[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"adverse-effect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:adverse-effect":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,86,112,128],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100635749","phase-3-comparison-of-ferrous-salt-vs-liposomal-iron-in-adult-women-with-iron-deficiency-anemia-100635749",false,"NCT07556731","Comparison of Ferrous Salt vs. Liposomal Iron in Adult Women With Iron-Deficiency Anemia","IDA","Inclusion Criteria:\n\n* Female patients of reproductive age (15 to 49 years) with a diagnosis of iron-deficiency anemia secondary to dysfunctional uterine bleeding.\n* Patients with iron-deficiency anemia who are treatment-naïve or whose last administration of iron therapy, either oral or parenteral, occurred at least three months prior to enrollment and who continue to have anemia.\n* Patients with a functional oral route.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Patients with abnormal uterine bleeding secondary to cancer\n* Severe intolerance to iron supplementation\n* Patients with gastritis or chronic use of proton pump inhibitors\n* Concomitant treatment with dietary supplements rich in calcium, magnesium, or zinc\n* Patients with endocrine disorders (hypothyroidism, hyperthyroidism)\n* Uncontrolled type 2 diabetes mellitus\n* Associated gastrointestinal bleeding\n* Patients with esophageal disorders","FEMALE","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","The goal of this study is to compare ferrous salt and liposomal iron for the treatment of iron-deficiency anemia in adult women. The study will also evaluate how well each treatment is tolerated.\n\nThe main questions this study aims to answer are:\n\nDoes liposomal iron increase hemoglobin levels as effectively as ferrous salt?\n\nAre there differences in side effects, especially gastrointestinal symptoms, between the treatments?\n\nDoes dosing ferrous salt every other day improve tolerance compared to daily dosing?\n\nResearchers will compare three oral iron treatment strategies to determine which approach provides the best balance between effectiveness and tolerability.\n\nParticipants will:\n\nBe adult women diagnosed with iron-deficiency anemia\n\nBe randomly assigned to one of three groups:\n\nDaily ferrous salt Ferrous salt taken every other day Daily liposomal iron Take the assigned iron treatment for 3 months Have blood tests at the beginning and end of the study to measure hemoglobin and iron levels Report any side effects or intolerance during treatment",[26,27,28,29],"Iron-deficiency Anemia (IDA)","Hemoglobin","Iron Deficiencies","Adverse Effect",[31,32,33,34,35],"Iron-deficiency anemia treatment comparision","Oral iron dosing","Liposomal iron","Iron replacement therapy","ferritin","NOT_YET_RECRUITING","2026-04-22",{"date":39,"type":40},"2026-04-29","ACTUAL",{"date":42,"type":20},"2026-05-01",{"date":44,"type":20},"2027-07-01",{"name":46,"class":47},"Hospital General de Mexico","OTHER_GOV",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":17,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":48},"100621148","feasibility-and-safety-of-sciatic-nerve-paraneural-sheath-block-using-a-mid-femoral-lateral-approach-100621148","NCT07366853","Feasibility and Safety of Sciatic Nerve Paraneural Sheath Block Using a Mid-Femoral Lateral Approach","Feasibility and Safety of Intraneural Sciatic Nerve Block Via Lateral Mid-femoral Approach: A Clinical Study","iSNB-LF","Inclusion Criteria:\n\n1. Patients scheduled for elective unilateral surgery below the knee (e.g., internal fixation for ankle, metatarsal, or calcaneal fractures; hallux valgus correction; flatfoot reconstruction).\n2. American Society of Anesthesiologists (ASA) physical status class I or II.\n3. Aged 18 to 65 years.\n4. Ability to understand the study procedure and provide written informed consent.\n\nExclusion Criteria:\n\n1. Contraindications to peripheral nerve block:\n\n   * Known allergy or history of toxicity to local anesthetics.\n   * Pre-existing neuropathy in the operative limb.\n   * Severe coagulopathy.\n   * Infection at the intended needle puncture site.\n   * Systemic infection.\n2. Requirement for simultaneous surgery at a site other than the unilateral lower limb below the knee.\n3. Previous surgery or significant scarring in the area of the planned needle insertion for the sciatic nerve block.\n4. Body mass index (BMI) \\> 35 kg\u002Fm².\n5. Patients receiving chronic pain therapy or with a history of opioid abuse.\n6. Inability to communicate or cooperate with the study assessments (e.g., due to cognitive impairment, language barrier, or psychiatric disorder).\n7. Pregnancy or lactation.",true,"ALL","65 Years",{"count":61,"type":20},200,[63],"NA","This study is designed as a randomized controlled trial aiming to evaluate the feasibility and safety of ultrasound-guided mid-femoral lateral approach sciatic nerve paraneural sheath block, in order to provide a new sciatic nerve block approach for clinical practice that offers greater patient comfort and higher precision, thereby facilitating its use for specific patient populations and less experienced operators.",[29,66,67],"Feasibility Study","Safety and Effectiveness",[69,70,71,72,73,74,75],"Sciatic Nerve Block","Subparaneural Block","Lateral Mid-femoral Approach","Popliteal Approach","Ultrasound-guided","Feasibility","Safety","2026-01-16",{"date":78,"type":40},"2026-01-26",{"date":80,"type":20},"2026-01-01",{"date":82,"type":20},"2026-10-01",{"name":84,"class":85},"General Hospital of Ningxia Medical University","OTHER",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":57,"sex":58,"minAge":17,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":21,"phases":95,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":108,"leadSponsor":110,"locationsCount":48},"100559937","addressing-unintentional-leakage-when-using-nasal-cpap---study-b-100559937","NCT06570629","Addressing Unintentional Leakage When Using Nasal CPAP - Study B","Mechanisms of Weight Gain During CPAP Treatment in Patients With Obstructive Sleep Apnea","Inclusion Criteria:\n\n* Diagnosis of moderate and severe obstructive sleep apnea;\n* Use of CPAP with a nasal mask;\n* 95th percentile of unintentional leak from the last 7 days above 24 l\u002Fmin, or at least 4 sudden drops of leak over one night of nasal CPAP\n* Persistence of excessive leak at the end of Study A.\n\nExclusion Criteria:\n\n* Patients who experience unintentional leakage from the mask\u002Faccessories.\n* Diagnostic polysomnography examination with a predominance of central apnea;\n* Patients with unstable heart disease, bedridden, neurodegenerative diseases, severe psychiatric disorders and COPD;\n* Previous surgery for obstructive sleep apnea;\n* Severe nasal obstruction (NOSE questionnaire score equal or greater then 55 points).",{"count":94,"type":20},50,[63],"Oral unintentional leak is a common side effect of continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA) treatment. Management of oral unintentional leakage has not been standardized and the effectiveness of potential approaches have not been studied in controlled studies. Higher levels of CPAP are associated with higher leak. In the present study, a sequential approach to control excessive unintentional leak will be tested. In study A, the reduction of therapeutic CPAP level will be tested. In study B, oronasal CPAP will be compared to nasal CPAP with a chinstrap.",[98,29,99],"Continuous Positive Airway Pressure","Obstructive Sleep Apnea",[101,102,99],"CPAP","Excessive leak","RECRUITING","2025-04-27",{"date":106,"type":40},"2025-04-30",{"date":106,"type":20},{"date":109,"type":20},"2028-12-31",{"name":111,"class":85},"University of Sao Paulo General Hospital",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":57,"sex":58,"minAge":17,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":21,"phases":120,"briefSummary":96,"conditions":121,"keywords":122,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":123,"startDateStruct":124,"completionDateStruct":125,"leadSponsor":126,"locationsCount":127},"100559936","addressing-unintentional-leakage-when-using-nasal-cpap---study-a-100559936","NCT06570616","Addressing Unintentional Leakage When Using Nasal CPAP - Study A","Strategies for Controlling Unintentional Leakage in the Treatment of Obstructive Sleep Apnea With Continuous Positive Airway Pressure","Inclusion Criteria:\n\n* Diagnosis of moderate and severe obstructive sleep apnea;\n* Use of CPAP with a nasal mask;\n* 95th percentile of unintentional leak from the last 7 days above 24 l\u002Fmin or at least 4 sudden leak line drop events\n\nExclusion Criteria:\n\n* Patients who experience unintentional leakage from the mask\u002Faccessories.\n* Diagnostic polysomnography examination with a predominance of central apnea;\n* Patients with unstable heart disease, bedridden, neurodegenerative diseases, severe psychiatric disorders and COPD;\n* Previous surgery for obstructive sleep apnea;\n* Severe nasal obstruction (NOSE questionnaire score equal or greater then 55 points).",{"count":19,"type":20},[63],[98,29,99],[101,102,99],{"date":106,"type":40},{"date":106,"type":20},{"date":109,"type":20},{"name":111,"class":85},2,{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":58,"minAge":135,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":139,"phases":4,"briefSummary":140,"conditions":141,"keywords":145,"overallStatus":103,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":155,"leadSponsor":157,"locationsCount":48},"100551973","frequency-of-adverse-events-in-pediatric-patients-receiving-sedation-for-magnetic-resonance-imaging-100551973","NCT06467045","Frequency of Adverse Events in Pediatric Patients Receiving Sedation for Magnetic Resonance Imaging","Frequency of Adverse Events and Factors Causing Adverse Events in Pediatric Patients Receiving Sedation for Magnetic Resonance Imaging: Observational Study","Inclusion Criteria:\n\n* All non-intubated patients under the age of 16 were included in the study.\n\nExclusion Criteria:\n\n* Intubated pediatric patients or older than 16 years patients were excluded.","0 Days","16 Years",{"count":138,"type":20},500,"OBSERVATIONAL","Introduction:The application of anesthesia outside the operating room for pediatric patients has increased in recent years. For diagnostic and treatment follow-up purposes, magnetic resonance imaging (MRI) requires the pediatric patient to remain still, necessitating sedation. The study aimed to determine the frequency of adverse effects and influencing factors in pediatric patients undergoing sedation during MRI.\n\nMethods: Between 19.06.2024 and 16.09.2024, estimated 500 pediatric patients who underwent MRI under sedation will be prospectively observed. All non-intubated patients under the age of 16 will be included in the study. The demographic data, comorbidities, and medications of the patients, the procedures performed, the anesthetic drugs used, the expertise duration of the anesthesiologist, and the adverse effects encountered will be recorded.",[142,143,144,29],"Sedation","Pediatric Anesthesia","Magnetic Resonance Imaging",[146,147,148,149,150],"pediatric","adverse effects","magnetic resonance imaging","sedation","anesthesia","2024-06-24",{"date":153,"type":40},"2024-06-25",{"date":151,"type":40},{"date":156,"type":20},"2024-10-05",{"name":158,"class":85},"Sisli Hamidiye Etfal Training and Research Hospital"]