[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adult-spinal-deformity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adult-spinal-deformity":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,44,74,90,112,138,166],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100619190","essential-amino-acid-supplementation-in-adult-spinal-deformity-patients-100619190",false,"NCT07341399","Essential Amino Acid Supplementation in Adult Spinal Deformity Patients","Effects of EAA Consumption on Recovery and Rehabilitation in Adult Spinal Deformity (ASD) Patients Undergoing Surgery","Inclusion Criteria:\n\n* Males and Females, 40 to 65 years old\n* Diagnosed with adult spinal deformity\n* Scheduled for ASD corrective procedure at UAMS (\\>2 weeks prior to surgery)\n* Live near Little Rock and scheduled to attend physical therapy in Little Rock\n* COVID-19 negative and\u002F or asymptomatic\n\nExclusion Criteria:\n\n* Subject who does not\u002Fwill not eat animal protein sources.\n* Diagnosed metabolic or hormonal disease (i.e., renal, cardiovascular, thyroid, polycystic ovary syndrome, or type I\u002FII diabetes mellitus).\n* Currently pregnant.\n* Gave birth or was lactating within previous 12 months.\n* History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment.\n* Clinically significant weight gain or loss (\\>5% change) in the last 12 months.\n* Consuming metabolism-altering drugs or medications (i.e., corticosteroids, stimulants, insulin).\n* Diagnosis of autoimmune disease\n* Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy.\n* Diagnosis of muscular degenerative\u002Fdystrophy disease\n* Unwilling to fast overnight.\n* Unwilling to avoid using other protein or amino-acid supplements during participation.","ALL","40 Years","65 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This will be a randomized double-blind placebo controlled clinical trial to determine if supplementing with essential amino acids (EAAs) for two weeks prior to, and 3 months after corrective spinal surgery in adults with spinal deformity can stimulate greater muscle protein turnover and whole-body protein balance, and enhance recovery after surgery when compared to a calorie matched placebo.",[27],"Adult Spinal Deformity",[29,30],"essential amino acids","protein balance","NOT_YET_RECRUITING","2026-06-10",{"date":34,"type":35},"2026-06-12","ACTUAL",{"date":37,"type":21},"2026-07-01",{"date":39,"type":21},"2027-05-15",{"name":41,"class":42},"University of Arkansas","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100430451","prospective-evaluation-of-complex-adult-spinal-deformity-cad-treated-with-minimally-invasive-surgery-100430451","NCT04885244","Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery","Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery (MIS)","MIS","Inclusion Criteria:\n\n1. \\>18 years of age at the time of treatment\n2. Diagnosis of adult congenital, degenerative, idiopathic, neuromuscular, inflammatory or iatrogenic spinal deformity\n3. EOS full body or standing 36\" AP \\& Lateral images of entire spine\n4. Surgery to be schedule to take place within 6 months (otherwise PROMs\u002FRadiographic images to be recollected)\n\n   AND Either:\n5. One of the following Radiographic criteria:\n\n   1. PI-LL ≥ 25 degrees\n   2. Thoracolumbar\u002Flumbar scoliosis ≥ 20 degrees\n   3. SVA \\>10cm\n   4. PT \\> 30 OR\n6. One of the Following Procedural criteria:\n\n   1. Surgery to include \\> 3 levels percutaneous posterior spinal instrumentation or 3 level stand-alone interbody. (Levels = vertebra (i.e. percutaneous screws at L2, L3, L4 would be eligible for posterior instrumentation and\u002For L3-L4, L4-L5 would be eligible as stand-alone for interbodies)\n   2. Posterior UIV and LIV must be placed percutaneously\n   3. Single-position surgery ≥ 3 levels fused (Levels=vertebra; S1 is counted as a level; S2 \\&\u002For pelvis\u002Filium is not)\n   4. Staged ≥ 3 levels fused with percutaneous pedicle screws\n   5. 3 column osteotomy with percutaneous fixation\n   6. ACR incorporating open or percutaneous fixation as long as UIV and LIV are percutaneous screws\n\nExclusion Criteria:\n\n1. Deformity due to acute trauma\n2. Active spine tumor or infection\n3. Patient is unwilling or unable to complete questionnaires\n4. Women who are pregnant\n5. Prisoners\n6. Open Posterior spinal fusion is planned (Open Anterior, i.e. ALIF, is acceptable)","18 Years",{"count":54,"type":21},500,"OBSERVATIONAL","Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients treated with minimally invasive approach, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.",[27,58,59,60],"Scoliosis","Kyphosis","Sagittal Imbalance",[58,59,60,62],"Spinal Deformity","RECRUITING","2026-02-12",{"date":66,"type":35},"2026-02-17",{"date":68,"type":35},"2021-07-28",{"date":70,"type":21},"2034-12-31",{"name":72,"class":42},"International Spine Study Group Foundation",12,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":78,"conditions":82,"keywords":83,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":84,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":88,"locationsCount":89},"100430670","prospective-multicenter-case-control-analysis-of-the-versatie-posterior-fixation-system-to-prevent-proximal-junctional-failure-in-long-posterior-spinal-fusion-constructs-for-adult-patients-100430670","NCT04888104","Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional Failure in Long Posterior Spinal Fusion Constructs for Adult Patients","Inclusion Criteria:\n\n1. \\>18 years of age at the time of treatment\n2. EOS full body or standing 36\" AP \\& Lateral images of entire spine\n3. Posterior spine fusion with pedicle screw fixation construct of 5 or more levels\n4. Pedicle screw fixation to be supplemented proximally with NuVasive VersaTie system\n5. Upper instrumented vertebra (UIV) terminating at a newly instrumented level\n6. Lowest instrumented vertebra (LIV) sacrum\u002Fpelvis\n7. Surgery scheduled to take place in the next 6 months\n\nExclusion Criteria:\n\n1. Active spine tumor or infection\n2. Deformity due to acute trauma\n3. Prisoners\n4. Women who are pregnant\n5. Patient is unwilling or unable to complete questionnaires",{"count":81,"type":21},225,[27,58,59],[58,59,60],{"date":66,"type":35},{"date":86,"type":35},"2021-07-09",{"date":70,"type":21},{"name":72,"class":42},9,{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":98,"targetDuration":100,"studyType":55,"phases":4,"briefSummary":101,"conditions":102,"keywords":103,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":105,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},"100377408","complex-adult-deformity-surgery-cads-100377408","NCT04194138","Complex Adult Deformity Surgery (CADS)","Multi-Center Prospective Evaluation of Complex Adult Spinal Deformity Surgery","CADS","Criteria:\n\nInclusion Criteria:\n\n1. Diagnosis of adult congenital, degenerative, idiopathic or iatrogenic spinal deformity\n2. Full body EOS radiographic assessment (sagittal and coronal visualization from skull to foot)\n3. Complex patients are defined as and meeting any one of the subsequent criteria:\n\n   1. Radiographic criteria:\n\n      * PI-LL ≥ 25 degrees\n      * TPA ≥ 30 degrees\n      * SVA\\>15cm\n      * Thoracic scoliosis ≥ 70 degrees\n      * Thoracolumbar\u002Flumbar scoliosis ≥ 50 degrees\n      * Global coronal malalignment \\>7cm\n   2. Procedural criteria:\n\n      * Posterior spinal fusion \\> 12 levels\n      * 3 column osteotomy or ACR\n   3. Geriatric criteria:\n\n      * Age \\>65 years and minimum 7 levels of spinal instrumentation during surgery\n\nExclusion Criteria:\n\n1. Age \\\u003C18 years of age\n2. Active spine tumor or infection\n3. Deformity due to acute trauma\n4. Neuromuscular conditions\u002Fdiseases (Parkinson's, Multiple Sclerosis, Post-polio syndrome)\n5. Syndromic scoliosis\n6. Inflammatory arthritis\u002Fauto immune diseases (Rheumatoid arthritis, Lupus, Ankylosing Spondylitis)\n7. Prisoners\n8. Women who are pregnant\n9. Non English speaking patients",{"count":99,"type":21},1500,"10 Years","Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.",[27,58,59,60],[58,59,60,104],"Spinal deformity",{"date":66,"type":35},{"date":107,"type":35},"2018-07-30",{"date":109,"type":21},"2032-07-31",{"name":72,"class":42},18,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":43},"100601030","feasibility-of-wireless-continuous-vital-sign-monitoring-and-impact-on-patients-undergoing-adult-spinal-surgery-in-a-general-ward-100601030","NCT07105189","Feasibility of Wireless Continuous Vital Sign Monitoring and Impact on Patients Undergoing Adult Spinal Surgery in a General Ward","Inclusion Criteria:\n\n* Included are adult patients (\\>=18 years) scheduled for ASD surgery with estimated a \\>3 day expected post-operative stay. ASD-surgery is defined as a posterior instrumented fusion of at least five spinal levels including instrumentation to the pelvis, caused by a degenerative condition of the spine.\n* Registered nurses and nurses' assistants employed at the orthopedic ward during the study period will be included if they have experience working with wCVSM during the study period. The study includes both sexes, variation of level of education and years of work experience. Included nurses and nurses' assistants should be proficient in the Danish language.\n\nExclusion Criteria:\n\n* Exclusion criteria are patients who are unable to wear continuous monitoring due to a pacemaker or allergy.\n* Patients who are not proficient in the Danish language will be excluded.",{"count":119,"type":21},150,[24],"The goal of this feasibility study is to explore the use of wireless continuous vital sign monitoring in an orthopaedic setting among orthopaedic nurses and patients undergoing adult spinal deformity surgery. In addition to the standard care National Early Warning Score the participants in this study will be monitored by CPC12S a wearable sensor that is worn on the chest using electrodes measuring electrocardiography single lead (ECG), Heart rate, respiratory rate, SpO2, blood pressure and temperature.\n\nMain hypotheses:\n\nThe use of wireless continuous vital sign monitoring in daily clinical practice for patients undergoing ASD surgery is feasible in terms of increased acceptability among orthopeadic surgical nurses measured over 12 months with a response rate of at least 80% with an average score of ≥5 at the last measurement in each of the four dimensions of the USE questionnaire: Usefulness, ease of use, ease of learning and satisfaction.\n\nThe following parameters will be evaluated:\n\nPrimary outcome:\n\n1. The feasibility in terms of acceptability of the concept of wCVSM among orthopedic surgical ward nurses.\n\n   Secondary outcomes:\n2. The feasibility in terms of acceptability of the concept of wCVSM in patients undergoing ASD surgery.\n3. The technical fidelity of wCVSM, assessed by data collected of vital signs, display of alerts to staff nurses and response to the alerts.\n4. The frequency of vital sign deviations in patients after ASD surgery using wCVSM compared to NEWS2.\n5. Clinical outcomes of patients undergoing ASD surgery including surgical complications, reinterventions, ICU admissions, unplanned ward transfer, and admissions to another department.",[27,123,124,125,126,127,128],"Wireless Continuous Vital Signs Monitoring","Wireless Vital Signs Monitoring System","Acceptability","ASD Surgery","Remote Monitoring","Feasibility Studies","2026-01-06",{"date":131,"type":35},"2026-01-08",{"date":133,"type":35},"2025-12-10",{"date":135,"type":21},"2026-08-30",{"name":137,"class":42},"Rigshospitalet, Denmark",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":146,"sex":16,"minAge":147,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":162,"leadSponsor":164,"locationsCount":43},"100616770","gait-and-paraspinal-semg-in-degenerative-spinal-diseases-100616770","NCT07309926","Gait and Paraspinal sEMG in Degenerative Spinal Diseases","Comparative Analysis of Spatiotemporal Gait Parameters and Paraspinal Surface Electromyography Parameters in Degenerative Spinal Diseases: A Cross-Sectional Study Using Motion Capture and Electromyographic Ensemble Averaging","TDGKSEPDSD","Inclusion Criteria:\n\n1. Patients with the following single disease: degenerative scoliosis, coronal imbalance, lumbar spinal stenosis, lumbar disc herniation, spinal cord-type cervical spondylosis;\n2. Age ≥ 60 years, regardless of gender;\n3. Planned to undergo elective open spinal fusion surgery;\n4. Voluntarily participate in the study, understand and agree to the study content, and sign the informed consent form.\n\nExclusion Criteria:\n\n1. History of previous spinal surgery;\n2. Combined with other neuromuscular diseases (such as Parkinson's disease), inflammatory diseases (such as ankylosing spondylitis), infectious diseases (such as spinal tuberculosis), sepsis, tumors, or lower limb joint diseases that may cause low back and lower limb pain, affecting physical activity;\n3. Suffering from severe cardiovascular, cerebral, liver, or kidney disease;\n4. Suffering from mental illness, dementia, or unable to cooperate to complete clinical research.\n\n   * Skin rupture in the waist;",true,"60 Years",{"count":149,"type":21},120,"This cross-sectional observational study aims to quantitatively compare three-dimensional gait parameters, surface electromyography (EMG) patterns, and radiological parameters among patients with different degenerative spinal conditions-including lumbar disc herniation (LDH), lumbar spinal stenosis (LSS), lumbar sagittal imbalance (LSI), degenerative lumbar scoliosis (DLS), and cervical spondylotic myelopathy (CSM)-alongside a healthy control group. The analysis focuses on spatiotemporal gait characteristics (step length, stride length, cadence), lower limb kinematics and kinetics (hip\u002Fknee\u002Fankle joint angles, moments, and powers during stance and swing phases), and surface EMG amplitudes (thoracic erector spinae, multifidus, gluteus maximus, and rectus abdominis muscles) during standardized walking tasks. Additionally, radiological parameters (e.g., pelvic incidence-lumbar lordosis mismatch, C2-C7 sagittal vertical axis, coronal Cobb angle) will be correlated with gait and muscle activation deviations. The study employs motion capture systems, force plates, and high-density EMG to objectively differentiate disease-specific movement impairments. Findings from this study may establish biomechanical and neuromuscular signatures for each degenerative condition, providing a framework for personalized rehabilitation strategies, gait retraining, and surgical outcome assessment in spinal disorders. Comparative analysis with healthy controls will further elucidate pathological alterations in gait and muscle recruitment patterns caused by degenerative spinal diseases.",[27,152,153,60,154,155,156,157],"Degenerative Scoliosis","Sagittal Deformity","Coronal Vertical Axis","Lumbar Spinal Stenosis","Lumbar Disc Herniation","Cervical Spondylosis With Myelopathy","2025-12-15",{"date":160,"type":35},"2025-12-30",{"date":133,"type":21},{"date":163,"type":21},"2029-12-01",{"name":165,"class":42},"Xuanwu Hospital, Beijing",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":22,"phases":176,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":43},"100552212","a-novel-classification-of-sagittal-spinal-alignment-to-aid-surgical-planning-for-adult-spinal-deformity-100552212","NCT06470152","A Novel Classification of Sagittal Spinal Alignment to Aid Surgical Planning for Adult Spinal Deformity","Pelvic Incidence-Dependent Clustering of Sagittal Spinal Alignment: A Novel Classification to Aid Surgical Planning for Adult Spinal Deformity","CSSAASD","Inclusion Criteria:\n\n1. ≥ 18 years of age at the time of treatment;\n2. Complete radiographic data, including standing posteroanterior and lateral whole-spine radiographs, lumbar computed tomography, and lumbar magnetic resonance imaging;\n3. Radiographic evidence of ASD: sagittal vertical axis ≥ 50 mm, pelvic tilt ≥ 25°, pelvic incidence-lumbar lordosis mismatch ≥ 10°, and\u002For thoracic kyphosis ≥ 60°.\n\nExclusion Criteria:\n\n1. Any type of previous spinal surgery;\n2. Other musculoskeletal problems impeding walking ability, syndromic or neuromuscular diseases such as Parkinson\\'s disease, inflammatory conditions such as ankylosing spondylitis, infectious conditions such as spinal tuberculosis, metabolic diseases such as severe osteoporosis, and\u002For serious general medical conditions such as sepsis or malignancy;\n3. Pathology of deformity as follows: post-traumatic deformity, adult idiopathic scoliosis of the thoracic spine, or de-novo lumbar scoliosis;\n4. Hip joint Kellgren-Lawrence grade ≥ II, history of hip joint and\u002For knee joint pain, and\u002For previous joint replacement.",{"count":175,"type":21},200,[24],"Surgical outcomes, including radiographic outcomes, patient-reported outcomes, postoperative complications, and revision surgery rates, were compared in patients with adult spinal deformity who underwent correction surgery with reference to our pelvic incidence-dependent (PI-dependent) clustering of sagittal spinal alignment and existing standards (sagittal age-adjusted score \\[SAAS\\], global alignment and proportion \\[GAP\\] score, and Roussouly classification). Our findings may provide tangible guidance for surgical decision-making in ASD.",[27,153,179,60],"Sagittal Alignment","2024-06-17",{"date":182,"type":35},"2024-06-24",{"date":184,"type":21},"2024-12-01",{"date":186,"type":21},"2027-12-01",{"name":165,"class":42}]