[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aerobic-capacity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aerobic-capacity":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,61,97,135,164,187,219,250,276,304,342],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":60},"100644079","effect-of-cordyceps-supplementation-timing-on-physiological-responses-and-aerobic-adaptation-in-athletes-100644079",false,"NCT07664345","Effect of Cordyceps Supplementation Timing on Physiological Responses and Aerobic Adaptation in Athletes","Optimization of Athlete Recovery: Effects of Cordyceps Supplementation Timing on Inflammatory Response, Oxidative Stress, Muscle Damage, and Aerobic Adaptation Following Acute and Chronic Exercise Training","CORD-RECOV","Inclusion Criteria:\n\n* Male or female participants aged 19-21 years.\n* Students enrolled in the Sport Coaching Education Program (Pendidikan Kepelatihan Olahraga).\n* Apparently healthy and free from known cardiovascular, metabolic, respiratory, neuromuscular, or musculoskeletal disorders that could affect participation in exercise training.\n* Regularly participate in physical exercise at least three times per week during the previous three months.\n* Willing to comply with all study procedures, exercise protocols, supplementation schedules, and assessment sessions.\n* Provide written informed consent before participation.\n\nExclusion Criteria:\n\n* Current injury or musculoskeletal condition that limits participation in exercise training.\n* History of cardiovascular disease, uncontrolled hypertension, diabetes mellitus, respiratory disease, or other medical conditions that may increase exercise-related risk.\n* Use of antioxidant supplements, herbal supplements, ergogenic aids, or anti-inflammatory medications within four weeks prior to study enrollment.\n* Known allergy or hypersensitivity to Cordyceps or any component of the study supplements.\n* Smoking or excessive alcohol consumption during the study period.\n* Failure to comply with supplementation or exercise protocols.\n* Participation in another research study during the study period.\n* Participants presenting acute infection, fever, or inflammatory conditions within two weeks prior to baseline assessment.",true,"MALE","19 Years","21 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","Athletes frequently perform high-intensity exercise to improve physical performance and aerobic capacity. However, such training can induce exercise-induced muscle damage, oxidative stress, and inflammatory responses that may delay recovery and compromise subsequent training adaptations. Optimizing recovery strategies is therefore essential to maintain performance, reduce injury risk, and support long-term athletic development.\n\nCordyceps is a medicinal mushroom that contains several bioactive compounds, including cordycepin and polysaccharides, which have demonstrated antioxidant, anti-inflammatory, and immunomodulatory properties. Although previous studies have reported beneficial effects of Cordyceps supplementation on exercise performance and physiological function, limited evidence exists regarding the optimal timing of supplementation relative to exercise.\n\nThis study aims to investigate the effects of different Cordyceps supplementation timing strategies on physiological responses and aerobic adaptation following acute and chronic exercise training. Participants will be assigned to receive Cordyceps supplementation before exercise, after exercise, or placebo. The study will evaluate biomarkers of inflammation (IL-6), oxidative stress (MDA), muscle damage (CK), aerobic capacity (VO2max), and neuromuscular performance assessed using countermovement jump (CMJ) testing.\n\nThe findings of this study are expected to provide evidence-based recommendations regarding nutritional recovery strategies and supplementation timing to optimize recovery and training adaptation in athletes and physically active individuals.",[29,30,31,32,33],"Exercise Recovery","Exercise-induced Muscle Damage","Oxidative Stress","Sports Performance","Aerobic Capacity",[35,36,37,29,38,39,31,40,41,42,43,44,45,46,47],"Cordyceps","Cordyceps Supplementation","Supplement Timing","Athletic Performance","Sports Nutrition","Inflammation","Creatine Kinase","Interleukin-6","Malondialdehyde","VO2max","Countermovement Jump","VALD ForceDecks","Exercise Adaptation","NOT_YET_RECRUITING","2026-06-17",{"date":51,"type":52},"2026-06-24","ACTUAL",{"date":54,"type":23},"2026-07-01",{"date":56,"type":23},"2026-09-15",{"name":58,"class":59},"Surabaya State University","OTHER",1,{"id":62,"slug":63,"hasResults":11,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":4,"eligibilityCriteria":67,"healthyVolunteers":17,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":24,"phases":73,"briefSummary":74,"conditions":75,"keywords":81,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":60},"100626821","lower-limb-muscle-mass-and-cardiovascular-and-muscular-performance-in-males-and-females-100626821","NCT07440615","Lower-Limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females","The Relationship Between Lower-limb Muscle Mass and Cardiovascular and Muscular Performance in Males and Females.","Inclusion Criteria:\n\n* absent of lower body injuries that could impact testing;\n* were moderately physically active\n* did not ingest ergogenic aids or stimulant drugs for at least 6 months prior to the start of the study.\n\nExclusion Criteria:\n\n\\-","ALL","18 Years","30 Years",{"count":72,"type":23},235,[26],"The aim of this study will be to examine the relationship between leg muscle mass and muscle strength, aerobic capacity, anaerobic power, and jumping performance in young adults. In addition, these physical performance measures will be compared between male and female participants.\n\nRecreationally active young adults will be recruited to participate in the study. Body weight and leg muscle mass will be assessed using a body composition analyzer. Participants will perform isokinetic and isometric leg strength tests, an aerobic fitness test (VO₂max), an anaerobic power test (Wingate), and a countermovement jump (CMJ) test.\n\nThis study aims to improve the understanding of the effects of leg muscle mass on physical performance and to identify possible differences between males and females. The findings are expected to contribute to exercise prescription, performance assessment, and future research in sports and health sciences.",[76,77,78,33,79,80],"Physical Performance","Leg Muscle Mass","Muscle Strength","Anaerobic Power","Jumping Performance in Young Adults",[82,83,84,85,86],"lean mass","isokinetic","isometric","aerobic capacity","force","RECRUITING","2026-06-05",{"date":90,"type":52},"2026-06-09",{"date":92,"type":52},"2026-02-20",{"date":94,"type":23},"2026-08-15",{"name":96,"class":59},"Uludag University",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":17,"sex":68,"minAge":104,"maxAge":69,"enrollmentInfo":105,"targetDuration":4,"studyType":24,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":60},"100638861","individualized-training-to-improve-aerobic-capacity-and-2000-m-rowing-performance-in-youth-rowers-100638861","NCT07602244","Individualized Training to Improve Aerobic Capacity and 2,000 m Rowing Performance in Youth Rowers","Effects of Ventilatory Threshold-Based Individualized Training on Aerobic Capacity and 2,000 m Rowing Performance in Youth Rowers From Valdivia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Active membership in Club de Remeros Arturo Prat of Valdivia.\n* Age between 14 and 18 years.\n* Systematic rowing training of at least 3 sessions per week under technical supervision.\n* Participation in federated competitions or internal selection processes.\n* Medical clearance for intense physical exercise issued by a treating physician or competent institution, such as a pre-participation medical evaluation.\n\nExclusion Criteria:\n\n* History of uncontrolled cardiovascular, respiratory, or metabolic disease that contraindicates intense exercise, such as structural heart disease, clinically significant arrhythmias, or uncontrolled asthma.\n* Acute or chronic musculoskeletal injury that prevents completion of the training program or study assessments.\n* Use of medications that may substantially modify the physiological response to exercise, such as beta-blockers, or declared history of doping.\n* Acute illness at the time of assessment, including fever, infection, or respiratory symptoms.\n* Cognitive, language, or behavioral difficulties that prevent understanding instructions or complying with the study protocol.\n* Simultaneous participation in another exercise intervention study.","14 Years",{"count":106,"type":23},44,[26],"The goal of this randomized clinical trial is to learn whether an individualized rowing training program based on ventilatory thresholds can improve aerobic capacity and 2,000 m rowing performance in youth rowers from Valdivia, Chile. The study will include male and female rowers aged 14 to 18 years who train regularly at Club de Remeros Arturo Prat.\n\nThe main questions it aims to answer are:\n\nDoes ventilatory threshold-based individualized training improve maximal oxygen uptake compared with the usual club training program? Does ventilatory threshold-based individualized training improve 2,000 m rowing ergometer performance compared with the usual club training program?\n\nResearchers will compare an individualized training group with a usual training group to see if prescribing exercise intensity based on each rower's ventilatory thresholds produces greater improvements in aerobic capacity, rowing performance, and related physiological measures.\n\nParticipants will:\n\nComplete baseline and post-intervention assessments, including a cardiopulmonary exercise test on a rowing ergometer, blood lactate measurements during an incremental rowing test, a 2,000 m rowing ergometer test, body composition assessment, and respiratory muscle strength testing.\n\nBe randomly assigned to either an individualized training group or a usual training group.\n\nComplete a 12-week rowing training program. Use heart rate monitors during study training sessions so that training intensity, adherence, and safety can be monitored.\n\nReport any discomfort, injuries, or adverse events during the study.\n\nThe individualized training group will train according to heart rate zones derived from each participant's ventilatory thresholds measured at baseline. The usual training group will continue the club's regular training program. The study will also explore individual variability in training response and the proportion of participants who respond or do not respond to each training approach.",[38,33,110],"Rowing Performance",[112,113,114,115,116,117,44,118,119,120,121,122,123,124,125],"Rowing","Youth Rowers","Youth Athletes","Ventilatory Threshold","Individualized Training","Aerobic Training","2,000 m Rowing Ergometer","Cardiopulmonary Exercise Testing","Blood Lactate","Exercise Performance","Training Response","Interindividual Variability","Responders and Non-Responders","Respiratory Muscle Strength","2026-05-15",{"date":128,"type":52},"2026-05-22",{"date":130,"type":23},"2026-06",{"date":132,"type":23},"2026-10",{"name":134,"class":59},"Universidad San Sebastián",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":17,"sex":68,"minAge":143,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":60},"100496395","shape-test-for-preoperative-risk-stratification-100496395","NCT05743673","SHAPE Test for Preoperative Risk Stratification","A Feasibility Study of the SHAPE™ Test of Aerobic Fitness in Older Adults Presenting for Moderate to High-risk Surgery","SHAPEPAT","Inclusion Criteria:\n\n* Aged \\>60 years\n* Scheduled for pre-surgical evaluation for moderate to high-risk surgical procedure.\n* RCRI \\\u003C2 based on screening of preoperative co-morbidities.\n* Provision of signed and dated informed consent form\n\nExclusion Criteria:\n\n1. Age \\\u003C60 years old\n2. Subjective METS \\\u003C4\n3. Inability to give independent informed consent\n4. Revised Cardiac Risk Index (RCRI) \\>2\n5. Neurological impairment with motor limitations\n6. Mental impairment leading to inability to cooperate\n7. Recent NSTEMI or STEMI type myocardial infarction (within 6 months)\n8. Angina (stable or unstable, within 6 months)\n9. Uncorrected severe valvular heart disease (severe aortic, tricuspid, or mitral stenosis)\n10. Recent exacerbation of congestive heart failure (requiring hospitalization, within 6 months)\n11. Acute pulmonary embolism or deep vein thrombosis (within past 6 months)\n12. Uncontrolled pulmonary edema\n13. Uncontrolled symptomatic arrhythmias\n14. Active endocarditis\n15. Acute myocarditis or pericarditis\n16. Active wheezing or home oxygen use\n17. Recent exacerbation of chronic obstructive pulmonary disease or asthma or pneumonia (requiring hospitalization, within 6 months)\n18. Inability to perform components of the SHAPE test (severe hip flexion limitation, severe osteoarthritis of knee or hip, limb immobilization, ambulation with a walker, can or crutches, baseline balance irregularities\n19. Diagnosis of vertigo\n20. Known allergic reactions to components of the SHAPE medical system apparatus disposable mouthpiece.\n21. Active enrollment in an interventional clinical trial within the enrollment period of the study.","60 Years",{"count":145,"type":23},371,"OBSERVATIONAL","This study is looking at whether a simplified exercise test called the SHAPE-HF cardiopulmonary testing system can be used before surgery in older adults. Doctors often need to know how well a patient's heart, lungs, and body handle physical activity before moderate- to high-risk surgery. This information may help them better understand a patient's fitness for surgery and possible risk of complications afterward.\n\nThe study will enroll adults older than 60 years who are being evaluated before planned moderate- to high-risk noncardiac surgery. The first goal is to determine if this was feasible in older adults and to learn whether patients can be successfully recruited to complete this pre-surgery test. Secondly, the study will also look at how results from the SHAPE-HF system compare with common ways doctors now estimate fitness, such as asking patients about their physical activity and using a standard questionnaire.\n\nParticipants will attend one in-person study visit lasting about 35 minutes. During that visit, they will answer questions about their activity level and complete testing with the SHAPE-HF system. The test uses short periods of lower-intensity exercise to estimate aerobic fitness. After the visit, participants will be contacted by phone about 24 hours later to check for any problems related to the study test.\n\nLastly, researchers will also review information from the medical record for 30 days after surgery to see whether test results are related to recovery, short-term health problems after surgery, or major complications. No extra surgery or change in planned medical care is part of this study. The information learned may help improve how doctors evaluate older adults before surgery in the future.",[149,33],"Perioperative\u002FPostoperative Complications",[151,152,153,154],"perioperative risk stratification","submaximal cardiopulmonary exercise testing","postoperative complications","perioperative complications","2026-04-30",{"date":157,"type":52},"2026-05-07",{"date":159,"type":52},"2023-05-03",{"date":161,"type":23},"2026-05-29",{"name":163,"class":59},"Yale University",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":17,"sex":18,"minAge":171,"maxAge":143,"enrollmentInfo":172,"targetDuration":4,"studyType":24,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":185,"locationsCount":60},"100607952","the-effect-of-lemongrass-on-aerobic-performance-100607952","NCT07195240","The Effect of Lemongrass on Aerobic Performance","The Effect of Lemongrass on Aerobic Performance and Sexual Wellbeing Following High-Intensity Interval Training Training in Males","Inclusion Criteria:\n\n* Age ≥ 40 and ≤ 60 years.\n* Body Mass Index (BMI) ≥ 19 and ≤ 35 kg\u002Fm2.\n* Willingness and ability to comply with the protocol in the opinion of the Investigator.\n* Judged by the Investigator to be in good health as assessed by a health screening questionnaire.\n* Currently identifies as the same biological sex as at birth.\n* Currently deemed to be between a physical activity status of sedentaryy to moderately trained (Meet World Health Organization minimum activity guidelines: Adults aged 18-64 years old completing at least 150 to 300 min moderate-intensity activity or 75-150 min of vigorous-intensity activity a week, plus muscle-strengthening activities 2 or more days a week).\n* Have a blood pressure \\\u003C 140\u002F90 mmHg.\n\nExclusion Criteria:\n\n* A history of heart disease.\n* Any disease that might interfere with the absorption of nutrients (e.g. Chron's disease, celiac disease).\n* Recent musculoskeletal or soft tissue injury (within the last 3 months).\n* The habitual use of medication that is antihypertensive or antidiabetic medication or might inhibit the ability to complete the study participation.\n* Alcohol Intake of greater than 21 units per week.\n* A change in bodyweight of more than 3kg within the month preceding the study.\n* Currently following a weight-loss or weight-gain programme.\n* Any known bleeding disorder or reaction to withdrawal of blood samples","25 Years",{"count":173,"type":23},40,[26],"The goal of this experimental study is to examine the influence of Lemongrass extract on aerobic training parameters following a 6-week training programme in males. A secondary aim will be to explore the influence on sexual wellness. Participants will attend 23 visits to the laboratory involving:\n\n* fitness testing (some to exhaustion).\n* blood sampling (capillary and venous samples).\n* a supervised 6 week high-intensity interval training (HIIT) programme.\n* consuming either the lemongrass extract or placebo in the form of tablets, once a day during the 6 week training.",[177,33,178],"Sexual Wellness","Exercise Efficiency","2026-04-08",{"date":181,"type":52},"2026-04-13",{"date":183,"type":52},"2025-10-24",{"date":130,"type":23},{"name":186,"class":59},"Northumbria University",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":17,"sex":194,"minAge":195,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":24,"phases":198,"briefSummary":201,"conditions":202,"keywords":205,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":60},"100612376","phase-2-effect-of-a-short-term-multi-strain-probiotic-supplementation-in-endurance-athletes-100612376","NCT07252778","Effect of a Short-term Multi-strain Probiotic Supplementation in Endurance Athletes","Effect of a Short-term Multi-strain Probiotic Supplementation on the Exercise- Associated Gastrointestinal Disturbances in Trained Female Athletes Under Controlled Conditions During Professional Training Cycle","Inclusion Criteria:\n\n* belonging to the national rowing team;\n* training experience ≥5 years;\n* a currently issued medical certificate confirming\n* good health and capacity to practice sports;\n* good health without chronic health disorders;\n* written informed consent to participate.\n\nExclusion Criteria:\n\n* injury, any health contraindication or failure to perform exercise procedures;\n* gastrointestinal infections, diseases, disorders;\n* past history of gastrointestinal surgery, and\n* other self-reported gastrointestinal issues;\n* reporting symptoms of infection or taking any medication (e.g. antibiotics) for 4 weeks before the study protocol;\n* current supplementation of prebiotics,\n* probiotics, synbiotics (last 4 weeks);\n* current intake of pharmaceutical agents (e.g., nonsteroidal anti-inflammatory drugs, laxatives, antidiarrhea agents, antacids, and\u002For antiemetics) (last 4 weeks);\n* failure to follow the study protocol;\n* declared general feeling of being unwell;\n* pregnancy or current pregnancy planning.","FEMALE","16 Years","50 Years",{"count":22,"type":23},[199,200],"PHASE2","PHASE3","The aim of this project is to evaluate and identify the effect of a short-term 2-week multi-strain probiotic (MPRO) supplementation on the exercise-associated gastrointestinal (GI) symptoms and perturbations in high level female athletes of the Polish national team during strictly controlled conditions of a training camp, based on recommendations for best practices for probiotic (PRO) research in athletes and assessment of EX-associated GI perturbations.",[39,203,121,33,204],"Biochemical Markers","Supplementation",[206,207,208,112,209],"Probiotics","Gastro-intestinal markers","Microbiota","Females","2025-11-18",{"date":212,"type":52},"2025-11-28",{"date":214,"type":23},"2025-11-20",{"date":216,"type":23},"2027-06-30",{"name":218,"class":59},"Krzysztof Durkalec-Michalski",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":17,"sex":68,"minAge":69,"maxAge":226,"enrollmentInfo":227,"targetDuration":4,"studyType":24,"phases":229,"briefSummary":230,"conditions":231,"keywords":235,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":60},"100603009","molecular-hydrogen-inhalation-effects-on-health-exercise-capacity-and-inflammatory-response---in-vivoin-vitro-studies-100603009","NCT07130942","Molecular Hydrogen Inhalation: Effects on Health, Exercise Capacity and Inflammatory Response - in Vivo\u002Fin Vitro Studies","The Effect of Inhalation Using a Molecular Hydrogen Generator on the Level of Exercise Capacity and Inflammatory Response, Anti-cancer Potential of Human Blood Serum in the Light of in Vivo\u002Fin Vitro Studies","Inclusion Criteria:\n\nThe study will be used purposeful selection of the following criteria:\n\n* age 18-25,\n* not taking medicines during the study,\n* negative history of cardiovascular disorders,\n* negative history of autonomic nervous system disorders,\n* negative history of mental disorders,\n* negative history of cerebrospinal traumas,\n* negative history of other diseases that may directly affect obtained results,\n* good health status (no concurrent injuries),\n* no drugs intake,\n* no supplements consumption,\n\nIn the study as a not training grope age and morphologically appropriate participation will take part. Participants will be recruited basing on a voluntary letter of intent. All representatives of the analysed group participating in the pre-qualification research will fill in the physical activity sheet - Global Health Activity Questionnaire - World Health Organization in Polish adaptation. This will allow to eliminate people who report high levels of physical activity (similar to the level of sport training individuals).\n\nExclusion Criteria:\n\n* taking medicines during the study,\n* history of cardiovascular disorders,\n* history of autonomic nervous system disorders,\n* history of mental disorders,\n* history of cerebrospinal traumas,\n* history of other diseases that may directly affect obtained results,\n* concurrent injuries,\n* drugs intake,\n* supplements consumption.","49 Years",{"count":228,"type":23},250,[26],"Summary To comprehensively address the research aims and explore the state of knowledge of the mechanisms of biochemical response to specific tissue affecting method in form of a molecular hydrogen inhalation and will allow to determine its role on the post-exercise response in form of changes in biochemical markers secretion, expression of selected trophic factors and changes in iron metabolism in this process.\n\nMoreover, this project will try to take into account the role of hepcidin, vitamin D and cfDNA. Additionally, the present project may contribute to the determination of the role of presented inhalation procedure on cells proliferation, as example of anty-tumor proprieties, regulation of the expression of genes related to the stress response (HSF-1, NF-kB, TNF-dependent pathway), muscle cell growth (e.g. myostatin gene), energy pathways (e.g. GAPDH, LDH) and the membrane transport and the hedgehog pathway ls (including Gli1), Hif-1-alpha and NF-kB.\n\n1.1. Primary Objectives\n\n1. Demonstration relationship between post-exercise oxidative stress parameters, and two weeks of daily inhalation with the use of a molecular hydrogen generator.\n2. Indicate of whether and how daily inhalation with the use of a molecular hydrogen generator will affect BDNF and hepcidin, erytropheron (ERFE) and erythropoietin (EPO).\n3. Show how daily inhalation with the use of a molecular hydrogen generator and physical activity procedures effects human serum anti-tumor potential, and is it associated with Vitamin D status and Iron metabolism.\n\n1.2. Secondary Objectives\n\n1. Examine the relationship between two weeks of daily inhalation using a molecular hydrogen generator and the expression of genes related to the stress response (HSF-1, NF-kB, TNF-dependent pathway).\n2. Show the relationship between the expression of genes related to muscle cell growth (e.g. myostatin gene), intracellular metabolism, energy pathways (e.g. GAPDH, LDH) and the effect of molecular hydrogen inhalation?\n3. Show the molecular hydrogen inhalation effects on the expression of genes responsible for membrane transport and the hedgehog pathway in muscle cells (including Gli1), expression of transcription factors: Hif-1-alpha (hypoxia-inducible factor) and NF-kB and selected genes dependent on their activity.\n\n1.3. Hypotheses\n\nIn the project on the basis of current knowledge, the following hypotheses are stated:\n\n1. Daily inhalation with the use of a molecular hydrogen will increase the concentration of BDNF, which will correlate with higher skeletal muscle resistance to damage;\n2. Two week daily inhalation with the molecular hydrogen will increase the concentration of BDNF, which will persist over a longer period compering to a single inhalation with the molecular hydrogen session;\n3. Daily inhalation with the molecular hydrogen and physical activity effects on vitamin D binding protein, megalin, cubilin concentration changes.\n4. Daily inhalation with the molecular hydrogen protects muscles and reduces oxidative stress induced by physical exercise and protects against oxidative stress induced by high Iron concentration (lower inflammation process and cfDNA concentration).\n5. Daily inhalation with the molecular hydrogen effects human serum anti-tumor potential against human LNCaP prostate cancer cells.\n\nIII. Research project methodology In order to achieve the objectives of the study 80 people will be recruited, then randomly divided into two groups: Experimental ((N=40) and Control (N=40). Furthermore, groups will be divided into subgroups to implement the assumptions of one-time and 10-time inhalation with the use of a molecular hydrogen generator on the level of induced muscle damage and the level of maximum anaerobic and aerobic capacity. The whole study will be carried out using the assumptions of the experiment - a blind test (inhalation with normal air but under the use of H2 generator (switched of), and in accordance with the principles of the experiment.\n\nIn the study an experiment based on an ex post facto research plan will be used, due to the lack of manipulation of the grouping variable. Study will be based on comparative analysis and regression analysis. In the independent variable test, the group (non-trainees), variables dependent on molecular hydrogen inhalation and the anaerobic\u002Faerobic performance characteristics, biochemical blood indicators. Minimal (40 people each) sample size was calculated according to Kirby et all (2002) and Kadam and Bhalerao (2010).\n\nIV. The study will consist of twelve parts. For anaerobic power of the lower limbs measurement of double Wingate anaerobic test (WAnT) will be conducted on a cycle ergometer,\n\n* For the measurement of Aerobic Components of Fitness and post-aerobic exercises response Bruce Treadmill Test will be performed.\n* The blood collection for diagnostic tests will be strictly dependent on the requirements of a particular designation,",[232,233,33,79,234],"Physiological Adaptations","Sport Performance","Sport Recovery",[236,237,238,239,240],"molecular hydrogen","anti-cancer potential","inflammatory response","exercise capacity","inhalation","2025-08-18",{"date":243,"type":52},"2025-08-19",{"date":245,"type":23},"2025-10-01",{"date":247,"type":23},"2030-12-31",{"name":249,"class":59},"Gdansk University of Physical Education and Sport",{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":68,"minAge":256,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":260,"conditions":261,"keywords":264,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":60},"100594443","evaluation-of-the-effectiveness-of-physical-exercise-on-aerobic-capacity-in-patients-with-cardiovascular-disease-100594443","NCT07019506","Evaluation of the Effectiveness of Physical Exercise on Aerobic Capacity in Patients With Cardiovascular Disease","Inclusion Criteria:\n\n* Records between 2015 and 2024\n* Men and women, between 35 and 90 years old.\n* Clinical diagnosis of cardiovascular disease.\n* Must be patient from Clínica el Rosario.\n* Participants must have completed a baseline exercise stress test and a post-intervention stress test after the 20 sessions, and must have attended at least 90% of the prescribed sessions\n\nExclusion Criteria:\n\n* Records containing incomplete data","35 Years","90 Years",{"count":259,"type":23},200,"According to the Pan American Health Organization (PAHO), non-communicable chronic diseases-primarily cardiovascular diseases-are the leading cause of death and disability worldwide. These conditions result in long-term health consequences and require significant ongoing treatment and care. Among them, ischemic heart diseases-most notably acute myocardial infarction-are highly prevalent. Globally, cardiovascular diseases are closely linked to physical inactivity as a major modifiable risk factor. In this context, exercise and physical activity have become public health priorities, with international guidelines recommending at least 150 minutes of moderate-intensity activity per week.\n\nIn Colombia, physical exercise is recognized as a key strategy for the prevention and management of non-communicable chronic diseases, as outlined in the national ten-year public health plan. However, evidence shows that few clinical services at the national or regional level consistently monitor or follow up on the proper prescription of exercise as a therapeutic strategy for cardiovascular disease management.\n\nThis study aims to describe the effectiveness of structured physical exercise on the aerobic capacity of patients with cardiovascular disease.",[262,263,33],"Cardiovascular Diseases","Exercise",[265,266,85],"cardiovascula diseases","exercise","2025-07-08",{"date":269,"type":52},"2025-07-11",{"date":271,"type":52},"2025-01-01",{"date":273,"type":23},"2026-08-30",{"name":275,"class":59},"Fundacion Universitaria Maria Cano",{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":4,"eligibilityCriteria":282,"healthyVolunteers":11,"sex":68,"minAge":283,"maxAge":4,"enrollmentInfo":284,"targetDuration":4,"studyType":24,"phases":286,"briefSummary":287,"conditions":288,"keywords":290,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":60},"100589223","optimizing-aerobic-fitness-in-older-adults-100589223","NCT06951620","Optimizing Aerobic Fitness in Older Adults","Optimizing Aerobic Fitness and Functional Response to Exercise in Older Adults","Inclusion Criteria:\n\n* \\>65 years old\n* ambulatory\n* enrolled in CR at our center following a recent clinical diagnosis of myocardial infarction or percutaneous intervention will be recruited\n\nExclusion Criteria:\n\n* have an active malignancy (excluding non-melanoma skin cancer or low grade prostate cancer under surveillance)\n* unwilling to comply with the exercise prescription they may be assigned to\n* have a submaximal performance on entry exercise tolerance test, defined as respiratory exchange ratio \\\u003C1.0","65 Years",{"count":285,"type":23},114,[26],"Hospitalization and treatment for cardiovascular disease is one of the main contributors to disability in older adults. Moderate intensity continuous aerobic and resistance training have been the cornerstone of cardiac rehabilitation (CR) for decades to remediate hospital-acquired functional deficits, but some groups receive less or minimal functional benefit from this training. The proposed studies seek to optimize recovery of aerobic fitness and physical function among older cardiac patients using a novel high intensity training regimen with the long-term goal of reducing subsequent disability and improving clinical outcomes.",[33,289],"High Intensity Interval Training",[291,292,293,294,85],"cardiac rehabilitation","HIIT","MICT","exercise in older adults","2025-06-06",{"date":297,"type":52},"2025-06-08",{"date":299,"type":52},"2025-04-17",{"date":301,"type":23},"2029-06-30",{"name":303,"class":59},"University of Vermont Medical Center",{"id":305,"slug":306,"hasResults":11,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":310,"eligibilityCriteria":311,"healthyVolunteers":11,"sex":68,"minAge":312,"maxAge":104,"enrollmentInfo":313,"targetDuration":4,"studyType":24,"phases":315,"briefSummary":316,"conditions":317,"keywords":327,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":60},"100587090","controlled-evaluation-of-an-exercise-program-for-overweight-adolescents-100587090","NCT06923865","Controlled Evaluation of an Exercise Program for Overweight Adolescents","Now! Project - a Controlled Evaluation of a Physical Activity Program for Adolescents With Overweight","Now!","Inclusion Criteria:\n\n* BMI above the 90th percentile for their age and gender (WHO reference table)\n* Deficits in movement motivation and motor skills\n* No health complaints or movement-restricting conditions\n* No health risks for maximal exertion\n* Ability to verbally communicate pain or discomfort\n* Unremarkable PAR-Q questionnaire\n* Signed parental consent form\n\nExclusion Criteria:\n\n* Acute or chronic illness\n* Inability to follow the study procedures (e.g., language barriers, psychological disorders)","12 Years",{"count":314,"type":23},150,[26],"Physical activity decreases as young people get older, especially during the shift from early to late adolescence. Unfortunately, around 81% of school-aged children worldwide between the ages of 11 and 17 do not meet the recommendation of at least one hour of physical activity per day - and this is also true in Switzerland. Not being active enough, whether normal weight or overweight, can lead to long-term health problems and is a major factor in becoming overweight over time. This results in healthcare costs and negatively affects quality of life. Supporting physical activity in overweight youth requires well-rounded, thoughtful programs.\n\nThe investigators studying the impact of the movement programs now! and now!+ on the physical activity and health of young people. The goal is to look at both physical and mental changes equally.\n\nTaking part in this study involves minimal physical or mental risk for the participants. These small risks from the testing methods and activities are taken into account in how the program is explained and carried out.\n\nThe benefits for the participants - feeling healthier and fitter physically, and more confident and capable mentally - clearly outweigh any potential risks, thanks to the additional, guided, and personalized exercise program.\n\nThe participants take part in the now! and now!+ exercise programs run by the Basel-Stadt Sports Office and the DSBG. now! is a 90-minute group session with up to 14 young people, while now!+ is a 90-minute small-group session with 2 to 4 participants. Both programs take place once a week over a 12-month period and pause during school holidays (38 training weeks in total).\n\nEach session includes a warm-up, a strength or endurance training block, and a coordination phase. The program is modular and adapted to the physical and personal needs of each participant. This ensures that overweight adolescents are not overstrained and don't develop symptoms like pain, frustration, or lack of motivation (Behringer et al., 2011), while still allowing for a training stimulus that supports physical improvement.\n\nThe results of the evaluations are directly used to improve and further develop the exercise program. The overall project includes three rounds, each consisting of one year of training and three test sessions, each lasting about two hours. The now! and now!+ programs are held weekly for a total of 38 weeks per year, with breaks during school holidays.\n\nEach of the three test sessions includes the same set of assessments (see \"Study Intervention\") and follows a set order: The process begins with measuring body size and blood pressure, followed by a static retinal vessel analysis. After these medical checks, participants do a 5-minute warm-up on a stationary bike at a set resistance level. Then, strength tests are performed: knee extension on the IsoMed 2000, handgrip strength, and jump power on the Leonardo force plate. The endurance test using spiroergometry marks the end of the physical assessments.\n\nFinally, impulse control is tested, and participants complete a set of questionnaires. At the end of the session, each participant is given an actigraph (a small motion sensor worn on the body) to track their physical activity over the following seven days.",[318,319,320,321,322,323,324,325,326,33],"Adolescent","Pediatric Obesity","Exercise Therapy","Health Promotion","Program Evaluation","Impulse Control Disorders","Quality of Life","Retinal Vessels","Strength Training Effects",[328,329,330,331,332],"Overweight adolescents","Youth physical activity","Motor performance in children","Impulse control and fitness","training in peer groups","2025-04-04",{"date":335,"type":52},"2025-04-11",{"date":337,"type":23},"2025-06-01",{"date":339,"type":23},"2029-12",{"name":341,"class":59},"University Hospital, Basel, Switzerland",{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":4,"eligibilityCriteria":348,"healthyVolunteers":11,"sex":194,"minAge":69,"maxAge":283,"enrollmentInfo":349,"targetDuration":4,"studyType":146,"phases":4,"briefSummary":350,"conditions":351,"keywords":352,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":4},"100569358","investigation-of-burnout-musculoskeletal-system-and-aerobic-capacity-in-nurses-100569358","NCT06693206","Investigation of Burnout, Musculoskeletal System and Aerobic Capacity in Nurses","Investigation of Burnout, Musculoskeletal System, Physical Performance and Perception of Exercise Benefit \u002F Obstacle and Aerobic Capacity in Nurses","Inclusion Criteria:\n\n* 18-65 years old\n* At least 1 year of experience\n* Nurses not working in the academic field\n\nExclusion Criteria:\n\n* Pregnancy\n* Malignancy\n* Nurses with lower extremity problems",{"count":22,"type":23},"The aim of our study was to evaluate the relationship of aerobic capacity with burnout status, musculoskeletal system, physical performance and exercise benefit\u002Fobstacle perception in nurses, who have an important place in the health profession group, and to bring the results to the literature. Demographic information will be obtained from the participants who volunteered to participate in the study. Burnout, musculoskeletal pain and physical performance will be evaluated with relevant scales and aerobic capacity will be measured with a bicycle ergometer.",[33],[353,85,354],"nurse","burnout","2024-11-15",{"date":357,"type":52},"2024-11-18",{"date":359,"type":23},"2024-11-10",{"date":361,"type":23},"2024-12-20",{"name":363,"class":59},"Firat University"]