119,"type":20},100,[58],"This is a 12 week randomized controlled study on the effects of omega-3 fatty acids in youth with attention deficit hyperactivity disorder (ADHD) with omega-3 deficiency.",[123,27,28],"ADHD",[125,126,127,128,123,129],"omega-3","epa","dha","children","adolescents","2026-01-22",{"date":132,"type":37},"2026-01-26",{"date":134,"type":37},"2021-09-04",{"date":136,"type":20},"2026-07-31",{"name":138,"class":44},"China Medical University Hospital",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":15,"minAge":146,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":21,"phases":150,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":162,"locationsCount":45},"100609881","digital-phenotyping-for-psychosocial-screening-in-adolescents-and-young-adults-with-cancer-100609881","NCT07220343","Digital Phenotyping for Psychosocial Screening in Adolescents and Young Adults With Cancer","Using Digital Phenotyping to Optimize Psychosocial Risk Screening and Personalized Care: a Pilot Study in Adolescents and Young Adults With Cancer","Inclusion Criteria:\n\n* 10-25 years old\n* Recent cancer diagnosis (\\>2 and \\\u003C18 months since diagnosis)\n* Willing to carry smartphone on their person for duration of study participation\n* Willing to wear smartwatch for duration of study participation\n\nExclusion Criteria:\n\n* Significant physical or mental disability that prevents completion of study activities\n* Lack of proficiency in English or Spanish","10 Years","25 Years",{"count":149,"type":20},25,[58],"The overall goal of the proposed study is to use digital phenotyping to identify and triage at-risk patients and accelerate access to critical mental health services.",[153,28],"Cancer",[155,153],"Smartphone","2025-12-29",{"date":158,"type":37},"2025-12-30",{"date":160,"type":37},"2025-01-29",{"date":106,"type":20},{"name":163,"class":44},"Stanford University",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":171,"sex":15,"minAge":53,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":21,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":45},"100445924","evaluation-of-trauma-center-based-intervention-for-adolescent-traumatic-injury-survivors-100445924","NCT05086757","Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors","Evaluation of Trauma Center-Based, Technology Enhanced Stepped Care Intervention for Adolescent Traumatic Injury Survivors.","Inclusion Criteria:\n\n* adolescent ages 12-17 admitted following traumatic injury\n* scored significantly on the peritraumatic distress scale (PDI \u002F ITSS)\n\nExclusion Criteria:\n\n* if the injury was self-inflicted\n* injuries are so severe, they prevent participation (e.g., head or spinal cord injuries that prevent verbal communication)",true,"17 Years",{"count":174,"type":20},300,[58],"Pediatric traumatic injury (i.e., injury of sudden onset and severity requiring immediate attention) is the leading cause of death and morbidity among US adolescents and are associated with mental health and health risk outcomes, including posttraumatic stress and depression (affecting between 19-42%), deficits in physical recovery, social functioning and quality of life, which if unaddressed, may contribute to increased use of health care services. The investigators partnered with three accredited Level I and II pediatric trauma centers to conduct a multi-site hybrid 1 effectiveness-implementation trial with 300 adolescent (ages 12-17) traumatic injury patients to assess the extent to which the Trauma Resilience and Recovery Program (TRRP), a scalable and sustainable, technology-enhanced, multidisciplinary stepped model of care, promotes improvement in quality of life and emotional recovery and gather preliminary data on the potential for TRRP to be implemented in other Level I trauma centers. Directly in line with NICHD's Pediatric Trauma and Critical Illness Research and Training (PTCIB) Strategic Research and Training agenda, this study will provide valuable data on the efficacy, preliminary effectiveness and potential for implementation of an innovative, cost-effective, sustainable technology-enhanced intervention designed to address the unique needs of adolescent injury patients and mitigate short- and long-term impact of injury on mental health, quality of life, and overall well-being.",[178,179,180,28],"Traumatic Injury","Technology","Posttraumatic Stress Disorder","2025-08-08",{"date":183,"type":37},"2025-08-11",{"date":185,"type":37},"2022-07-01",{"date":187,"type":20},"2027-08-30",{"name":189,"class":44},"Medical University of South Carolina",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":171,"sex":15,"minAge":146,"maxAge":53,"enrollmentInfo":198,"targetDuration":4,"studyType":21,"phases":200,"briefSummary":201,"conditions":202,"keywords":206,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":45},"100525882","peanut-consumption-on-cognitive-weight-and-inflammation-100525882","NCT06127511","Peanut Consumption on Cognitive, Weight, and Inflammation","Peanut Consumption on Cognitive Performance, Weight Management, and Inflammation in Young Adolescents","PEANUTY","Inclusion Criteria:\n\nEligible participants will be young adolescents, boys and girls, aged between 10 and 12 years who attend regular primary schools in Barcelona. The schools will assist with the participant recruitment through the classes and after that, a total of one-hundred students will be randomly included in each group. In all cases, participation will be voluntary and informed consent will be obtained prior to the study.\n\nExclusion Criteria:\n\nThe exclusion criteria will be history of allergy or intolerance to peanuts, any medical conditions or dietary restrictions that would affect peanut consumption, being able to understand Spanish or Catalan, and use of antibiotics in the month prior to the study.",{"count":199,"type":20},200,[58],"A multi-school, two-arm parallel cluster-randomized controlled trial will be conducted in 200 healthy young adolescents from Barcelona (Spain) to evaluate the effect of peanut consumption on cognitive performance, weight management and inflammation. Schools willing to participate will be randomly assigned to either the intervention or the control group. After the recruitment, the participants will follow a peanut-free diet for two weeks. Both arms will receive a multidimensional educational intervention designed by the Gasol Foundation to promote healthy dietary habits based on Mediterranean diet recommendations, along with exercise performance, healthy sleeping habits and emotional knowledge. Half of the participants (intervention group) will consume 25 g of whole skin roasted peanuts as a daily snack to be incorporated into their diet for six months.",[203,204,205,28],"Cognitive Performance","Inflammation","Weight Change, Body",[207,208,209,210,211,212,213,214,215,216,217,218],"peanut","cognitive","inflammation","weight","adolescent","obesity","gut microbiota","healthy dietary","physical activity","sleeping","behaviour habits","Mediterranean diet","2025-03-31",{"date":221,"type":37},"2025-04-03",{"date":223,"type":37},"2024-01-29",{"date":225,"type":20},"2025-12-31",{"name":227,"class":44},"University of Barcelona",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":171,"sex":15,"minAge":146,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":21,"phases":238,"briefSummary":239,"conditions":240,"keywords":248,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":45},"100566113","integration-to-improve-adolescent-health-and-hpv-vaccination-in-laos-100566113","NCT06650956","Integration to Improve Adolescent Health and HPV Vaccination in Laos","Integrated Service Delivery to Improve Adolescent Health and HPV Vaccination in Lao PDR: a Quasi-Experimental Mixed-Methods Study","Inclusion Criteria:\n\n* Female aged 10-13 years for HPV vaccination and SRH education\n* Male aged 10-13 years for SRH education\n* 10-13-year-old male and female students in randomly selected schools with at least 100 students in target classes (year-5 primary, year-1, 2 and 3 secondary)\n* 10-13-year-old males and females who are out-of-school and living in 2 remote villages each from four randomly selected health centers located around the selected schools\n\nExclusion Criteria:\n\n* males and females younger than 10 years or older than 13 years","13 Years",{"count":237,"type":20},700,[58],"The goal of this study is to find out if adding HPV vaccination to adolescent health services works to increase HPV vaccine uptake in 10-13-year-old girls in Laos. The study will also look at the effects of adding HPV vaccination on the use of other health services in 10-13-year-old boys and girls.\n\nThe main questions the study aims to answer are:\n\n1. Does adding HPV vaccination to adolescent health services increase HPV vaccine uptake in girls aged 10-13 years compared to girls who only receive standard HPV vaccination services?\n2. Does adding HPV vaccination to adolescent health services increase the use of other health services in 10-13-year-old adolescent boys and girls compared to adolescents who only receive standard HPV vaccination services?\n3. What are the barriers and facilitators to using the combined intervention in Laos?\n4. What are the opinions of adolescents, caregivers, healthcare providers, and other stakeholders on the combined intervention?\n5. How much does it cost and how well it works to combine HPV vaccination with adolescent health services, as opposed to providing HPV vaccination alone?\n\nResearchers will compare a combined intervention to standard HPV vaccination services to see if the combined intervention works to increase HPV vaccination uptake and the use of other health services. The combined intervention includes HPV vaccination given at schools, health facilities, and through community outreach. It also includes education on sexual and reproductive health, counseling, and other health services. Participants in the combined intervention group will:\n\n1. Receive the HPV vaccine at school or at a health facility.\n2. Take part in group discussions about sexual and reproductive health.\n3. Take part in individual counseling sessions.\n4. Use other health services as needed.\n\nParticipants in the comparison group will receive standard HPV vaccination services, including:\n\n• HPV vaccination given at schools, health facilities, and through community outreach.",[241,28,242,243,244,245,246,247],"Healthy","Integrated, Community-Health Systems","HPV Vaccines","Sexual and Reproductive Health","Knowledge","Attitude","Health Workers",[249,250,251,252,253,254],"hpv vaccination","adolescent health","integration","lao pdr","cervical cancer prevention","sexual and reproductive health","2025-03-10",{"date":257,"type":37},"2025-03-12",{"date":259,"type":37},"2024-11-01",{"date":261,"type":20},"2025-05",{"name":263,"class":44},"Health Poverty Action",{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":11,"sex":15,"minAge":172,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":273,"phases":4,"briefSummary":274,"conditions":275,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":45},"100582318","correlation-between-smart-phone-overuse-craniovertebral-angle-cervical-muscle-endurance-and-temporomandibular-proprioception-in-adolescents-100582318","NCT06861751","Correlation Between Smart Phone Overuse, Craniovertebral Angle, Cervical Muscle Endurance and Temporomandibular Proprioception in Adolescents","Inclusion Criteria:\n\n1. Both genders will be included.\n2. Adolescents with age ranging from 17 to 19 years.\n3. Adolescents using smart phone daily for not less than 4 years for 4 years.\n4. All participants will be free from any medical disease, visual or hearing problem.\n5. No history of temporomandibular joint complaints or disorder.\n\nExclusion Criteria:\n\n1. Adolescent who cannot understand or follow instructions.\n2. Congenital or acquired spinal deformities.\n3. Adolescents with obesity.\n4. Athlete adolescents.\n5. Any neck or upper extremity Injury.\n6. Neurological, musculoskeletal, and cardiopulmonary disease.\n7. Adolescent with teeth braces during last 4 years","19 Years",{"count":272,"type":20},160,"OBSERVATIONAL","The study was done to:\n\n1. Investigate the correlation between smart phone overuse and craniovertebral angle in adolescents.\n2. Investigate the correlation between smart phone overuse and cervical muscle endurance in adolescents.\n3. Investigate the correlation between smart phone overuse and temporomandibular joint proprioception in adolescents.",[276,277,278,28],"Smart Phone Addiction","Craniovertebral Angle","Temporomandibular Proprioception","2025-03-01",{"date":281,"type":37},"2025-03-06",{"date":283,"type":37},"2024-07-01",{"date":285,"type":20},"2025-05-01",{"name":287,"class":44},"Cairo University",{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":294,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":15,"minAge":53,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":21,"phases":299,"briefSummary":300,"conditions":301,"keywords":305,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":318,"locationsCount":4},"100569085","understanding-and-acting-to-regulate-suicidal-behavior-100569085","NCT06689657","Understanding and Acting to Regulate Suicidal Behavior","Randomized Study of Two Modalities of Cognitive-behavioral Group Therapy in Adolescents with Suicidal Ideation or Suicidal Behavior","CARES","Inclusion Criteria:\n\n* Age from 12 to 16 years 11 months old\n* Active suicidal ideation and\u002For suicidal behavior during the last 6 months\n* The patient is referred by a healthcare professional\n\nExclusion Criteria:\n\n* Intellectual developmental disorder\n* Non-french speaking\n* Planned travel not allowing the complete following of the study\n* The patient, the parents or the legal guardian can not be correctly informed\n* The patient presents symptoms that prevent him from group interaction (behavior disorders, hallucinations, delirium)\n* The family already followed the same kind of program\n* The patient is already enrolled in a clinical trial or is taking a treatment off full market approval during 4 weeks before screening\n* The patient and the family are not affiliated to any healthcare insurance\n* No signed consent from parents or a legual guardian nor one of the parental authority holder\n* The patient did not consent","16 Years",{"count":298,"type":20},108,[58],"Data from Santé Publique France show that since the onset of the health crisis (covid-19), there has been an increase in emergency room visits for mood disorders among children under 15 years of age, with a notable rise in the number of visits since early September 2020 compared to previous years. Recent literature considers Dialectical Behavior Therapy (DBT) as the only approach that has demonstrated (albeit weak to moderate) effects on the recurrence of self-harming behaviors. It is within this context, and based on these various findings, that the CARES program was developed (Understanding and Acting to Regulate Emotions and Suicidal Behaviors), aimed at adolescents who have engaged in suicidal behaviors or who have active suicidal ideation.\n\nThe objective of this study is to compare the CARES program for adolescents alone to the CARES program for adolescents combined with a parent group using Non-Violent Resistance (NVR) on the occurrence of self-harming behaviors among adolescents who have engaged in suicidal acts and\u002For have active suicidal ideation, six months after the conclusion of the intervention.\n\nThis is a prospective, randomized, open-label, single-center, controlled study with two parallel arms, with blinded assessment of the outcome measures.",[302,303,304,28],"Suicidal Ideation","Suicidal Behavior","Self-harm Behavior",[306,307,308,309,310],"Suicide prevention","Cognitive-behavioral therapy","Dialectical Behavior Therapy","Non pharmacological intervention","Adolescent","2024-11-13",{"date":313,"type":37},"2024-11-14",{"date":315,"type":20},"2025-01-06",{"date":317,"type":20},"2028-07-06",{"name":319,"class":44},"University Hospital, Montpellier",{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":324,"acronym":325,"eligibilityCriteria":326,"healthyVolunteers":171,"sex":15,"minAge":89,"maxAge":296,"enrollmentInfo":327,"targetDuration":4,"studyType":21,"phases":329,"briefSummary":330,"conditions":331,"keywords":335,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":45},"100535654","effectiveness-of-a-multicomponent-intervention-to-promote-physical-activity-levels-during-the-school-day-moveschool-100535654","NCT06254638","Effectiveness of a Multicomponent Intervention to Promote Physical Activity Levels During the School Day (MOVESCHOOL)","MOVESCHOOL","Inclusion Criteria:\n\n* Adolescents in 1st, 2nd and 3rd year of ESO.\n* Adolescents with informed consent signed by the family\u002Fguardian.\n* Schools with at least 80 students enrolled in 1st, 2nd and 3rd ESO.\n* Schools belonging to the regions of Cáceres and Cádiz.\n\nExclusion Criteria:\n\n* Adolescents with any physical disability or health condition that may limit physical activity levels.\n* Schools participating in any other physical activity or health promotion program.",{"count":328,"type":20},900,[58],"Study based a multicomponent school-based intervention during the school-day (i.e., Physically active learning, active breaks, and active recess) on Physical Activity, health, educational, and cognition outcomes in adolescents.",[332,28,333,334],"Physical Activity","Physical Fitness","Cognition",[336,337,338,339,340,341],"Active Break","Physically active learning","Active Recess","Motivational variables","Sedentary time","Academic indicators","2024-09-12",{"date":344,"type":37},"2024-09-19",{"date":346,"type":37},"2023-09-01",{"date":348,"type":20},"2026-08-31",{"name":350,"class":44},"University of Extremadura",{"id":352,"slug":353,"hasResults":11,"nctId":354,"briefTitle":355,"officialTitle":355,"acronym":356,"eligibilityCriteria":357,"healthyVolunteers":171,"sex":15,"minAge":89,"maxAge":296,"enrollmentInfo":358,"targetDuration":4,"studyType":21,"phases":360,"briefSummary":361,"conditions":362,"keywords":363,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":371,"locationsCount":45},"100561433","effectiveness-of-integrating-physically-active-learning-through-co-teaching-in-extremadura-activa-mente-project-100561433","NCT06590103","Effectiveness of Integrating Physically Active Learning Through Co-teaching in Extremadura: ACTIVA-MENTE Project","ACTIVA-MENTE","Inclusion Criteria:\n\n* Adolescents in 1st, 2nd, 3rd and 4th year of ESO.\n* Adolescents with informed consent signed by the family\u002Fguardian.\n* Schools with at least 210 students enrolled in 1st, 2nd, 3rd and 4th year of ESO.\n* Schools belonging to the Autonomous Community of Extremadura.\n\nExclusion Criteria:\n\n* Adolescents with any physical disability or health condition that may limit physical activity levels.\n* Schools participating in any other physical activity or health promotion program.",{"count":359,"type":20},800,[58],"Study based on a school-based physically active learning intervention during the school day on physical activity, fitness, health and education outcomes in adolescents.",[332,28,333],[364,339,340,341],"Physuca active learning","2024-09-06",{"date":344,"type":37},{"date":368,"type":37},"2024-09-02",{"date":370,"type":20},"2025-06-15",{"name":350,"class":44},{"id":373,"slug":374,"hasResults":11,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":11,"sex":15,"minAge":53,"maxAge":172,"enrollmentInfo":379,"targetDuration":4,"studyType":21,"phases":381,"briefSummary":382,"conditions":383,"keywords":387,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":399,"locationsCount":45},"100553484","centralized-virtual-sbirt-for-pediatric-primary-care-100553484","NCT06486688","Centralized Virtual SBIRT for Pediatric Primary Care","Virtual SBIRT for Pediatric Primary Care: Increasing Access to Screening, Brief Intervention and Referral to Treatment for Alcohol and Other Drug Use Via Telehealth","Inclusion Criteria:\n\n• The sample will include all adolescents aged 12 through 17 years seen for a Well Visit, who are at risk of AOD use disorder defined as endorsing monthly or more frequent AOD use OR any AOD use and past-two-week depressive symptoms or suicidality.\n\nExclusion Criteria:\n\n• N\u002FA - all adolescents with a Well Visit are eligible",{"count":380,"type":20},22320,[58],"Adolescent alcohol and other drug (AOD) use is a significant public health problem which contributes to high levels of mortality, morbidity and healthcare costs in young people, and identification and early intervention for these problems is critical to improving outcomes. Screening, Brief Intervention and Referral to Treatment (SBIRT) in pediatric primary care is an evidence-based strategy for addressing these problems, but has not been widely and systematically implemented, for a variety of reasons, including lack of training and staffing resources to support its implementation. This pragmatic, Type 1 Hybrid Comparative Effectiveness Implementation study will examine whether a centralized, virtually-delivered modality of SBIRT, rapidly accessible by multiple pediatric primary care clinics, can be cost-effectively implemented to improve early identification and treatment for AOD use and comorbid mental health problems among adolescents identified as being at high or severe risk of AOD use disorder during adolescent Well Visits.",[384,385,386,28],"Adolescent Alcohol Use","Mental Health Issue","Alcohol Related Disorders",[28,388,389,390,391],"Alcohol","SBIRT","Screening","Drug","2024-07-04",{"date":394,"type":37},"2024-07-08",{"date":396,"type":37},"2024-02-13",{"date":398,"type":20},"2027-08-31",{"name":400,"class":44},"Kaiser Permanente"]