[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"age-related-impaired-alveolar-epithelial-repair\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:age-related-impaired-alveolar-epithelial-repair":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":5},"100602885","rspo3sdc-1-pathway-dysfunction-in-alveolar-repair-after-ards-in-older-adults-100602885",false,"NCT07129330","RSPO3\u002FSDC-1 Pathway Dysfunction in Alveolar Repair After ARDS in Older Adults","Role and Mechanisms of RSPO3\u002FSDC-1 Pathway Dysregulation in Impaired Alveolar Epithelial Repair Post-ARDS in Older Adults","Inclusion Criteria:\n\nClinical diagnosis of acute respiratory distress syndrome (ARDS) according to the Berlin Definition Age ≥ 65 years at enrollment First diagnosis of ARDS made within 24 hours prior to study entry Receiving either spontaneous (non-invasive) breathing support or invasive mechanical ventilation\n\nExclusion Criteria:\n\nCoexisting severe cardiac, hepatic or renal failure (NYHA Class III-IV) Active pulmonary infection (e.g. pneumonia or lung abscess) Significant coagulation disorders Receipt of any cytokine-based therapy within the past 3 months Participation in another interventional clinical study within the past 3 months","ALL",{"count":18,"type":19},1000,"ESTIMATED","OBSERVATIONAL","Acute respiratory distress syndrome (ARDS) is a serious lung condition in which fluid builds up in the air sacs, making it hard to breathe and often requiring intensive care. Older adults fare worse because their lung-lining cells lose the ability to heal properly after injury This study will explore two key molecules-RSPO3 and Syndecan-1 (SDC-1)-that normally help alveolar (air-sac) cells regenerate. We will collect small blood samples from ARDS patients and, when patients undergo elective lung surgery, tiny pieces of healthy lung tissue. In the lab, we will also grow three-dimensional \"lung organoids\" from these samples to see how boosting or blocking RSPO3\u002FSDC-1 affects cell repair\n\nOur goals are to:\n\nMeasure RSPO3\u002FSDC-1 activity alongside inflammatory markers (e.g., IL-6, TNF-α) to understand their roles in age-related repair failure.\n\nBuild an integrated platform for early diagnosis, disease monitoring, and treatment evaluation in older ARDS patients.\n\nIdentify molecular targets that could lead to new therapies, helping older adults recover lung function more effectively.",[23,24],"Acute Respiratory Distress Syndrome (ARDS)","Age-related Impaired Alveolar Epithelial Repair","NOT_YET_RECRUITING","2025-08-12",{"date":28,"type":29},"2025-08-19","ACTUAL",{"date":31,"type":19},"2025-09-01",{"date":33,"type":19},"2029-12-30",{"name":35,"class":36},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine","OTHER"]