[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"aerobic-exercise\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:aerobic-exercise":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,49,82,139,161,201,230,260,289,309,341,364,387,417,443],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100641741","stroke-rehabilitation-through-intensive-exercise-100641741",false,"NCT07650500","Stroke Rehabilitation Through Intensive Exercise","S-THRIVE","Inclusion Criteria:\n\n* Age between 18 and 70 years.\n* History of a first-ever stroke occurring at least 6 months before enrollment.\n* Independence in personal activities of daily living (e.g., dressing, undressing, and using the toilet).\n* Ability to take a few steps indoors without a walking aid and without supervision; use of an orthosis is permitted.\n\nExclusion Criteria:\n\n* Unstable cardiovascular disease or exercise-induced epilepsy.\n* Insufficient cognitive ability to participate in group-based training, including the capacity to understand, follow, and maintain verbal instructions during exercise tasks.\n* Blood pressure \\>140\u002F90 mmHg at the first visit.","ALL","18 Years","70 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn whether combining moderate to high intensity aerobic exercise with constraint-induced movement therapy (CI therapy) can improve walking ability in adults who have had a stroke. The study will also learn if telerehabilitation at home can support long-term recovery after intensive rehabilitation.\n\nThe main questions this study aims to answer are:\n\n* Does moderate to high intensity aerobic exercise before CI therapy improve walking ability, balance and lower extremity function in people with long-lasting gait difficulties after stroke?\n* Does CI therapy alone lead to similar or different improvements in walking ability, balance or lower extremity function?\n* Does telerehabilitation help participants maintain or further improve their function after the intensive rehabilitation period?\n\nResearchers will compare two groups. One group will receive 4 weeks of CI therapy, 5 days per week, plus 20 minutes of moderate-to-high-intensity aerobic exercise before the rehabilitation session on 3 of these days, and the other group will receive 4 weeks of CI therapy, 5 days per week, without preparatory aerobic exercise.\n\nAfter the completion of CI therapy, all participants will be offered an individualized 8-week telerehabilitation program to follow at home. They will use a mobile application to report physical activity and follow instructions for telerehabilitation.\n\nAll participants will complete two assessment visits (about 3 hours each), 1-2 weeks before and 1-2 weeks after CI therapy. They will also complete questionnaires electronically after the telerehabilitation program.\n\nDaily activity will be measured twice during the study: once during a week after the intensive rehabilitation and once during a week after the telerehabilitation program. A small movement sensor worn on the thigh will be used. The sensor is attached with a soft strap or an adhesive patch and is comfortable to wear all day. The sensor shows how much a person walks, stands, or sits in everyday life. It is light, does not disturb normal activities, and only collects movement information for the study. An instruction sheet will be included to make it easy to use.",[27,28,29,30,31,32],"Stroke","Rehabilitation","Rehabilitation Outcome","Aerobic Exercise","Telerehabilitation","Gait Impairment in Stroke Patients",[34,35,36],"Aerobic exercise, stroke rehabilitation, constraint-induced movement therapy","telerehabilitation","gait impairment","NOT_YET_RECRUITING","2026-06-11",{"date":40,"type":41},"2026-06-16","ACTUAL",{"date":43,"type":21},"2026-08-01",{"date":45,"type":21},"2029-06-30",{"name":47,"class":48},"The Swedish School of Sport and Health Sciences","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":17,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100472611","phase-2-modulating-exercise-dosage-to-improve-concussion-recovery-100472611","NCT05434130","Modulating Exercise Dosage to Improve Concussion Recovery","Modulating Exercise Dosage to Improve Concussion Recovery: A Randomized Clinical Trial","MEDIC","Inclusion Criteria:\n\n* 13-18 years of age\n* Post-Concussion Symptom Scale (PCSS) score \\>10 to ensure participants are not recovered by enrollment\n* Concussion diagnosis by a sports medicine physician\n\nExclusion Criteria:\n\n* Pre-existing neurological disorders\n* Exercise contraindications\n* Concussion \\\u003C6 months before enrollment (excluding the current injury)","13 Years",{"count":59,"type":21},216,[61],"PHASE2","Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.",[64,65,30,66,67],"Concussion, Brain","Treatment","Inflammation","Depression, Anxiety",[69,70],"intervention","mild traumatic brain injury","RECRUITING","2026-05-04",{"date":74,"type":41},"2026-05-06",{"date":76,"type":41},"2022-08-05",{"date":78,"type":21},"2027-02-01",{"name":80,"class":48},"University of Colorado, Denver",3,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":89,"minAge":17,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":108,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":138},"100571149","aerobic-exercise-and-its-impact-on-sensory-musculoskeletal-and-psychosocial-aspects-in-migraine-100571149","NCT06716489","Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine","Influence of Aerobic Exercise on Sensory Perception, Musculoskeletal and Psychosocial Alterations in Patients With Migraine","Inclusion Criteria:\n\n* Women aged between 18 and 48 years.\n* Diagnosed with migraine by an experienced neurologist specialized in headaches, following the criteria of the International Classification of Headache Disorders (ICHD).\n* Frequency of headache between 3 and 8 days per month, to ensure adherence to the treatment.\n\nExclusion Criteria:\n\n* Presence of any other type of concurrent headache.\n* Medical conditions affecting sensitivity and autonomic modulation, such as peripheral neuropathies, autonomic disorders, severe neurological diseases, and others.\n* Conditions that prevent physical activity, such as severe musculoskeletal injuries, cardiovascular diseases, or related conditions.\n* Premature ovarian failure.\n* Regular physical exercise in the past year.\n* Body Mass Index (BMI) above 30.0.\n* Smokers or individuals using drugs that interfere with sensitivity and cardiac modulation (e.g., beta-blockers).\n* Abuse of abortive medications.","FEMALE","48 Years",{"count":92,"type":21},100,[24],"Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors. Aerobic exercise is a low-cost, non-pharmacological strategy that has shown potential benefits for migraine management, but its effects on sensory perception and musculoskeletal function are not yet fully understood.\n\nThis randomized controlled trial will investigate the effects of a supervised aerobic exercise program combined with pain neuroscience education compared with an active control condition in women aged 18 to 48 years diagnosed with migraine. Participants will be randomly allocated to either an intervention group, which will perform supervised aerobic exercise three times per week for 16 weeks and receive one session of pain neuroscience education, or a control group, which will receive recommendations for unsupervised physical activity at home.\n\nOutcomes related to migraine-related disability, self-reported symptoms, sensory sensitivity, and musculoskeletal function will be assessed at baseline and after the intervention period. Questionnaires will also be collected at a 6-month follow-up. The results of this study may contribute to the development of accessible and low-risk non-pharmacological treatment strategies for people with migraine.",[96,97,98,99,100,101,102,103,30,104,105,106,107],"Migraine","Migraine Disease","Migraine Disorder","Migraine Disorders, Brain","Headache","Headache (Migraine)","Headache Disorders","Headache Disorders, Primary","Pain Management","Sensory Disorders","Psychosocial Factors","Quality of Life",[109,110,111,112,113,114,115,116,117,118,119,106,120,121,122,123,124,125,126,127,128],"migraine","aerobic exercise","sensory perception","exercise","headache","disability","musculoeskeletal alterations","quality of life","neck pain","cervical pain","Sensory Thresholds","Physical Fitness","Exercise Intervention","Central Sensitization","Physical Therapy","Migraine Management","Non-pharmacological Treatment","Clinical Trial","Headache Relief","sensitization","2026-04-27",{"date":131,"type":41},"2026-04-28",{"date":133,"type":41},"2026-03-03",{"date":135,"type":21},"2028-11-30",{"name":137,"class":48},"University of Sao Paulo",1,{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":22,"phases":148,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":138},"100609585","pilot-study-of-aerobic-exercise-during-immune-checkpoint-inhibitor-therapy-in-early-stage-tnbc-100609585","NCT07216495","Pilot Study of Aerobic Exercise During Immune Checkpoint Inhibitor Therapy in Early-Stage TNBC","Pilot Study of an Aerobic Exercise Intervention During Immune Checkpoint Inhibitor Therapy in Early-stage Triple Negative Breast Cancer","Inclusion Criteria\n\n1. female and male participants 18 years or older and willing to provide Informed Consent\n2. clinical stage 2 or 3 TNBC (estrogen receptor and progesterone receptor ≤ 10% by immunohistochemistry (IHC) and human epidermal growth factor-2 (HER2) negative (IHC 0, IHC1+, or IHC 2+ with negative fluorescence in situ hybridization))\n3. Physically able to walk independently without assistive device and able to march in place for 30 seconds without assistive device\n4. Eastern Co-Operative Oncology Group (ECOG) Performance Status 0-1\n5. Planned receipt of neoadjuvant chemoICI therapy (carboplatin\u002Ftaxane in combination with pembrolizumab; taxane options are weekly paclitaxel or every 3 week docetaxel)\n6. clearance to participate in the study by the patient's medical oncologist\n7. normal bone marrow function\n8. able to read\u002Fcomplete study forms\u002Fassessments and understand instructions in English\n\nExclusion criteria:\n\na) Any physical condition which hinders the ability to safely participate in exercise including: uncontrolled or symptomatic cardiac\u002Frespiratory disease (e.g. uncontrolled angina, unusual shortness of breath, congestive heart failure, symptomatic peripheral vascular disease), stroke\u002Fmyocardial infarction in the past year, fragility fracture, recent or planned orthopedic surgery, or any comorbid condition precluding exercise per the treating physician b) receipt of medications known to influence immune function including corticosteroids (\\>10 mg prednisone equivalent), other immune-suppressive medication, or beta blockers47 c) Any infection or vaccination within the last 4 weeks d) e) Known HIV-positive participants on combination antiretroviral therapy f) concurrent participation in a therapeutic clinical trial or other exercise program g) pregnant h) medically advised to not exercise i) Unable to walk on a motor-driven treadmill for \\~30 minutes at study enrollment j) Adults unable to consent k) No external catheters\u002Fdrains (e.g., nephrostomy tube, foley catheter). A colostomy or Ileostomy is acceptable.\n\nl) Prior or concurrent non-breast malignancy. Those with prior cancers treated with curative intent are eligible. Participants with known (or history) of hepatitis B positive, or hepatitis C positive infection",{"count":147,"type":21},33,[24],"To learn if participating in a supervised exercise program can help participants with early-stage TNBC who are receiving ICI therapy before undergoing breast surgery.",[30,151],"Early Stage Triple Negative Breast Cancer","2026-04-14",{"date":154,"type":41},"2026-04-15",{"date":156,"type":41},"2026-02-23",{"date":158,"type":21},"2030-10-30",{"name":160,"class":48},"M.D. Anderson Cancer Center",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":169,"sex":16,"minAge":170,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":22,"phases":174,"briefSummary":175,"conditions":176,"keywords":185,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":138},"100631596","pain-in-aging-former-athletes-masters-athletes-and-nonathletes-100631596","NCT07502742","Pain in Aging Former Athletes, Master's Athletes, and Nonathletes","Pain in Athletes INtervention (PAIN): A Randomized Crossover Clinical Trial in Aging Former Athletes, Master's Athletes, and Nonathletes","PAIN","Inclusion Criteria (General):\n\n* Age: 35 years through 65 years\n* Current master's athlete, former competitive athletes, or non-athlete control (see details below)\n* Ability to participate in exercise and exercise testing based on the Physical Activity Readiness Questionnaire (PAR-Q+)\n\nExclusion Criteria (General):\n\n* Currently pregnant or planning to become pregnant during the study\n* Currently taking heart rate lowering medications (e.g., betablockers) that would impact exercise testing\n* Contraindications to ice such as Raynaud's, cryoglobulinemia, cold urticaria, and\u002For impaired circulation or sensation\n* Fibromyalgia and\u002For chronic regional pain syndrome (CRPS)\n* Myocardial infarction or pulmonary embolism in the last 12 months, active cancer, a pacemaker, or any additional condition or disease that would preclude the individual from being able to perform the tests safely\n\nParticipants will be enrolled into one of the following three mutually exclusive groups according to the following criteria:\n\n1. Former Competitive Athlete: Prior participation in competitive sports at the Tier 3 level or above as per McKay et al. (2022): i.e., \"national-level representatives who are performing structured and\u002For periodized training and are developing proficiency in skills required to perform their sport at the highest level; this tier includes individuals participating in Provincial\u002FState or Academy Programs\" or higher participation in sport; Not currently participating in any recreational or competitive sports over the last 5 years (Tier 2 or above)\n2. Master's Athlete: Currently (within the past year) participating in sports at the Tier 2 level or above (i.e., committed to sports-specific training at least 3 times per week with the intent to compete)(McKay et al., 2022)\n3. Nonathlete Control: No prior participation in sport at the Tier 3 (Highly Trained\u002FNational) Level or above and not currently participating in any competitive sports (i.e., Tier 2 or above) (McKay et al., 2022) for at least 5 years",true,"35 Years","65 Years",{"count":173,"type":21},90,[24],"The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus aerobic) compared with both current master's athletes and nonathletes.\n\nThe main questions this study aims to address are:\n\n1. How do former athletes, master's athletes, and nonathletes experience pain?\n2. How do different types of moderate-intensity exercise (strength versus aerobic exercise) influence pain in former athletes, master's athletes, and nonathletes?\n\nParticipants will complete 3 different testing sessions:\n\n1. Baseline testing including assessments of strength, cardiorespiratory fitness, and pain;\n2. Strength exercise: pain assessments will occur before and after moderate-intensity strength training exercise;\n3. Aerobic exercise: pain assessments will occur before and after moderate-intensity aerobic exercise.\n\nThere will be a washout period of approximately one week or greater between each of the three different testing sessions. The order of conditions (strength versus aerobic exercise) will be randomized (crossover randomized trial design).",[177,104,178,179,180,181,30,182,183,107,184],"Pain","Athlete","Exercise Training","Sports Medicine","Strength Training Effects","Strength Training","Aging","Sports",[186,187,177,188,189,190,28,183,191],"Former Athlete","Master's Athlete","Quantitative Sensory Testing","Randomized Crossover Clinical Trial","Exercise","Sport","2026-03-27",{"date":194,"type":41},"2026-03-31",{"date":196,"type":41},"2026-03-02",{"date":198,"type":21},"2028-05",{"name":200,"class":48},"Marquette University",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":11,"sex":16,"minAge":208,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":22,"phases":210,"briefSummary":211,"conditions":212,"keywords":216,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":138},"100629045","effects-of-an-aerobic-exercise-program-on-cardiovascular-risk-in-patients-with-chronic-kidney-disease-or-rheumatoid-arthritis-100629045","NCT07469540","Effects of an Aerobic Exercise Program on Cardiovascular Risk in Patients With Chronic Kidney Disease or Rheumatoid Arthritis","PARCA","Inclusion Criteria:\n\n* Diagnosis of Chronic Kidney Disease (CKD) or Rheumatoid Arthritis (RA), with no other risk factors related to the disease.\n* Having a glomerular filtration rate between 45 and 20 ml\u002Fmin\u002F1.73 m², corresponding to stages III and IV not on dialysis for patients with CKD ; or have a DAS 28 score ≥ 2.6 points for patients with RA.\n* Have a medical certificate stating that there are no adverse reactions to physical activity.\n* Affiliation with a French social security scheme or beneficiary of such a scheme.\n\nExclusion Criteria:\n\n* Unstabilised corticosteroid therapy and\u002For \\>10mg prednisone\u002Fday\n* Uncontrolled high blood pressure\n* Pregnant women\n* Impaired higher functions making it impossible to understand and adhere to an aerobic exercise program\n* Inability to perform physical exercise, regardless of the cause (neurological, central or peripheral, cardiovascular or respiratory, or musculoskeletal)\n* Legal incapacity or limited legal capacity\n* Subject unlikely to cooperate with the study and\u002For low cooperation anticipated by the investigator\n* Subject without health insurance\n* Subject is in the exclusion period of another study involving human subjects that may interfere with the results of this study, particularly by affecting inflammatory status and the cardiovascular system.","50 Years",{"count":173,"type":21},[24],"The goal of this clinical trial is to determine whether an aerobic exercise program can reduce cardiovascular risk in patients with systemic inflammation, such as those with rheumatoid arthritis and chronic kidney disease.\n\nThe main questions this study aims to address are:\n\n* Does an individualized aerobic exercise program reduce cardiovascular risk, as assessed arterial stiffness and endothelial function ?\n* What are the effects of this exercise program on inflammation and immunosenescence?\n\nResearchers will compare an individualized aerobic exercise program with a therapeutic education program (consisting of educational phone calls only) and a control group with no intervention.\n\nParticipants will:\n\n* Perform three physical activity sessions per week for six weeks (45-minute sessions at 60-80% of heart rate reserve);\n* Attend clinic visits at baseline, after the 6-week intervention, and at a 6-week follow-up after the intervention;\n* Undergo assessments including pulse wave velocity, hyperemic reactivity, and blood analyses.",[30,213,214,215],"Rhumatoid Arthisis","Chronic Kidney Disease","Cardiovascular (CV) Risk",[217,218,219,220],"Systemic Inflammation","Arterial Stiffness","Hyperemic reactivity","Blood analyses","2026-03-10",{"date":223,"type":41},"2026-03-13",{"date":225,"type":21},"2026-03-16",{"date":227,"type":21},"2026-12-31",{"name":229,"class":48},"Jérôme Bouchan",{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":16,"minAge":170,"maxAge":238,"enrollmentInfo":239,"targetDuration":4,"studyType":22,"phases":241,"briefSummary":242,"conditions":243,"keywords":247,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":138},"100527811","mind-foods-and-aerobic-training-in-black-adults-with-htn-100527811","NCT06152614","MIND Foods and Aerobic Training in Black Adults With HTN","MIND Foods and Aerobic Training in Black Adults With HTN: An ADRD Prevention Pilot RCT","MAT","Inclusion Criteria:\n\n1. Fluent in English\n2. Marion County resident\n3. 35-75 years\n4. Self-identified non-Hispanic and Black\u002FAfrican-American\u002Fbiracial including African-American\n5. Systolic BP of ≥140 in prior 12 months from a primary care visit\n6. Ability to see and read street signs (self report)\n7. Stable housing with independent access to kitchen, including functional stove or hotplate, oven, refrigerator, and freezer (self report)\n8. Activity independence per functional activities questionnaire (FAQ; \\\u003C3 responses of \"Require Assistance\" and 0 responses of \"Dependent\")\n9. Normal cognition per six-item screener (SIS; score of ≥ 5)\n10. Less than 20min on usual day of moderate or vigorous physical activity\n11. Able to exercise safely per abbreviated Exercise Assessment for You (EASY) or primary care provider clearance\n12. Mean systolic BP of ≥130 from 3 standard BP measurements taken by research staff following standardized wait periods.\n\nExclusion Criteria:\n\n1. lives in nursing home\n2. diagnosis of dementia or Alzheimer disease or mild cognitive impairment; Parkinson disease; brain tumor\u002Finfection\u002Fsurgery (within the last 10 years with residual symptoms and\u002For functional loss\u002Fdeficit, such as impaired learning, memory, or communication); cancer with short life expectancy, or current chemotherapy or radiation therapy; psychosis, schizophrenia, or bipolar disorder\n3. ICD 10 code I11\u002Fhypertensive heart disease, ICD 10 code I12\u002Fhypertensive CKD, ICD 10 code I13\u002Fhypertensive heart disease and CKD, ICD 10 code I15, or ICD 10 code I16\n4. current or past prescription of donepezil, memantine, rivastigmine, or galantamine\n5. alcohol consumption ≥ 8 drinks per week for women, or ≥15 drinks per week for men\n6. drug use\u002Fabuse (excluding marijuana) per EMR\n7. moving out of area during study timeline\n8. scheduling conflicts with intervention schedule\n9. unwilling to use a touchscreen\n10. unwilling to be on video conferencing\n11. low communicative ability, functional status, or other disorders (examiner rated) that would interfere with interventions and assessments\n12. unable to provide informed consent\n13. participation in any lifestyle modification\u002Fweight loss program (e.g., Weight Watchers, etc.)","75 Years",{"count":240,"type":21},128,[24],"The goal of this randomized controlled trial is to determine the impact of Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) diet and aerobic training on cognition in Black adults with high systolic blood pressure.\n\nResearchers will compare Food Delivery and Cooking PLUS Aerobic Training (FoRKS+) versus Enhanced Usual Care (EUC) to evaluate the effects on cognition.\n\nParticipants will complete cognitive and cardiovascular assessments, 24-hr blood pressure monitoring, standard blood pressure measurements, weight, fingerstick for HbA1c point-of-care testing, and questionnaires.\n\nParticipants may also choose to participate in an optional blood draw for DNA Repair Capacity testing as a modifiable risk factor for aging-associated diseases.",[244,245,246,30],"Cognitive Decline","Hypertension","Diet",[248,249,112,250],"nutrition","cooking","hypertension","2026-02-03",{"date":253,"type":41},"2026-02-05",{"date":255,"type":41},"2023-11-28",{"date":257,"type":21},"2028-05-31",{"name":259,"class":48},"Indiana University",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":89,"minAge":17,"maxAge":267,"enrollmentInfo":268,"targetDuration":4,"studyType":22,"phases":270,"briefSummary":271,"conditions":272,"keywords":276,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":138},"100598384","combined-upper-extremity-resistance-and-aerobic-exercise-training-in-patients-with-breast-cancer-100598384","NCT07070791","Combined Upper Extremity Resistance and Aerobic Exercise Training in Patients With Breast Cancer","Investigation of the Effect of Combined Upper Extremity Resistance and Aerobic Exercise Training on Arm Exercise Capacity, Peripheral Muscle Strength and Arm Functionality in Patients With Breast Cancer","Inclusion Criteria:\n\n* To be between 18-80 years old,\n* Volunteering to participate in the research,\n* At least 15 months after breast cancer surgery,\n* No problems in reading and\u002For understanding the scales and being able to co-operate with the tests.\n* Physically inactive (60 minutes of structured exercise per week \\\u003C).\n\nExclusion Criteria:\n\n* Presence of active infection,\n* Presence of bilateral breast cancer,\n* History of surgical, neurological or orthopaedic problems that may affect upper extremity functionality other than breast cancer surgery,\n* Having a neurological disease or other clinical diagnosis that may affect cognitive status,\n* Musculoskeletal and neurological disease that may affect exercise performance, symptomatic heart disease, previous lung surgery and malignant disease.\n* Presence of unstable hypertension or diabetes mellitus.","80 Years",{"count":269,"type":21},40,[24],"According to updated data from the International Agency for Research on Cancer (IARC) for 2022, breast cancer in women is responsible for one in four cancer cases and one in six cancer deaths worldwide and is the second leading cause of global cancer incidence, accounting for 11.6% of all cancer cases, and the fourth leading cause of cancer deaths worldwide, accounting for 6.9% of all cancer deaths. During or after breast cancer treatments, there is exposure to a variety of direct (local\u002Fregional treatment, systemic treatment and supportive care) and indirect factors (modifiable and non-modifiable risk factors) that may have adverse effects on treatment-related haematological, cardiovascular, pulmonary and musculoskeletal components. Upper limb dysfunction and lymphoedema have been reported to be two of the most common side effects affecting the quality of life of breast cancer patients after breast cancer treatments. The elastic resistance band, which is widely used in strength training, has the advantage of being applied to various classes because it provides resistance angles in various postures and has a low risk of injury. However, few studies have been conducted on elastic resistance band application in patients with breast cancer. At the same time, evidence on the effectiveness of upper extremity aerobic exercise training in patients with breast cancer is limited. Therefore, this study aimed to investigate the effects of upper extremity aerobic exercise training combined with progressive resistance training and upper extremity aerobic exercise training alone on upper extremity exercise capacity, upper extremity functionality, sarcopenia, frailty, quality of life and lymphedema in patients with breast cancer.",[273,274,275,30],"Breast Cancer","Upper Extremity","Resistance Exercise",[277,274,278,279],"breast cancer","resistance exercise training","Aerobic exercise training","2025-12-25",{"date":282,"type":41},"2025-12-29",{"date":284,"type":41},"2025-07-08",{"date":286,"type":21},"2026-07-01",{"name":288,"class":48},"Hacettepe University",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":11,"sex":89,"minAge":296,"maxAge":297,"enrollmentInfo":298,"targetDuration":4,"studyType":22,"phases":300,"briefSummary":301,"conditions":302,"keywords":303,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":304,"startDateStruct":305,"completionDateStruct":306,"leadSponsor":308,"locationsCount":138},"100598383","arterial-stiffness-in-individuals-with-breast-cancer-100598383","NCT07070778","Arterial Stiffness in Individuals With Breast Cancer","The Effect of Upper Extremity Aerobic Exercise Training on Arterial Stiffness in Individuals With Breast Cancer","Inclusion Criteria:\n\n* To be between the ages of 40-69,\n* Baseline left ventricular ejection fraction (LVEF) \\>50%,\n* Absence of coronary artery disease and haemodynamically significant valvular heart disease,\n* Absence of carotid atherosclerotic plaques,\n* Volunteering to participate in the research,\n* At least 15 months after breast cancer surgery,\n* No problems in reading and\u002For understanding the scales and being able to co-operate with the tests.\n* Physically inactive (60 minutes of structured exercise per week \\\u003C).\n\nExclusion Criteria:\n\n* Presence of active infection,\n* Presence of bilateral breast cancer,\n* History of surgical, neurological or orthopaedic problems that may affect upper extremity functionality other than breast cancer surgery,\n* Having a neurological disease or other clinical diagnosis that may affect cognitive status,\n* Left ventricular dysfunction and severe liver and kidney dysfunction before starting chemotherapy\n* Musculoskeletal and neurological disease that may affect exercise performance, symptomatic heart disease, previous lung surgery and malignant disease.\n* Presence of unstable hypertension or diabetes mellitus.","40 Years","69 Years",{"count":299,"type":21},18,[24],"The aim of this study was to evaluate vascular toxicity induced by anthracyclines and other anticancer drugs and to measure arterial stiffness in women with breast cancer and, in addition, to evaluate the acute and chronic arterial stiffness responses of upper extremity aerobic exercise training.",[30,273,218],[277,279,218],{"date":282,"type":41},{"date":284,"type":41},{"date":307,"type":21},"2026-12-01",{"name":288,"class":48},{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":316,"targetDuration":4,"studyType":22,"phases":318,"briefSummary":319,"conditions":320,"keywords":324,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":138},"100593106","whole-body-vibration-therapy-in-individuals-with-type-2-diabetes-100593106","NCT07002125","Whole Body Vibration Therapy in Individuals With Type 2 Diabetes","The Effect of Whole Body Vibration Therapy on Muscle Oxygenation in Individuals With Type 2 Diabetes: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Volunteering to participate in the research\n* Being diagnosed with type 2 diabetes\n* 18 years of age or older\n* HbA1c level to be 6.5-10%\n* Having a clinical history of diabetes between 2-10 years\n* Receiving oral hypoglycemic agent treatment\n* At least three HbA1c measurements within 12 to 24 months\n* Hemoglobin variability score (HVS) \\\u003C50\n* Being able to walk independently\n* Mini mental test score ≥ 24\n* Vastus lateralis muscle adipose tissue thickness \\\u003C20mm\n* BMI \\\u003C30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Previous or concurrent psychiatric, neurological, orthopedic or systemic illness\n* Use of insulin in treatment\n* Diabetic neuropathy\n* Foot ulcer\n* Participation in any exercise program in the last 6 months\n* History of major hypoglycemia in the last 12 months\n* Working or have worked in a job with high exposure to mechanical whole body vibrations\n* Conditions that may contraindicate whole body vibration (deep vein thrombosis, severe osteoporosis, active cancer, implanted medical devices, etc.)\n* Hearing, vision and perception problems that may affect research results",{"count":317,"type":21},20,[24],"The aim of this interventional study is to investigate the effect of whole body vibration therapy on muscle oxygenation, vibration sensation, functional capacity and balance in individuals with Type 2 diabetes.\n\nThe main questions aimed to be answered are:\n\n* Does whole body vibration therapy affect peripheral muscle oxygenation?\n* Does whole body vibration therapy improve vibration sense, functional capacity and balance compared to aerobic exercise? Participants' muscle oxygenation, vibration sensation, functional capacity and balance parameters will be assessed. They will participate in a whole body vibration therapy or aerobic training program.",[321,322,323,30],"Type 2 Diabetes","Whole Body Vibration","Muscle Oxygenation",[325,326,327,328,329,330,331],"Aerobic exercise","diapason","balance","HbA1c","type 2 diabetes","whole body vibration","muscle oxygenation","2025-08-25",{"date":334,"type":41},"2025-08-26",{"date":336,"type":41},"2025-08-01",{"date":338,"type":21},"2025-12-31",{"name":340,"class":48},"Ankara Medipol University",{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":169,"sex":16,"minAge":17,"maxAge":348,"enrollmentInfo":349,"targetDuration":4,"studyType":22,"phases":350,"briefSummary":351,"conditions":352,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":138},"100541531","square-step-exercises-in-healthy-young-adults-100541531","NCT06331078","Square Step Exercises in Healthy Young Adults","Comparison of the Effects of Square Step Exercises and Aerobic Exercise on Cognitive Functions and Physical Fitness in Healthy Young Adults","Inclusion Criteria:\n\n* International Physical Activity Questionnaire score \\\u003C600 Metabolic Equivalents (METs),\n* No neurological or orthopedic problems affecting gait, balance and lower extremities\n* No vision or hearing problems, and no history of musculoskeletal surgery.\n\nExclusion Criteria:\n\n* Participants who have pain due to a musculoskeletal problem\n* Participants who are continuing another routine exercise program","30 Years",{"count":20,"type":21},[24],"This study aims to compare the effectiveness of Square Stepping Exercise and aerobic exercise on cognitive function and physical fitness in young adults. Participants aged 18-30 with low physical activity levels will be randomly assigned to either the Square Stepping Exercise Group or Aerobic Exercise Group. Both interventions will be supervised by a physiotherapist, performed twice a week for 40 minutes over 4 weeks. Cognitive function will be assessed using various tests, including attention, short-term memory, and executive function evaluations. Physical fitness will be evaluated through jump tests and balance assessments. Blinded assessors will conduct evaluations at baseline and post-intervention in both groups to determine the impact of square stepping exercise and aerobic exercise on cognitive and physical health in young adults.",[190,353,30,354,120],"Square Step Exercises","Cognitive Function","2025-08-14",{"date":357,"type":41},"2025-08-19",{"date":359,"type":21},"2025-12-01",{"date":361,"type":21},"2027-12-01",{"name":363,"class":48},"Fenerbahce University",{"id":365,"slug":366,"hasResults":11,"nctId":367,"briefTitle":368,"officialTitle":369,"acronym":4,"eligibilityCriteria":370,"healthyVolunteers":169,"sex":16,"minAge":171,"maxAge":4,"enrollmentInfo":371,"targetDuration":4,"studyType":22,"phases":372,"briefSummary":373,"conditions":374,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":4},"100591429","comparing-music-supported-and-traditional-aerobic-training-in-geriatric-health-outcomes-100591429","NCT06980311","Comparing Music-Supported and Traditional Aerobic Training in Geriatric Health Outcomes","Comparison of the Effects of Music Therapy-Based Aerobic Exercise and Traditional Aerobic Exercise Training on Cardiopulmonary Functions, Functional Capacity, Balance, Peripheral Muscle Strength, Cognitive Functions, Depression, and Quality of Life in Geriatrics","Inclusion Criteria:\n\n* Being 65 years of age or older\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Presence of uncontrolled hypertension (≥180\u002F110 mmHg) or severe complications of diabetes (e.g., diabetic neuropathy, proliferative retinopathy, uncontrolled hypoglycemic episodes)\n* Presence of respiratory diseases such as Chronic Obstructive Pulmonary Disease (COPD), asthma, etc.\n* Presence of chronic neurological disorders such as Multiple Sclerosis (MS), Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), etc.\n* Diagnosis of any oncological disease\n* Presence of acute musculoskeletal conditions that would prevent participation in exercise (e.g., fracture, advanced osteoarthritis, severe musculoskeletal injuries)\n* Having undergone any surgical operation within the past 6 months\n* Presence of visual or auditory impairments that could interfere with the assessment procedures\n* A score of ≤24 on the Mini-Mental State Examination (MMSE), indicating cognitive impairment\n* Participation in a regular exercise program within the last six months",{"count":147,"type":21},[24],"The aim of this study is to comparatively evaluate the effects of a music therapy-based aerobic exercise program and traditional aerobic exercise training on cardiopulmonary functions, functional capacity, balance, peripheral muscle strength, cognitive functions, depression level and quality of life in geriatric individuals.",[375,30,376,377],"Geriatric","Music Therapy","Physiotherapy and Rehabilitation","2025-05-17",{"date":380,"type":41},"2025-05-20",{"date":382,"type":21},"2025-06-01",{"date":384,"type":21},"2027-06-01",{"name":386,"class":48},"Bezmialem Vakif University",{"id":388,"slug":389,"hasResults":11,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":4,"eligibilityCriteria":393,"healthyVolunteers":169,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":394,"targetDuration":4,"studyType":22,"phases":396,"briefSummary":397,"conditions":398,"keywords":401,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":411,"completionDateStruct":413,"leadSponsor":415,"locationsCount":138},"100576654","effect-of-aerobic-exercise-with-synchronous-music-on-functions-among-medical-students-100576654","NCT06788106","Effect of Aerobic Exercise With Synchronous Music on Functions Among Medical Students","Effect of Different Aerobic Exercise Intensities With Synchronous Music on Psychophysiological, Attentional, Executive Functions and Brain Functional Connectivity Among Medical Students in Jiangsu Province, China","Inclusion Criteria:\n\n* Medical students willing to participate in aerobic training\n* Population of low questionnaire evaluation results\n* Subjects achieved a result of 7met or more on the Treadmill Test using the Bruce protocol\n* The medical students with low to moderate physical activity level. They are able to exercise, once or twice per week, but are not in the habit of doing so daily\n\nExclusion Criteria:\n\n* History of major depressive disorder in the past 6 months\n* Have a history of alcohol, drug abuse or use of psychiatric drugs\n* Have a history of head trauma, neurological disease or other serious illness",{"count":395,"type":21},134,[24],"Researchers invite participants to volunteer to participate in this cross-sectional, interventional study. This research examines the effects of 8-week aerobic exercise of different intensities combining synchronized music on psychology, attention, and executive function among Chinese college students, and also validates the reliability and validity of the Chinese version of Brief College Student Hassles Scale, the Perceived Stress Scale for Medical Students, Brief Multidimensional Students'Life Satisfaction Scale, Positive Thinking Skills Scale, Attentional Function Index, Procrastination Assessment Scale-Student and Behavioral Assessment of the Dysexecutive Syndrome-College version, providing a research basis for aerobic exercise to improve the cognitive function and mental health level of Chinese college students. Participants will be invited to participate in the intervention study, in which participants will be assigned to the intervention group and control group. Participation in this study will last approximately 8 weeks for a total of 24 sessions, 40 minutes each session, and participants will not be forced to participate in this study if they do not wish to. This study will include up to 134 participants who will be assigned to the intervention and control groups in a randomized manner.",[399,30,400],"Psychological Stress","Medical Students",[402,403,404,405,406,407],"medical students","mental health","psychophysiological function","attentional function","executive funcion","brain functional connectivity","2025-03-24",{"date":410,"type":41},"2025-03-26",{"date":412,"type":41},"2025-02-26",{"date":414,"type":21},"2025-12-21",{"name":416,"class":48},"Universiti Sains Malaysia",{"id":418,"slug":419,"hasResults":11,"nctId":420,"briefTitle":421,"officialTitle":421,"acronym":422,"eligibilityCriteria":423,"healthyVolunteers":169,"sex":16,"minAge":17,"maxAge":424,"enrollmentInfo":425,"targetDuration":4,"studyType":22,"phases":427,"briefSummary":428,"conditions":429,"keywords":431,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":437,"completionDateStruct":439,"leadSponsor":441,"locationsCount":138},"100428650","the-role-of-the-time-of-day-in-the-effects-of-exercise-on-memory-in-heathy-young-adults-100428650","NCT04861818","The Role of the Time of Day in the Effects of Exercise on Memory in Heathy Young Adults","TEEMY","Inclusion Criteria:\n\n* Between the ages of 18-25.\n* Currently meeting the American College of Sports Medicine's recommended guidelines of activity (at least 90 min\u002Fweek of moderate and\u002For vigorous physical activity).\n* Willing to participate for 4 days (2 visits) and refrain from exercise outside of the lab for 4 days (1 day before and the day of two visits).\n\nExclusion Criteria:\n\n* Any known history of cardiac, pulmonary, or metabolic disease (e.g. cardiovascular disease, asthma, diabetes).\n* A current musculoskeletal injury, mental illness (e.g., depression, anxiety, or stress disorders), or sleep disorder.","25 Years",{"count":426,"type":21},80,[24],"Cumulative evidence indicates that a single bout of exercise has beneficial impacts on memory in young adults. From a physiological perspective, acute exercise leads to changes of heart rate variability (HRV), which is associated with memory retrieval process. From a psychological perspective, acute exercise increases the arousal level and thus facilitates cognitive processing including memory storage and retrieval. Such HRV- and\u002For arousal-based effects of exercise on memory could be differed by the time of day in young adults based on their circadian rhythms of HRV. Moreover, young adults prefer afternoon or evening to morning in their circadian rhythms, demonstrating less wakefulness and lower memory performance in the morning relative to afternoon. Based on the potential psychophysiological mechanisms, exercise could impact young adults' memory differently by the time of day. The investigators aim to 1) determine the extent to which the time of day modulates how moderate-intensity cardiovascular exercise impacts verbal-auditory and visuospatial short- and long-term memory in young adults, and 2) consider potential psychological and physiological markers that may mediate exercise's effects on cognitive performance. As cognitive benefits of exercise might differ by the time of day, it is important to investigate such interaction and make the right recommendations of the timing of exercise for young adults in academic settings.",[30,430],"Cognitive Change",[325,432,433],"Physical activity","Cognition","2024-12-12",{"date":436,"type":41},"2024-12-17",{"date":438,"type":41},"2021-06-21",{"date":440,"type":21},"2025-12-30",{"name":442,"class":48},"University of North Carolina, Greensboro",{"id":444,"slug":445,"hasResults":11,"nctId":446,"briefTitle":447,"officialTitle":447,"acronym":448,"eligibilityCriteria":449,"healthyVolunteers":11,"sex":16,"minAge":450,"maxAge":4,"enrollmentInfo":451,"targetDuration":4,"studyType":452,"phases":4,"briefSummary":453,"conditions":454,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":4},"100552419","tailoring-upper-limb-exercise-advice-for-people-with-parkinson-disease-100552419","NCT06472843","Tailoring Upper Limb Exercise Advice for People With Parkinson Disease","ICEBERG","Inclusion Criteria:\n\n* Adults over 19 with a clinical diagnosis of PD.\n\nExclusion Criteria:\n\n* Medical contraindication to aerobic exercise, such as unstable cardiovascular disease, or physical disability that precludes arm exercise.\n* Individuals will be excluded if, upon screening with the Canadian Society for Exercise Physiology (CSEP) Get Active Questionnaire and International Physical Activity Questionnaire Short Form (IPAQ-SF) a need for further evaluation before exercise is identified","19 Years",{"count":317,"type":21},"OBSERVATIONAL","The investigators will explore the impact of hand cycling, on hand function in people with Parkinson's Disease (PD). The study will compare the effects of two different hand cycling approaches-steady-state and interval efforts-on improving hand dexterity in people with PD. Conducted as a clinical trial, it aims to understand if a single session of hand cycling can temporarily enhance hand function and if the nature of the exercise influences the benefit.",[455,456,30],"Parkinson Disease","Upper Limb","2024-06-18",{"date":459,"type":41},"2024-06-25",{"date":461,"type":21},"2024-07-01",{"date":463,"type":21},"2024-09",{"name":465,"class":48},"University of British Columbia"]