[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adverse-childhood-experience\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adverse-childhood-experience":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100644755","a-two-part-intervention-to-target-cardiovascular-health-100644755",false,"NCT07673172","A Two-Part Intervention to Target Cardiovascular Health","Autism Research Consortium on Physical Health: A Two-Part Intervention to Target Cardiovascular Health","Inclusion Criteria:\n\n* • Have a diagnosis of autism or be told by a healthcare provider that you have autism\n\n  * Be between the ages of 9 and 26\n  * Have a BMI greater than the 84th percentile\n  * English speaking\n\nExclusion Criteria:\n\n* • Children younger than 9 years of age\n\n  * Adults older than 26 years of age\n  * Individuals without a diagnosis of autism\n  * Individuals with a BMI less than the 84th percentile","ALL","9 Years","26 Years",{"count":20,"type":21},130,"ESTIMATED","INTERVENTIONAL",[24],"NA","Obesity is one of the most common health conditions among autistic young people and its prevalence rises at faster rates for autistic-relative to non-autistic-individuals. This places them at heightened risk for cardiovascular disease (CVD) and mortality before they enter adulthood. Studies have identified three key contributing factors to CVD outcomes in autistic individuals: unhealthy lifestyle behaviors, Adverse Childhood Experiences (ACEs), and chronic stress.\n\nThis study will explore the effectiveness of two CVD-focused primary care interventions for autistic individuals (ages 9-26): (1) lifestyle medicine consultations tailored towards supporting health-promoting behaviors; and (2) a Cognitive Behavioral Therapy (CBT) intervention tailored towards addressing chronic stress that contributes to excess weight and maladaptive eating behaviors and results in obesity and CVD. Participants and their caregivers will be randomly placed into either the Lifestyle Medicine Group, CBT Group, or combined Lifestyle Medicine with CBT Group. Participants will respond to questionnaires and surveys measuring lifestyle habits, stress, and psychological risk factors at their first visit, 6-month visit, and 3 months post-intervention visit. Over the course of 6 months, participants will attend virtual sessions (up to three times a month) in accordance with their intervention group.",[27,28,29,30],"Autism","Adverse Childhood Experience","Stress","Cardiovascular (CV) Risk",[32,33,34,35],"autism","adverse childhood experiences","stress","cardiovascular risk","NOT_YET_RECRUITING","2026-06-22",{"date":39,"type":40},"2026-06-29","ACTUAL",{"date":42,"type":21},"2026-07-01",{"date":44,"type":21},"2028-08-31",{"name":46,"class":47},"University of California, Los Angeles","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":68,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100611763","probing-the-role-of-mitochondrial-oxidative-stress-in-impaired-vascular-function-among-young-adults-with-early-life-adversity-100611763","NCT07244809","Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity","PROMISE","Inclusion Criteria:\n\n* 18-29 years\n* ACE score \\>=4\n\nExclusion Criteria:\n\n* Resting arterial blood pressure \\>140\u002F90 mmHg\n* BMI \\\u003C=17 or \\>= 35\n* Are on a weight-loss diet or involved in a formal weight-loss program or are not intentionally weight stable for 6 months (+\u002F- 5 kg) prior to the study.\n* Cardiovascular or metabolic prescription drug use\n* Vasoactive antidepressant drug use (SSRIs and clonidine)\n* Current heavy alcohol use, as defined as binge drinking on 5 or more days in the last month, or consuming more than 7 (women) or 14 (men) drinks per week in the last month (per NIAAA definition)\n* Current or recent (within the last 6 mo.) illicit drug use disorder as indicated by a score of 3 or greater on the Drug Abuse Screening Test (DAST-10)\n* Current tobacco or nicotine use\n* Vaping\n* Regular vigorous (\\>6 METs) aerobic exercise (\\>4 bouts\u002Fweek, \\>30 min\u002Fbout)\n* dietary supplementation with antioxidants or habitual use of NSAIDs\n* Currently pregnant or breastfeeding",true,"18 Years","29 Years",{"count":59,"type":21},300,[24],"Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction. Greater exposure to ACEs are associated with greater increases in the risk of cardiovascular diseases and death. Our laboratory has previously observed that vascular function is disrupted in young adults with prior ACE exposure, even though these individuals appear to be healthy clinically (i.e., no classic clinical cardiovascular disease risk factors). There is a need to identify and understand the biological mechanisms underlying these vascular impairments to inform effective interventions to reduce cardiovascular risks the millions of individuals affected by ACEs.\n\nThe body's response to stress is coordinated across various systems, all of which depend on energy supplied by mitochondria (often referred to as the \"powerhouse of cells\"). Based on new evidence across multiple physiological systems from our team, our overarching hypothesis is that disruption of mitochondrial function contributes to cardiovascular impairments among young adults with ACEs. Here we propose the initial pilot work necessary to begin to understand these associations, which will directly inform identification of individuals who may be most vulnerable to stress-related cardiovascular risk and the development of interventions to promote cardiovascular-stress resilience.\n\nOur aims are to:\n\n1. Determine whether mitochondrial oxidative stress contributes to impaired vascular function among young adults who experienced early life adversity.\n2. Determine whether reducing mitochondrial oxidative stress improves the cellular stress and integrated cardiovascular response to laboratory-based psychosocial stress among young adults who experienced early life adversity.",[28,63,64,65,66,67],"Endothelial Function (FMD)","Endothelial Injury","Mitochondrial Function","Oxidative Stress","Psychosocial Influence on Cardiovascular Disease",[69,70,71,72,73],"flow mediated dilation","mitoquinone mesylate","placebo","early life adversity","trier social stress test","RECRUITING","2025-11-17",{"date":77,"type":40},"2025-11-24",{"date":79,"type":40},"2025-10-13",{"date":81,"type":21},"2026-12-31",{"name":83,"class":47},"University of Iowa",1,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":84},"100524226","chinese-community-sample-of-hierarchical-model-of-psychopathology-100524226","NCT06105970","Chinese Community Sample of Hierarchical Model of Psychopathology","Chinese Community Sample of Hierarchical Model of Psychopathology : Validation and Analysis of Underline Trans-diagnostic Risk Factors","Inclusion Criteria:\n\n1. Chinese citizens\n2. Years of education \\> =9 years.\n3. age \\>= 18 years old.\n\nExclusion Criteria:\n\n(1)Subjects who have insufficient self-awareness, and are unable to obtain complete informed consent, such as: schizophrenia, manic episode of bipolar disorder, severe depression.",{"count":93,"type":21},4000,"OBSERVATIONAL","By validating Hierarchy Model of psychopathology(HiTOP) in Chinese community samples, this study aims for illumating the problem of diagnostic heterogeneity and high comorbidity within existing psychiatric classification systems in Chinese culture. Concurrently, this study also focuses on exploring trans-diagonostic risk and proctective factors underline HiTOP dimensions.\n\nthe main questions it aims to answer are:\n\n1. Explore HiTOP model cultural differences between western culture and eastern culture.\n2. Understand the impact of different dimension of adverse childhood experience on HiTOP structure.\n3. Investigate the relationship between individual unique psychological variables and psychopathological dimensions.\n\nParticipants will receive a detailed survey trying to measure their psychopathology symptoms, adverse childhood experience and psychological variables. This study expects to fallow up participants for 4 years to monitor the symptom changes.",[97,28],"Mental Health Issue",[99],"Hierarchical Model of Psychopathology","2025-07-05",{"date":102,"type":40},"2025-07-10",{"date":104,"type":40},"2023-09-26",{"date":106,"type":21},"2027-11-01",{"name":108,"class":47},"Shanghai Mental Health Center"]